http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
기니픽에서 Salicylate가 변조이음향방사와 청성뇌간반응에 미치는 영향
이오영,박용호,이석호,남부현,박찬일 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.7
Background and Objectives:Salicylates are well-known for producing reversible hearing loss and tinnitus. However, the site and mechanism of salicylate ototoxicity remain unresolved. Recent experiments sugest that reversible biochemical and/ or metabolic changes in the cochlea seem to play an important role in salicylate ototoxicity. The purpose of this study was to Materials and Method:ABRs and DPOAEs were observed after intraperitoneal injection of 500 mg/kg of sodium salicylate on 24 ears of guinea pigs. Results:Salicylate pro-duced a significant increase in the ABR threshold. Maximum changes were obtained in 4 hours, and recovered to the base-line in 24 hours after salicylate administration. The pattern of hearing loss shown by latency-intensity function was compatible with the cochlear type of hearing loss. The echo amplitude on DPOAEs at f2=2, 4, 6, 8 hours, and returned to the baseline in 24 hours after salicylate administration. The time course of the change of DP-OAEs was parallel with that of ABRs. Conclusion:These results reflect that the cochlear outer hair cells may be the main site of lesion in salicylate ototoxicity. (Korean J Otolaryngol 2002;45:646-50)