노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

CD34+ 조혈 모세포 이식 2례

김정아,정현식,김원석,윤성수,이홍기,박찬형,박성규,김동욱,이종욱,한치화,민우성,김춘추,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1

Background: In most solid tumors, the CD34 antigen has not been detected, so positive selection of CD34+ cells may reduce tumor cell contamination and the CD34+ cells are capable of reconstituting hematopoiesis. We tried CD34+ cell transplantation in two patients. Method: CD34+ cells from chemotherapy + G-CSF mobilized PBPCs or bone marrow were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). Case 1. One course of chemotherapy using cyclophosphamide(200㎎/㎡) and etoposide (4.2g/㎡), combined with G-CSF(5㎍/㎏) S.C. was used in a relapsed lymphoma patient. This patient responded to the induction chemotherapy. CD34+ cells from harvested bone marrow were selected by the CellPro immunoadsorption column. The total number of mononuclear cells loaded onto the CellPro was 2.4×10^(8)/㎏, with 1.1% CD34+ cells. After column separation, the total number of positively selected cells was 5.16×10^(6)/㎏. The number of CFU-GM was 76.8×10⁴/㎏. This patient was treated with melphalan (140㎎/㎡) and TBI (1200cGy) and the positively selected CD34+ cells were infused. The time to neutrophil recovery greater than 0.5×10^(9)/L was 19 days and the time to platelet recovery greater than 50×10^(9)/L was 21 days. Case 2. Two courses of mobilizing chemotherapy were given 4 weeks apart using taxol(210㎎/m2) and adriamycin(60㎎/m2), combined with G-CSF(5㎍/㎏) S.C. in a breast cancer patients with 7 axillary node metastasis. CD34+ cells from each single leukapheresis product were selected by the CellPro immunoadsorption column. In the first collection, the total number of nucleated cells was 4.4×10^(8)/kg, with 0.42% CD34+ cells. In the second collection, the total number of nucleated cell was 2.8× 10^(8)/㎏ with 0.43% CD34+ cells. After colum separation, the total numbers of collected cells were 4.0×106/kg and 4.8×10^(6)/kg, the total number of CD34+ cells were 1.2×10^(6)/㎏ and 0.82×10^(6)/㎏. Colonogenic assays of positively selected CD34+ cells gave rise to myeloid erythroid, and multilineage colonies, with a median of 190 CFU-GM, 190 BFU-E, and 164 CFU-GEMM per 1×10³ adsorbed cells, respectively. High-dose chemotherapy with cumulative doses of 40mg/㎡ mitoxantrone, 750mg/㎡ thioptepa, and 1000mg/㎡ carboplatin was administered. Positively selected CD34+ cells were rapidly infused 24 hours after the end of high-dose chemotherapy. The time to neutrophil recovery greater than 0.5×10^(9)/L was 16 days and the time to platelet recovery greater than 50×10^(9)/L was 20 days.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

효율적인 현장체험학습을 위한 암남공원의 지질에 관한 연구

한영욱,김상권,유병태 부산교육대학교 과학교육연구소 2004 科學敎育硏究 Vol.29 No.-

The purpose of this study is to find out the study of the effective field experience learning method through the geological survey of the Amnam Park. The field experience learning has been used in the general subjects and in that case data supply is common. But the data supply is lack in the programs of the earth science especially in Busan , it is rare to learn geological matters with topography of Busan. With the results of this study it is possible to maximize the learning effect by using the outdoor environments. The Amnam Park which is accessible to students with convenient transportations has the effective stratum outcrops for the different rocks, faults, folds, intrusion of magma, metamorphic-contact transformation rocks what show the various lithosphere change phenomenon and the lithosphere leveling. With the results of the concentrative survey of the Amnam Park, this study proposes the localization of the text of the local environment of nature, application and shows the way of the teaching and learning effects. As the results are as follows. First the Amnam Park specifies the geological history of Busan observing the stratum outcrops of that place which was consist of terrestrial deposit(accumulative layer) in the Lake or swamp environments. Second the Amnam Park shows the topographical characteristics formed by the lithosphere leveling and the movement of seawater and various topographical facts for example weathering, erosions, coast terrace, erosion by seawater caves. Third the Park has the variety of the stratum outcrops and evidences of lithosphere transformation relatively in the Small space. It has the advantage for the worthy geological learning place owing to accessible location. Using the field experience learning relating the geological unit in the Elementary School has effective learning for the students. The field experience learning with the text of localization provides the students with the love for their own place and the spirit for the preservation of nature as the accessory effects.

제주 돼지의 사육개선을 위한 기초조사 연구

한성욱,김형균,강태숙 제주대학교 1971 논문집 Vol.3 No.-

. The raising and feeding of swine in outhouses(Toilet) arose long ago and become a habit or custom for excrement control. The primary reason for practice is that most Cheju people simply do not like to tauch human feces. As a result of swine living in outhouses (Toilet) there is a great danger to humans of infection with cysticercus cellulosae from eating improperly cooked pork. Farmers do not recognize the offet of cysticercus cellulosae on human beings and must receive adequate education. We can slowly eliminate this problom by teaching and re emphasizing the unsanitary conditions and economic loss arising from this practice of W, C swine raising. The local governments and educated citizens as well as know ledgeable farmers must give continuous instruction and guidance in sanitary practices if we are to alter and eliminate swine feeding in the toilet 1. In Cheju-do the family does not include married children, thus the families are necessarily smaller than the mainland and the number of pigs at any house depends upon number of peoples in the family thus it is usually impossible to feed more than one pig since human feces are utilized as pig feed. 2. Since farmers have only a small amount of feed and feces and aware that the growth rate during a pig's first year is greater than its growth rate during the second year thus indicating a highly efficient utilization of feed during the first year, the farmers usually sell the pig within the first year. 3. Since there is a shortage of sanitary pig feed in Cheju-do greater use should be made of the waste products left over from sweet potato starch production. 4. The primary reason for raising the pig in the toilet is that about 90% of the people do not like to touch human feces out of habit. 5. The first objective in improving the feeding of Cheju swine is the instruction of farmers in the sanitation and health problems and econmic loss involved in raising pigs in the toilet because about 50% of the farmers are ignorant of even the existence of cysticercus cellulosae and its due effect on human beings.

대구, 경북 지역의 토양 환경상태 연구 : 토양 용도별 및 토양오염지표에 의한 평가 Assessment by Soil Divisions and Soil Pollution Index

한성욱,양득석,김복조 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

We analysed the soil quality of Taegu and Kyungbuk region according to the 12 different sampling sites. The soil pH of the downtown area near road was lower than that of the other roads, which indicated that this acidification was probably attributed to the acid rain caused by the traffic exhaust gas such as SO_x and NO_x, Acidification was slightly severe in the rice paddy area than in the dry farming area. All concentration of 6 different heavy metal(Cu, As, Pb, Cd, Hg, Cr^+6) and organic contaminants (Cyanide, organic-p, PCBs, phenols) were found to be lower than the standard of soil pollution or not detected. An assessment using the SPI(Soil Pollution Index), which was developed to estimate soil quality, was performed. Each SPC(Soil Pollution Score) were evaluated with the results of the data from this study. The soil quality of most area of Taegu and kyungbuk was determined to Class 1, which indicated that the soil was healthy.

한국 재래산양에서 Bovine Viral Diarrhea, Bovine Herpesvirus-1, Parainfluenza Type-3 바이러스에 대한 혈청학적 연구

한동운,권용국,문진산,윤소라,위성환,장환,탁동섭,이태욱,강문일 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.3

The 948 goat sera were serologically tested for ten pathogens including bovine viral diarrhea (BVD), bovine herpes virus type-1 (BHV-1) and parainfluenza virus type-3 (PI-3). By viral neutralizaion test, three pathogens including BVD virus, BHV-1, PI-3 were applied for screening each neutralizing antibody and its titration. Among 948 sera, there were 215 seropositives (22.7%) against BVD virus, 25 (2.6%) against BHV-1 virus, and 161 (17.0%) against PI-3 virus, respectively. In the seropositive cases to BVD virus, provincial prevalence of them were recorded as Gyeongnam(30.8%) for the highest one, while as Jeonbuk (15.8%) and Gyeongbuk(l6.7%) relatively for the lower ones. Among them, higher than 1:8 in antibody titration was classified as 74 cases (34.4%) which were suspected the cycle of its infection in their herds. Among the seropositives to BHV-1, it was relatively lower prevalence rate ranging from 1.7% to 6.7% that those of BVD virus and PI-3, but more importantly they were prevailing across the country. Most of the seropositive cases (42.9%) to PI-3 were classified as 1:4-1:16 in titration, but also distributed all around the country. The prevalence in goats varied according to areas (15.8 to 30.8%). Related to the provincial prevalence of three viral agents in Korean goats, it seemed that three viral pathogens would be directly or indirectly involving in various disorders as primary or secondary causative agents resulting in decreased productivity.

"IKUTON" 醱酵 고구마 澱粉粕의 養豚飼料 代替에 關한 硏究

韓成郁,鄭昌朝 충남대학교 농업과학연구소 1976 農業技術硏究報告 Vol.3 No.2

Study was conducted to estimate the nutritional effect of substitution levels of "IKUTON" (R) inocculate fermented sweet potato pulp for the growing-finnishing pig rations. Twenty five Large white X Landrace cross-breed (15 kg), mixed sex were used in group feeding at the substitution levels of 0, 10, 20, 30, and 40%. The results obtained were summarized as follow: Voluntary feed intake of experimental diets was lowest in 40%. No significant difference in voluntary feed intake was found in 10, 20, and 30% levels except 40%P<0.05). The feed efficiency was highest in 20%; (3.43), 30%;(3.80), 10%; (3.97), control; (4.53), and 40%; (4.20) respectively. There was tendency toward increasing feed efficiency in 10, 20, 30% levels than control. However, the lowest feed efficiency was found in 40% level. The weeks required to gain 80 kg of live weight were 12 weeks for 10%, 13 weeks for control, 14 weeks for 20%, and 30%, but in 40% level of substitution, no 80kg live weight was found up to the end of experiment (15 weeks). Pigs in 40% level were gained live weight only 64% of control animals. The digestibility of experimental diets was 75.2-78.5%, and water intake per kg dry matter intake was 1.95-2.01ℓ. No significant effects of feed offer interval to the digestibility and water consumption.

판폭두께비에 따른 콘크리트 충진 HSS 가새부재의 구조성능

한상환,김욱태 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

The purpose of this study is to evaluate the effect of width-thickness ratio (w/t ratio) on structure performance of concrete-filled Hollow Structural Section(HSS) bracing members. It has been found that bracing that experience more rapid strength deterioration and earlier fractures with increasing their w/t ratio. In order to reduce such poor behavior of bracing members having a large w/t ratio, concrete filled tubular bracing members can be used. This study investigated the effect of infilled concrete on bracing members having different w/t ratios. Experimental tests were carried out using quasi-static reversed cyclic loading with a symmetric compression and tension. Five full-scale test specimens were made. The test results showed that concrete filling delayed the occurrence of initial local buckling. Infilled concrete also changed the local buckling mode and reduced the severity of local buckling, thereby the occurrence of cracking and fracture in the concrete filled specimens were delayed. Furthermore, this study showed that infilled concrete is more influential to the specimens having a larger w/t ratio.

악성 위궤양의 형태를 보인 원발성 위결핵 1예

한종대,이동욱,심성준,류운석,안현택,박찬욱,김배영,이미선 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2