한국 성인에서 악력감소가 망막 정맥 폐쇄에 미치는 영향: 인구기반 연구

정규철,이지웅,김은아 한국망막학회 2025 Journal of Retina Vol.10 No.1

Purpose: This study investigates whether diminished handgrip strength, potentially indicative of sarcopenia, serves as an independent risk factor for retinal vein occlusion (RVO) in non-obese adults in South Korea. Methods: In this nationwide cross-sectional study, adults aged ≥40 years from the 2017–2019 Korea National Health and Nutrition Examination Survey were included if they had recorded measurements of height, weight, handgrip strength, and at least one gradable fundus photograph. Those with a history of cerebrovascular disease with any sequelae or who were pregnant were excluded. Odds ratios for RVO were calculated using stepwise multivariate regression, comparing non-obese individuals with diminished handgrip strength, obese individuals with preserved handgrip strength, and obese individuals with diminished handgrip strength, using non-obese individuals with preserved handgrip strength as the reference group. Covariates included age, sex, comorbidities, physical activity, and smoking history. Results: A total of 10,950 individuals were included. The estimated prevalences of RVO and diminished handgrip strength were 0.6% and 9.7%, respectively. Multivariate analysis revealed that non-obese individuals with diminished handgrip strength had a 4.6-fold higher risk of RVO compared to non-obese individuals with preserved handgrip strength. Obese individuals with preserved handgrip strength exhibited a 2-fold increased risk, while no significant association was found between RVO risk and having both obesity and diminished handgrip strength. Additionally, lack of high-intensity physical activity was associated with a 13.2-fold higher risk in the multivariate analysis. Conclusions: Diminished handgrip strength may be independently associated with an increased risk of RVO, particularly in non-obese individuals. These findings underscore the importance of considering “possible sarcopenia” as an independent risk factor for RVO, especially in non-obese populations in South Korea.

연 흡수에 의한 δ-aminolevulinic acid 탈수효소 활성치의 변동

정규철,장임원 중앙대학교 의과대학 의과학연구소 1975 中央醫大誌 Vol.1 No.1

This study was conducted in an attempt to clarify the interrelationship among blood lead level, erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) activity and urinary δ-aminolevulinic acid (δ-ALA) excretion as an indication of lead absorption in lead workers in Korea. Blood lead level, δ-ALAD activity and urinary δ-ALA excretion were measured with samples obtained from 37 lead workers and 33 non-lead workers (coal miners) as a control group. Analytical methods used for this study were atomic spectrophotometric method using Jarrel-Ash 82-500 atomic absorption spectrophotometer (Fisher Scientific Co.) by Hessel's method (1968) for blood lead level, Bonsignore's method modified by Weissberg (1971) for erythrocyte δ-ALAD activity, and Mauzerall and Granick's method modified by Wada et al (1969) for urinary δ-ALA excretion. Erythrocyte δ-ALAD activity in relation to blood lead level and urinary δ-ALA excretion was discussed as a measure of lead absorption. The following results were obtained: 1. There was no difference in blood lead level among workers of different age groups, and on the other hand, there was a definite tendency of increase in blood lead level with duration of working years at lead workplaces. 2. Mean erythrocyte δ-ALAD activity was 70.9±12.00 units for the non-lead workers and the value decreased sharply to 45.6±14.25 units and to 19.6±9.00 units as the blood lead levels increased to 10-19 ㎍% and 20-39 ㎍%, respectively. The rate of decrease of the erythrocyte δ-ALAD activity was lessened when the blood lead level increased higher than 40 ㎍%. 3. Mean urinary δ-ALA excretion amounted to 2.6±1.36 ㎎/g creatinine on an average in non-lead workers, and increased proportionally with blood lead level showing linear regressional relationship of urinary δ-ALA excretion (Y: ㎎/g creatinine) on blood lead level (X: ㎍%) expressed by equation: Y=0.3627 X-0.3974 (r=0.8853). 4. Regressional relationship of erythrocyte δ-ALAD activity (Y: unit) on blood lead level (X: ㎍%) was expressed by the equation log Y=log226-0.689 logX (r=-0.8257), and that of erythrocyte δ-ALAD activity (Y: unit) on urinary δ-ALA excretion (X: ㎎/g creatinine) by logY=log109-0.728 logX (r=-0.7003).

서울시내 국민학교 아동의 호기속도-용량곡선

정규철,이정희 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.2

Maximal expiratory flow rates: PEFR, PEF25%, FEF50%, FEF75%, FEF25-75% were measured on 378 primary school children aged from 5 to 12 years in Seoul (183 males and 195 females) using Collins Survery Spirometer with Eagle One Microprocessor (Warren E. Collins, Inc,, U.S.A.). Mean values of PEFR and FEF25-75% were 4.66±0.99 and 2.61±0.59 1/sec for males and 3.98±1.00 and 2.54±0.64 1/sec for females showing at FEF25-75% amounted to approximately 60% of PEFR. Mean values of FEF25%, FEF50%, and FEF75% were gradually decreased in order in both sexes. Variability of the maximal expiratory flow rates was quite big in all measurements: indicating 20% in males and 25% in females for PEFR, FEF50% and FEF25-75%, and about 30% in both sexes for FEF75%. Maximal expiratory flow rates were closely correlated with age and physical growth, especially stature. Simple regression equations of maximal expiratory flow rates on stature and multiple regression equations on age and physical growth were derived for both sexes. These equations were proved to be valid in predicting maximal expiratory flow rates of primary school children.

흡연이 건강에 미치는 영향

정규철,Chung, K.C. 대한예방의학회 1980 Journal of Preventive Medicine and Public Health Vol.13 No.1

흡연이 건강에 미치는 영향

정규철 한국만성질환관리협회 1981 월간성인병 Vol.11 No.-

CO 중독과 그 증상

정규철 중앙대부설한국의과학연구소 1969 한국의과학 Vol.1 No.11

산업의학에서 본 눈의 장해

정규철 중앙대부설한국의과학연구소 1971 한국의과학 Vol.3 No.2

공해의 보건상위해와 그 영향

정규철 대한의학협회 1970 대한의학협회지 Vol.13 No.12

서울시(市) 대기오염(大氣汚染)이 시민보건(市民保健)에 미치는 영향(影響)에 관(關)한 조사연구(調査硏究)

정규철,Chung, Kyou-Chull 대한예방의학회 1969 Journal of Preventive Medicine and Public Health Vol.2 No.1

The urban population of our country is rapidly increasing due to many factors of social structure, and sociologists are predicting that the increase rate of the urban population will be over 50% in 1980's. Above all, the population of the capital city of Seoul, is at present more than four millions. Such centring of people in cities, together with the improvement of the standards of living, caused rapid increase in the amount of fuel consumption, and this consumption of fuels became one of the primary sources of the air pollution in cities. Moreover, the heavy traffic, construction of many tall buildings, and the increasing number of new factories due to the industrial development-all these are contributing to make the matter of air pollution worse and worse in the Metropolitan, whose geographical location is quite unfavorable considered from the view point of air pollution. Most homes in Seoul use briquet as fuel, while oils are used in tall buildings. The CO, $SO_2$, and smoke that come from burning of these fuels are a great threat to the health of the urban population. With the purpose of examining the influence of air pollution upon the public health, written inquiries were made upon respiratory diseases, and the carboxyhemoglobin saturation in the blood was measured to determine whether the air pollution may affect the health of the urban population. Method of Health Examination (1) Investigation of Respiratory Diseases Patients' records were examined to figure out the monthly ambulance rate of respiratory patients to the total number of patients treated. On the other hand, by using the questionnaire form approved by the Medical Research Council's Committee on Research into Chronic Bronchitis, investigators interviewed the examinees and inquired into the respiratory symptoms. (2) Measuring of Carboxyhemoglobin Saturation From the ear lobe of the examinees, with the use of the melangeur for the white blood cell counting, blood was taken, and after diluting it ten times with 0.1% $Na{2}CO_{3}$, again diulting it 20 times with 0.5% $Na_{2}\;CO_{3}$, its absorbancy was measured. The following results are obtained from the investigation. (1) It was found out that 7.7% of the total patients under treatment were suffering from upper respiratory infection, acute or chronic bronchitis, bronchial asthma, pulmonary emphysema and bronchiectasis. Of them all, patients with upper respiratory infection numbered the greatest with 4.8% and patients with acute or chronic bronchitis the next with 2.1%, and their monthly ambulance rate was high from December to February during the winter, and from April to May and from September to October during the changeable seasons. (2) The daily ambulance rate of respiratory patients, it was revealed, had a close connection with the concentration of $SO_2$ and CO in the air. (3) It was found out that men were more subject to respiratory disease than women, and both men and women were more liable to the diseases with the advancing of age. (4) People living at Choong-ku with the heavy traffic and in the industrial zones of Yeungdungpo had high frequency of respiratory symptoms. (5) Considered from the view point of occupations, high frequency was found among those without job, with jobs unknown, merchants and intdustrial workers, whose social status was rather low and traffic policemen who were always exposed to the exhaust gas of cars. As for women, the frequency was detected in the order of those from high to low, housewives who were exposed to briquet gas, women with jobs unknown, women without jobs, whose social status was low. (6) Ex-smokers rather than smokers, of both sexes, had higher frequency. As for men, heavy smokers had high frequency, while in women light smokers had rather high frequency which was presumed to be due to their average old age. (7) Men's average of carboxyhemoglobin saturation was 9.48%, while women's was 11.3%, higher than men's. (

구미 각국의 대기오염과 그 관리실태

정규철 대한의학협회 1971 대한의학협회지 Vol.14 No.10