Aucubin의 약리및 독성

장일무,윤혜숙,양규환 대한약학회 1984 약학회지 Vol.28 No.1

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

우리나라 사람들에게는 유달리 높은 간염 발병률이 나타나고 있고 더우기 바이러스성 간염의 경우 풍토병 내지 전염병이라고 할 정도의 양상을 띠고 있다. 현재까지는 이러한 간질환에 적절한 치료약이 없는 점을 감안하여 저자들은 생약으로 부터 간질환에 유효한 성분을 분리하여 치료약으로 사용할 수 있도록 하기위하여 집중적인 연구를 지난 5년간 계속하여 왔다. 연구의 내용은 동서양의 고전및 연구보문을 조사하여 간보호 및 치료학으로 사용한 생약에 관한 문헌적 조사, 이들 생약중 채집 및 구입이 가능한 식물을 구하여 생약엑기스 제조, 이들 엑기스를 간염 동물 모델의 하나인 $CCl_{4}$로 유발시킨 간독성에 대한 보호작용의 검색, 보호작용을 나타내는 생약중에서 자원적 측면을 고려하여 국내에서 많이 생산되는 차전자(Plantago asiatica seeds)를 선택하였고, 차전자로 부터 간보호 작용을 나타내는 유효성분으로 iridoid 계열물질인 aucubin을 분리하였다. 그러나 aucubin이 차전자에 소량 밖에 없으므로 aucubin이 다량 함유된 식나무(Aucuba japonica)로 aucubin 추출자료생약을 바꾼후 aucubin의 간보호 작용을 간염 동물모델인, $CCl_{4}$ D-galactosamine 및 $\alpha$-amanitin등으로 유발시킨 간독성에 대한 보호작용을 보여 주었기 때문에, 이러한 간보호작용의 기전을 규명하는 연구를 진행하였고, 다음은 aucubin 자체의 급성 독성 및 기타 독성 유발여부를 밝히는 연구 등으로 요약 될 수 있다.

Angiotensin II AT1 수용체 길항제인 SK-1080의 적출심장에 대한 허혈후 재관류시의 작용 및 혈소판응집과 혈액응고에 대한 효과

우수경(Su Kyoung Woo), 최상수(Sang Su Choi), 이병호(Byung Ho Lee), 권광일(Kwang Il Kwon) 대한약학회 2000 약학회지 Vol.44 No.6

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

SK-1080 is one of the newly developed orally active nonpeptide angiotensinII AT1-receptor antagonist that selectively acts at AT1 receptor with high affinity. The cardiac effect on ischemia/reperfusion injury of SK-1080 was compared with those of losartan, a prototype of this class, in isolated rat hearts. Isolated perfused rat heart was pretreated with drug for 10 min and then subjected to global ischemia for 30 min followed by reperfusion with- or without drug for 30 min. The possible additive effect of SK-1080 on the platelet aggregation and coagulation in human blood was also studied. We investigated whether SK-1080 effects the platelet aggregation induced by ADP, a platelet agonist partially dependent on thromboxaneA2. The clotting times in the prothrombin time (PT) and activated partial thromboplastin time (APTT) were also examined in human plasma in vitro as coagulation screening test. SK-1080 improved reperfusion function (LVDP, left ventricular developed pressure; PRP, rate-pressure product) in a dose-dependent manner. SK-1080 reduced ADP-induced platelet aggregation compared with vehicle but less than losartan, and did not affect clotting times.

수용액중 Caffeine 또는 Nicotinamide 에 의한 Complex 형성에 대한 연구 Lidocaine 또는 Saccharin에 대한 Caffeine 또는 Nicotinamide의 상호작용

채동규(Dong Kyu Chae) 대한약학회 1963 약학회지 Vol.7 No.1

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

This investigation is the studies on the solubility analysis for several pharmaceuticals. The equilibrium reactions leading to complex formation of Caffeine and Nicotinamide with Lidocaine and Saccharin have been studied. The equilibrium constant of each complexes have also been calculated. It is shown that complex formation may lead to an increase in the solubilities of the reactants, and that Nicotinamide has more complexing activity than Caffeine. The influence of chemical structure of each components on interaction is also discussed.

Flavin mononucleotide (1,4-butanediamine) Pt(II) Complex와 Cisplatin의 세포주기에 대한 유세포 분석 및 ICR계 생쥐에서의 신장독성에 대한 생화학적 분석

권영이(Y. E. Kwon), 황규자(K. J. Whang), 김안근(A. K. Kim), 김국환(K. H. Kim), 김원규(W. K. Kim), 안동춘(D. C. Ahn) 대한약학회 2000 약학회지 Vol.44 No.2

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

Flavin mononucleotide (1,4-butanediamine) Pt(II) complex (7FMN) was synthesized and screened anticancer activity [J.Pharm.Soc.Korea 43(6), 762-770 (1999)]. 7FMN have good water solubility and moderate anticancer activity. In this paper, cell-cycle specificity and nephrotoxicity were studied. Interaction of DNA with cisplatin and synthesized 7FMN was analyzed by flow cytometry, and showed G2 arrest in L1210 cell fine. It means that cell-cycle on L1210 was inhibit in S phase by cisplatin and 7FMN. In order to biochemically analyze nephrotoxicity of cisplatin and 7FMN, after injecting each agent intrapenritoneary, blood was exsangumated after 6 hours, 1 day, 3 days and 7 days, respectively. Then, serum was separated from the blood. The serum level of BUN, creatinine and uric acid in cisplatin and 7FMN administrated mice (25-35g, ICR strain, a dose each 8, 12 and 16 times of the IC50 value, cisplatin; 7 times) were determined by autochemistry analyzer. In cisplatin-administered mice group, BUN level was elevated than normal control group at 3rd day and repaired at 7th day. In 7FMN administrated group was not elevated. Crea@e and uric acid level were no difference with the normal control group. Therefore synthesized 7FMN is less toxic than cisplatin in nephrotoxicity.

지역약국 실무실습 후 실습에 대한 약학대학 학생들의 인식과 평가에 대한 분석

양영모,이지은,이익수,최은주,Yang,,Young-Mo,Lee,,Jieun,Lee,,Ik-Soo,Choi,,Eun,Joo 대한약학회 2014 약학회지 Vol.58 No.3

Pharmacy practice experiences play a central role in improving the professional abilities and roles of student pharmacists in the changed '2+4'-year curricula of Korean pharmacy schools. For the first 3 years, the students usually learn theoretical areas, and for the last year, they apply learned knowledge to actual pharmacy practice environments. Especially, in order for community pharmacy practice experiences to become firmly established, it is important to evaluate students' feedbacks of community pharmacy practice experiences. However, there have been little studies regarding this area in Korea. This study was to analyze pharmacy students' perceptions and evaluations after community pharmacy practice experiences. The self-reported questionnaire using a 5-point Likert scale was utilized to collect data from the pharmacy students completing community pharmacy practice experiences. Total 62 students responded to the survey questionnaires. The average of students' evaluations of preceptors for overall evaluation items was 4.31 whereas that of student evaluations of practice sites for them was 4.03. The self-evaluations of students' expertises were mostly positive except for that of populations care. The evaluation item 'I believe this experience will help me be a better pharmacist' received the highest satisfaction. According to the results regarding open-ended questions, the students learned the needs for academic motivations and self-developments, and they thought that the curriculum should be standardized and systematized in order to improve contents for community pharmacy practice experiences. Furthermore, based on these results, the guidelines of community pharmacy practice experiences should be modified, and researches on the validation and evaluations of the modified guidelines should be implemented.

한미 FTA와 제약산업 육성정책

임숙영 대한약학회 2007 大韓藥學會 總會 및 學術大會 Vol.2007 No.1

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

근 · 현대사 이후 한국인의 최다 선호 일반의약품의 추이에 대한 연대별 분석 및 종합적 의의에 대한 평가

이윤정,강태진,임성실 대한약학회 2016 약학회지 Vol.60 No.3

Over-the-counter (OTC) drugs refer to medicines that are generally safe when used according to the productlabel. We aimed to assess and reflect upon changes in perception of health and health-related demands by decades in Koreaaccording to the consumption and sales trends of OTC drugs. This study was conducted by literature search on the productionand sale rankings of OTC drug market in Korea. Changes in the OTC drug market were analyzed and organizedby decades to evaluate changes in drug demands and the influence of national and societal factors. There was a specifictrend in the most popular drugs by decades. In the 1950s, drugs of top necessity were antibiotics and helminthics. In the1960s, the pharmaceutical industry quickly grew and invigorators, such as Bacchus®, Alps®, Aronamin®, were top manufactureddrugs. Popularity of these invigorating drinks and vitamin products continued until the 1990s. In 1990s, salesof topical nonsteroidal anti-inflammatory drugs (Ketotop Plaster®, Trast Patch®), and in 2000s, gum disease medicine(Insadol®) and liver and intestine supplement (Ursa®) were prominent. However, after the separation of prescribing anddispensing in 2000, the sales of OTC drugs decreased dramatically from 58.7% of the total market share in 1990s to 39.6%in 2000 and this trend has continued. In 2012, thirteen OTC drugs were allowed to be sold in convenience stores, andas the sales of health functional foods have been expanding beyond pharmacies, sales of invigorators and nutritional supplementsin pharmacies have continued to decrease. As government's drug expenditure will continue to grow, reclassificationof OTC drugs based on established safety information and deliberate team efforts on continued development ofOTC drugs to meet the health demands of Koreans are required by the healthcare professionals, pharmaceutical industries,and the government.

실험적 뇌허혈 및 저산소증에 대한 Flunarizine의 약효 뇌장해에 대한 Flunarizine 효능

김은미(Eun Mi Kim), 김영진(Young Jin Kim), 신정희(Jeoung Hee Shin), 윤재순(Jae Soon Yun) 대한약학회 1988 약학회지 Vol.32 No.5

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

Recent hypothesis suggested that intracellular accumulation of calcium is a common denominator of ischemic celullar damage. Flunarizine, a calcium entry blocker, posses vasodilating properties in cerebral vascular beds and clinically used in circulatory disorders. The present study was designed to evaluate the effect of flunarizine on ischemic and hypoxic brain damage. An ischemic model was made by bilateral carotid artery ligation (BCAL) in Wistar strain rat. Hypoxic model was made by intravenous injection(i.v.) of KCN to rats and mice. In mice, flunarizine not only reduced the mortality of KCN, but also delayed the onset time of convulsion. The contents of ATP, creatine phosphate and glucose, cerebral energy metabolite, decreased 30 minutes after BCAL and KCN i.v., while that of lactate increased. But these variations were suppressed by flunarizine. Furthermore, increase in the dosage of flunarizne generally promoted the recovery of cerebral energy metabolites in hypoxic animals. The results suggest that flunarizine had a protective effect against ischemic and hypoxic brain damage due to its ameliorating action on the cerebral energy metabolism.

국내에서 재배하는 수종의 한약재에 대한 산지별 항균효과

LEE,Young,Mi,TAE,Jin,CHOI,Yeon-Ah,PARK,Hye-Jung,GIL,Gi-jeong,DO,Eun-Soo,SEO,Young-Bae,KIM,Yoon-Kyoung,KWON,Dong-Ryul,HONG,Seung-Hun 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

슈퍼제네릭 의약품에 대한 임상적 고찰

박경호(Kyoung Ho Park) 대한약학회 2007 大韓藥學會 總會 및 學術大會 Vol.2007 No.1

'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.