한국형출혈열 (韓國型出血熱)

이명철(李明哲), 조경삼(趙京杉), 양경호(梁涇鎬), 박성대(朴成大) 대한바이러스학회 1979 Journal of Bacteriology and Virology Vol.9 No.1

관절경을 이용한 족관절의 골연골병변의 치료

이명철,성상철,강승백 대한슬관절학회 1993 대한슬관절학회지 Vol.5 No.1

Over the past few years the arthroscope has played a major role in the evaluation and treatment of the chondral and osteochondral lesions of ankle joint. But its technique is very difficult and require considerable expertise with instrument. We reviewed 10 ankles in 10 patients who underwent arthroscopic treatment of the osteochondral lesion of ankle at Seoul National University Hospital from 1986 to 1991. The mean age at the time of surgery was 30 years (reange,16 to 49 years). There were eight males and two females, All patients had history of trauma and conservative treatment under the diagnosis of ankle sprain. The mean follow-up was 2 years and 9 months (range, 1 year and 2 months to 6 years and 7 months). Preoperative diagnosis were osteochondritis dissecans in 7 ankles, loose osteochondral body in one and degenerative arthritis in two through CT or MRI. Arthroscopic diagnosis were osteochondritis dissecans with crater and loose body in 6 ankles, loose osteochondral body with no osteochondral defect in one and posttraumatic degenerative arthritis in three. Six ankles with crater and loose body were treated with arthrosopic abrasion and loose body removal. One aknle with loose osteochondral body was treated with loose body removal and 3 ankles with degenerative arthritis were treated with resection of body spur and osteochondral ridge. At last follow up, 8 ankles showed excellent and two showed good result. Postoperatively one patient complained transient dorsal numbness and there were no permanent complications. Arthroscope would play a definite role in the diagnosis and treatment of the osteochondral lesions of ankle.

앞으로 한국고분자학회의 더욱 큰 발전을 기대

이명철 한국고분자학회 2016 고분자 과학과 기술 Vol.27 No.5

F-18-FDG PET을 이용한 유방종괴의 감별진단과 유방암의 병기설정

이명철,이동수,정준기,노동영,강건욱,여정석 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.6

Purpose: F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been proven to be useful in the differential diagnosis of breast mass and staging of breast cancer. This study assessed the diagnostic accuracy of F-18-FDG PET in the differentiation of breast mass and staging of breast cancer. Materials and Methods: Total 42 patients who had breast mass underwent F-18-FDG PET (all female, 40±10 year old). We compared F-18 FDG PET results with pathologic findings in 24 patients Results: In the differentiation of breast mass, sensitivity and specificity were 95% (19/20) and 77% (7/9) respectively. Three false positive cases were due to inflammation and one false negative patient had small tumor less than 1 cm. In the assessment of axillary lymph node status, sensitivity and specificity were 73% (8/11) and 100% (7/7) respectively. We found distant metastasis that were not suspected before F-18-FDG PET in 2 patients. Conclusion: F-18-FDG PET shows good diagnostic performance in differentiation of breat mass and staging of breast cancer.

국산 항 CEA 항체의 I - 131 , Tc - 99m 표지법 확립 및 면역학적 특성 분석

이명철,최석례,정홍근,정준호,고창순,이동수,정준기,홍미경,서일택 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2

Caneer cells have several tumor-associated antigens on the cell surfaces, and antibodies against these antigens have been developed by many investigators. Radiolabeled antibodies have been used as new methods to diagnose and treat malignant tumors. Especially anti- carcinoembryonic antigen (CEA) is the most popular antibody for these purposes. In this investigation, we tried to label (131)^I and Tc-99m to anti-CEA monoclonal antibodies which were developed in the Seoul National University College of Medicine. We found CEA-79 and CEA-92 antibodies had the better immunological characteristics among 8 anti-CEA monoclonal antibodies. And radioiodination of CEA-79 could be performed by chloramine-T method, while radioiodination of CEA-92 by iodogen method. To label these antibodies with Tc-99m, we used pretargeting transchelation as direct labeling method. At first, Tc-99m was bound to glucaric acid, and monoclonal antibody was reduced by β-mercaptoethanol. When these were incubated together, Tc -99m bound to glucarte was switched to monoclonal antibody because of higher affinity. We established conditions of several steps in this method. Anti-CEA monoclonal antibodies labeled with (131)^I and Tc-99m are expected to be used valuably in the detection and treatment of malignant tumors.

유방암에서 포도당운반체(GLUT-1) 발현정도와 양전자단층촬영시 F-18-FDG 섭취와의 관계

이명철,이용진,장자준,이동수,정준기,노동영,정재민,여정석,천기정,김보광 대한암학회 2000 Cancer Research and Treatment Vol.32 No.6

Purpose: Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has been proven to be useful in the detection of breast cancer. However, the degree of FDG uptake was variable. In this study, we evaluated the relationship between glucose transporter-1 (GLUT-1) expression with the FDG uptake in patients with breast cancer. Materials and Methods: l5 patients with proven breast cancer underwent F-18-FDG PET. After surgical resection, anti-GLUT-1 immunohistochemical staining was performed in tumor tissues to measure the GLUT-1 expression. We evaluated the correlation between semi-quantitative FDG uptake by standardized uptake value (SUV) and GLUT-1 expression. Results: In total 15 patients, there was no significant correlation between SUV and GLUT-1 expression. We separated the patients into two groups according to the tumor size. In the group of large tumor (short diameter $gt;2 cm), there was no significant correlation. However, in the group of small tumor (short diameter $lt; 2 cm), there was a significant correlation between the FDG uptake and GLUT-1 expression (rho=0.812, p=0.047). Conclusion: GLUT-1 expression can influence the FDG uptake in the small breast cancers. For large breast cancers, other factors as well as GLUT-1 expression may influence the FDG uptake.

폐로 전이된 악성 Schwannoma

이명철,김상규 한국의학사 1991 診斷과治療 Vol.11 No.10

역 L형 절골술과 Liou 신연기를 이용한 넓은 치조열의 교정

이명철,유대현,박병윤,권순만 대한성형외과학회 2009 Archives of Plastic Surgery Vol.36 No.4

Purpose: A successful surgical treatment for a wide alveolar cleft with bone graft is difficult to achieve due to several factors such as the limitation of gingivoperiosteal flap, the presence of large scar tissues, and the poor blood circulation. To overcome these problems, alveolar distraction osteogenesis using Liou alveolar distraction device was applied. We analyzed the consequences of this surgical treatment. Method: Between 2006 January and 2007 August, we have conducted analysis on the methods and consequences of Liou alveolar distraction osteogenesis for 6 patients. The age of patients was 12 years and 6 months in average. The follow up period was 19 months in average. The Reverse L osteotomy followed by the placement of the Liou alveolar distraction device was performed. After serial distraction, the distractor was removed after 5 months of the process of osteogenesis, and the result was analyzed using the computed tomography and the x-ray films of the alveolar bone and the teeth. Results: The alveolar cleft with 12.5 ㎜ in average width was filled with 8.5 ㎜ of newly formed bone tissue in average width after 5 months of osteogenesis. Among the 6 cases, 5 required the additional bone graft and 1 case only required the gingivoperioplasty. The newly formed bone tissues did not show any signs of bone resorption. However, a considerable degree of teeth displacement was shown. Conclusion: For the alveolar cleft too wide to be reconstructed by a general bone graft, it is strongly recommended to perform the reverse L osteotomy of the cleft side with Liou alveolar distraction device to initiate the alveolar osteogenesis. However, the migrated teeth showed some degree of relapse, thus, the orthodontic treatment is essential following the distraction osteogenesis treatment. Purpose: A successful surgical treatment for a wide alveolar cleft with bone graft is difficult to achieve due to several factors such as the limitation of gingivoperiosteal flap, the presence of large scar tissues, and the poor blood circulation. To overcome these problems, alveolar distraction osteogenesis using Liou alveolar distraction device was applied. We analyzed the consequences of this surgical treatment. Method: Between 2006 January and 2007 August, we have conducted analysis on the methods and consequences of Liou alveolar distraction osteogenesis for 6 patients. The age of patients was 12 years and 6 months in average. The follow up period was 19 months in average. The Reverse L osteotomy followed by the placement of the Liou alveolar distraction device was performed. After serial distraction, the distractor was removed after 5 months of the process of osteogenesis, and the result was analyzed using the computed tomography and the x-ray films of the alveolar bone and the teeth. Results: The alveolar cleft with 12.5 ㎜ in average width was filled with 8.5 ㎜ of newly formed bone tissue in average width after 5 months of osteogenesis. Among the 6 cases, 5 required the additional bone graft and 1 case only required the gingivoperioplasty. The newly formed bone tissues did not show any signs of bone resorption. However, a considerable degree of teeth displacement was shown. Conclusion: For the alveolar cleft too wide to be reconstructed by a general bone graft, it is strongly recommended to perform the reverse L osteotomy of the cleft side with Liou alveolar distraction device to initiate the alveolar osteogenesis. However, the migrated teeth showed some degree of relapse, thus, the orthodontic treatment is essential following the distraction osteogenesis treatment.

게이트 Tc-99m-MIBI SPECT 와 Cedars 소프트웨어를 이용한 심근 기능 측정의 재현성

이명철,안지영,이동수,정준기,천기정 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.5

Purpose: We investigated reproducibility of the quantification of left ventricular volume and ejection fraction, and grading of myocardial wall motion and systolic thickening when we used gated myocardial SPECT and Cedars quantification software. Materials and Nethods: We performed gated myocardial SPECT in 33 consecutive patients twice in the same position after Tc-99m-MIBI SPECT. We used 16 frames per cycle for the gatingof sequential Tc-99m-MTBI SPECT. After reconstruction, we used Cedars quantitative gated SPECT and calculated ventricular volume and ejection fraction (EF), Wall motion was graded using 5 point score. Wall thickening was graded using 4 point score. Coefficient of variation for re-examination of volume and fraction were calculated. Kappa values (k-value) for assessing reproducibility of wall motion or wall thickening were calculated. Results: Enddiastolic volumes (EDV) ranged from 58 mi to 248 ml (122 ml +/- 42 ml), endsystolic volumes (ESV) from 20 mi to 174 mi (65 ml +1- 39 ml), and EF from 20% to 68% (51% +/- 14%). Geometric mean of standard deviations of 33 patients was 5.0 ml for EDV, 3.9 ml for ESV and 1.9% for EF. Their average differences were not different from zero (p>0.05). k-value for wall motion using 2 consecutive images was 0.76 (confidence interval: 0.71-0.81). k-value was 0.87 (confidence interval:0.83-0.90) for assessment of wall thickening. Conclusion: We concluded that quantification of functional indices, assessment of wall motion and wall thickening using gated Tc-99m-MIBI SPECT was reproducible and we could use this method for the evaluation of short-acting drug effect.

해양 스포츠 발전을 위한 중요 쟁점 요인 분석

이명철,윤양진 釜山大學校 附設 體育科學硏究所 2014 體育科學硏究所 論文集 Vol.31 No.-

This study's purpose is analyzing the pending issue and main issue of marine sporting world. In this study, the question investigation was conducted to 50 people who had been selected from marine sports experts(research expert, association administrator, staff) population by having target sampling. First, all the research participants choose the order of priority like this; 1st, financeguarantee, 2nd, abouttheleader, 3rd, educational institution, 4th, abouttheinstitution, 5th, aboutthelawandsystem. Second, each parts of marine sports specialist choose the order of priority little bit differently; researchspecialistchoose 1st, finance guarantee, 2nd, abouttheleader, associationadministratorchoose 1st, finance guarantee, 2nd, about the institution, workerchoose 1st, about the leader, 2nd, financeguarantee. Third, for the details of top 3 of research participants order of priority is that for about the leader is 1st, treatment, 2nd, specialeducationalprogram, for about the finance guarantee is 1st, support of city executive, 2nd, support of an athletic as sociation and each events association, for about the institution is 1st, number of possession of equipment ,2nd, lack of space per number of user. 본 연구는 해양스포츠계가 안고 있는 현안 문제점과 쟁점화 되고 있는 사안 중 중요 쟁점요인을 분석하는데 목적을 두고 해양스포츠 전문가(연구전문가, 협회행정가, 종사자)를 모집단으로 설정하여 유목적적표집법을 이용하여 50명을 선정, 설문조사를 실시하였다. 자료분석은 SPSS/PC 21.0 Windows Program의 기술통계를 이용하여 해양스포츠전문가들이 선택한 중요 쟁점요인에 대한 우선순위를 분석하여 다음과 같은 결론을 얻었다. 첫째, 연구참여자 전체가 선택한 우선순위에서 1순위 재정확보, 2순위 지도자관련, 3순위 교육기관, 4순위 시설관련, 5순위 법·제도관련 등의 순으로 나타났다. 둘째, 해양스포츠 전문가의 위치에 따른 우선순위에서 연구전문가가 선택한 우선순위에서 1순위 재정확보, 2순위 지도자관련, 협회행정가는 1순위 재정확보, 2순위 시설관련, 종사자가 선택한 우선순위에서 1순위 지도자관련, 2순위 재정확보로 나타났다. 셋째, 연구참여자의 상위 3순위에 대한 세부내용으로 지도자관련 요인에 대한 세부내용 우선순위는 1순위 처우, 2순위 전문적 교육프로그램 지원, 재정지원 요인의 세부내용 우선순위는 1순위 시도행정의 지원, 2순위 체육회 및 각 종목별 협회의 지원, 시설관련 요인에 대한 세부내용 우선순위는 1순위 장비보유 수, 2순위 사용인원 대비 공간부족에 관한 순으로 나타났다.