A simple approach to estimate the mechanical properties of collagen-like microfibrils surrounded by water

Young-june Yoon,Cheol-soo Bae,Ho-sik Park 한국멀티미디어학회 2010 한국멀티미디어학회 국제학술대회 Vol.2010 No.-

The effective Young's modulus of a microfibril surrounded by water may be simply calculated by using the upper (Voigt) and lower (Reuss) bounds. The result is compared to the Young's modulus estimated by using the Steered Molecular Dynamics (SMD) (Zhang et al. 2007). Our result shows 9.2% difference from the result estimated by SMD, but the steps using these bounds are much simpler than SMD..

포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

복합재료역학을 이용한 콜라겐 단백질 마이크로피브릴의 탄성율 예측 개선

윤영준,배철수,Yoon, Young-June,Bae, Cheol-Soo 대한의용생체공학회 2010 의공학회지 Vol.31 No.3

The effective Young’s modulus of a microfibril surrounded by water may be simply calculated by using the upper (Voigt) and lower (Reuss) bounds, which is one way to estimate the Young’s modulus in composite materials. The Steered Molecular Dynamics (SMD) has been used for estimating the Young’s modulus of a microfibril surrounded by water. In this paper, the result estimated by the upper (Voigt) and lower (Reuss) bounds shows 9.2% to 21.8% discrepancy from the result estimated by SMD, but introducing “efficiency of reinforcement parameter” removes the discrepancy and shows good agreement with the result estimated by SMD. We found the best fit for the Young’s modulus against the size of the gap between microfibrils. Also the steps using these bounds are much simpler than SMD.

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

海洋微生物에 의한 高濃度鹽分含有 廢水處理의 基礎硏究 (Ⅰ)

尹星閏,河淸根,李泰永,張哲鉉,朴勝祚 동아대학교 환경문제연구소 1989 硏究報告 Vol.12 No.1

This study considered organic matter decomposition by ocenic microbes as researching organic matter decomposition on kinetics which is in salinity wastewater under condition that the salinity contains 18,000㎎/l Cℓ^(-) The results of this study are obtained as following : 1. Oceanic microbe of this study is yeast, R. glutinis var. salinaria of marina of Rhodotorula genuses. 2. When retention time of filter bed in Bio-coal tower is 24 hr, 1/2V_(max) is 33.75㎎/l·hr, When 72hr, 1/2V_(max) is 15㎎/l·hr, When 120hr, 1/2V_(max) is 10㎎/l·hr. 3. The reaction between oceanic microbes and organic matter is said to be first order and when contact time of filter bed is 2.0hr, k is 0.40 day^(-1).

Benzoate 분해균주의 분리 및 특성

윤영빈,정원철,최언호 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.9 No.-

Twenty-seven bacterial colonies capable of growing on benzoate as the sole source of carbon were isolated from streamside soils. Three of isolates were found to be extremely effective in metabolizing the benzoate, when they were incubated in the basal salt medium containing 2,000ppm of benzoic acid at 30℃ for 48hrs. The three isolates, Y205, W212 and J211 were identified Pseudomonas aeruginosa, Bacillus fastidiosus, and Aeromonas sp. respectively through morphological and physiological examination. Optimal temperature and pH for benzoate degradation of the isolates appeared to be 35℃ and pH for Pseudomonas sp. Y205 and Bacillus. sp. W212, and 30℃ and pH 7.0 for Aeromonas sp. J211. The highest degradation of benzoate by the three isolates was obstained in the growth media containing ammonium sulfate as nitrogen source. Optimal concentration of ammonium sulfate was 6.0g/l for Pseudomonas sp. Y205 and Aeromonas sp. J211, and 4.0g/l for Bacillus. sp. W212. When the three isolates were cultivated in basal salt medium containing 2,000ppm benzoate under optimal condition, they showed a logarithmic phase growth 12hours and a stationary phase growth 18hours after innoculation, and the benzoate degradation of 91.15-92.40% after 72-hours incubation. Benzoate degradation increased in parallel with the cell growth.

무세정 Wave Soldering 공정 기술에 관한 연구

윤준호,장인철,신영의 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

본 연구는 저잔사 무세정 플럭스를 사용한 솔더링 공정에 대한 실험을 수행하였다. 일반적으로 세정이 요구되는 플럭스와 같은 조건에서 실험할 후 비교하여 육안 검사와 인장 시험을 통해 저잔사 플럭스의 특성과 문제점 그에 따른 최적 조건을 검토하였다. 실험한 결과로부터 기존의 플럭스와 저잔사 무세정 플럭스의 결함 발생 조건을 검토하였고, 시편이 접합력 측정하여 품질을 평가하였다. 접합력에 있어서는 저잔사 무세정 플럭스가 기존 플럭스보다 약 10~20N 정도로 높게 나타났지만, 변동폭도 크게 나타나 접합의 재현성면에서 문제가 있는 것으로 생각되며, 솔더링 공정 상 (특히 예열온도, 예열 시간, 납조 접촉 시간)의 보다 세심한 주의를 요하는 것으로 사려된다. Wave soldering with low residue, non-cleaning flux has been studied from perspective initial solderability using visual inspection and mechanical tensile test. Soldering fillet including joining force with non-cleaning flux and cleaning flux were compared in wave soldering process. As a result of visual inspection, for low residue non-cleaning flux, optimal conveyor speed was 1.0~2.0 m/min and optimal preheat temperature was 50~125℃. For cleaning type flux, optimal conditions were 0.6~1.0 m/min, 110~125℃. As result of tensile test, initial tensile force of non-cleaning flux is lower than cleaning flux. It is recommenced to use non-cleaning flux for demanding higher strength and to use cleaning flux for demanding on repeatability. The influences of filling the holes on tensile force are also explored. To inspect that holes was filled with solder are more important than the lower- side fillet deformed well in PTH(PIH)devices.

형법 제230조(공문서부정행사죄)에 있어서 "부정행사"의 개념

윤영철 한국비교형사법학회 2003 비교형사법연구 Vol.5 No.1

Das Oberste Gerlcht in Korea hat in seiner Entscheldung vom 19. 04. 2003 seine bisherige Ansicht dadurch gea ndert, die Identita tsbesta tigung des Fu hrerscheins - dessen nebensachlichen Verwendungszweck - als dessen hauptsa chlichen Verwendungszweck auszulegen und es fu r unredlichen Gebrauch o ffentlicher Urkunden nach § 230 KStGB zu halten, wenn jemand das Fu hrerschein von Anderen gerade fu r die Besta tigung seiner Identita t zeigt. Zu beurteilen ist, daB in dieser Entscheidung die Ansicht des Obersten Gerichts selbst u ber ,,unredlichen Gebrauch" als Tatbestandsvoraussetzung des § 230 KStGB - wenn zum Gebrauch unbefugte o ffentliche Wrkunden nach derer hauptsa chlichern Verwendungszweck wie befugte gebrauchen nicht gea ndert wurde. Aber realer odor nebensa chlicher Verwendungszweck von o ffentlichen Urkunden galt als derer hauptsa chlichen, indem der Umfang der letzteren als Kempunkt unredlichen Gebrauchs in dieser Entscheidung weiter als in seiner vorherigen ausgelegt wurde. Es scheint eine vemu nftige huslegung innerhalb des Anwendungsbe-reiches des § 230 KStGB zu sein. Aber diese Entscheidung du rfte zur Erweiterung des Begriffes ,,unredlichen Gebrauchs" selbst und weiters zur Ausweitung des Handlungsobjekts des § 230 KStGB fu hren gerade durch die weitgehende Auslegung des Unterbegriffes in Hinsicht auf unredlichen Gebrauch als Tatbestandsvoraussetzung des § 230 KStGB. Demzufolge gera t sie in Widerspruch zum Analogieverbot und Bestimmtheitsgebot, das zu Prinzipien des liberalen Rechtsstaats gehort. Unter diesen Gesichtspunkten mu Bte es zutreffend sein, daB die Entschei-dung des Obersten Gerlchts vom 19. 04. 2003 gerade dessen vorhengen Entscheidung folgt, in der der Anwendungsbereich und Bestrafungsumfang des § 230 KStGB sachgerecht beschra nkt wurde, indem die letztere das Handlungsobjekt und den Begriff unredlichen Gebrauchs im § 230 KStGB begrenzt auslegte.