사염화탄소 투여 흰쥐에서 간섬유화 진행에 따른 Propranolol 의 약동학적 지표들의 변화

이민호,강주섭,강문수,윤병철,이오영,함준수,변재원,윤창옥 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2

Background/Aims : This study was designed to determine the effect of hepatic fibrotic severity on pharmacokinetics of propranolol in CC1q - treated rats. Methods - 1 mL/kg of 10% CC14 in olive oil was injected intramuscularly to rats twice weekly for 4, 6, 8 and 10 weeks, respectively (n=6). Control (n=6) was a sham - injected equal dose of olive oil for 10 weeks. After intravenous bolus injection of 2 mg/kg propranolol to rats, the serum propranolol concentrations were analyzed for 4 hours at various time points by a HPLC - fluorimetric system, and pharmacokinetic parameters such as Co, MRT, AUC, Vdss, tl/2(p) and CLp were determined. Then, a small amount of hepatic tissue was obtained and subjected to determination of the hepatic 4 - hydroxyproline content, which confirmed the hepatic fibrotic severity. Results : The serum concentrations of propranolol at 0.5, 1, 2 and 4 hours were significantly increased in CC1q-treated rats (p$lt;0.01). In proportion to the duration of CC4 treatment, Co and AUC were significantly increased, and Vdss and CLp were significantly decreased (p$lt;0.001). But MRT and t1/2(β) were not significantly changed. The hepatic 4 -hydroxyproline content was gradually increased in CC4-treated rats (p$lt;0.001). Conclusion - Gradual changes in pharmacokinetic parameters of propranolol were seen to be dependent on the hepatic fibrotic severity. We suggest that gradual dosage modification, according to their hepatic fibrotic severity, is necessary for many drugs administered to patients with chronic liver disease.(Korean J Hepatol 2001;7:181-188)

産學蓮繫에 依한 醫學技術敎育 改善方案에 關한 硏究

金惠順,朴銀秉,李昌珪,黃善哲 高麗大學校 倂設 保健大學 保健科學硏究所 1989 保健科學論集 Vol.16 No.1

The field of medical laboratory science, like many other allied health professions, is currently experiencing a number of noteworthy changes. One of the obvious changes is the multitude of new tests and instruments being rapidly introduced into the practice of laboratory sciences. As results of these technological innovations, the duties and responsibilities of laboratory manpower have also been changed. Requisition to the development of competency based curicula in the medical laboratory science is the translation of competency statement into terminal performance objectives so that the achievment of career-entry competence can be measured. In order to study laboratory tasks in depth, and to provide data for logically reconstructing job roles, a task inventory based on professional practices for their respective areas of the clinical laboratory had been investigated. Results of this task analyses could be in identifying objectives necessary to develop a task-oriented curriculum. The implications of the result of this study are summarized in the following. 1. For the purpose of updating and practicing curriculum for medical technology established curriculum total credit hours should be increased within the limits of the possibility. 2. The curriculum should provide opportunities for students to apply theory in to practice through correlated and supervised instiution in clinical practice areas. 3. The teaching program must be well organized on the educational curriculum comprised of humanities and related science subjects. 4. While the student/instructor ratio in the medical laboratory sciences courses should be appropriate more balanced ratio is emphasized. 5. Based on the data studied, it can be concluded that some major courses are lacking its uniformities. 6. It should ascertained that the affiliation between academic institutions and hospital facilities must be compulsory for enhancing competency oriented education.

한국인 담석증에 대한 임상적 고찰

김광하(Gwang Ha Kim),옥창민(Chang Min Ok),김병진(Byung Jin Kim),주형준(Hyung Jun Joo),송철수(Chul Soo Song),송근암(Guen Am Song),조몽(Mong Cho),양웅석(Ung Suk Yang) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aitns: It has been reported frequently that clinical features of gallstone diseases in Koreans were different from those of Occidentals. These differences were thought to be due to inherent racial difference and acquired living habits. The purpose of this study is to evaluate whether the pattern of gallstone disease changes or not in Korea. Methods: We analyzed 5,488 cases of gallstone diseases which were reported in Korea frorn 1966 to 1994. We divided the period into 6 groups: the first period was 1,000 cases reported from 1966 to 1970, the second was 331 cases from 1971 to 1975, the third was 1,000 cases from 1976 to 1980, the fourth was 1,957 cases from 1981 to 1985, the fifth was 1,000 cases from 1986 to 1990, and the sixth was 200 cases from 1991 to 1993. Results: The age group of highest incidence was the fifth and sixth decade. The incidence below the third decade showed a decreasing tendency. In contrast, the incidence above sixth decade showed an increasing tendency. The male to female ratio was 1:1.25 to 1:1.71 and had no periological change. The duration of illness of highest frequency was below 6 months. In the case of duration above 5 years these was a decreasing tendency. The major complaints of biliary stone were right upper quadrant pain and tenderness. Nausea, vomiting, jaundice, and radiating pain showed a decreasing tendency. The major laboratory findings were leukocytosis, elevated SGOT and SGPT, elevated alkaline phosphatase, hyperbilirubinemia and hypoalbuminemia. Of these, only hypoalbuminernia had a decreasing tendency. By the second period, the main diagnostic procedures were oral cholecystogram and intravenous cholecysto- graphy. From the fourth period, ultrasonography, ERCP, CT and PTC were been used comrnonly. For the location of gallstone, the gallbladder stone revealed the only increasing tendency, the common bile duct stone had a decreasing tendency, and the intrahepatic duct stone had no periological change. From 1980, the cholesterol stone became the main composition of gallstones. But, there was no periological change between early and late 1980s. Positive bacterial culture rate was 57.0% and the most common microorganism was E. coli. Klebsiella and Enterobacter. Pseudomonas showed an increasing tendency. Of the diseases associated with gallstone, only diabetes had an increasing tendency. The frequency of residual stone had an increasing tendency. Conclusions: The age of peak incidence of gallstone diseases was the fifth and sixth decades and there was a little predominance in females. From 1980, the cholesterol stone becarne the main composition of gallstones. For the location of gallstone, the gallbladder stone showed an increasing tendency and the common bile duct stone revealed a decreasing tendency. These suggested clinical features of gallstone diseases in Koreans are somewhat similar to those of Occidentals. (Korean J Gastroenterol 1997;29:352 - 361)

상백피봉약침요법(桑白皮蜂藥鍼療法)을 포함한 한방치료(韓方治療)로 증상(症狀)은 소실(消失)되었으나 CT추적관찰상(追跡觀察上) 변화(變化)가 없는 요추(腰椎) 추간판(椎間板) 탈출증(脫出症) 1예(例)

이병훈,김철홍,서정철,윤현민,송춘호,안창범,장경전,Lee, Byung-Hoon,Kim, Cheol-Hong,Seo, Jung-Chul,Youn, Hyoun-Min,Song, Choon-Ho,Ahn, Chang-Beohm,Jang, Kyung-Jeon 대한약침학회 2001 Journal of pharmacopuncture Vol.4 No.2

By process of treatment for a case which diagnosed as HNP of left posterolateral aspect of L4/5 disc and treated from the 10th, May 2001 to the 23rd, Jun 2001, the results are as follows. Method & Results : This patient was medicated Hwallaktang-gami, taken acupuncture, phototherapy, TENS, electric acupuncture, exercises, Mori Cortex-bee venom acupuncture. As a result, the patient's clinical symptom were improved but a computed tomagraphy confirmed L4/5 and L5/S1 HNP was not changed as seen on repeated CT scanning. Conclusion : These results suggest that among conservative therapies the oriental medical treatments including Mori Cortex-bee venom acupuncture improve clinical symptom effectively. But in this case, the structure of herniated disc was not changed.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

구순 구개열 환자의 성장후 측모형태에 관한 두부계측방사선학적 연구

장익준,손우일,송재철,진병로 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Cleft lip and palate deformity have unknown patterns of maxillofacial growth and development. The maxillofacial growth can be affected either by congenital or environmental factors such as infection and trauma. Surgical repair of cleft lip and palate may interfere the subsequent growth and development of maxillofacial region. The purpose of this study is to evaluate the characteristics of maxillofacial growth patterns in adult cleft lip and palate patients. Materials and Methods: The material for this study consisted of 17 adult male patients with cleft lip and palate. Cephalometric tracing and measurements were done by one investigator. The relationship between 17 cleft lip and palate patients and Korean norms were evaluated statistically Results: There were statistically differences in Na. perpendicular to point A, SNA angle, effective maxillary length, maxillofacial differencial, Wit's appraisal and upper incisor to point A(p<0.01). Pogonion to Na. perpendicular also statistically differed(p<0.05). Other measurements didn't statistically differ. Conclusion: It was evident that in adult cleft lip and palate patients, maxilla was retruded and short. Careful cleft lip and palate repair and treatment are recommended for facilitating normal growth of maxilla.

분자선 Epitaxy법에 의해 MgO(100) 및 MgO/Si(111) 기판위에 증착된 YBa_2Cu_3O_7-x 박막의 초전도 및 결정특성(Ⅰ)

장호정,김병철 단국대학교 신소재기술연구소 1993 신소재 Vol.3 No.-

분자선 Epitaxy법에 의해 MgO(100) 및 MgO/Si(111) 기판위에 기판온도 590℃, chamber압력 9.5×10^-5 Torr의 증착조건에서 YBA_2Cu_3O_7-x (YBCO)박막을 제작하여 초전도 및 결정특성을 조사하였다. MgO(100) 단결정 기판위에 증착된 YBCO박막은 초전도 전이온도 Tc_zero 86K의 표면이 거칠은 단결정 박막을 재현성있게 얻을 수 있었다. 또한 MgO/Si(111)기판위에 증착된 박막시료의 경우 Tc_zero 75K의 다결정의 결정특성을 나타내었다. XRD분석결과 양쪽시료 모두 기판위에 수직한 c축 배향구조를 나타내었고, rocking curve의 FWHM(Full width at half maximum) 값은 MgO(100)기판위에 증착된 박막이 0.65°로써 더 작은 값을 나타내어 c축 배향성이 개선되었음을 알 수 있었다. SEM에 의해 표면조직을 관찰한 결과 박막표면에 과성장 핵(outgrowth nuclei)이 관찰되었으며, 이는 증착중 a, b축과 c축의 결정성장 속도의 차이에 기인하는 것으로 사려 되었다. MgO(100) 기판위에 증착된 Tc_zero 83K의 YBCO박막시료의 임계전류밀도(Jc)값은 온도 4.2K 1 Tesla 자장하에서 5.1×10^6A/㎠이었다. The YBa_2Cu_3O_u-x(YNCO) thin films were grown on MgO(100) and MgO/Si(111) substrate at the substrate temperature of 590℃ and the chamber pressure of 9.5×10^-5 Torr by a molecular beam epitaxy method. The superconductivity and crystalline quality were investigated. The YBCO film on MgO(10)substrate showed Tc zero 86K with single crystal phase in RHEED observation. Whereas, the YBCO film deposited on the MgO/Si(111) substrate was Tc zero 75K with polycrystalline nature under the same deposition condition. The X-ray diffraction (XRD) analysis for the both samples showed preferentially c-axis oriented superconducting phases perpendicular to the film surface. The FWHM (Full Width at Half Maximum) of (005) rocking curve for the YBCO film on MgO(100) substrate was 0.65° and was increased to 1.72° when the YBCO film was deposited on MgO/Si(111) substrate. This large value of FWHM means that the degree of preferred orientation was lowered. The critical current density (Jc) for the films deposited on MgO(100) substrate was found to be 5.1×10^6 A/㎠ at 4.2K and 1 Tesla in applied magnetic field.

Wolff-Parkinson-White 증후군의 외과적 치료 : 초기 10례치험 보고 CLINICAL EXPERIENCE OF INITIAL 10 CASES

장병철,김성순,홍유선,윤치순,방서욱,조범국 대한의학협회 1990 대한의학협회지 Vol.33 No.5

Using XML for Describing Sensing Data

Ki Chang Park,Im Chul Kang,Young Hyuk Ko,Byung Ki Kim 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12

The SDK (Software Development Kit) of each device is required in developing contents using TUIs (Tangible User Interfaces). Generally, it is used to adapt a specific sensor to the UIs of contents, which causes duplicated and time-consuming efforts in developing contents if the contents development platform is changed. In this paper, we propose a method which describes signal information of TUIs using XML and show the example of contents development over Virtools and XNA platform using a proposed method. The proposed method allows the sensing data exchange between a device module and a contents module and reduces module coupling between them.

경사진 육면체에서 태양열에 의한 증발 현상에 관한 연구

김병철,장원택,윤재원,박준성 朝鮮大學校 機械技術硏究所 2006 機械技術硏究 Vol.9 No.1

Four solar stills that were fabricated each with cubes and glazing tilted angles of 15°, 30°, 45°, 60°, were compared with the quantities of condensed water. The quantities of condensed water were analysed with the weather conditions and temperatures for three months, On fine days, the quantity of average condensed water was more similar to those of 15° and 30°than to those of 45° and 60°, The quantity of condensed water produced by those of 45° and 60° were very irregular compared to those of 15° and 30", On rainy days, the quantity of condensed water was the most in that of 30° than those of the other angles and in cloudy, rainy and sunny conditions, the condensation quantity was the largest in that of 60°.