RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
          • 원문제공처
          • 등재정보
          • 학술지명
          • 주제분류
          • 발행연도
          • 작성언어
          • 저자

        오늘 본 자료

        • 오늘 본 자료가 없습니다.
        더보기
        • 무료
        • 기관 내 무료
        • 유료
        • Mitral Loop Cerclage Annuloplasty for Secondary Mitral Regurgitation

          Park, Y.H.,Chon, M.K.,Lederman, R.J.,Sung, S.C.,Je, H.G.,Choo, K.S.,Lee, S.H.,Shin, E.S.,Kim, J.S.,Hwang, K.W.,Lee, S.Y.,Chun, K.J.,Kim, C.M.,Kim, J.H. Elsevier 2017 JACC. Cardiovascular interventions Vol.10 No.6

          <P>OBJECTIVES This is an early feasibility clinical test of mitral loop cerclage annuloplasty to treat secondary mitral valve regurgitation. BACKGROUND Secondary mitral regurgitation is characterized by cardiomyopathy, mitral annular enlargement, and leaflet traction contributing to malcoaptation. Transcatheter mitral loop cerclage applies circumferential compression to the mitral annulus by creating a loop through the coronary sinus across the interventricular septum, protecting entrapped coronary arteries from compression, and interactive annular reduction under echocardiographic guidance. This is the first human test of mitral loop annuloplasty. METHODS Five subjects with severe symptomatic secondary mitral regurgitation underwent mitral loop cerclage, with echocardiographic and computed tomography follow-up over 6 months. RESULTS Mitral loop cerclage was successful in 4 of 5 subjects and aborted in 1 of the 5 because of unsuitable septal coronary vein anatomy. Immediately and over 6 months, measures of both mitral valve regurgitation (effective orifice area and regurgitation fraction) and chamber dimensions (left atrial and left ventricular volumes) were reduced progressively and ejection fractions increased. Two with persistent and permanent atrial fibrillation spontaneously reverted to sinus rhythm during follow-up. One subject experienced a small myocardial infarction from an unrecognized small branch coronary occlusion. Another, experiencing cardiogenic shock at baseline, died of intractable heart failure after 6 weeks. CONCLUSIONS In this first human test, mitral loop cerclage annuloplasty was successful in 4 of 5 attempts, caused reverse remodeling (reduction in secondary mitral regurgitation and heart chamber volumes), and suggested electrical remodeling (reversion of atrial fibrillation). Further evaluation is warranted. (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.</P>

        • Orbital hybridization mechanism for the enhanced photoluminescence in edge-functionalized sp<sup>2</sup> carbon clusters

          Kang, B.,Choi, Y.,Kim, B.S.,Youn, I.S.,Lee, G. Pergamon Press ; Elsevier Science Ltd 2016 Carbon Vol.109 No.-

          <P>Using the first principles methods, we performed systematic study on the effect of edge-functional groups on the electronic energy levels and the optical properties of sp(2) carbon clusters. It is found that the intrinsic pi and pi* orbitals are weakly altered by oxygen-bearing functional groups, but it is significantly disrupted by pyrrolic groups. Thereby the oscillator strength of the lowest-energy transition is found to be much stronger for the pyrrolic group functionalized cluster than for the carboxyl group. From our results being consistent with the experimental reports, we suggest that the photoluminescence enhancement is caused by a perturbation of the intrinsic, frontier molecular orbitals by edge groups. (C) 2016 Elsevier. Ltd. All rights reserved.</P>

        • SCISCIESCOPUS

          Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin

          Manokruang, Kiattikhun,Lym, Jae Seung,Lee, Doo Sung Elsevier 2014 Materials letters Vol.124 No.-

          Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. (C) 2014 Elsevier RV. All rights reserved.

        • WITHDRAWN: Spectroscopic characterization of selected functionalized fullerenes - IR absorption and Raman scattering studies

          Lewandowska, K.,Barszcz, B.,Graja, A.,Nam, S.Y.,Han, Y.S.,Kim, T.D.,Lee, K.S. Elsevier Science Publishers 2014 Materials chemistry and physics Vol.148 No.3

          The Publisher regrets that this article is an accidental duplication of an article that has already been published in <Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 118, (2014) 204 - 209>, http://dx.doi.org/<10.1016/j.saa.2013.08.102>. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

        • Ceramide synthases as potential targets for therapeutic intervention in human diseases

          Park, Joo-Won,Park, Woo-Jae,Futerman, Anthony H. Elsevier 2014 Biochimica et biophysica acta, Molecular and cell Vol.1841 No.5

          <P>Ceramide is located at a key hub in the sphingolipid metabolic pathway and also acts as an important cellular signaling molecule. Ceramide contains one acyl chain which is attached to a sphingoid long chain base via an amide bond, with the acyl chain varying in length and degree of saturation. The identification of a family of six mammalian ceramide synthases (CerS) that synthesize ceramide with distinct acyl chains, has led to significant advances in our understanding of ceramide biology, including further delineation of the role of ceramide in various pathophysiologies in both mice and humans. Since ceramides, and the complex sphingolipids generated from ceramide, are implicated in disease, the CerS might potentially be novel targets for therapeutic intervention in the diseases in which the ceramide acyl chain length is altered. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. (C) 2013 Elsevier B.V. All rights reserved.</P>

        • Direct spraying approach for synthesis of ZIF-7 membranes by electrospray deposition

          Aceituno Melgar, Ví,ctor Manuel,Kwon, Hyuk Taek,Kim, Jinsoo Elsevier 2014 Journal of membrane science Vol.459 No.-

          <P>Zeolitic imidazolate frameworks (ZIFs) are promising materials for advanced membrane applications clue to their desirable properties, which enable them to recognize specific target molecules based on the molecular sieving mechanism and/or adsorption affinity. However, their large scale commercial applications still remain a challenge because of the absence of a synthesis method that offers reproducibility, scalability, and cost-effectiveness. To this end, here we report our work of synthesizing supported zeolitic imidazolate framework ZIF-7 films and membranes in a facile and time-efficient manner at ambient pressure using a simple electrospray deposition technique. A governing parameter which dominantly affected the microstructures and crystal integrity of the membranes was deposition temperature while precursor flow rate and applied voltage to the precursor solution were important variables to obtain a stable spraying mode which is essential to have a uniform coating. Our method, which is an electrostatic force-assisted coating approach, has the following attractive advantages over conventional synthetic routes such as in situ and secondary growth methods: (1) dramatic reduction in synthesis time and precursor consumption, (2) simplification in the activation process, and (3) potential scalability. Furthermore, the membranes obtained under optimized conditions outperformed previously reported ZIF-7 membranes for H-2/CO2 separation while showing rather noticeable improvement in H-2 permeance which is roughly 4-10 times higher than the previous counterparts. (C) 2014 Elsevier B.V. All rights reserved</P>

        • Effect of thermal history on lattice expansion and guest distribution of tetrahydrofuran clathrate hydrate with air molecules

          Koh, D. Y.,Kang, H.,Park, Y.,Lee, H. Elsevier Science B.V., Amsterdam. 2014 Chemical physics letters Vol.597 No.-

          Air hydrates can form under the high-pressure and low-temperature conditions found in deep ice sheets of the Arctic and Antarctic regions. These hydrates can play a major role in the analysis of data gathered in these regions. Through this Letter, we investigate on thermal expansivity and guest-molecule dynamics of THF + air clathrate hydrate provided by a neutron scattering experiment and address two noteworthy features. First is the effect of thermal history on host water-lattice expansion and related gas-inclusion effect on thermal expansion coefficients. Second is the changes in guest-molecule distribution during the degassing process caused by thermal stimulation. (C) 2014 Elsevier B.V. All rights reserved.

        • SCISCIESCOPUS

          Control of secondary pore dimension of bimodal mesoporous silicas prepared from CTAOH and Brij mixed template

          Bae, Sang-Eun,Huh, Seong Elsevier 2014 Materials letters Vol.122 No.-

          We prepared a series of bimodal mesoporous silicas (BMSs) using a mixed template system. Cetyltrimethylammonium hydroxide (CTAOH) and varying concentrations nonionic auxiliary templates, including Brij76, Brij72, Brij52, and Brij30, were employed as templates. These mixed template syntheses led to BMS materials with two different length scales of mesopores. The small mesopore was thought to be generated by the CTA(+) template, while the secondary large pore was produced by the auxiliary template. Depending on the chemical structure of the auxiliary template, the dimensions of the secondary large pore had systematically changed. 2014 Elsevier B.V. All rights reserved.

        • Standing wave design and optimization of a simulated moving bed chromatography for separation of xylobiose and xylose under the constraints on product concentration and pressure drop

          Lee, Chung-gi,Choi, Jae-Hwan,Park, Chanhun,Wang, Nien-Hwa Linda,Mun, Sungyong Elsevier 2017 Journal of chromatography A Vol.1527 No.-

          <P>The feasibility of a simulated moving bed (SMB) technology for the continuous separation of high-purity xylobiose (X2) from the output of a beta-xylosidase X1 -> X2 reaction has recently been confirmed. To ensure high economical efficiency of the X2 production method based on the use of xylose (X1) as a starting material, it is essential to accomplish the comprehensive optimization of the X2-separation SMB process in such a way that its X2 productivity can be maximized while maintaining the X2 product concentration from the SMB as high as possible in consideration of a subsequent lyophilization step. To address this issue, a suitable SMB optimization tool for the aforementioned task was prepared based on standing wave design theory. The prepared tool was then used to optimize the SMB operation parameters, column configuration, total column number, adsorbent particle size, and X2 yield while meeting the constraints on X2 purity, X2 product concentration, and pressure drop. The results showed that the use of a larger particle size caused the productivity to be limited by the constraint on X2 product concentration, and a maximum productivity was attained by choosing the particle size such that the effect of the X2-concentration limiting factor could be balanced with that of pressure-drop limiting factor. If the target level of X2 product concentration was elevated, higher productivity could be achieved by decreasing particle size, raising the level of X2 yield, and increasing the column number in the zones containing the front and rear of X2 solute band. (c) 2017 Elsevier B.V. All rights reserved.</P>

        • SCISCIESCOPUS

          Purification of O-specific polysaccharide from lipopolysaccharide produced by Salmonella enterica serovar Paratyphi A

          Kothari, Sudeep,Kim, Jeong-Ah,Kothari, Neha,Jones, Christopher,Choe, Woo Seok,Carbis, Rodney Elsevier 2014 Vaccine Vol.32 No.21

          The O specific polysaccharide (OSP) of the lipopolysaccharide (LPS) of Salmonella enterica serovar Paratyphi A is a protective antigen and the target for vaccine development. LPS is the major constituent of the outer membrane of S. Paratyphi A with the OSP exposed on the surface, in addition to the cell associated LPS a large amount of free LPS was present in the fermentation broth. A purification method was developed to take advantage of both sources of LPS and to maximize recovery of OSP. After fermentation the bacterial cells were concentrated and washed, the permeate containing the free LPS was processed separately from the cells. The free LPS was concentrated and washed on a 100 kD ultrafiltration membrane to remove low molecular weight impurities. The LPS was then detoxified by separation of the lipid A from the OSP using acid hydrolysis at 100 degrees C, the precipitated lipid A was removed by 0.2 mu m membrane filtration. Contaminants were then removed by acid precipitation in the presence of sodium deoxycholate. The OSP was concentrated and washed with 1 M NaCl then water using a 10 kD ultrafiltration membrane then sterile filtered through a 0.2 mu m membrane filter. The cells were treated by acid hydrolysis at 100 degrees C, the remaining cells, cell debris and precipitate was removed by centrifugation. The filtrate was then treated in the same way as described above for the free LPS. The combined yield of purified OSP from free LPS plus the cells was greater than 880 mg/L of culture broth. The method developed yields large amounts of OSP, is scalable and compatible with cGMP so would be readily transferrable to developing country vaccine manufacturers for low cost production of vaccine against S. Paratyphi A. (C) 2014 Elsevier Ltd. All rights reserved.

        맨 위로 스크롤 이동