흉부결핵의 외과적 치료

이정상 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery Vol.32 No.2

Background: The author studied to define the current indications for surgical management of chest tuberculosis and to analyze the results of the operative procedures. Material and Method: The records of 87 patients among 107 patients operated on between January 1992 and May 1995 were reviewed. These patients were divided into 4 groups. Group I patients (n=45) underwent decortication with or without wedge resection of the lesion. Group II patients(n=23) underwent radical curettages of chest wall involving rib caries with or without thoracotomy. Group III patients(n=12) underwent standard pneumonectomy or pleuropneumonectomy. Group IV patients(n=7) underwent exploratory thoracotomy or wedge resection of tuberculous lung lesion. Result: Statistical analysis revealed an inverse correlation between AIs and intratumoral microvessel densities in squamous cell lung carcinoma(Spearman rank correlation coefficient r=- 0.229, p=0.047). Conclusion: The author concludes that surgery for chest tuberculosis is the definite management for therapeutic indications and surgical radication of tuberculous carriers for management of chest tuberculosis is safe and has satisfactory results.

Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice

이정상,Hyun Soo Kim,Ki Baik Hahm,서영준 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.1

COX-2 has been inappropriately overexpressed in various human malignancies, and is considered as one of the representative targets for the chemoprevention of inflammation-associated cancer. In order to assess the role of COX-2 in colitis-induced carcinogenesis, the selective COX-2 inhibitor celecoxib and COX-2 null mice were exploited in an azoxymethane (AOM)-initiated and dextran sulfate sodium (DSS)-promoted murine colon carcinogenesis model. The administration of 2% DSS in drinking water for 1 week after a single intraperitoneal injection of AOM produced colorectal adenomas in 83% of mice, whereas only 27% of mice given AOM alone developed tumors. Oral administration of celecoxib significantly lowered the incidence as well as the multiplicity of colon tumors. The expression of COX-2 and inducible nitric oxide synthase (iNOS) was upregulated in the colon tissues of mice treated with AOM and DSS, and this was inhibited by celecoxib administration. Likewise, celecoxib treatment abrogated the DNA binding of NF-κB, a key transcription factor responsible for regulating expression of aforementioned pro-inflammatory enzymes, which was associated with suppression of IκBα degradation. In the COX-2 null ( COX-2 –/–) mice, there was about 30% reduction in the incidence of colon tumors, and the tumor multiplicity was also markedly reduced (7.7 ± 2.5 vs. 2.43 ± 1.4, P < 0.01). As both pharmacologic inhibition and genetic ablation of COX-2 gene could not completely suppress colon tumor formation following treatment with AOM and DSS, it is speculated that other pro-inflammatory mediators, including COX-1 and iNOS, should be additionally targeted to prevent inflammation-associated colon carcinogenesis. Key Words Chemoprevention, Celecoxib, Colitis, Colon cancer, COX-2

구치소 재소자의 자아존중감 및 대인관계 향상을 위한 집단상담 프로그램의 효과

이정상,김현아 한국상담학회 2011 상담학연구 Vol.12 No.5

This study tried to verify the effect of the group counseling program for jail inmates. The group counseling program was developed to improve inmates' self-esteem and interpersonal relationship. Inmates of jail in C City were randomly composed for treatment group(n=18) and control group(n=11). Treatment group were treated with group counseling program and control group did not receive nay treatment. The group counseling program is composed of 10 sessions in total and it takes about 20 hours as a total each session. Rosenberg's(1965) Self-esteem scale and Schlein, Guermey & Stover's(1971) Relationship Change Scale for inmate of jail was used to measure pre, post and follow-up(4 weeks) treatment level of self-esteem and interpersonal relationship. Schlein, Guermey & Stover's scale was composed of seven factors: satisfaction, communication, confidence, intimacy, sensitivity, openness, and appreciation. The statistical analysis of t-test, ANCOVA, repeated ANOVA, were used. This analysis was done in order to find the factors that affected the self-esteem and interpersonal relationship. The study's result first showed that the level of self-esteem in the experimental group was not more improved than the control group. Second, the level of interpersonal relationship in the experimental group was more increased than the control group. Third improved self-esteem and interpersonal relationship were kept up after 4 weeks. Finally, Implication and limitation of study are discussed. 본 연구에서는 구치소 재소자를 대상으로 한 집단상담 프로그램이 자아존중감 및 대인관계에 미치는 효과를 평가해 보고자하였다. 2009년 3월-6월까지 C지역 ** 구치소 재소자를 대상으로 1주일에 1회 총 10회 두 시간씩 총 20시간의 구조화된 집단상담 프로그램을 실시하였다. 실험집단의 연구대상자는 자발적 참여와 추천에 의하였고, 통제집단의 경우 무선 표집 하였으며 실험집단 18명, 통제집단 11명이었다. 종속변인은 Rosenberg (1965)의 자아존중감 척도와 Schlein, Guermey와 Stover(1971)의 대인관계 변화 척도를 사용하였고, 실험처치(실험집단, 통제집단)와 측정시기(사전, 사후)에 따른 차이를 알아보기 위해 사전검사를 공변인으로 공변량분석(ANCOVA)을 하였다. 또한 집단상담 프로그램의 효과가 장기간 유지되는 지 알아보기 위한 추후연구에서는 실험집단에 대한 측정시기(사전, 사후, 추후)의 차이를 보기 위해 반복측정 분산분석을 실시하였다. 연구결과 재소자를 위한 집단상담 프로그램은 자아존중감에 있어서 사후검사 시에는 통계적으로 유의한 효과가 없었지만 추후 연구에서 지속적인 상승을 보였고, 대인관계는 통계적으로 유의한 효과가 있었으며 대인관계 하위 요인 중 대인관계 만족감과 이해성에 효과가 있었다. 실험집단에 대한 4주 후 추후연구에 있어서도 대인관계 향상이 효과적으로 유지되고 있는 것으로 나타났다. 마지막으로 본 연구결과의 활용방안, 연구 의의 및 후속연구에 대한 제안을 하였다.

혈액투석

이정상 대한의학협회 1979 대한의학협회지 Vol.22 No.3

응급환자에서의 수액요법

이정상 한국의학사 1986 診斷과治療 Vol.6 No.8

신장질환의 개요

이정상 한국만성질환관리협회 1986 월간성인병 Vol.64 No.-

회원사 소개: 문화방송 자료실

이정상 한국조사기자협회 1997 조사연구 Vol.10 No.-

비정상/비압축 Navier-Stokes 방정식을 이용한 2차원 곤충날개 운동의 수치적 연구

이정상,김종암 한국산업응용수학회 2006 한국산업응용수학회 학술대회 논문집 Vol.1 No.1

곤충 날개의 2차원적 운동인 “8자 운동”을 전산유체역학으로 해석하였다. 날개 운동의 모델은 Nachtigall[1]이 검정금파리(phormia regina)에 대한 tethered flight 실험에서 얻은 결과를 이용하였다. 곤충 날개 주위의 유동은 와류의 복잡한 거동과 같은 비정상(unsteady)적인 특성을 지니며 또한 유동의 속도로 음속에 비해 매우 낮기 때문에 지배방정식은 비정상/비압축성 NAvier-Stokes 방정식을 이용하였다. 날개 운동의 궤적은 Fourier 급수로 나타낼 수 있다. 해석 결과 나타난 유동장에서는 매우 복잡한 와류들이 보여지며, 이는 양력과 추력의 발생에 있어 물리적으로 비정상적인 메커니즘을 제공한다는 사실을 알 수 있었다. 특히 upstroke의 마지막에서 발생되는 추력의 갑작스러운 생성은 순환(circulation)과 밀접한 연관이 있을 것으로 보여진다.

韓國學生들의 政治的 關心과 그 參與

李晶相 이화여자대학교 문리과대학 사회학과 사회학회 1963 社會學硏究 Vol.- No.2

재발성 자연 기흉에 대한 정중액과 개흉술과 비디오 흉강경수술의 비교연구

이정상 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery Vol.32 No.1

Background: Although treatment of spontaneous pneumothorax by video-assisted thoracic surgery(VATS) has generally shown better clinical results than conventional thoracotomy, treatment of spontaneous pneumothorax by midaxillary thoracotomy(MAXT) has also shown good clinical results. The author studied to compare the clinical results of MAXT group I and VATS group II. Material and Method : Group I included 30 midaxillary thoracotomy among 83 operative cases of spontaneous pneumothorax from Jan. 1992 to Dec. 1993. Group II included 30 VATS among 101 operative cases of pneumothorax from Jan. 1994 to Aug. 1995. The author selected the 30 patients, age 18 to 25 years, with recurrent spontaneous pneumothorax in each group. The author analyzed the operative indication, gender, operating time, amounts of the used staplers, tube drainage, total amounts of analgesics used during postoperative 24hr, tube stay time, postoperative complications and mortality. Result: The follow-up periods of both procedures were from 6 to 43 months. The operating time from start of skin incision to end of skin closure was 84.79${\pm}$21.70(from 40 to 150) minutes in MAXT group I and 108.8${\pm}$42.02(from 58 to 120) minutes in VATS group II(P<0.001). The numbers of the used staples useo was 1.31${\pm}$0.6(from 0 to 3) in group I and 3.41${\pm}$2.37(from 0 to 11) in group II. The amounts of postoperative 24hour tube drainage were 220.76${\pm}$106.73(from 65 to 400) ml in group I and 260.63${\pm}$233.18(from 70 to 320) in group II(P>0.05). The amounts of postoperative 24 hourly used analgesics(Tarasyn ) was 1.38${\pm}$1.32(from 0 to 5) amples in group I and 0.72${\pm}$1.02(from 0 to 4) amples in group II (P<0.05). The postoperative tube stay is 5.45${\pm}$30.9 (from 3 to 7) days in group I and 4.75${\pm}$3.1(9 from 2 to 14) days in group II(P>0.05). The number of complications after operations was 2 cases of prolonged air leakage in group I, and in group II. (P is not significant). The number of recurrence after the operation was one in group I and also one in group II(P is not significant). In conclusion, there were no statistical differences in the postoperative 24 hour chest tube drainage, days of postoperative tube stay, postoperative complications and recurrence in the analysis between group I and group II. Conclusion: The author found that group II of VATS between 18 years and 25 years of age in recurrent spontaneous pneumothorax, statistically, requires longer operative time, more number of autosuture staples and less postoperative analgesic dosage than the midaxillary thoracotomy group I.