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음프록시캄 겔을 이용한 음파영동이 경피투과와 염증에 미치는 효과
최석주,김태열,윤세원,Choi, Sug-Ju,Kim, Tae-Youl,Yoon, Se-Won 대한물리치료과학회 2003 대한물리치료과학회지 Vol.10 No.1
This study was performed that how phonophoresis using ultrasound for piroxicam affects transdermal permeation and anti-inflammative effects. Transdermal permeation study conducted by using hairless mouse had two categories: control group and ultrasound group. Transdermal permeation was observed according to duty cycle and intensity. Anti-inflammatory effects were determined using in Sprague-Dawley rat. The subjects were divided into three groups of six SD rat each 24 hour, 48 hour, 72 hour. The results of this study were as follows: 1. Transdermal permeation of piroxicam was measured according to ultrasound duty cycle. This research demonstrates that ultrasound group retains more transdermal permeation than control group, and that pulsed ultrasound group holds a little more transdermal permeation than continuous ultrasound group. 2. The transdermal permeation of piroxicam is closely related with ultrasound intensity. Effect of each group of transdermal permeation was significant rises in proportion to ultrasound intensity. 3. By observing inflammation of the tissue caused by trauma, phonophoresis group showed more significant of anti-inflammatory effect. The conclusion of phonophoresis was found to improve significantly the transdermal permeation and the anti-inflammatory effect.
최석주 한국소음진동공학회 1997 소음 진동 Vol.7 No.4
선진 각국(독일, 영국, 일본 등)은 1970년대를 전후하여 건설공사장에서 발생하는 소음.진동이 크게 문제되어 그 저감대책에 대한 많은 연구가 진행되어 왔다. 본 고에서는 1970년대부터 최근까지 선진각국 특히 일본에서 발생한 건설소음진동의 현상과 그 저감을 위하여 그동안 어떠한 노력을 어떻게 수행해 왔는가에 대하여 정리하였다.
최석주,귤수수,박병권,Choi Seok Joo,Tachibana Hideki,Park Byeong Jeon 한국음향학회 1989 韓國音響學會誌 Vol.8 No.5
유한요소법은 일반적으로 변분원리를 이용해 정식화를 하고 있으나, 본 연구에서는 웨이티드 잔차법으로 아주 좋은 근사해를 얻을 수 있다는 Galerkin법에 의해 Helmholtz방정식으로부터 직접 유산요소 정식화하는 방법을 소개하고, 정식화한 수치계산법을 2, 3차원 음장의 고유모드 및 음향방사상태해석에 응용하였다. 또한 수치 계산결과를 확인하기 위하여 간단한 모형을 제작, 실내음향 모드와 음압분포 등의 측정도 병행하였으며 그 결과, 유한요소법에 의한 수치해석결과의 측정치가 잘 맞는 것을 알았다. The finite element method is usually formulated by utilizing the variation principle. In this paper, we introduce the approximate equation of finite element from Helmholtz eqation by means of the Galerkin method, which provides the best approximation of those methods known as the method of weighted residuals, and a numerical simulation based of the finite element method is applied to analysing the acoustic modes and the pattern of sound radiation in two and three dimensional sound fields. Beside the numerical calculations, the acoustic modes and the sound pressure level are mesured by scale model experiments. The finite element analysis of the model shows very good agreement with the mesured results.