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자동차 부품 사업장에서의 작업환경 개선을 통한 근골격계질환의 예방효과에 대한 연구
김철홍,문명국,노상철,이재은,이명행 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
본 연구는 국내 모 자동차 부품 및 플랜트 제조 사업장을 대상으로 2004년과 2007년 두차례에 걸쳐 실시한 근골격계질환의 실태에 관한 조사를 통하여 작업환경 개선을 통한 예방 효과를 알아보고자 하였다. 연구 결과 설문조사를 통한 근골격계질환 관련 통증 호소정도에 있어서는 2004년 대비 전체적으로 2.1%증가한 것으로 나타났으나, 의학적 검진을 요하는 인천대학교 기준의 경우 A공장(28.4%)이 증가한 반면 B 공장의 경우 31.7% 감소한 것으로 나타났다. B 공장의 유소견자 비율이 감소한 원인으로는 A공장에 비하여 2004년 이후 작업환경의 개선 정도가 영향을 미친 것으로 추정된다. 따라서 사업장의 근골격계질환 예방은 사업장의 실태를 정확히 파악한 후, 각 공정에 대한 정확한 평가와 함께, 인간공학적인 개선이 요구된다는 것을 알 수 있다.
김철홍,김영철,김용환,Anne J. Anderson 한국식물병리학회 2014 Plant Pathology Journal Vol.30 No.2
The GacS/GacA system in the root colonizer Pseudomonaschlororaphis O6 is a key regulator of many traits relevant to the biocontrol function of this bacterium. Proteomic analysis revealed 12 proteins were down-regulated in a gacS mutant of P. chlororaphis O6. These GacS-regulated proteins functioned in combating oxidativestress, cell signaling, biosynthesis of secondary metabolism, and secretion. The extent of regulation was shown by real-time RT-PCR to vary between the genes. Mutants of P. chlororaphis O6 were generated in two GacS-regulated genes, trpE, encoding a protein involved in tryptophan synthesis, and prnA, required for conversionof tryptophan to the antimicrobial compound, pyrrolitrin. Failure of the trpE mutant to induce systemic resistance in tobacco against a foliar pathogen causing soft rot, Pectobacterium carotovorum SCCI, correlated with reduced colonization of root surfaces implying an inadequate supply of tryptophan to support growth. Although colonization was not affected by mutation in the prnA gene, induction of systemic resistance was reduced, suggesting that pyrrolnitrin was an activator of plant resistance as well as an antifungal agent. Study of mutants in the other GacS-regulated proteins will indicate further the features required for biocontrol-activity in this rhizobacterium.
호도약침액(胡桃藥鍼液)의 유리기(遊離基) 소거(消去)와 항산화(抗酸化) 효과(效果)에 대한 실험적(實驗的) 연구(硏究)
김철홍,윤현민,장경전,송춘호,안창범,Kim, Cheol-hong,Youn, Hyoun-min,Jang, Kyung-jeon,Song, Choon-ho,Ahn, Chang-bum 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4
This study was performed to determine if Juglandis semen extract(JSE) has free radical scavenging and antioxidant activities. Superoxide anion generation by xanthine oxidase/xanthine and in neutrophils activated by phorbol-12, 13-dibutyrate was inhibited by JSE and its effect was dose-dependent. JSE also inhibited generation of $H_2O_2$ induced by glucose oxidase/glucose and in opossum kidney cells treated with antimycin A. JSE exerted a direct $H_2O_2$ scavenging effect. Exposure of opossum kidney cells to 1mM tBHP caused a significant increase in lipid peroxidation, which was prevented by JSE. JSE also prevented tBHP-induced LDH release. These data suggest that JSE has free radical scavenging and antioxidant activities. However, further studies should be carried out to find the active ingredient(s) of JSE that exerts radical scavenging action.