Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

單層 空心 코일 間의 結合係數의 特性에 關한 硏究

崔宇勝,李鎔求,金周弘 동국대학교 산업기술대학원 1993 산업기술논문집 Vol.1 No.-

The measurement method using voltage ratio is able to measure a coupling coefficient k which is a parameter of power transmission between coils. We verified that the coupling coefficient k between couples of the similar coil with different size equal reciprocally and the coupling coefficient k between two coils on the same axle differ little from the mutual diameter ratio. The coupling coefficient k on the distance between the center point of coils have linear change characteristics.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

3個의 耕耘날을 利用한 平衡振動式 耕耘裝置(Ⅴ) : 運動解析과 要因分析

金成泰,金容煥,崔圭洪,金成泰 慶尙大學校 1988 論文集 Vol.27 No.1

This is the fifth part of series of reports on the study on a blanced-type oscillating tillage implement using triple blades system. Previous reports were made on the characteristics of power requirement and vibration with which tillage implements were oscillated parappep and perpendicular to the travelling direction. In this paper, the locus and motion analysis of the tillage blade and factor analysis were carried out. Obtained results are as follows : 1. The loci od the blade edge were described as helix curve at vertical oscillation and as lacerated curve at horizontal oscillation to the soil bin movement. 2. The motion equations of blade edge are estimated as follows. Vertical forced vibration ?? ?? Horizontal forced vibration ?? ?? 3. The multiple regression equations for resultant oscillating acceleration draft, specific resistance, and torque were established by using frequency, amplitude, life angle of tillage blade, and velocity of carriage as indepentent vibrations, respectively. 4. By reducing the velocity ratio is increased providing higher effect of the reduced draft. But this effect contradicted to achieve the reduced osillating acceleration. Both effects should be considered simultaneously to find out the optimum operating condition. 5. The reduction effect of the oscillating acceleration was slightly favoured to the horizontal forced vibration type, but traction efficiency could be lowered due to the increased slippage. Therefore, it can be concluded that the vertical forced vibration type is more appropriate considering overall performances. 6. From the experimental results, the optimum operating conditions of the vertical forced vibration type are recommended as follow ; life angle 30 degree, operation velocity 0.15 metre per second, amplitude 4-6 millimetre, and frequency 22.5 hertz.

최고경영자, 전략 및 구조요인이 중소기업의 성과에 미치는 영향

최용호,신진교,김승호 한국중소기업학회 2003 中小企業硏究 Vol.25 No.2

본 연구에서는 중소기업의 성과에 대한 최고경영자 특성, 전략 및 조직구조의 영향을 분석하고 있다. 131개 중소기업을 대상으로 자료를 수집·분석한 결과 중소기업의 최고 경영자-전략 및 구조-성과에 대한 연구모형은 타당한 것으로 나타났으며, 최고경영자 특성, 마케팅차별화전략, 분권화 및 계층화가 중소기업의 성과에 유의한 영향을 미치는 것으로 나타났다. 본 연구가 발견한 특징적인 현상은 중소기업이 분권화와 계층화를 동시에 높일 때 성과가 향상된다는 사실이다. 이는 소위 모순경영에 관한 이론적 함의를 제공하는 것으로 볼 수 있다. 또한 중소기업 최고경영자의 특성은 성과에 직접적인 영향을 미치기도 하지만, 전략 및 구조를 통해 간접적인 매개효과도 동시에 지니는 것으로 나타났다. 마지막으로 본 연구결과에 대한 해석과 토론, 이론적 및 실무적인 시사점과 한계점, 그리고 향후의 연구방향이 논의되고 있다. This study investigated the impact of top management, management strategy, and organizational structure on the organizational performance. The data were collected from 131 small and medium sized firms located in Daegu. Empirical results indicated that characteristics of top management, marketing differentiation strategy, decentralization, and stratification influenced on organizational performance significantly. And characteristics of top management have both direct and indirect effect on the organizational performance through management strategy and organizational structure. This study also shown that to improve organizational performance, small and medium sized firms have to persue both decentralization and stratification. In doing so, they appear to be faced with a management of paradox. The implications of these findings, limitations, and future research directions were discussed.

이완훈련이 고혈압자의 상태불안 및 혈압에 미치는 영향

최승욱,박철용 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This research aims to prove that relaxation practice that includes abdominal breathing and progressive relaxation is an effective method in lowering the blood pressure by comparing·approving the effect on state anxiety and the blood pressure, which was proceed to divide middle-aged women into relaxation practiced group, aerobic trained group and controlled group randomly and to compare each group and the period of measurement with the data of state anxiety and blood pressure were measured before the test, during the test and after the test under rest from the program was performed for 4 weeks. The research was carried out from Aug. 05 to Sep. 06, 2002 with the measurement that includes the test of 2 times of high pressure under rest for one week to the subject of 21 persons of woman hypertensives from forties to sixties who reside in Busan and then, with the instruction of abdominal breathing and progressive relaxation 2 times a week to the relaxation practiced group, the instruction of aerobic exercise 3 times a week for 4 weeks to aerobic trained group and non-instruction to controlled group. 2 weeks after the test, state anxiety and blood pressure were measured and post investigation was made after then. For the process of data using SPSS Program 10.0, repeated measure ANOVA was used at significant level p=.05 in the comparison of each group and the change of relevant variable, one-way ANOVA was used in the analysis of the period of the test among each group and multiple comparison by Tukey test was made in the post approval. From this process of date, the following conclusion was drawn. First, state anxiety of relaxation practiced group was decreased significantly in comparison to that of aerobic trained group and controlled group. Second, the systolic blood pressure of relaxation practiced group was decreased significantly in comparison to that of aerobic trained group and controlled group. Third, the diastolic blood pressure of relaxation practiced group was decreased steadily in comparison to that of aerobic trained group and controlled group, but statistical significant decrease was not found Consequently, its been proved that the relaxation practice which consists of abdominal breathing and progressive relaxation didn't affect on the diastolic blood pressure but did affect on the control of state anxiety and the systolic blood pressure.