정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조기위암의 임상적 연구

박태준,양은수,류종철,박태군,이희승,신원창,이진호,김관엽 인제대학교 1994 仁濟醫學 Vol.15 No.1

1989년 9월부터 1993년 7월까지 인제대학교 의과대학 상계백병원에서 실시한 위내시경 소견이 조기위암이며 내시경 직시하 생검결과 선암으로 판명되어, 근치적 위절제술을 시행받은 23명의 환자에서 임상적 특징을 알아보고, 문헌고찰과 함께 보고하는 바이다. The incidence and mortality rate of stomach cancer ranks well ahead of all malignancies in Korea. The prognosis is excellent in early gastric cancer of which the overall 5 years survival rate of 85∼95% is comparative with that of advanced gastric cancer of 15∼49%. So early detection with very sensitive mordality of gastroscope and surgery is the only premise to decrease the mortality rate of gastric cancer. This report deals with the clinical aspects of 23 cases of early gastric cancer, which were confirmed with histopathologic examination of resected stomach during the 4 years from September 1989 to July 1993 at Sanggye Paik hospital, Seoul, Korea. Out of 23 cases of early gastric cancer, 14 cases were male, 9 cases were female, and the male to female ratio was 1.6 : 1. The most common type of early gastric cancer was talc type(43.5%), IIc and its combined type comprised most of them(87.0%). The most prevalent sloe of lesion was gastric angle(43.5%) and the most common direction was lesser curvature(73.9%) 19 cases of 23(78.3%) were between 1∼3cm in size, and there was no statistical significance between the size of the lesion and lymph node metastasis. Of the 9 cases with mucosal lesion, there were 2 cases with lymph node metastasis(22.2%), but 7cases(50.0% ) of 14 cases with submucosal lesion presented lymph node metastasis. Diagnostic accuracy of endoscopy on detection of early gastric cancer was 17 cases(73.9%) of total 23 cases in our study. As with other report, histopathulogic examination of resected stomach revealed adenocarcinoma, tubular type as the most common type. Frequent complaint of patients with early gastric cancer was epigastric pain(65.2%), and duration of the symptom was less than 12 months in 17 cases(73.1%) of 23 patients with early gastric cancer.

토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학

박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.

한국인 6-17세 아동의 성장과 발육에 관한 준종단적 연구 : 제 2 세부과제 : 두개 및 안면 연조직의 성장변화 Part Ⅱ : Growth Change of Craniofacial Soft Tissue

박영철,이기준,이장열,한희경 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.4

현대의 교정치료에 있어 치열궁의 문제뿐 아니라 안모에 관한 비중이 높아지고 있고, 특히 안모형태를 결정하는 연조직의 중요성이 부각되고 있다. 과거의 교정학 발달을 살펴볼 때 두부방사선 계측사진을 통한 경조직성장에 관한 연구는 많이 이루어 졌으나 연조직 성장변화에 관한 연구는 아직 미비하다고 볼 수 있다. 특히 국내에서의 이러한 연구는 연구대상자 수와 분석방법, 계측방법에 있어서 상당한 다양성을 보이고, 성장변화에 대한 연구는 태부족한 현실이다. 이에 본 연구는 남, 녀 6세에서 17세 사이의 악안면 성장과 발육에 관한 조 종단적 연구의 일부로 시행되었으며 3년간에 걸쳐 전신질환이 없고 발육상태가 양호하며 정상교합을 갖는 6-17세의 남자 409명과 여자 436명의 아동을 대상으로 하였다. 이들 아동의 성장에 따른 안면부 연조직의 변화양상을 연구하기 위해 두개안면계측사진을 촬영하여 안모의 형태, 입술의 위치 및 형태, 코의 형태 그리고 입술의 두께 등을 계측한 후 연령별, 성별 평균과 표준편차를 구하고 도표로 표시하여 다음과 같은 결론을 얻었다. 결론 1. 일반적으로 안모의 형태(facial form)는 여자에서보다 남자에서 더 장기간 성장이 지속되었으며 안면의 상부에 비하여 안면 하부구조의 길이가 더욱 큰 증가율을 보였다. 2. 상순과 하순의 두께는 연령의 증가에 따라 큰 변화가 없었으나, 서양아동에 비하여 돌출된 입술의 양상을 보였다. 3. 코의 수평방향으로의 길이는 연령의 증가와 함께 증가하였다. 4. 하안면부의 수평적인 두께는 연령에 따라 증가하였으며 상순의 비저부위의 두께[A-Sn(FH)]의 성장이 다른 부위에 비하여 크게 증가하였다. Along with traditional goal of 'straightening teeth', today`s orthodontics put more and more emphasis on facial esthetics. Naturally, the importance of soft tissue, which dictates one`s facial form, is noticed. There have been many cephalometric studies on growth of hard tissue; however, only a few on that of soft tissue. In Korea, various methods of sampling, measuring and analysing were used to study soft tissue changes, and yet, soft tissue changes along with process of normal growth have not been studied. The author carried out this study as a part of semi-longitudinal study on craniofacial growth and development of Korean children from ages of six to seventeen. 409 boys and 436 girls who`d had no systemic disease for the last three years and shown normal developmental and occlusal status were chosen as subjects. Cephalometric X-rays were taken of each subject, and facial form, lip position & form, nose form, and lip thickness were measured. Mean values and standard deviations were calculated according to age and gender, and figures and tables were drawn accordingly. The following results were obtained: 1. In respect to facial form, boys showed growth for longer period compared to girls. Also, lower face showed higher growth rate than upper face. 2. There was not much change in thickness of upper and lower lips with age; however, they appeared more prominent compared to caucasian children. 3. Nose grew horizontally with age. 4. Horizontal thickness of lower face increased with age, and upper lip thickness at nose base[A-Sn(FH)] showed more growth than anywhere else.

韓國과 日本에 있어서의 學校外敎育에 關한 比較敎育人類學的 考察

朴俊熙 이화여자대학교 한국문화연구원 1982 韓國文化硏究院 論叢 Vol.40 No.-

Out-of-school education(Kwaaekongbu) has, for many years, provoked serious and concentrative efforts among teachers, educational administrators, parents, and community leaders. as one of the serious social problems of Korea and Japan, However, past efforts have been hampered by lack of "attractive devices;" hence, it has been studied from the standpoint of "normal educational development." It is, therefore, an area of study that should be deeply examined from the standpoint of comparative and educational anthropology from which "devices" can be proposed. Actually, there are many similar phenomena concerning out-of-school educational activities in Korea and Japan. The similarities in terms of national character and the attitudes toward the western influence between Korea and Japan are the reason why such phenomena would be occurred in relation to their out-of-school educational activities. As we understand, there are no so serious social problem surrounding out-of-school educational activities, in the developed countries, especially regarding entrance to uppergrade school. It is point that there lies a significant difference of the comparative educational activities between the "developed countries" and Japan and Korea. This is the reason why deeper investigation must be made to understand more fully, the anthropological and comparative factors of "out-of school" education. The results from this study took into account the deeply rooted cultural traditions, ways of thinking, and the national character which is based upon the confuscioustic patterns of life. However, there numerous "devices" from the standpoint of short term plans but few "devices" from a long term point of view. In Korea there have been a number of discussions and studies addressing this problem from the standpoint of the national policy of education. However, these discussions were genualy short term, phenomenological, and were not from a cultural, historical and anthropological point of view. Comparatively, Korea has addressed this problem in greater detail than in Japan. Moreover, Korea has taken positive steps toward rectifying the problem; however, Japan still lacks a genual policy. Moveover, both activities have experienced great difficulties to solve this problem because fundamental considerations were not introduced. However, it can be expected that the problem can be solved from the standpoint of educational anthropology. In otherwords, it is not an administrative and political problem but a greater problem of eduoational anthropology.

한국무용 참가동기와 생활만족의 구조방정식 모형 분석

박준희,정혜선 朝鮮大學校 스포츠科學硏究所 2005 스포츠科學硏究 Vol.16 No.-

This study was to analyze the life satisfaction by korean dance participation's motivation. Specifically. this study was to test relationship among, participation motivation, active satisfaction and life satisfaction. The subjects(N=191) were selected in highschool and university located at Kwangju province by convenience random sampling. This study organized a self-administration reporting questionaire which was named<The survey on the life satisfaction by korean dance participation's motivation>. The result of reliability about questionaire was Chronbach' a=.758-902. The reliability analysis and SEM were used as statistic analysis techniques. On the basis of the results, the conclusions were drawn as follows; First. There was a signfticant influence between outer participating motivation and active satisfaction. Second, There was a significant influence between active satisfaction and life satisfaction. Third, the model which was generally coincided on X^(2) = 145.701 (P=.000), RMSEA = .073, TLI = .939, NFI = .910, CFI = .952, explained adequate relationship among korean dance participation's motivation, active satisfaction and life satisfaction.

사면안정 해석방법의 차이에 의한 안전율의 비교 연구

박춘식,장정욱,안준희 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

This study performed slope stability analysis by changing analysis methods and shear strength with the slope stability analysis program. The conclusions of the study are as follows. 1) The safe factor of clayey soil applied with Bishop's simple method turned out to be similar to or slightly higher than those of other methods, for both dry and saturated conditions. 2) The safe factor of sandy soil applied with GLE method turned out to be slightly higher than those of other methods. But when applied with Bishop's simple method, it appeared to be slightly higher than those of other methods. 3) The safe factor of ordinary soil applied with GLE method showed the highest result. 4) Janbu method showed the lowest safe factor among all the methods for the above three types of soils.

5세 남아의 Influenza 종격동기종 및 대엽성 폐렴 1례

오희성,한유진,연은경,선동신,송준환,박경배,박준수,김영통,남해선,최영진,김용배 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3S

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여성 복압성요실금에서 술 전 발살바요누출압에 따른 Suprapubic Arch 술식의 결과

박준명,유지형,성락희,정재용,노충희 인제대학교 2008 仁濟醫學 Vol.29 No.-

Objective : There were variant results for correlation between the postoperative cure rate and valsalva leak point pressure (VLPP) for female stress urinary incontinence (SUI). Therefore the aim of this study was to assess the influence of VLPP on the outcome of suprapubic arch (SPARC) procedure. Materials and Methods : A retrospective analysis was made of 246 women who underwent SPARC procedure for SUI. Based on VLPP, the patients were divided into 2 groups: group A (VLPP<60cmH2O) and group B (VLPP≥60cmH2O). The objective success rate and subjective success rate were assessed. Before surgery, the patients were evaluated with history taking, physical examination, urinalysis and urodynamic studies. The objective success rate was evaluated by clinical examination and the 1-hour pad test postoperatively and the subjective satisfaction rate was assessed using questionnaires for the patients' satisfaction and evaluated by recommendation rates of SPARC procedure to other patients. The objective success rate included cure and improvement, the subjective success rate included satisfaction and fair. Results : The number of patients in each group was 145 patients (group A) and 101 patients (group B). The objective success rate was 99.3% (group A) vs 98.0% (group B) (p=0.285). The subjective success rate was 98.6% (groupA) vs 98.0% (group B) (p=0.500). Recommendation rates of SPARC procedure was 94.5% (group A) vs 95.0% (group B) (p=0.422). Conclusion : It is our belief that SPARC procedure for female SUI is efficacious and safe regardless of preoperative VLPP.

自由中國 就學前 敎育政策 樹立過程의 敎育人類學的 理解

朴俊熙 이화여자대학교 한국문화연구원 1981 韓國文化硏究院 論叢 Vol.38 No.-

In the late of the 18th century, the Republic of China was becoming aware of necessity for educational modernization with concern in the educational system, facility, materials and the methods of teaching. Also, she tried to reorganize and change from the traditional situation to the modernized European nations models for the making the so-called developed and modernized one. The purpose of the transition from the traditional situations of education to modernized, was to assure that she was going to make her country a new nation through education. First of all, for the accomplishment of the purpose, she tried to study the educational systems, facilities, materials and methods of teaching of the advanced countries like England, France, Germany and America. Then she tried to reorganize the educational system of her own country and at the same time, she never has forgotten but rather as an informal or very fundamental education in relation to home education in early childhood, especially and traditional carried out by herself from the ancient. Therefore, the present educational system which she has developed is mostly, in its frame, imitated from the systems of advanced countries. And so, nowadays the pre-school education in the Republic of China has been well developed in comparison with the pre-school education of Korea and Japan. In Taiwan, for instance, the private pre-school education institution reaches almost one thousand and one-third in its ratio. This number and ratio shows a much more advanced situation in comparison with Korea and Japan in relation to the total population, the scale of the land and at the same time the wealth of those countries. The reason why and how she could make that development of the pre-school education and at the same time emphasize so much importance of its is very interesting from the standpoint of educational anthropology and so it might be deeply considered. Historically and culturally it can be classified into two categories, One is that is has come from the value of education the Chinese people have stressed due to their traditional Confucian way of thinking. The other is from the characteristics of the Chinese culture which they also has built based on the same way of life as follows; 1. Historically, from the first, most of the Chinese people have emphasized home education for children to promote the development of a nationalistic ethical idea and personality, and they thought of the home education as the foundation of the nationalistic development of the people. At the same time, they thought of the home education as the foundation of all kinds of educational systems and activities. 2. From the standpoint of the Chinese culture, there are these kinds characteristics: (1) The Chinese culture has both characteristics of conservativeness and innovativeness. (2) The Chinese personality is very continental and they could well accommodate foreign culture or values without feeling any anxiety about it. (3) The Chinese language is, in its structure from the standpoint of grammar, very similar to the western language and thus they have similar ways of thinking. (4) The style of living of the Chinese people is also similar, in many ways, to the style of western people. (5) The Chinese people are excellent in their economic idea for the making of the wealth for their living and at the same time their skills for their commercial activities in their personality.