심한 상부 위장관 출혈을 유발한 십이지장 정맥류 3예

이진헌,강진경,박인서,송건훈,정재복,송시영,이용찬 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.3

The bleeding duodenal varices are a rare complication in patients with portal hypertension, but present a difficult diagnostic problem. If there is no bleeding esophageal, gastric fundal varices or ulcer in a patient with upper gastrointestinal bleeding and portal hypertension, the possibility of bleeding duodenal varices should be kept in mind. Thorough endoscopic examination of the entire duodenal mucosa is essential to document bleeding from duodenal varices. As an initial treatment, endoscopic sclerotherapy has had limited success in controlling active duodenal variceal bleeding. However, rebleeding rate is high, surgical treatment including shunt operation may be required for permanent control of bleeding and portal decompression. We report three cases of duodenal varices causing massive hemorrhage. All the patients had portal hypertension caused by liver cirrhosis of various etiologies and had varices in their esophagus. The second portion of the duodenum was the site of duodenal varices in all cases. The management was tailored to the condition of each patient, but only one patient among three survived.

제2차 한국환경보건종합계획의 발전을 위한 제언

이진헌 한국환경보건학회 2020 한국환경보건학회 학술대회 자료집 Vol.2020 No.1

다클로로벤지딘에 폭로된 흰쥐의 간장세포와 방광 상피세포에 형성된 DNA adducts의 P-postlabeling과 GC/MS-SIM에 의 한 분석

이진헌,신호상,장미선 한국환경보건학회 2002 한국환경보건학회 학술대회 자료집 Vol.2002 No.-

피부에 폭로된 폐가솔린엔진오일의 표적장기 DNA adducts 형성과 케로신의 세척효과에 관한 연구

이진헌,그린탈라스카 한국산업위생학회 1998 한국산업보건학회지 Vol.8 No.2

Used gasoline engine oils(UGEO) are carcinogenic in long term studies and capable of increasing the number of carcinogen-DNA adducts in short term studies when dermally applied to mice. The carcinogenic risk of UGEO has been attributed to the concentration of polycyclic aromatic hydrocarbons(PAH) which accumulate in the lubricating system during the combustion of gasoline. When dermally exposed to UGEO, the use of hand cleanser was commonly recommended for removing it. But generally workers who dermally exposed oils, use kerosene as cleaner which make skin trouble. During this study, female mice aged 4-6 weeks were utilized to evaluate the efficiency of kerosene, as solvent-based cleanser, following dermal exposure to UGEO. DNA adduct were detected at skin and lung tissues by using the ^(32)P-postlabeling method. Washing with cleansers were done at two different interval times following dermal application of UGEO. The total DNA adducts in skin and lung tissues were statistically significantly increased in positive control groups, and of which the total adduct level in skin tissues was statistically significant higher than those in lung tissues(p=0.005). When washing kerosene, the DNA adduct level in skin tissues was statistically significantly decreased(p=0.0001). But DNA adducts in lung tissue was statistically increased(p=0.0039), and that washed at 8hr post exposure was more severly increase(p$lt;0.05). The slope of regression between DNA adducts of lung between skin tissues was 1.0802. In conclusion, skin cleaning with kerosene facilitates passage of carcinogens to the lungs of animals dermally treated with used gasoline engine oils(UGEO).

江原道 一部 農村 部落 飮用水의 水質에 關한 調査 硏究

李鎭憲 대한보건협회 1990 대한보건연구 Vol.16 No.2

This survey was performed to investigate the degree of contamination and the significance of each items in drinking water, which was collected from rural villages between May and June 1990. The results of this survey were as follows. 1. The items which were over the criteria were temperature, NH_3-N, NO_2-N, standard plate count(S.P.C) and coliform in the rural villages. 2. Total mean concentrations at Y-village were significantly higher than at S-village in colour, hardness, NH_3-N, NO_2-N, standard plate count(S.P.C) and coliform, and significantly lower than at S-village in pH. 3. The percentages of total families to be over the criteria were 51.7% in pH, 36.0% in NH_3-N, 91.0% in NO_2-N, 83.1% in standard plate count(S.P.C) and 59.6% in coliform, and in Y-village 78.8% in pH, 46.2% in NH_3-N, 96.2% in NO_2-N, 100% in standard plate count and 63.5% in coliform. 4. The correlation coefficients with significant(p<0.001) difference between items were as follows. colour and NO_2-N r=0.9566 colour and NH_3-N r=0.6777 colour and S.P.C. r=0.6855 hardness and NO_3-N r=0.8252 NH_3-N and NO_2-N r=0.8238 S.P.C and NO_2-N r=0.7246 NH_3-N and S.P.C r=0.7231 5. The comparisons of results between first-test and second-test on the same family-drinking water were as follows. · The first-test was very significantly lower in pH, very significantly higher in S.P.C. than the second-test. · NH_3 and NO_2-N were detected in first-test, and coliform was positive in both tests. In conclusion, these rural villages have many problems with their drinking water, especially so when it rains.

환경교육 직무연수를 통한 교사들의 의식변화와 양면가치태도 변화 분석

이진헌,성정진,최진하 한국환경교육학회 2005 環境 敎育 Vol.18 No.1

This study investigated the changes of consciousness and ambivalent attitudes about the important environmental issues among the teachers who enrolled the environmental education training. Experimental and control groups were composed with 47 and 30 person, respectively. Environmental issues were constructions of sea-wall, nuclear power plant and dam. Cronbach alpha of the self-developed questionnaire was 0.6909∼0.8992. Score were made with 5 Likert scales for consciousness, and with semantic differential half scale for ambivalent attitudes. Almost teachers(94.0% and 97.1%) have above 10 years teaching career. Strangers in environmental program were 53.2%.After environmental training, teachers' consciousness was significantly changed to negative about the construction of sea-wall for the farm field and industry complex area(p= 0.019), and about the construction of dam for disaster like flood(p=0.026), and for adverse effects of citizen by fog(p=0.042). They were also significantly changed to negative about the construction of nuclear power plant for economical energy(p=0.004)', no-emission of greenhouse gases(p=0.033)', 'alternative energy(p=0.000)', 'destruction of ecology(p=0.052)' and 'social fear (p=0.009)'. The consciousness of teachers who have the experience of environmental training, were significantly changed to negative about the construction of nuclear power plant.Scores of teachers' ambivalent attitudes were made lower in experimental than control group about the construction of sea-wall and nuclear power plant. After education training, they were made lower so much as -10.0% in control, but higher much as +4.4% in experimental, and severely higher much as 86.5% in teachers who had experienced the environmental training about construction of sea-wall. Their scores were made lower so much as -3.3% in control, but much as -6.4% in control.

디클로로벤지딘으로부터 대사물질의 합성과 분리방법에 대한 연구

이진헌,이범규 한국환경보건학회 2003 한국환경보건학회지 Vol.29 No.2

3,3-dichlorobenzidine is suspected to be cancinogenic in experimental animal and human. Several studies have investigated excretion of metabolites in urine, hemoglobin adduction and cancer incidence among workers occupationally exposed to 3,3'-dichlorobenzidine. In these researches, metabolites of 3,3'-dichlorobenzidine had a very important role, and were required as highly purity. The purpose of this study was synthesis and isolation of its metabolites from 3,3'-dichlorobenzidine. 3,3'-dichlorobenzidine was partially dissolved in benzene, ether, ethanol and methanol, and completely dissolved in 70% acetic acid on mixtures of citric acid containing less than 1% DCB, pyridine, a mixture of 0.5N NaOH and toluene(1:2), and phenol saturated with 20mM TRIZA base. DCB, monoacetyl-DCB and diacetyl-DCB were measured by using gas chromatography/mass spectrometry(GC/MS). Detection for checking them was nitrogen phosphorous detection mode(NPD), and for identifying them was selected ion monitoring mode(SIM). The base peaks were 252 m/z in DCB, 252, and 294 m/z in monoacetyl-DCB, and 252, 294 and 336 m/z in diacetyl-DCB, respectively. Diacetyl-DCB was synthesized by titrating DCB solution of pyridine with sufficient acetyl chloride. Precipitation was diacetyl-DCB, which was purity of 98.7%. And its supernatant was composed of DCB, monoacetyl-DCB and diacetyl-DCB. By using acetic acid as controller of acetylation, monoacetyl-DCB was isolated from diacetyl-DCB. And residual pyridine was removed by using acetone. The purity of monoacetyl-DCB was 98.8%. 3,3'-디클로로벤지딘(DCB)는 실험동물에 발암물질로 밝혀졌고, 사람에게 암을 유발시킬 수 있는 발암물질로 의심되고 있다. 많은 연구자들이 사업장에서 DCB에 폭로된 근로자들을 대상으로 뇨중에 배설된 대사물질, 헤모글로빈 부가체, 그리고 암 발생율 등에 대하여 연구를 하고 있다. 이러한 연구를 하기 위해서는 표준물질로 되어 있는 DCB의 대사물질이 꼭 필요하다. 따라서 본 연구의 목적은 DCB를 이용하여 이들의 대사물질을 합성하여 표준물질로 사용코자 함니다. DCB는 벤젠, 에테르, 에탄올, 메탄올 등에 부분적으로 용해되지만, 구연산이 1% 이하로 함유된 70% 아세트산, 피리딘, 0.1N NaOH와 톨로엔이 1:2로 섞인 혼합물, 20 mM TRIZA염으로 포화된 페놀 등에는 완전히 용해되기 때문에 본 연구에서는 DCB를 피리딘에 녹여서 사용하였다. DCB와 대사물질인 mono-acetyl-DCB 및 diacetyl-DCB는 가스크로마토그래피(GC/MS)로 분석하였고, 검출기는 NPD와 SIM를 사용하였다. DCB의 기본피크는 252 m/z이었고, mono-acetyl-DCB의 기본피크는 252와 294 m/z로 구성되어 있었으며, diacetyl-DCB의 기본피크는 252, 294, 336 m/z로 구성되어 있었다. Discetyl-DCB는 피리딘에 용해된 DCB에 염소아세틸를 충분히 적정하여 합성하였다. 이렇게 얻은 diacetyl-DCB의 순도는 98.7%이었다. 침전물위에 있는 용해물질 속에는 DCB, mono-acetyl-DCB, diacetyl-DCB가 함유되어 있었는데, 아세트산을 아세틸화를 조절하는 물질로 사용하여 DCB를 모두 아세틸화시키었고, diacetyl-DCB로부터 mono-acetyl-DCB를 분리하여 추출하였다. 추출된 mono-acetyl-DCB는 아세톤으로 세척하여 98.8%의 순도를 얻었다. I. Introduction

공진형 무선전력전송 시스템의 최대허용가능전력에 관한 연구

이진헌,박영민,변진규 한국자기학회 2015 한국자기학회 학술연구발표회 논문개요집 Vol.2015 No.11

유기수은 노출로 인한 흰쥐 태자골격성장 지연에 대한 마늘의 보호효과

이진헌,박경렬,김대선,Lee, Jin-Heon,Park, Kyung-Lyoul,Kim, Dae-Seon 한국환경보건학회 2008 한국환경보건학회지 Vol.34 No.2

This study evaluates the protective effects of Korean garlic juice against the toxicity of methyl mercuric chloride (MMC) in relation to fetal ossification in pregnant Fischer 344 rats. This study has as its basis, both theory and data that neutral amino acids in garlic juice have protective effects against mercury poisoning. Pregnant rats were dosed in various combination with 20 mg MMC/kg body wt. and 0.5 or 1.0 garlic juice/kg body wt. on the 7th day of gestation. Fetuses were extracted from the dams on 20th day of gestation, and the fetal bones were stained and measured. The results obtained are as follows: 1. Fetal body weights, body lengths, and head length were significantly decreased by as much as 23.5%, 21.3%, 15.5% respectively in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were almost similar to the controls. 2. The ossification centers were significantly decreased by as much as 35.1% in pelvic phalanges, 53.5% in pectoral phalanges, 74.1% in ternebrae, 76.2% in tail in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $81.2{\sim}88.7%$ and $94.8{\sim}98.9%$ of controls. 3. The ossified pectoral girdles were significantly decreased by as much as 66.6% in clavicle, and in other areas $74.2{\sim}87.4%$ in the 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $81.2{\sim}88.7%$ and $94.8{\sim}98.9%$ of the controls. 4. The ossified pelvic girdles were significantly decreased by as much as 57.1% and 56.1% in two ischium, $67.2{\sim}81.7%$ in metacarpals in the 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $67.0{\sim}85.6%$ and $90.1{\sim}98.7%$ of the controls. 5. The ossified terenebrae were unchanged or significantly decreased; 0.0% in 5th, 54.1% in 1st, 83.9% in 2nd, 75.0% in 3rd, 72.7% in 4th, 79.8% in 6th of 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $29.5{\sim}55.1%$ and $54.5{\sim}84.0%$ of the controls. 6. The ossified ribs were significantly decreased by as much as $8.3{\sim}18.0%$ in 20 mg/wt kg methyl mercuric chloride groups (p<0.05). But in the garlic treated groups, they were significantly increased by as much as $87.1{\sim}93.5%$ and $96.3{\sim}99.7%$ of the controls. In conclusion, Korean garlic juice significantly protected against the toxicity of MMC in relation to the fetal ossification in pregnant rats.

염화메틸수은이 임신된 흰쥐의 모체와 태자에 미치는 영향에 대한 연구

이진헌 인제대학교 낙동강환경연구소 1993 심포지움(인제대학교 부설 환경연구소 발표논문집) Vol.- No.2