방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

대형물의 RP 작업을 위한 절단 알고리즘의 개발

채희창,강희용,유상훈,이승현,문홍렬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.2

Nowadays, as the development period of new products becomes shorter and consumer's requirement is more various, the importance of Rapid Prototyping Technology has been rapidly increased. Rapid Prototyping makes prototypes or functional parts directly using the 3D CAD data. But RP machines can make protypes in limit size. For making large size prototype, we slice solid, which is made of STL file, and then glue sliced solid. And if contact area of part is small, union solid will be easily destroyed for going down of adhesion. So we need to expand contact area, I suggest making a section into stair shape. This paper is concerned with slicing solid on STL file and improving on adhesion.

扶正解毒湯의 抗癌活性과 免疫調節作用에 관한 硏究

朴相采,宋昊哲,金東熙,徐榮培,朴陽春,金聖勳 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

To evaluate the antitumm activity and immune rsponse of Bujunghoedo!aaCtnng(BJHDn, studies were done experimentally. The rsulLF were OMaineed as fallow: 1. BJHDT e m c b erhibitcd a wmk eytotoxieity against SKOV-3, and SK-MELJ cell lines, while it showed a good effectivaes against BlE-FIO up to 80% of control at concenmion of over 0.25mg/ml 2. BJHDT emcG signifimtly showed an inhibitor, effect on DNA topowmewz I from calf thpw at 500 mglmf. 3. BJHDT eXhaetS showed antiadhesive rates against A549, 30% at 0.5 dm!, 80% at 1 mplm!. 4. BJHDT exmcb inhibited CAM angiogenesis up to 40%. 6. BIHDT extracb prolonged life span of ICR mice bearing S-180 sarcoma cells up to 127.1%. 7. In FACS analysis, the population of helper T cell and tended to increase. 8. Pmliferatbn rate of splenoeyte WBS inneased at 0.5mglml or more in a dase dependent fashim as compared with Control. These resulb suggested that BIHDT exham might k usefully applied for treatment of cancer and also it was necessary m do more studies about its mechanisms.

골다공성 척추 압박골절 환자에 대한 경피적 척추체성형술 : 최근 2년간 경험 Recent 2-year Experience

김상대,박정율,김세훈,서중근,이태수,채수원 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objective: To describe the therapeutic outcome of percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures(OVCF) in recent years with review of literature. Methods: The authors have retrospectively reviewed a consecutive group of patients who underwent percutaneous vertebroplasty in our institution between May 2000 and October 2002. The procedures were performed with Jamshidi needle via transpedicular approach followed by injection of polymethyl- methacrylate(PMMA) into the involved vertebral bodies. Prolo's economic and functional rating scale was used for therapeutic outcome assessments. Results: There were 91 patients(69 female, 22 male) with OVCF, with involvement of 147 vertebral bodies. The mean age was 72 years. The average BMD t-score was -3.78, indicative of severe osteoporosis. Minimal follow-up period was three months. And among these patients, 82.5% of patients were maintained over good condition. Extrusion of PMMA cement beyond the confines of the vertebral body was obseved in 13 cases(8.8%). Although most of them improved with conservative treatments without morbidities, two developed serious complications, one being pulmonary embolism and the other paraparesis. Conclusion: Percutaneous vertebroplasty is one of the effective minimal invasive treatment modalities in OVCF. However, proper biomechanical studies supporting these procedures are not fully evidenced. Serious complications, although rare, should be prevented with the aid of improved techniques and newer biocompatible materials along with better understanding of biodynamic and biomechanical impact on normal and already compromised vertebraes.

점박이응애에 대한 몇가지 살비제의 방제 효과

김상수,백채훈,유상선 順天大學校 1998 論文集 Vol.17 No.1

점박이응애에 대한 몇가지 살비제의 약효를 검정한 결과, 실내시험에서 S-1283의 50, 100ppm과 hexythiazox는 난, 유충과 전약충 등의 발육태에는 매우 우수한 효과가 있었으나 성충태에 대해서는 상당히 낮은 약효를 나타내었다. S-1283+fenpropathrin, chlorfenapyr+flufenoxuron, azocyclotin과 tebufenpyrad는 점박이응애의 모든 태에 대하여 우수한 약효가 있었다. S-1283과 hexythiazox 처리에서 생존한 자성충들의 부화율은 큰 폭으로 감소되었으나, 산란수에 있어서는 유의차가 인정되지 않았다. 포는 S-1283과 S-1283+fenpropathrin의 약효가 가장 우수했으며, tebufenpyrad, chlorfenapyr+flufenoxuron, azocyclotin, 과 hexythiazox의 효과도 기대되었다. Acaricidal activity of some acaricides on twospotted spider mite, Tetranychus urticae, was evaluated in laboratory and field studies. In a laboratory study, S-1283 and hexythiazox were highly effective against immature stages, but ineffective to adults. S-1283+fenpropathrin, chlorfenapyr+flufenoxuron, azocyclotin, and tebufenpyrad were effective against all stages of T. urticae. In adult females treated with S-1283 and hexythiazox, we observed substantial reduction in egg hatchability but there was no significant difference on number of eggs laid. As a result of field study, S-1283 and S-1283+fenpropathrin were the most effective on mixed developmental stages of T. urticae, followed by tebufenpyrad, chlorfenapyr+flufenoxuron, azocyclotin, hexythiazox.

하악 이부확장 시 하악골 이동 양상과 응력 분포에 관한 삼차원 유한요소법적 연구

이도훈,홍현실,채종문,조진형,김상철 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.1

하악 이부확장에서 골 절단선의 위치 및 종류와 견인 장치의 종류에 따른 차이를 알아보고자 삼차원 유한요소법으로 하악골의 이동 양상 및 응력 분포를 조사하였다. 골 견인장치의 종류로는 치아 의존형과 골 의존형, 혼합형, 30˚ 기울여 위치한 치아 의존형의 4가지를, 골절단 위치와 방법으로 하악 중절치 간 수직절단과 하악 정중이부를 관통하는 계단식 골절단 등의 2가지를 설정하였다. 연구 결과, 골절단의 위치 및 방법과 견인장치의 종류에 관계없이 과두를 포함한 하악골의 모든 부위에서 외측방 변위를 보였으며 상하적이나 전후방적 변위는 적은 양이었으나 방향에 있어 군간에 차이를 보였다. 치아 의존형 장치에 의한 골절단면 이개 양태는 V형이었으나 골 의존형 장치는 역V형이고 혼합형 장치는 평행하게 확장되었다. 골 의존형 장치에 의한 하악각의 외측 변위량이 다른 장치에 비해 컸다. 30˚ 기울여 위치한 치아 의존형에서의 변위는 측방적, 전후방적 면에서 좌우 차이가 인정되었다. Objective: The objective of this study was to evaluate the displacement pattern and the stress distribution of the finite element model 3-D visualization during symphyseal widening according to the osteotomy position, osteotomy type, and distraction device. Methods: The kinds of distraction devices used were tooth-borne type, hybrid type, bone-borne type and tooth-borne type 30˚ angulated, and the kinds of osteotomy design were vertical osteotomy line between the central incisors and step osteotomy line through the symphysis. Results: All reference points of the mandible including the condyles were displaced laterally irrespective of the osteotomy position, osteotomy method and distraction device. The anteroposterior or vertical displacements showed small differences between the groups. The widening pattern of the osteotomy line in the tooth-borne type of device was v shaped, and that of bone-borne type was a reverse v shape. However, the pattern in the hybrid type was parallel. The lateral displacement of the mandibular angle by the bone-borne device was more remarkable than the other types of devices. The displacement by the 30˚ angulated tooth-borne type was different between the left and right sides in both the transverse and anteroposterior aspects. Conclusion: The design of the distraction devices and osteotomy line can influence the displacement pattern and the stress distribution during mandibular symphyseal distraction osteogenesis procedures.

부산지역 소방공무원의 폐기능과 호흡기증상

김성훈,김정원,,김종은,손병철,김정호,이창희,장상환,이채관 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 본 연구에서는 소방관 집단의 호흡기 증상과 폐기능을 조사하여 호흡기 질환의 유병 정도를 비교 분석함으로써 소방관의 호흡기 질환과 화재 노출과의 관련성을 규명하고자 하였다. 방법: 2004년 11월 13일부터 동년 12월 15일까지 부산 소재 4개 소방서와 부속 파출소의 남성 소방공무원 699명을 대상으로 폐기능 검사와 호흡기 설문조사를 실시하였다. 호흡기 증상 설문은 BMRC에서 개발한 설문조사표를 이용하였다. FVC, FEV_(1), MMEF 예측치는 Morris의 폐기능 예측식을 사용하여 계산하였고, 폐기능 검사 이상을 판정하기 위하여 미국 NHNES 기준에 따라 정하였다. 폐기능 측정치와 호흡기 증상은 노출유무와 흡연여부로 집단을 나누어 각각 비교분석하였다. 유의수준은 p<0.05로 정하였다. 결과: 폐기능 비교에서 화재노출군이 FVC, FVC%, FEV_(1), FEV_(1)%, FEF_(25%)는 비노출군에 비해 통계학적으로 유의하게 저하되어 있었고, 이를 흡연여부에 따라 층화하였을 때, FVC 와 FEV_(1)은 흡연여부와 관계없이 노출 여부에 따른 차이를 보이나 FVC%, FEV_(1)%, PEFR은 흡연군에서만 차이를 보였다. 폐기능 검사 이상을 비교하면 전체적으로 화재노출군이 비노출군보다 폐기능 이상자의 수가 많았고 흡연군에서 FEV_(1) 이상자의 차이는 통계적으로 유의하였다. FVC, FEV_(1), MMEF를 종속변수로 하여 다중회귀분석을 시행하였을 때, FVC와 FEV_(1)은 부분적으로 화재노출유무와 관련성이 있었다. 호흡기 증상 조사에서 화재노출군은 비노출군에 비해 코막힘, 목아픔, 흉부압박감의 증상의 호소율이 통계학적으로 유의하게 높았으나, 이를 흡연여부에 따라 층화하면 이들 증상들은 경계역의 차이를 보였다. 결론: 이러한 결과들을 종합하면 소방관은 화재진압과정에서 노출되는 많은 호흡기 유독물질로 인해 급성 폐기능 저하와 높은 호흡기 증상 호소율을 보이며, 이는 화재노출 외에 흡연의 부가적 효과가 영향을 미친다고 생각된다. 따라서 폐기능이 저하된 경방군에서 주기적인 폐기능 검사가 실시되어야 하며, 금연과 호흡기 보호구의 철저한 착용이 권장되어야 하겠다. Objective: The purpose of this study was to evaluate the relationship between respiratory disorders and fire exposure by investigating and analyzing the lung function and respiratory symptoms of firefighters. Methods: The health effects of firefighting on respiratory function were investigated in 699 male fire officers in 4 fire departments in Busan by recording respiratory symptoms and measuring lung function. The data were analysed according to fire exposure and smoking habits. Results: Mean spirometric data showed significantly decreased levels in the fire-exposed group (FVC, -0.20 L; FVC%, -4.2%; FEV_(1) -0.21 L; FEV_(1)%, -5.1%; FEF25%, -0.13 L/SEE p<0.05). After stratification by smoking habits, FVC and FEV1 showed a significant difference between groups. The prevalence of spirometric abnormality was greater for the fire-exposed group than for the non-exposed group. Significantly higher prevalences of nasal stiffness (16.7% vs. 10.9%), sore throat (17.7% vs. 14.2%) and chest tightness (6.5% vs. 2.5%) were recorded in fire fighters compared to controls (p<0.05). However, after stratification by smoking habits, the 3 symptoms were showed only marginal differences in the smoking group. Conclusions: This study demonstrated that fire-exposed firefighters generally suffer a decline of lung function and a higher prevalence of respiratory symptoms. These results suggest that the exposure to routine firefighting activity is associated with adverse health effects to the respiratory system.

黃江의 水質과 植物플랑크톤群集에 관한 硏究

文成基,洪菜圭,李相薰,鄭鍾文 慶星大學校 1994 論文集 Vol.15 No.2

A Study on water quality and phytoplakton community was carried out from April, 1992 to March, 1993 in Hwang-Kang. The results obtained on this study are as follows. The value of environmental factors about water quality such as water temperature, pH, precipitation, DO, BOD, NH??₄-N, NO??₂-N, NO??₃-N and PO??₄-P were ranged 1.8-30℃, 6.7-8.4, 3.0-183.6mm, 8.4-14.8 mg/l, 0.7-3.0mg/l, 0.01-0.09 mg/l, 0.10-3.80 mg/; and 0.01-0.19 mg/l respectively. The phytoplankton are identified as 235 taxa including 78 genera, 202 species, 29 varieties and 4 forms. In these study areas the common species occurred frequently were Cyclotella meneghiniana, Fragilaria crotonensis, Melosira varians and Synedra ulna. The causative species of red ride were identified as Microcystis aeruginosa, Trachellomonas hispida, Ceratium hirundinella, Peridinium cinctum, Melosira italica and Staurastrum dorsidentiferum var. ornatum in the areas. The lowest standing crops(20.1 cells/ml) were recorded on January, 1993 and the highest(1,993 cells/ml) were recorded on May, 1992. According to the seasonal succession, dominant species were Fragillaria crotonensis in Spring, Actinastrum hantzschii var. elongatum, Peridinium bipes, Scenedesmus ellipsoidus for. flagellispinosus in Summer, Ceratium hirundinella, Melosira granulata var. angustissima in Autumn and Fragillaria crotonensis in Winter. Saprobic index showed that all stations were β-mesosaprobic.

도시 노인의 댄스스포츠 참여도에 따른 여가 만족도에 미치는 효과

송채훈,사상순 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

While the old have much higher interests in both their health through the exercise and the participation in life-gymnastics by various mass media, there are hardly any facilities and professional trainers for them. As one of the solutions to the problems, the professional programs of dance sports for the old should be developed, the sports facilities should be increased and the professional trainers should be raised. The study is as follows: How much one of the activities in old people's spare times, dance sports for the old affect the degree of leisure satisfaction, with the result that it will be able to provide the fundamental materials for the dance sports to land as the activity for their leisure program. According to the participation of dance sports, not the age, gender, and school but the participation time and term have meaningful effect on the old. Therefore the relationship p<.05 between the common items and the degree of leisure satisfaction is not meaningful. Next, the relationship between the participation time and the degree of leisure satisfaction is r=.171(p<.01). That is, the more the old take part in the dance sports, the more satisfaction they have. Lastly, the relationship between lasting time and the degree of leisure satisfaction is r=.6821(p<.01). Also, the longer they take part in dance sports, the higher they satisfy with their leisure. Considering of these conclusions, dance sports have affirmative effects on the old people's satisfaction with their activities for their leisure times. So the encouragement of dance sports will contribute to the rule of life sports such as the increase of health and the vitality of life. For this, we should make the old people the professional programs for the creative experience and the social activities.