Energy storage capabilities of nitrogen-enriched pyropolymer nanoparticles fabricated through rapid pyrolysis

Yun, Young Soo,Kim, Yu Hyun,Song, Min Yeong,Kim, Na Rae,Ku, Kyojin,An, Ji Su,Kang, Kisuk,Choi, Hyoung Jin,Jin, Hyoung-Joon Elsevier 2016 Journal of Power Sources Vol.331 No.-

<P><B>Abstract</B></P> <P>Nanostructured pyropolymers contain significant amounts of redox-active heteroatoms, have high specific surface areas, and a defective carbon microstructure, indicating good potential for pseudocapacitive charge storage. In this study, nitrogen-enriched pyropolymer nanoparticles (N-PNs-50) are fabricated from polyaniline nanotubes through rapid pyrolysis at 50 °C min<SUP>−1</SUP>. N-PNs-50 exhibit a nitrogen content of 9.8 wt%, a high specific surface area of 875.8 m<SUP>2</SUP> g<SUP>−1</SUP>, and an amorphous carbon structure with an I<SUB> <I>D</I> </SUB>/I<SUB> <I>G</I> </SUB> intensity ratio of 0.95. These unique characteristics lead to good electrochemical performances, in which reversible capacities of 660 and 255 mAh g<SUP>−1</SUP> are achieved for Li-ion and Na-ion storage, respectively, with favorable voltage characteristics (<1.5 V for Li-ions and <1.2 V for Na-ions). This study provides a more feasible production method for nitrogen-doped pyropolymers and their practicable electrochemical performances for use as an anode in energy storage devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanostructured pyropolymers (N-PNs-50) were fabricated by rapid pyrolysis. </LI> <LI> N-PNs-50 exhibited a nitrogen content of 9.8 wt% and amorphous carbon structure. </LI> <LI> N-PNs-50 exhibited a high specific surface area of 875.8 m<SUP>2</SUP> g<SUP>−1</SUP>. </LI> <LI> 660 and 255 mAh g<SUP>−1</SUP> were achieved for Li-ion and Na-ion storage, respectively. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Nitrogen-enriched pyropolymer nanoparticles (N-PNs-50) were fabricated from polyaniline nanotubes through rapid pyrolysis at 50 °C min<SUP>−1</SUP>, showing superior electrochemical performances.</P> <P>[DISPLAY OMISSION]</P>

Mutation in PMR1, a Ca^2+ -ATPase in Golgi, Confers Salt Tolerance in Saccharomyces cerevisiae by Inducing Expression of PMR2, an Na^+ -ATPase in Plasma Membrane

Park, Shi-Young,Seo, Soo Boon,Lee, Soo-Jung,Na, Jong-Gil,Kim, Yung-Jin 부산대학교 유전공학연구소 2001 분자생물학 연구보 Vol.17 No.-

Sodium tolerance in yeast is enhanced by continuous activation of calcineurin, a Ca^2+/calmodulin-dependent protein phosphatase that is required for modulation of the Na^+ efflux mechanism. We isolated several salt-tolerant mutations with the treatment of ethylmethane sulfonate under high salt stress. One of the mutations was mapped in the PMR1 gene. Pmr1p, the P-type Ca^2+ -ATPase in the Colgi apparatus, regulates a cytosolic Ca^2+ level in various responses. Cytosolic Ca^2+ concentration in the pmr1 mutant is highly maintained, and thus calcineurin is activated continuously. The treatment of FK506, a specific inhibitor of calcineurin, abolishes the salt-tolerant phenotype of the pmr1 mutant. Activates caicineurin induces the expression of PMR2, encoding the P-type Na^+-ATPase, through the specific transcription factor, Tcn1p/Crzlp. Also, experssion of the PMR2::lacZ reporter gene in the pmr1 higher than that in wild type. We propose that the pmr1 mutation confers salt tolerance through continuous activation of calcineurin and that Pmr1p might act as a major Ca^2+-ATPase under high salt stress.

원위부 신세뇨관성 산증에서 산-염기 운반체의 결손

김혜영,한진석,이정상,김현리,김진,이중건,이서진,김근호,진호준,전은실,주권욱,나기영,정우경,오지은,엄재호,궁성수 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5

The purpose of this study was to elucidate whether the molecular defect of acid-base transporters in renal tubules is related to the functional defect of urinary acidification in distal renal tubular acidosis(RTA). We performed NH₄Cl, furosemide, or bicarbonate loading test to evaluate renal acidification function, and immunohistochemistry using antibodies to H^+ -ATPase, Cl^-/HCO₃^- exchanger(band-3 protein), and Na^+/K^+ -ATPase in kidney tissue in 6 patients with RTA and renal cell carcinoma patients as normal controls. Kidney tissue was obtained either by percutaneous needle biopsy(RTA) or nephrectomy(NC). The results were as follows; 1) In all six RTA patients, proton secretory defect of distal acidification was shown by a failure to lower the urine pH after NHC1 loading or furosemide test or abnormally low urine-blood pCO₂ difference during bicarbonate loading. In two patients with RTA, proximal acidification defect was combined, which was demonstrated by increased fractional excretion of bicarbonate. 2) In mal control, intense H^+ -ATPase and band-3 protein staining was observed in collecting ducts. 3) In distal RTA patients, H6+ -ATPase and band-3 protein staining was not demonstrable or markedly decreased in the intercalated cells of distal nephron. 4) In two patients who had both proximal and distal RTA, H^+ -ATPase staining was markedly decreased in the brush border of proximal tubules as well as the distal nephron. In conclusion, the defect of acid-base transporters in renal tubule was related with the functional defect of urinary acidification in distal RTA.

이뇨제의 저항성과 내성 기전

오윤규,나기영,김근호,김소영,한진석 대한신장학회 2001 대한신장학회잡지 Vol.20 No.5

품종별 무화과의 영양성분 비교

나환식 ( Hwan Sik Na ),김진영 ( Jin Young Kim ),박학재 ( Hak Jae Park ),최경철 ( Gyeong Cheol Choi ),양수인 ( Soo In Yang ),이지헌 ( Ji Heon Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.3

국내에서 주로 재배되는 무화과 품종인 도후인(Dauphine)2종, 봉래시(Horaish)2종, 바나네(Banane) 1종을 대상으로 이화학적 특성을 분석한 결과, 무화과의 수분은 85.37~87.28%, 회분 0.38~0.43%, 조지방 0.20~0.26%, 조단백질 0.39~0.81%로 품종별 차이는 보이지 않았으며 조섬유는 바나네가 7.55±0.13%로 다른 품종 5.12~7.60%에 비해 다소 높은 결과를 보였다. 무기성분 함량은 모든 품종에서 K>Ca>Mg>Na순으로 나타났으며 전체 함량의 경우 도후인 품종이 타 품종에 비해 조금 높은 결과를 보였다. 바나네 품종과 봉래시 품종의 총 유리아미노산 조성은 glutamic acid>proline>aspartic acid 순으로 높은 분포를 보였으며, 전체 함량의 51.68~58.71%를 차지하고 있으며, 도후인 품종의 경우 glutamic acid>aspartic acid>alanine이 전체의 약 50%를 차지하고 있었다. 또한 기억력 감퇴 예방 등 학습 능력에 도움을 주는 기능성 물질인 γ-aminobutyric acid(GABA) 함량은 바나네에서 26.69mg/100g으로 상당히 높은 함량을 보였다. 총 폴리페놀 함량은 도후인이 198.91~261.64mg/kg, 봉래시 품종이 169.90~174.33mg/kg, 바나네 품종이 211.07mg/kg으로 나타났으며 총 플라보노이드 함량은 바나네(84.95mg/kg), 도후인(60.47~68.71mg/kg), 봉래시(44.12~44.60mg/kg)순으로 바나네가 가장 높았으며 품종간의 차이를 보였따. 플라보노이드성분 중 quercetin과 kaempferol은 각각 2.40~3.54mg/kg, 1.09~1.16mg/kg으로 분석되었다. In this study, the proximate compositions, minerals, free amino acids, total polyphenol and flavonoids of figs were analyzed according to their cultivars. The proximate compositions showed moisture at 85.37~87.28%, crude ash at 0.38~0.43%, crude lipid at 0.20~0.26%, crude protein at 0.39~0.81%, carbohydrate at 11.23~13.66% and crude fiber at 5.12~7.55% (dry base). The amounts of the following minerals in the figs were highest, in this order: K > Ca > Mg > Na. The total polyphenol contents were highest in this order: Dauphine (198.91~261.64mg/kg), Banane (211.07 mg/kg) and Horaish (169.90~174.33 mg/kg). The total flavonoid contents were highest in this order. Banane (84.52 mg/kg) > Dauphine (60.47~68.71 mg/kg) > Horaish (44.12~44.60mg/kg). The quercetin contents were highest in this order. Dauphine, 2.40~3.54 mg/kg; Banane, 3.54 mg/kg; and Horaish, 2.40~2.75 mg/kg; but the flavonoid contents were lowest in this order. Dauphine, 1.11~1.16 mg/kg; Banane, 1.14 mg/kg; and Horaish, 1.09~1.11 mg/kg. The free amino acid content of the figs was 199.70~328.77 mg/100g; their essential free amino acid contents, 46.45~67.46 mg/100 g; and their GABA (γ-aminobutyric acid) contents, 13.57~26.69 mg/100 g.

Hierarchically nanoporous pyropolymer nanofibers for surface-induced sodium-ion storage

Yoon, Hyeon Ji,Lee, Min Eui,Kim, Na Rae,Yang, Seung Jae,Jin, Hyoung-Joon,Yun, Young Soo Pergamon Press 2017 Electrochimica Acta Vol. No.

<P><B>Abstract</B></P> <P>Surface-driven charge storage materials based on both electrochemical double layer (EDL) formation and pseudocapacitive behavior can deliver high energy and power capabilities with long-lasting cycling performance. On the other hand, the electrochemical performance is strongly dependent on the material properties, requiring sophisticated electrode design with a high active surface area and a large number of redox-active sites. In this study, hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) were fabricated from electrospun polyacrylonitrile nanofibers by simple heating with KOH. The HN-PNFs have a hierarchically nanoporous structure and an exceptionally high specific surface area of 3,950.7m<SUP>2</SUP> g<SUP>−1</SUP> as well as numerous redox-active heteroatoms (C/O and C/N ratio of 10.6 and 16.8, respectively). These unique material properties of HN-PNFs resulted in high reversible Na-ion capacity of ∼292mAhg<SUP>−1</SUP> as well as rapid kinetics and stable cycling performance in the cathodic potential range (1-4.5V vs. Na<SUP>+</SUP>/Na). Furthermore, energy storage devices based on HN-PNFs showed a remarkably high specific energy of ∼258 Wh kg<SUP>−1</SUP> at ∼245Wkg<SUP>−1</SUP> as well as a high specific power of ∼21,500Wkg<SUP>−1</SUP> at ∼78 Wh kg<SUP>−1</SUP>, with long and stable cycling behaviors over 2,000 cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) were fabricated. </LI> <LI> HN-PNFs have a high specific surface area of ∼3,950m<SUP>2</SUP> g<SUP>−1</SUP> and numerous heteroatoms. </LI> <LI> HN-PNFs exhibit high capacities of ∼292mAhg<SUP>−1</SUP> and great rate/cycling performances. </LI> <LI> High energy (258Whkg<SUP>−1</SUP>) and high power (21,500Wkg<SUP>−1</SUP>) are achieved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Hierarchically nanoporous pyropolymer nanofibers (HN-PNFs) fabricated from electrospun polyacrylonitrile nanofibers by simple heating with KOH exhibited high electrochemical performance for Na-ion storage.</P> <P>[DISPLAY OMISSION]</P>

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Glyoxal-induced exacerbation of pruritus and dermatitis is associated with <i>staphylococcus aureus</i> colonization in the skin of a rat model of atopic dermatitis

Han, Rafael Taeho,Kim, Hye Young,Ryu, Hyun,Jang, Wooyoung,Cha, Seung Ha,Kim, Hyo Young,Lee, JaeHee,Back, Seung Keun,Kim, Hee Jin,Na, Heung Sik Elsevier 2018 Journal of dermatological science Vol.90 No.3

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induced aggravation of AD have hardly been studied.</P> <P><B>Objective</B></P> <P>To investigate the molecular mechanisms by which glyoxal, a PM-forming organic compound, exacerbates the symptoms of AD induced by neonatal capsaicin treatment.</P> <P><B>Methods</B></P> <P>Naïve and AD rats had been exposed to either fresh air or vaporized glyoxal for 5 weeks (2 h/day and 5 days/week) since one week of age. Pruritus and dermatitis were measured every week. The skin and blood were collected and immunological traits such as Staphylococcus aureus skin colonization, production of antimicrobial peptides and immunoglobulin, and mRNA expression of inflammatory cytokines were analyzed.</P> <P><B>Results</B></P> <P>Exposure to glyoxal aggravated pruritus and dermatitis in AD rats, but did not induce any symptoms in naïve rats. Staphylococcus aureus skin colonization was increased in the skin of both naïve and AD rats. Expression of antimicrobial peptides such as LL-37 and β-defensin-2 was also increased by exposure to glyoxal in the skin of both naïve and AD rats. The mRNA expression of Th1-related cytokines was elevated on exposure to glyoxal. However, serum immunoglobulin production was not significantly changed by exposure to glyoxal.</P> <P><B>Conclusion</B></P> <P>In AD rats, exposure to glyoxal exacerbated pruritus and cutaneous inflammation, which was associated with increased colonization of <I>S. aureus</I> and subsequent immunological alterations in the skin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Exposure to glyoxal aggravated the symptoms in AD rats, but did not induce AD in naïve rats. </LI> <LI> <I>S. aureus</I> skin colonization and subsequent expression of antimicrobial peptides were increased after exposure to glyoxal. </LI> <LI> Exposure to glyoxal elevated the production of Th1-related cytokines such as TNF-α and IFN-γ in the AD lesional skin. </LI> </UL> </P>

고속 주행 모드에서 자동차 디퓨저의 스트레이크 개수와 배치에 따른 공기저항 유동해석

이진호,박성하,최동석,한영진,곽나영,이상욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

This study proposes an optimized diffuser strake design that can improve driving performance for cars in high-speed driving mode. The speed of the vehicle is set to 160km/h, and the number of strake is set to 4, 6 and 8, and the angle of the diffuser is set to 4, 5 and 6 degrees. The arrangement of the strake is centered, edged and equally arranged. The optimized diffuser design induced with the Ansys Fluent analysis shows a drag coefficient of 16% less than the basic diffuser-free model at a diffuser angle of 6 degree, 8 strakes, and equal arrangement.

영아 급성 출혈설 부종 1례

나보미,이진석,하태선,윤태영 충북대학교 의과대학 충북대학교 의학연구소 2004 忠北醫大學術誌 Vol.14 No.1

영아 급성 출혈성 부종 (acute hemorrhagic edema of infancy, AHEI)은 4개월에서 2세 사시의 소아에서 주로 얼굴과 사지에 국한된 염증성 부종과 특징적인 자반성 피부 병변을 보이는 백혈구 파쇄성 혈관염으로, 내부 장기의 침범 없이 급성의 피부 병변을 보이며 대게 1-3주 내에 자연 치유되는 양성질환이다. 이 질환은 비슷한 임상양상이나 조직소견을 보이는 다양한 질환들과의 감별이 필요한데, 특히 소아에서는 Henoch-Schonlein 자반증과의 감별이 특히 중요하다. 이에 저자들은 자반성 피부병변과 얼굴과 사지의 부종 등의 특징적 피부증상과 피부 병리소견을 통하여 AHEI로 진단한 17개월 남아 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Acute hemorrhagic edema of infancy (AHEI) is a variant of leukocytoclastic vasculitis which is characterized by edema and pupuric skin lesions involving mainly the face and extremities. However, there is usually no visceral involvement. The onset of the disease is acute but self-limited, bearing a benign clinical course within 1 to 3 weeks. The main differential diagnosis of AHEI is Henoch-Schonlein purpura. We report a 17-month old boy with AHEI presenting purpuric skin lesions, edema on face and extremities, and leukocytoclastic vasculitis on skin pathology.