Activated macrophage 국소주사가 육아조직 혈관신생에 미치는 영향

손태중,안기영,한동길,박대환 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

The authors studies angiognesis of the granulation tissue elecited by thermal burns. Third degree burns were inflicted on the skin of inguinal area of 24 Spargue-Dawley rats, and then activated macrophages were injected into the local burn site as a stimulating factor of angiogenesis. The animals wee sacrified at 1, 4, 7, 14, 21 and 28 days after burn treatment and the granulation tissues of the burn site were excised and observed with light and eletron microscopy. The results are summarized as follows ; In the control group into which activated macrophages were not injected the burn site showed granulation tissue which revealed mild vascular proliferation without active endothelial proliferation was noted at 4days after burns. A proliferation of endothelial cells and pericytes with abundant cytoplasms and well developed intracellular organelles was noted. The newly formed vessels showed ill defined or distorted lumens and surrounded by many activated macrophages and fibroblasts. These featrues were observed continualy until 14days after burns. And then the numbers of Capillaries slightly decreased along with gradual maturity of vessels(21&28 days) With the above results it could be concluded that the locally injected activated macrophages induced active angiogenesis. The activated marcrophages are thought to secrecte a kind of angiogenic factor. And induction of angiogenesis may be helpful to treat the deep skin wound needed abundant granulation tissue. Application of this procedure injecting activated macrophages into burn sites seems favorably feasable in early treatments of burns.

타이타늄의 표면개질에 따른 표면형태의 변화

손동환 慶北大學校 齒科大學 1997 慶北齒大論文集 Vol.14 No.-

순수 Ti을 Hanks' 용액과 산도와 농도를 달리한 인산과 칼슘을 함유한 수용액에 침적한 후 주사전자현미경 관찰 및 X-선 회절시험으로 Ti 표면의 형태를 알아본 결과 다음과 같은 결론을 얻었다. · 전자주사 현미경으로 관찰 하였을 때 Hanks'액에만 침적한 군에서 보다 Hanks' 및 인산과 칼슘을 함유한 수용액에서 침적한 군에서 calcium phosphate apatite의 생성량이 많아졌다. · 약산성 및 중성의 표면처리액에 침적한 경우 침상과 판상의 apatite 생성을 관찰할 수 있었으며 약알칼리에서는 적층구조의 두꺼운 granule상의 apatite층이 관찰되었다. · 약산성 및 약알칼리에서는 농도회석시 apatite 생성량의 증가를, 중성에서는 5배 회석액에서 보다 원액 및 2배회석액에서 많은량의 apatite를 관찰할 수 있었다. · X-선 회절시험에서 N, A-1에서는 형성된 apatite량이 미세하여 Ti의 peak만 나타났으며 A-2, A-3, B-1, B-2, B-3, C-1의 조건에서는 brushite의 peak양상과 유사하였으나 C-2, C-3의 조건에서는 hydroxyapatite가 얻어짐을 알 수 있었다. The present study was investigated on the morphologic changes of Ti surface by one immersed only in Hanks' solution and the other immersing in an aqueous solution containing calcium and phosphate after Hanks' solution treatment and they were characterized by using SEM and XRD. Amouts of calcium phosphate apatite were increased by immersed in aqueous solution containing calcium and phosphate after Hanks' solution than immersing in Hanks' solution only. Needle and plate-like apatites were observed when immersed in weak acid and neutral solution, while granular multiple layers were seen in weak alkali solution. The precipitations of calcium phosphate on Ti were increased by dilution in weak acid and weak alkali solution. On the other hand, amounts of precipitates in neutral solution were increased in non-diluted and 2 times diluted solution than 5 times diluted solution. The results of XRD showed that only Ti peaks were detected in N, A-1 conditions because of fewer precipitates, while brushite were seen in A-2, A-3, B-1, B-2, B-3, C-1 conditions and synthetic hydroxyapatite were seen in C-2, C-3 conditions. For the precipitation of bioactive apatite, immersion in alkali solution is favorable by immersion method rather than neutral or acid solution and heat treatment is needed for high crystallinity.

타이타늄의 표면개질에 따른 표면형태의 변화

손동환,김도균,김교한 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The present study was investigated on the morphologic changes of Ti surface by the immersion in Hanks' solution and aqueous solutions containing calcium and phosphate ions in turns and the surface of the treated specimens were characterized by using SEM and XRD. Amounts of calcium phosphate apatite were increased by when immersed in aqueous solution containing calcium and phosphate after Hanks' solutes than when immersed in Hanks' solution only. Needle and plate-like apatites were observed when immersed in the solutions of weak acid and neutral condition, while granular multiple layers were seen in the solutions of weak alkali condition. The precipitations of calcium phosphate on Ti surface were increased by dilution in weak acid and weak alkali solution. On the other hand, amounts of precipitates in neutral solution were increased in non-diluted and 2 times diluted solution than 5 times diluted solution. The results of XRD showed that only Ti peaks were detected in N, Al conditions while peaks of brushite in A2, A3, B1, B2, B3, C1 conditions and peaks of synthetic hydroxyapatite were seen in C2, C3 conditions. For the precipitation of bioactive apatite, immersion in alkali solution is favorable by immersion method rather than neutral or acid solution.

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.

SJO¨GREN'S SYNDROME 환자에게 즉시 임프란트 술식을 행한 치험례

최정환,손동석,이지연,이윤서,안선희,이재목 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The old edentulous patients experience xerostomia commonly. They have considerable difficulty in wearing tissue-supported prosthesis and high risk rate of caries. One of them is Sj□gren's syndrome patient. Sj□gren's syndrome is a chronic inflammatory autoimmune disorder that results in a lymphocyte-mediated destruction of exocrine glands. We planned to place implants immediately after extraction in this case of autoimmune disease. The advantages of immediate implant placement include considerable decrease in time from tooth extraction to placement of the final prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plan. We present a case of Sj□gren's syndrome patient treated with immediate implant placement & immediate loading in anterior region and immediate implant placement in posterior region.

매복 과잉치 발거시의 전후방적 위치선정

최형준,손흥규,최병재,황동환 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

Surgical removal of impacted mesiodens can be performed easily when exact position of mesiodens is identified. This case report is argued about methodological approach of exact antero-posterior postioning of mesiodens using conventional cross-sectional occlusal film and periapical film. The author concludes, 1. Among various methods of positioning mesiodens, exact position of mesiodens can be determined with occlusal film and periapical film. 2. On operation, exact antero-posterior position of mesiodens can be determined with comparing occlusal images of adjacent teeth and anatomic structure to real ones. 3. It is important that exact removal course of mesiodens has to be determined in addition to exact determination of one's position, and that it has to be determined in regard to position, morphological basis, direction of impacted pattern of mesiodens and adjacent anatomic structure. 4. In 2 cases presented, both are mesiodens of inverted conical type, and impacted direction are class Ⅰ and Ⅲ respectively according to classification author suggested, and surgery can be performed with ease by different approach directions.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Design of Functional Blocks for Asynchronous RISC Microprocessor

Dong Hwan Lee,Jun Hwan Kim,Seung Gil Sohn,Moon Key Lee 대한전자공학회 1996 ITC-CSCC :International Technical Conference on Ci Vol.- No.-

Induction of apoptosis by tanshinone I in hepatic stellate cells

Sohn, Dong Hwan 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Development of Herbal Medicine on Hepatic Fibrosis from Salvia miltiorrhiza through Pharm aceutical Standardization

Dong Hwan Sohn 대한약학회 2008 大韓藥學會 總會 및 學術大會 Vol.2008 No.1