정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

법의 지배와 사법제도 - 정철, 『중국의 사법제도』, 경인문화사, 2009

정호경(Chung Ho Kyung) (서평자) 국민대학교 법학연구소 2009 법학논총 Vol.22 No.1

남자 고등학생의 흡연행위군별 성격특성

류미경,박경민,김정남,장은진,이충원,김대현,정철호 대한보건협회 2000 대한보건연구 Vol.26 No.2

The purpose of this study is to investigate the differences of personality characteristics using Minnesota Multiphasic Personality Inventory(MMPI) by current-smokers, ex-smokers and non-smokers among male high school students. The subjects for this study were 448 first and second year male students at general and vocational high school in Taegu and Kyung-Buk Province. Data was collected from August 25 to September 15, 1999. The instrument used in this study was the Validity Scale and the Clinical Scale, the Ego Strength Scale and the Personality Disorder Scale of the MMPI. The data was analysed by using the SPSS Program which included frequency, percentage, x^2-test, ANOVA, scheffe test and stepwise discriminant analysis. The results obtained from this study were as follows. (1) There were significant differences by smoking behavior groups in parents who smoke and who did not smoke(p=.044), intimate-friends who smoke and not(p=.000), academic record(p=.000), satisfaction with school life(p=.020), effect of smoking on health(p=.000), drinking experience(p=.000), drug-use experience(p=.007) and experience into No minors district(p=.000). (2) T-scores of subjects in this study were in the range of 40-60. Psychopathic Deviate Scale(Pd), Paranoid Scale(Pa), Psychasthenia Scale(Pt), Schizophrenia Scale(Sc), Histrionic Personality Disorder Scale(HST) and Anti-social Personality Disorder Scale(ANT) showed higher T-scores than other Clinical and Personality Disorder Scale. (3) The results of post-hoc in Validity Scale and Clinical Scale are as follows: T-scores of current-smokers were higher than that of ex-smokers and non-smokers in Hysteria Scale(Hy), Psychopathic Deviate Scale(Pd), Paranoid Scale(Pa), Psychasthenia Scale(Pt), Schizophrenia Scale(Sc) and Hypomania Scale(Ma); T-scores of non-smokers were higher than that of ex-smokers in Depression Scale(D), and T-scores of non-smokers were higher than that of current-smokers and ex-smokers in Social Introversion Scale(Si). (4) In Ego Strength Scale and Personality Disorder Scale, T-scores of ex-smokers were higher than those of current-smokers. In Histrionic Personality Disorder Scale(HST) and Narcissistic Personality Disorder Scale(NAR), T-scores of current smokers and ex-smokers were higher than those of non-smokers. In Borderline Personality Disorder Scale(BDL), Anti-social Personality Disorder Scale(ANT) and Paranoid Personality Disorder Scale(PAR), T-scores of current-smokers were higher than those of ex-smokers and non-smokers. In Schizotypal Personality Disorder Scale(STY), T-scores of current smokers were higher than that of ex-smokers. In Avoidant Personality Disorder Scale(AVD), T-scores of non-smokers were higher than those of current-smokers and ex-smokers. (5) As a result of stepwise discriminant analysis of the MMPI Scale by smoking behavior, a discrimination rate of the F Scale, Hypomania Scale(Ma), Social Introversion Scale(Si) and Psychopathic Deviate Scale(Pd) out of the Validity Scale and Clinical Scale was 51.1%, and that of Anti-social Personality Disorder Scale(ANT) and Avoidant Personality Disorder Scale(AVD) out of the Personality Disorder Scale was 51.6%, both of the rates were statistically significant. The Above results suggested that smoking by high school students is related with personality characteristics as well as external factors like family, school and their social environment. So school health professionals who are in charge of school health, should operate various smoking prevention or prohibition programs, taking into account personality characteristics. It might have an effect on smoking prevention and the reduction of the smoking rate.

신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

접착제의 요소로서 condensed tannin을 사용한 복합체의 접착 연구

丁炅鎬 水原大學校 1992 論文集 Vol.10 No.-

The search is on for materials to replace the petroleum-based resins used as adhesives in the composite products industry. Alternative adhesives have been recognized as important since the oil shortages of the 1970's. Adhsives from natural resources must be available in the event that instability in the Persian Gulf again makes supplies of petrochemicals inadequate or undependable. In this paper, the types of material used as an adhesive will be introduced and the basic properties will be studied.

151종 생약제 추출물이 B형 간염 바이러스 표면 항원(HBsAg)과 항체(HBsAb)의 결합반응 그리고 HBV DNA polymerase 활성에 미치는 효과 : 한국산 각종 생약제를 이용한 B형 간염치료제의 개발

정태호,김정철,김문규,이인선,채성철,김승래,정준모,이인수,김승호,함경수 慶北大學校 醫科大學 1992 慶北醫大誌 Vol.33 No.3

세계인구 43억명 중 B형 간염 바이러스 보균자는 2억 1천 5백만명이며 이중 78%인 1억 6천만명 이상이 아시아 대륙에 집중되어 있다. 한국도 B형 바이러스 간염의 침윤지대이다. 본 연구는 B형 바이러스 보균자 혹은 만성간염을 치료할 수 있는 생약제를 탐색할 목적의 일환으로 한국에서 시판하는 생약제 151종을 구입하여 증류수로 추출하고 여과한 후 냉동건조하여 HBs 항원에 대한 결합능, HBV DNA polymerase억제능, tumor necrosis factor(TNF) 유리에 미치는 영향, 그리고 galactosamine 유발 간염에 대한간장보호 작용을 조사하였다. 151종의 생약제중 0.16㎍/㎖ 농도에서 간염 vaccine 내에 함유된 HBs 항원과 결합하는 생약제는 지유, 가자, 복분자, 대황, 정향, 빈량, 산수유, 소목, 마황, 쇄양, 후박, 목과, 양강, 오약, 산사, 목단피 등 16종이었다. 이들 생약제중 대황(Rheum palmatum L. 大黃), 가자(Terminalia chebula R. 訶子), 지유(Sanguisorba officinalis L. 地楡), 복분자(Rubus coreanus M. 覆盆子)는 HBV DNA polymerase 활성도를 비교적 강하게 억제하였으며 빈량(Areca catechu L. 빈랑), 정향(Eugenia caryophyllata T. 丁香), 목과(Chaenomeles japonica L. 木瓜), 산수유(Cornus officinalis S. 山茱萸)는 약하게나마 HBV DNA polymerase 활성을 억제하였다. 또한 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 대상으로 TNF 유리에 미치는 영향을 조사한 결과 소목을 제외한 8종의 생약제 모두가 대식세포를 자극하여 TNF를 유리시켰다. 그리고 장차 임상에 사용함을 전제로 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 galactosamine 유발 간염(백서)에 투여하여 간기능 검사에 미치는 효과를 조사하였으나 간기능 검사상으로는 특별한 보호작용을 나타내지 못하였으며 생약제 단독 투여로서는 간기능에 대하여 나쁜 영향을 주지 않았다. Hepatitis B virus infection is major cause of acute and chrome hepatitis, cirrhosis of liver, and hepatocellular carcinoma. There are over 200 million carriers of hepatitis B virus in the world, nearly 80 % of whom live in the South East Asia, Korea is also highly endemic area of hepatitis B virus infection. This study was performed to evaluate the effect of extracts of traditional Korean herbal medicines on hepatitis B virus. 151 traditional herbs were extracted, filtered and lyophilized. Using 151 herbal extracts we tested binding capability to the HBs Ag, inhibition of HBV DNA polymerase, release of tumor necrosis factor (TNF), and protection against galactosamine induced liver damage. Among 151 herbs, 16 herbs (Sanguisorba officinalis L., Terminalia chebula R., rubus coreanus M., Rheum palmatum L., Eugenia caryophyllata T., Areca catechu L., Cornus officinalis S., Caesalpinia sappan L, Ephedra sinica S., Cynomorium songaricum R., Machilus thunbergii S., Chaenomeles japonica L., Alpinia officinarum H., Lindera strychnifolia V., Crataegus pinnatifida B., Paeonia suffruticasa A. ) had binding capability to HBs Ag which contained in the commercial hepatitis vaccine, at 16 ug/㎖ of concentratioa Among the above 16 herbs, Rheum palmatum L., Terminalia chebula R., Sanguisorba officinalis L., Rubus coreanus M. significantly inhibited the HBV DNA polymerase activity, and Areca catechu L., Eugenia caryophyllata T., Ephedra sinica S., Caesalpinia sappan L., Chaenomeles Japonica L., Cornus officinalis S. also inibited the HBV DNA polymerase activity but less effective. All of the herbs, except Caesalpinia sappan L., which inhibited the HBV DNA polymerase activity, actively stimulated the mononuclear cells to release tumor necrosis factor(TNF) in whole blood culture system. The herbs which inhibited the HBV DNA polymerase activity, did not show any protective effect in galactosamine-induced hepatitis in rats, but there was no direct toxic effect when herbs were administered alone.

老巨樹 管理實態에 關한 硏究

鄭鎭澈,田璟秀,張圭寬,崔正鎬 圓光大學校大學院 1993 論文集 Vol.12 No.-

The big trees have been keeping the relation to human's living way in various aspects, environment protection, emotion creation and tree worshiping through which they believed to be safe, happy and prosperous, and also giving more recreational opportunity to provincial particularly. This study was carried out to analyse the status of designation and management of big tree in Iri-Iksan province, Chollabuk-Do. The result are summarized as follows. 1. It was appeared that at present Big trees in the investigated area were 78 location (7 families, 9 genera, 11 species) that was identified. Among them the species appearing most frequently were Zelkova serrata(25), Salix glandulosa (20), Gingko biloba(15) and Celtis japonica(8) in that order. The order hand, designation grade of big tree classified into six categories, that is 1 botanic natural monument, 5 Si-Kun tree, 3 Eup-Myon tree, 1 maeul tree, 53 Restraint tree ad 15 Non-Designation tree. 2. In designation of nurse tree, there are key needs that are professionals in field survey. We suggested the futher designation plan stressed the importance of the value of big tree. 3. Government have to increase of the forestry staff who take sole charge of the protection of big tree, and must reach managers the technique for effective management of big tree. 4. We have to make an budget of big tree management, establish a protective facilities, control of insets and disease on time, and treat and operate on the injured big tree. Thus government should be positively concerned, and more research would need to understand the critical factors affecting the big tree.

Fatigue Crack Growth Behavior in Ultrafine Grained Low Carbon Steel

Ho,Kyung Kim,Myung-Il Choi,Chin-Sung Chung Dong-Hyuk Shin 대한기계학회 2002 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.16 No.10

Ultrafine grained (UFG) low carbon (0.15 wt.% C) steel produced by equal channel angular pressing (ECAP) was tested for investigating the effect of load ratio on the fatigue crack growth rate. Fatigue crack growth resistance and threshold of UFG steel were lower than that of as-received coarse grained steel. It was attributed to the less tortuous crack path. The UFG steel exhibited slightly higher crack growth rates and a lower △K_th with an increase of R ratio. The R ratio effect on crack growth rates and △K_th was basically indistinguishable at lower load ratio (R>0.3), compared to other alloys, which indicates that contribution of the crack closure vanishes. The crack growth rate curve for UFG steel exhibited a longer linear extension to the lower growth rate regime than that for the coarse grained as-received steel.<br/>

상미분방정식 경계치문제에서 경계치 추정

이경호,조정기 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

In this paper, we consider a parameter estimation problem for a boundary value problem. Using linear finite element scheme in the weak formulation, the boundary condition is estimated from the solution observations on some fixed positions. Numerical experimenents are reported.

반응형 폴리우레탄 핫멜트 접착제

정경호 수원대학교 산업기술연구소 1995 산업기술연구소논문집 Vol.10 No.-

Recent trend of the development of adhesive has been changed from mass production typed to diversifies small-quantity production type with the growth of automobile and electronics industry. Accordingly, the main purpose of this study is the development of functional hot melt adhesive using polyurethane to improve the conventional hot melt adhesives which have inherent problems against creep and heat resistance. The physical properties and adhesion strength of ethylene-vinyl acetate, polyamide, and polyurethane were compared. The key factor affecting the final adhesion strength was the toughness of adhesive itself and the surface topography of substrate contributed to the increase of adhesion strength.