한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

악성림프종 환자에서 복합화학요법으로 유발된 백혈구 감소증에 대한 인형 재조합 과립구 집락형성-촉진인자(rhG-CSF: Neutrogin)의 효과

박성규,전진우,기신영,유병우,김홍수,백승호,원종호,홍대식,박희숙 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Clinical effects of rhG-CSF were investigated in 17 patients receiving chemotherapy for non-Hodgkin's lymphoma. Patients were given G-CSF 2㎍/㎏/day after 2nd cycle chemotherapy for least 14 consecutive days, and clinical and laboratory results were compared to results of the first cycle. Treatment with G-CSF resulted in increase of mean WBC count(952.9±152.2㎜³vs 1882.4±350.4/㎜³) and neutrophil count(212.9±53.0/㎜³vs 841.5±238.0/㎜³), reduced the duration of leukocytopenic days(12.4±1.3 days vs 5.5±1.0 days, WBC count less than 4000/㎜³) and neutropenic days(4.5±0.9 days vs 2.3±0.7 days, neutrophil count less than 500/㎜³), and reduced the duration of neutropenic fever(5.8±1.1 days vs 0.9±0.5 days). The side effects of G-CSF were not so significant. These results demonstrated that G-CSF is safe and useful for the treatment of neutropenia induced by anticancer chemotherapy of non-Hodgkin's lymphoma and reducing the incidence of febrile periods and duration of antibiotic administration.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

中學校 科學科의 實驗實習敎材의 開發硏究Ⅱ

朴泳喆,韓麟傳,李春雨,權寧駿,朴弘緖 공주대학교 사범대학 과학교육연구소 1982 과학교육연구 Vol.14 No.1

In this study a few laboratory teaching materials have been developed to be available for the effective performance of experiments and practices- a heart of inquiry learning-as a continuance of 'A study on the Development of Laboratory Teaching Materials for Middle School Science Course I' The present condition of science education has been investigated by means of questionaires, interviews and literature, the results of the present condition and problems in junior high schools are as follows: 1. The hours for science classes are considerably little for the teaching contents of science textbooks. 2. The level of teaching is beyond the student's capability in terms of their experience and intellectual development. 3. Science teachers are overburdened with much tasks, and laboratories and laboratory facilities are too insufficient and furthermore teaching is mainly conducted on the lecture method as a preperation for various entrance exams. 4. Teachers' eagerness and desirable attitude for teaching are required. In this study, materials for every branch of science have been developed to be available for the effective performance of experiments and practices through inquiries. The materials developed in this study are as follows: 1. In physics, measure apparatus of extremely small masses, length, and very little time intervals are developed. 2. In chemistry, new methods for gas generating apparatus and materials. are developed. 3. In biology, the size of quadrate and the method to decide the time in facilitating for the purpose of survey of botany community are introduced. The results of the investigation of natural enemy on Hyphantria cunea, and the study on collecting, breeding of Planaria are also shown. 4. In earth science, the laboratory teaching materials are developed for observing continuous spectrum and line spectrum. Putting the above results of study together, the suggestions are made to the effect as follows: 1. The quantity of learning should be reduced and the levels lowered in the new textbooks. 2. The development and distribution of various teaching materials(film, T,P., cassettes film, supplementary, textbook, program teaching material, individual learning material) is required. 3. The experimental instruments should be timely manufactured and distributed on the basis of effective administrative support to ensure their solidity and accuracy. 4. The concrete design to eliminate the teacher's burden should be contrived and the system for senion teachers in charge of science teaching in secondary schools, should be improved. 5. Teacher's research activities should be encouraged through various research institutes(Institute of science education , graduate school of education and the other research institutes.) 6. The disposition of laboratory assistant should be considered. 7. More positive supports from other societies relevant with education are much expected to be made.

全南地方의 水稻白葉枯病菌 菌型과 그의 地域別 및 品種別 分布

朴淳直,金基淸,禹洪斗,崔容壽 全南大學校 農漁村開發硏究所 1986 農業科學技術硏究 Vol.21 No.-

This was carried out to identify the pathotypes of Xanthomonas campestris pv. oryzae collected from regional exhibition paddys and others in Jeonnam province, and to investigate the sub-regional and varietal distributions of them in 1982. Collected isolates were identified as pathotypes Ⅰ, Ⅱ, Ⅲ and 2 unknown groups with Korean differentials; Ⅰ, Ⅱ, Ⅲ, Ⅳ,Ⅴ and 4 unknown with Japanese; Ⅰ, Ⅱ and 2 unknown with IPPI's, respectively. The fact that unknown groups were isolated suggest that some differentiation is occurring among the previous pathotypes. Using Japanese differentials, pathotype was isolated from l1 sub-regions, Ⅱ and gⅢfrom 4, g from I, g from 3, and unknown 4 groups from 8, respectively. However, there was no sub-region where all 5 pathotypes were detected. Pathotypes with Japanese differentials was isolated from 6 varieties, Iri 346 and 347, Milyang 23 and 30, Jinjubyo and Nakdongbyo: pathotype Ⅱ from 6 varieties, Suvreon 294, Irl 342 and 347, Jinjubyo and Akihikari; pathotype Ⅲ from 5 varieties, Suweon 294, Iri 346, Milyang 30 and Nongrim 41; pathotype Ⅳ from 1 variety, Jinjubyo; pathotype V from 4 varieties, Suweon 294, Iri 347, Milyang 23 and Jinjubyo, respectively.

고속 주축 상태 모니터링용 광파이버 변위 센서 설계 제작 및 성능평가

홍준희,박찬규,신우철,이동주 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

This paper is focused on practical applicability of the optical fiber sensor considering the machine center which is going to use them. Optical fibers may be fluctuated because the machine center operates as column moving type. This causes distortion of the sensor output signal. To reduce this problem, we have improved the sensor structure and its bracket. And we evaluated performances of the sensor.

한국의 인권보장제도

朴洪佑 명지대학교 국제교육정보연구센터 2002 國際敎育情報硏究 Vol.4 No.-

기계적 피로결함 시험편 제조 및 결함 크기 평가

홍재근,김우성,손영호,박반욱 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

원자력발전소의 안전성등급 기기에 적용되는 비파괴검사는 실제 결함을 실현한 시험편을 사용하여 결함 탐지능력을 검증하도록 하는 기량검증이 요구되고 있다. 가동중인 원전에서 발생 가능한 균열으로는 기계적 피로균열, 열 피로균열 및 입계부식균열 등이 있으나 본 연구에서는 기계적 피로균열을 대상으로 하였다. 인장 피로하중을 사용하여 기계적 피로결함을 제조하기 위해서 시험편을 설계하였고 원하는 피로결함 파면의 조도를 얻기 위해서 인가하중의 크기 및 사이클 수를 조절하여 피로결함을 발생시켰다. 발생된 결함에 대한 정확한 크기와 위치에 대한 물리적 정보를 얻은 후에 결함이 설계된 크기와 위치에 존재하도록 기밀용접을 실시하였다. 기밀용접 후 잔여 용접 홈은 가스 텅스텐 아크용접 및 플럭스 코어드 아크용접으로 채워졌다. 최종 완성된 피로결함 시험편을 방사선투과검사 및 초음파탐상검사를 통하여 검사한 결과, 설계된 길이와 깊이로 피로결함이 형성되었음을 확인하였다. Performance demonstration with real flawed specimens has been strongly required for nondestructive evaluation of safety class components in nuclear power plant. Mechanical or thermal fatigue crack and intergranular stress corrosion cracking could be occured in the in-service nuclear power plant and mechanical fatigue crack was selected to study in this paper. Specimen was designed to produce mechanical fatigue flaw under tensile stress. The number of cycles and the level of stress were controlled to obtain the desired flaw roughness. After the accurate physical measurement of the flaw size and location, fracture surface was seal-welded in place to ensure the designed location and size. The remaining weld groove was then filled by using gas-tungsten arc welding(GTAW) and flux-cored arc welding(FCAW). Results of radiographic and ultrasonic testing showed that fatigue cracks were consistent with the designed size and location in the final specimens.

GIS를 이용한 양식어장 정보관리 시스템 구축

박성은,최우정,이원찬,구준호,정래홍,박종수 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

연안 양식어장의 정보 관리에 실용적인 지리정보시스템(GIS)을 적용함으로써 어업종사자와 연안 관리자에게 실현 가능한 관리방안을 제시하고 수산업 발전을 위한 유연한 의사결정의 기반을 마련하고자 하였다. 연안 양식어장의 효과적 관리는 경제적 실행 가능성과 운영비용에 영향을 미치며 양식 대상생물의 생산 및 사망률과도 관계가 있으므로 매우 중요하다. GIS는 양식어장 정보의 효율적인 관리도구로서 개인 및 공공분야에서 폭넓게 사용되고 있으며 해양수산 관련분야에서도 활발히 적용되고 있다 본 연구에서는 진해만을 대상으로 연안 양식장 자료의 3차원 가시화 모듈을 구축하였다. This paper illustrates some practical geographic information system (GIS) applications for aiding fishery managers and coastal area planners in analysing the likely control scheme of coastal farming areas, and in providing a flexible framework for decision making on fishery development and zoning issues. The effective management of marine farming operation is vitally important since it can greatly influence economic availability by determining capital outlay and by affecting running costs, rates of productions and mortality factors. GIS has been widely adopted elsewhere as a potent management tool in both the private and public sectors. GIS is now being extensively adopted in marine-associated activities. Here, we have used GeoMania v2. 5 GIS software and its 3D Analyst extension module to visualize marine farming areas data that were collected around the Jinhae bay.

복부둔상에 의한 간 손상의 임상적 고찰

홍순찬,최상경,박순태,하우송,이진석,권수인,이영준,정은정,조현언,정광근,임병찬 대한외상학회 2000 大韓外傷學會誌 Vol.13 No.2

Because of the merit of nonoperative management of blunt hepatic trauma, which is the avoidance of operative morbidity, the use of nonoperative management has been extended. However the indications for such treatment have not been sufficiently determined. To suggest possible criteria for nonoperative management, we reviewed 95 cases with blunt hepatic injuries which were confirmed by abdominal exploration or abdominal CT in Gyeong Sang National University Hospital from January 1992 to October 2000. Of the 95 patients, 38 patients were treated with operation and 57 patients treated with nonoperative management. We analyzed the patients for age, sex, cause of injury, injured organ, injury grade, transfusion amount, and shock on admission, complications and mortality. The results are as follows; 1) The peak incidence of age was in the 3rd decade (20%), and the male-to-female ratio was 3:1. 2) The most frequent injury mechanism was traffic accidents (40, 42%). 3) The most frequently used diagnostic modality was abdominal CT (95 cases) in the nonoperative and the operative group. 4) On the liver injury scale of the American Association for the Surgery of Trauma (AAST), 13 were grade I, 18 were grade II, 10 were grade III, 13 were grade IV, and 3 were grade V in the nonoperative group ; 1 were grade I, 6 were grade II, 18 were grade III, 8 were grade IV, 4 were grade V, and 1 were grade VI in the operative group. 5) Between the nonoperative and the operative groups, there were significant differences in the systolic blood pressure in the first 8 and 24 hours, transfusion amount, and GOT/GPT level (p$lt;0.05). 6) In comparison of complication, there were 3 cases of heaptic abscess,1 case of intrahepatic hematoma, 1 case of bile leakage, 1 case of rebleeding in operative group (15.7%). There were 2 cases of intrahepatic abscess, 2 cases of intrahepatic hematoma, 4 cases of biloma, 1 case of subcapsular hematoma in nonoperative group (15.7%). In mortality cases, 6patients died in operative group. Among them, 5patiens died from DIC (disseminated intravascular coagulation) and multiorgan failure, 1patient died from ARDS (adult respiratory distress syndrome) in operative group and 2patients died from hypovolemic shock in nonoperative group. In conclusion, i) nonoperative management may be considered as a first choice in children and adults with blunt abdominal trauma and stable vital signs. ii) Patients with hemodynamically stable hepatic injury 8 hrs after resuscitation, even with an AAST OIS grade 4 injury, may be candidates for nonoperative management.