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      • KCI등재

        Effect of Sertraline on Current-Source Distribution of the High Beta Frequency Band: Analysis of Electroencephalography under Audiovisual Erotic Stimuli in Healthy, Right-Handed Males

        이승현,현재석,권오영 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.8

        Purpose: The purpose of this study was to examine the cerebral changes in high beta frequency oscillations (22-30 Hz) induced by sertraline and by audiovisual erotic stimuli in healthy adult males. Materials and Methods: Scalp electroencephalographies (EEGs) were conducted twice in 11 healthy, right-handed males, once before sertraline intake and again 4 hours thereafter. The EEGs included four sessions recorded sequentially while the subjects were resting, watching a music video, resting, and watching an erotic video for 3 minutes, 5 minutes, 3 minutes, and 5 minutes, respectively. We performed frequency-domain analysis using the EEGs with a distributed model of current-source analysis. The statistical nonparametric maps were obtained from the sessions of watching erotic and music videos (p<0.05). Results: The erotic stimuli decreased the current-source density of the high beta frequency band in the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in the baseline EEGs taken before sertraline intake (p<0.05). The erotic stimuli did not induce any changes in current-source distribution of the brain 4 hours after sertraline intake. Conclusions: It is speculated that erotic stimuli may decrease the function of the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in healthy adult males. This change may debase the inhibitory control of the brain against erotic stimuli. Sertraline may reduce the decrement in inhibitory control. Purpose: The purpose of this study was to examine the cerebral changes in high beta frequency oscillations (22-30 Hz) induced by sertraline and by audiovisual erotic stimuli in healthy adult males. Materials and Methods: Scalp electroencephalographies (EEGs) were conducted twice in 11 healthy, right-handed males, once before sertraline intake and again 4 hours thereafter. The EEGs included four sessions recorded sequentially while the subjects were resting, watching a music video, resting, and watching an erotic video for 3 minutes, 5 minutes, 3 minutes, and 5 minutes, respectively. We performed frequency-domain analysis using the EEGs with a distributed model of current-source analysis. The statistical nonparametric maps were obtained from the sessions of watching erotic and music videos (p<0.05). Results: The erotic stimuli decreased the current-source density of the high beta frequency band in the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in the baseline EEGs taken before sertraline intake (p<0.05). The erotic stimuli did not induce any changes in current-source distribution of the brain 4 hours after sertraline intake. Conclusions: It is speculated that erotic stimuli may decrease the function of the middle frontal gyrus, the precentral gyrus, the postcentral gyrus, and the supramarginal gyrus of the left cerebral hemisphere in healthy adult males. This change may debase the inhibitory control of the brain against erotic stimuli. Sertraline may reduce the decrement in inhibitory control.

      • KCI등재

        주의력결핍 과잉행동 장애의 원인(原因) 및 병기(病機)에 따른 한방음악치료의 기법(機法)에 관한 연구

        이승현,김여진,Lee, Seung-Hyun,Kim, Yeo-Jin 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.1

        Objectives The purpose of this study is to introduce oriental medicine music therapy related to the treatment of ADHD. Methods This study observed ADHD from the oriental medical point of view and tried to treat this disease with the oriental medicine music therapy. Results ADHD is caused by excess of Yang energy, flaming-up of fire, blood deficiency of the heart and the spleen, deficiency of the kidney essence, and instability of emotions. The ADHD patients with the case of excess of Yang energy and flaming-up of fire, patients were played Fire-Gi rhythm as a treatment, and they listened to Metal-Gi music. Whereas, the ADHD patient with blood deficiency of the heart and the spleen, invigoration of vital energy music therapy can be used. Another case of ADHD patients with deficiency of the kidney, Water-Gi rhythm and replenishing vital essence music therapy can be used. According to the patients' seven modes of emotions, the proper music should be chosen. Conclusions Oriental medicine music therapy can be a new type of treatment for ADHD patients.

      • KCI등재

        가정폭력처벌법을 통해 본 입법쟁점과 개선방안

        이승현 이화여자대학교 젠더법학연구소 2019 이화젠더법학 Vol.11 No.2

        ‘The Act on Special Cases concerning the Punishment, etc. of Crimes of Domestic Violence(the Act for the Punishment of Domestic Violence)’ was established in 1997 to address ‘domestic violence’ as a societal problem. To improve the system of domestic violence legislation, it is needed to unify the structure of the legal system which is currently dualized by punishment and protection. A minimum boundary between criminal punishment and protective disposition should be established by creating exclusion reasons for family protection cases and restriction reasons for indictment suspension under the condition of consultation. Additionally, in the legislative purposes, there is a necessity to remove the phrase “to help restore the peace and stability of a family” for the active protection of domestic violence victims. In the execution of domestic violence cases, relevant regulations should be amended to enable temporary measures for violators with mental illness and to enable criminal penalties for noncompliance of temporary measures. To protect victims of domestic violence, the system of an attorney-at-law for victims should be introduced. In addition, provisions for the establishment of witness support facilities and for providing interpretation or translation services for foreign victims should be legislated. 「가정폭력처벌법」은 1997년 ‘가정폭력’이라는 사회적 문제를 해결하고자 입법화되었다. 「가정폭력처벌법」이 제정된 지 20년이 지났으나 이 법은 가정폭력 피해자의 보호에 충실하지 못하고, 변화하는 가정의 형태를 담아내지 못하다는 비판을 받고 있다. 「가정폭력처벌법」이 행 위자에 대한 처벌법에 머무르지 않고 피해자 및 그 구성원의 보호를 위한 법률이 되기 위해서 는 법률 전체에 대한 검토를 통해 개선할 점은 없는지, 실제 사문화된 규정은 없는지 등을 점검 하는 노력이 필요하다. 가정폭력법제의 체계 개선을 위해, 현행 처벌과 보호로 이원화되어있는 법체계 구조를 단일 화하고, 가정보호사건의 배제사유와 상담조건부 기소유예 제한사유를 마련하여 형사처분과 보호처분의 최소 경계를 마련하는 것이 필요하다. 또한 입법목적에서 “가정의 평화와 안정을 회복”이라는 부분을 삭제하여 피해자 보호에 적극적으로 대응하도록 해야 한다. 가정폭력의 개념정의와 관련하여, 가정폭력범죄에 현행 규정상 포함되지 않고 있는 살인미 수, 주거침입죄와 퇴거불응죄 규정을 포함하도록 하고, 가정구성원의 개념을 혼인관계에 한정 하지 않고 데이트관계 등 친밀한 관계에 의한 경우도 포함할 수 있도록 해야 한다. 가정폭력사건 집행에 있어서, 정신질환자를 위한 임시조치가 가능하도록 관련 규정을 개정하고, 임시조치 불이행에 대하여 형사처벌이 가능하도록 개정되어야 한다. 행위자에 대한 실질적 제재가 되기 위해서는 배우자 폭력 시 미성년 자녀에 대한 친권을 제한할 수 있도록 하고, 장기 감호시설에 대하여 별도규정을 마련하여야 한다. 가정폭력 피해자 보호를 위해, 피해자변호사제도를 도입하고, 증인지원시설 설치관련 규정을 법에 규정하며, 외국인 피해자에 대한 통역지원 서비스를 할 수 있도록 근거규정을 마련하여야 한다.

      • KCI등재

        건성안 환자의 눈물내의 케모카인 리간드4의 농도와 눈물표면인자와의 상관관계

        이승현,임성규,윤경철.Seung Hyun Lee. MD. Seoung Kyu Im. MD. Kyung Chul Yoon. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.3

        Purpose: To investigate the expression of CCL4/MIP-1β in tears of patients with dry eye syndrome and its correlation with the tear surface parameters. Methods: Forty patients with dry eye syndrome (seven Meibomian gland dysfunction and 33 non-Meibomian gland dysfunction patients) and 25 control subjects were recruited. The concentrations of CCL4 in tears were measured using an enzyme-linked immunosorbent assay. The correlations between CCL4 levels and tear surface parameters including tear film break-up time (BUT), basal tear secretion (BST), tear clearance test (TCR), corneal sensation, keratoepitheliopathy (KEP) and conjunctival goblet cell density (GCD) were analyzed in patients with dry eye syndrome. Results: The mean levels of MIP-1β were 4.3±5.2 pg/ml in patients with dry eye syndrome and 81.6±294.3 pg/ml in control subjects (p=0.03). The mean levels in non-Meibomian gland disease patients (90.4±313.9 pg/ml) were significantly higher than those of Meibomian gland dysfunction patients (20.3±23.2 pg/ml, p=0.02). CCL4 levels correlated significantly with BST, TCR, KEP and GCD (p<0.05). Conclusions: The level of MIP-1β is elevated in tears of patients with dry eye syndrome and correlates with disease severity and tear surface parameters. J Korean Ophthalmol Soc 2010;51(3):313-319

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