고령자 급성 췌장염의 임상적 고찰

이진헌,강진경,박인서,송건훈,정재복,백용한,송시영,서정훈 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3

Background/Aims: Inflammatory diseasas of the pancreas are not uncommon. The advanced age is one of the significant factors in assessing the severity of acute pancreatitis. It has been shown that the biliary tract disease is a more frequent cause of acute pancreatitis in the elderly than in the young. With the increased life span, the elderly are comprising a large proportion of the population. As a result, physicians are more often being faced with acute pancreatitis in the elderly. The purpose af this study was to evaluate clinical features of acute panereatitis in the elderly. Methods: A total of 188 patients with acute pancreatitis were reviewed. We investigated the differences of clinical characteristics between the elderly patients aged over 60 and the young patients aged under 60. Results: The sex distribution showed male preponderance in the young patients (M:F=2.4:1), but was nearly equal in the elderly patients (M:F=1.1:1). The most common cause of acute pancreatitis in the elderly was biliary tract disease (52.5%), while alcohol abuse was the most common cause in the young patients (38.8%), Local complications of acute pancreatitis, such as psuedocyst, necrosis, abscesses were not differently shown between the elderly (16.9%) and the young (20.2%) patients. Systemic complications including acute puhnonary failure occurred more frequently in the elderly patients than the young patients. The mortality rate of the elderly patients (5.1%) was not significantly different from that of the young patients (3.1%). Conclusions: To detect correctable underlying bihary tract diseases the elderly patients with acute pancreatitis should be completely investigated using endoscopic retrograde cholangiopancreatography (ERCP). In addition, the patient should be closely monitored for the development of the systemic complications during the disease process.

고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Histamine에 의한 가토 대동맥 평활근의 수축기전

서용희,김세훈,장석종 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

The action mechanism of histamine on the contraction were investigated in the helical strip of the aorta of a rabbit. The aortic strip was immersed in phosphate buffered Tyrode’s solution which was equilibrated with 100% O_2 at 35℃ and isometric tension was measured. The contraction was induced by histamine, norepinephrine(NE) or 40mM K^+ in the normal(1mM Ca_2+) or Ca^2+-free Tyrode’s solution. The effects of cimetidine, diphenhydramine, phentolamine, and verapamil on the contraction were observed at the same time. The contraction induced by histamine began at the concentration of 1×10 exp (-6)M and reached the maximum at 3×10 exp (-4)M. The ED_50 was 5×10 exp (-6)M. The maximal contraction by histamine corresponded to 79.5±3.0% of that by NE. The tonicity of peak tension by histamine was progressively decreased above the concentration of ED_50 but under the ED_50 the tonicity was relatively maintained well. Furthermore the maximal contraction by histamine was observed about 1mM of calcium. The contraction by histamine was induced additionally even after contraction by 40 mM K^+. And the contraction was not affected by cimetidine, but was completely suppressed by diphenhydramine phentolamine and verapamil. In the Ca^2+-free Tyrode’s solution the histamine also induced the contraction and it was completely suppressed by verapamil. From the above results it i suggested that the contraction induced by histamine in the aorata of a rabbit may be due to facts that histamine acts the H_1-receptor and mobilize the Ca^2+ from intracellular and extracellular sources.

비만 환자에서 비만관련 유전자 다형성에 따른 체중감량차이 : 지방흡수억제제를 복용한 환자를 대상으로 In Cases of Subjects with Orlistat for Weight Reduction

서영성,김대현,이인규,이근미,김영훈 대한비만학회 2003 The Korean journal of obesity Vol.12 No.4

비만 환자에서 비만관련 유전자 다형성에 따른 체중감량차이 : 지방흡수억제제를 복용한 환자를 대상으로 In Cases of Subjects with Orlistat for Weight Reduction

서영성,김대현,이인규,이근미,김영훈 대한비만학회 2003 The Korean journal of obesity Vol.13 No.4

연구배경: 지금까지 유전자 이상과 비만의 관계에 대한 연구는 대부분 단면연구이며 결과 또한 서로 상반된 경우가 많았다. 그러므로 이들 유전자가 비만에 미치는 영향을 보기 위해서 단면연구보다 장기적인 연구가 더 적절하다. 본 연구의 목적은 체중조절을 목적으로 인정된 약물 중 식욕, 대사율 증가및 지방분해에 직접 관여하지 않는 orlistat를 복용하는 비만환자에서 식욕에 관여하는 leptin 수용체 유전자와 지방의 분해와 기초대사량 증가에 관여하는 베타-3 아드레날린 수용체 유전자의 다형성에 따른 체중감량의 차이에 대하여 알아보고자 하였다. 방법: 대상군은 2001년 10월부터 2002년 8월까지 대구시내 3개 병원에 비만치료를 목적으로 내원한 환자 중 BMI 27 kg/m² 이상인 18∼65세 남녀로 orlistat를 복용한 환자 81명이었다. 이들은 매 방문시마다 신체계측하였고 2주마다 저열량 식사교육을 실시하였다. 유전자 분석은 베타-3 아드레날린 수용체 Trp64Arg 다형성과 렙틴수용체 Gln223Arg 다형성을 보았고 분석결과에 따라 두 군으로 나누었다. 결과: 1. Orlistat를 12주 복용한 결과 체중, 허리둘레 및 BMI는 각각 4.1±0.4 kg, 4.6±0.5 cm, 1.7±0.3 kg/m² 감소하였다. 2. 렙틴유전자 다형성에 따라 정상 동형접합체 및 이형접합체군과 변이 동형접합체군 간의 체중, 허리 둘레, 및 BMI 감소정도는 12주 후 체중이 변이 동형접합체에서 더 많이 감소하였으나 통계적인 차이는 없었다. 베타-3 아드레날린 수용체 유전자 다형성에 따라 정상동형접합체군과 이형접합체군 및 변이 동형접합체군 간의 체중 허리둘레 BMI 감소 정도는 12주 후 이형 및 변이동형접합체 군에서 더 많이 감소하였으나 현저한 차이는 없었다. 3. Orlistat를 12주 동안 복용한 56명 중 5% 이상 체중 감소한 환자는 렙틴수용체 유전자 다형성에 따른 변이 동형접합체군이 60.0%로 타 군의 38.1%에 비해 높았으나 통계학적인 차이는 없었다. 또한 베타수용체 유전자에 따른 체중감소율의 비교 결과 이형 및 변이 동형접합체군에서 5%이상 체중 감소한 환자율는 57.7%로 정상동형접합체군의 46.7%에 비해 높았으나 통계학적인 차이는 없었다. 결론: 한국인을 대상으로 시행된 본 연구 결과 렙틴수용체 유전자 및 베타-3 아드레날린 수용체 유전자의 다형성은 체중감소 치료에 미치는 영향이 적을 것으로 생각된다. Background: From a lot of cross-sectional studies, the relationship between obesity and variants of obesity related gene is inconsistent. In addition, some longitudinal studies showed different results, too. Therefore, we investigated the response of anthropometric data to 12 weeks weight loss program in obese patients with Trp64Arg variants in the β-3 adrenergic receptor and Gln223Arg variants in the leptin receptor gene. Method: 81 adult obese subjects with BMI >27 kg/m² were included for this study. They were recruited for weight management from 3 hospitals in Daegu and had taken orlistat for 4 week at least. Anthropometric measurements were weight, height, waist and hip circumference. The genotypes for both genes of study subjects were determined by protocols. Results: Subjects lost significantly more weight, waist circumference, and BMI than those of before study for 12 weeks (P<0.0001). Reductions in body weight, waist circumference, and BMI. There were not significantly different between Gln carriers and noncarriers of Gln223Arg variants in leptin receptor gene or Arg carriers and noncarriers of Trp64Arg variants in -3 adrenergic receptor gene (P>0.05). During the 12 weeks of treatment, 60.1% of patients in completer with Gln noncarriers of leptin receptor lost more than 5% of their initial body weight and, however, were not significantly different than 38.1% of those in completer with Gln carriers. Conclusion: These results suggest that the presence of Gln223Arg variants in the leptin receptor and Trp64Arg variants in the -3 adrenergic receptor in subjects with orlistat may not be a hindrance or a help to reduce body weight.

DSP 보드를 이용한 OFDM 모뎀 구현

오정훈,신인식,김영수,서덕영,김진상 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

본 논문에서는 무선 멀티미디어 서비스를 위해 요구되는 고속의 데이터 전송에 적하한 Orthogonal frequency Division Multiplexing(OFDM) 모뎀을 Texas Instrument(TI)사의 범용 DSP 프로세서인 TMS320C6701을 기반으로 한 PCI/C6701 보드를 이용해서 소프트웨어로 설계하였다. 모듈은 크게 보드를 제어할 수 있는 타겟 프로그램과 호스트 프로그램으로 구성되며, 타겟 프로그렘은 IEEE 802.11a Wireless LAN 규격 시스템으로 이루어지고, 호스트 프로그램은 타겟 프로그램의 다운로드와 BSP 프로세서에 의해 처리된 데이터의 디스플레이 또는 저장으로 이루어진다.

Water glass로부터 ZSM-5의 합성

우훈희,홍지숙,서정권,이관영,이정민 한국공업화학회 2002 응용화학 Vol.6 No.2

In order to seek optimum conditions for ZSM-5 formation in the absence of organic template,the effects of both starting composition and water glass as silica source were examined. Water glass was most inexpensive among silica sources, but this was difficulty in reactant control because of contained much alkali ingredient, Considering environmental problem and economic performance,chose alkali drawing-out method to use methanol newly to remove alkali ingredient of waterglass. Characterization of ZSM-5 was carried out by means of XRD, SEM.

L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전

殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.

헬름홀츠 코일을 이용한 강자성체의 와전류검사

성제중,서동만,신용훈,엄태건,서동섭 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

Ferromagnetic material like the steel tubes can easily distort eddy current testing signal due to increased magnetic permeability for defects. Because magnetic field of the test probe is affected in an inconsistent way when the material under the testing has permeability. This permeability effect can be reduced by magnetic saturation. In this paper eddy current testing system was developed to detect flaws on the steel tubes. Magnetic saturation probe with helmholtz coil was designed for saturation and inspection of the steel tubes. When using the designed test probe, the relationship between flaw signals and noises was obviously discriminated. Additionally, a high pass filter was included in the eddy current board to minimize noises due to DC magnetic field.