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- 저자 : 이승현 (검색결과 2,599 건) 검색분석정보 보기
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이승현,최재훈 대한면역학회 2016 Immune Network Vol.16 No.1
Aortic valve stenosis is a heart disease prevalent in the elderly characterized by valvular calcification, fibrosis, and inflammation, but its exact pathogenesis remains unclear. Previously, aortic valve stenosis was thought to be caused by chronic passive and degenerative changes associated with aging. However, recent studies have demonstrated that atherosclerotic processes and inflammation can induce valvular calcification and bone deposition, leading to valvular stenosis. In particular, the most abundant cell type in cardiac valves, valvular interstitial cells, can differentiate into myofibroblasts and osteoblast-like cells, leading to valvular calcification and stenosis. Differentiation of valvular interstitial cells can be trigged by inflammatory stimuli from several immune cell types, including macrophages, dendritic cells, T cells, B cells, and mast cells. This review indicates that crosstalk between immune cells and valvular interstitial cells plays an important role in the development of aortic valve stenosis.
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Different Working Mechanisms for a Graphene Resistive Memory Based on Oxygen-Ion Transport
이승현 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.70 No.1
A graphene sheet was used as one of the electrodes of a HfO2 metal-oxide-based resistive random access memory. We find dramatic differences in the device characteristics as voltages with opposite polarities are used to form the resistive memory devices. Using experimental measurements of the switching characteristics and the corresponding low and high resistance state, we compare the two different operating modes of a graphene-electrode-based resistive memory. Using a Raman raster scanning map, we verify that the transport direction of oxygen ions contributes to such dramatic differences in the device’s switching characteristics.
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Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome
이승현,김재형,박세진,원창윤,이주현,이성윤,박혜경,장선희,정훈,이성순,구현경 대한결핵및호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS. We reported a case of secondary vasculitis presenting as non-resolving pneumonia, later diagnosed as paraneoplastic syndrome of undiagnosed MDS. The cytopenia and vasculitis improved after a short course of glucocorticoid treatment, and there was no recurrence despite the progression of underlying MDS.
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