^(155,156)Gd 동의원소의 keV 영역 중성자 포획단면적 측정

정원정,황정훈,김현,노태익 東亞大學校 2004 東亞論叢 Vol.41 No.-

The Neutron Capture Cross-Section of ^(155,156)Gd were measured in a neutron energy region from 15 to 85 keV using the 3MV Pelletron accelerator of Tokyo Institute of Technology. Pulsed neutrons were produced from the ^(7Li)(p,n)^(7)Be reaction. The incident neutron spectrum on a capture sample was measured by means of a TOF method with a ^(6)Li-glass detector. The capture γ-ray were detected with a large anti-Compton NaI(TI) spectrometer. A pulse-height weighting technique was applied to measured capture γ-ray pulse-height spectra to derive capture yields. The capture cross sections were obtained by using the standard capture cross-section of ^(197)Au. The present results are corrected for isotope impurities of sample because the samples contain various isotope Godolinium. The present results are compared with the previous measurements and the evaluated data of ENDF/B-VI.

인문학 및 사회과학 학술지를 통해본 체제전환기 러시아 인문학·사회과학의 동향 : 1985-2000년대 초

한정숙,박원용,최우익 서울대학교러시아연구소 2002 러시아연구 Vol.12 No.2

This article is a parallel analysis to the database of seven sorts of Russian academic journals for the period of the transformation (from 1985 to the early 2000s.) The database was made by authors of this paper with the aim to offer an easy way to search the title, author and subject of writings (articles, translations, reminiscences, round table talks and dialogues) published in the fields of philosophy, history, politics, sociology and economics. This work gave us the chance to overview the study trends of humanities and social sciences in Russia by examining the changing subjects, theoretical premises and methodological approaches of the intellectuals productions published in the journals. Authors chose the above ` mentioned five academic disciplines as our study object because these are considered (so to say, as ideology-related disciplines) to have experienced the most remarkable transformation since the beginning of Gorbachev's policy of Perestroika and Glasnost. During the Soviet Period, studies and publications in these fields were under strong influence of the official ideology of the Communist Party, which always tried not to lose tight control of intellectual activities in almost all aspects. The gradual manifestation of arguments not subjected to the party line was possible since the middle of the 1980s, when Gorbachev's "reform of socialism" policy allowed critical approach to Stalinist legacy of the Soviet regime and search for alternatives to the existing economic and social (later, also political) system. Though each discipline differs in the degree and depth of change, authors of this paper are of the opinion that a remarkable process of transformation can be found in all the concerned fields especially after the collapse of the Soviet Union. The period of Perestroika was more devoted to self-criticism and search of alternative within the frame of socialist legacy. In general it was a time of a rather moderate iconoclasm. After the disintegration of the Soviet Union the genuine intellectual transformation began. All possible arguments emerged, but the construction of a new intellectual frame of reference for the Russians was not easy. In the early period of rapid system transformation, Russian scholars were rather hastily importing methodologies and perspectives of western scholars and tried to use them as tools for analysing circumstances of their own country as well as of the entire world. On the opposite side of the Westphilism one could also find a rather extreme trend of Russian nationalism (or neo-Slavophilism). It seemed that the Russian intellectuals wanted to compensate intellectual losses caused in the past by the Party control through absorbing every possible argument that stands outside of traditional Soviet intellectual horizon. This phenomenon was in itself understandable enough, but the whole sight of discourses was rather unclear and somewhat confusing too. It was a period of "search of exit in every direction". In recent years however, observers can ascertain a much stabler atmosphere among the Russian researchers in every academic discipline concerned. Authors of this paper share the view that Russian scholars and intellectuals are overcoming their once apparent extremism - whether in the direction to Westphilism or to nationalism. Open-minded to international scholarship and discussion, they are at the same time more self-confident than during the first half of the 1990s. One can hope that it would lead to intellectual works more productive and persuading for the Russians as well as for the entire world.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

조혈모세포이식 환자의 삶의 질에 대한 연구 : 화학요법 환자 및 정상인과의 비교

김병수,서재홍,최철원,김열홍,김준석,김정아,손상균,김재석,이경희,이제중,정익주,곽재용,안진석,이정애,박영석 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.1

연구배경: 조혈모세포이식후 신체 및 정신적 장애의 정도가 얼마나 환자의 '삶의 질(QOL)'에 영향을 미치는지에 대하여 외국에서는 연구들이 활발히 진행되고 있다. 그러나 우리나라에서는 조혈모세포이식이 비교적 활발히 시술되고 있음에도 불구하고 이에 대한 연구가 미미한 실정이었다. 연구자 등은 우리 나라에서 조혈모세포이식을 받은 환자들의 QOL은 어떤지를 알아보고자 하는 목적으로 본 연구를 시행하였다. 방법: 본 연구에 참여한 각 기관에서 조혈모세포이식을 받고 주된 치료가 끝난 후 1999년 2월 시점에서 최소 3개월이 지나고 관해상태에서 일상생활을 영위하고 있는 재생불량성 빈혈과 급성 및 만성 백혈병 환자들을 각각 자가 및 동종 조혈모세포이식을 시행받은 조혈모세포이식군(1군)과 항림프구 글로불린, 공고요법 등으로 치료를 끝낸 화학요법군(2군)으로 분류하고 연구자 병원에 내원한 건강한 환자 보호자들로 이루어진 정상대조군(3군)을 선정하여 각각의 QOL을 비교, 분석하였다. QOL의 측정은 EORTC QLQ-C30 문항을 우리나라의 실정에 맞게 번역하여 사용하였다. 결과: 조혈모세포이식군(1군)은 53명, 화학요법군(2군)은 57명, 정상대조군(3군)은 55명 이었고, 성별, 나이, 질환별 분포, 검사시점 등에서의 유의한 차이는 없었다. 각 군간의 QLQ-C30 평균 점수를 비교한 결과, 전반적인 삶의 질에서는 1군이 73.5, 2군이 51.7, 3군이 79.3으로 2군이 1.3군보다 낮았고 역할 및 사회기능은 각각 1군이 64.3/68.9, 2군이 57.6/70.3, 3군이 85.2/85.5로 1,2군이 3군에 비하여 낮았다.(P<0.01). 또한, 오심/구토가 1군은 8.7, 2군은 4.5, 3군은 3.2로 1군이 2, 3군보다 높았으며 통증은 1군은 17.0, 2군은 19.2, 3군은 9.6으로 1,2군이 3군에 비하여 높았다(p〈0.01). 기타 신체, 감정, 인식기능 및 피로에서는 각군간에 유의한 차이를 발견할 수 없었다. 결론: 본 연구에 참여한 조혈모세포이식환자들의 전반적인 삶의 질은 화학요법을 받은 환자들보다 우월하면서 정상인들과 유사하였으나 역할기능 및 사회기증, 통증에서는 화학요법 환자들처럼 정상인들에 비하여 열악하였고 오심/구토는 화학요법 환자들 및 정상인에 비하여 심한 양상을 보였다. 그러므로 본 연구를 바탕으로 하여 국내 실정에 맞는 QOL 측정 방법을 개발하고 조혈모세포이식을 시행받는 환자들의 삶의 질에 관한 연구들이 향후 계속 진행되어야 하리라고 생각된다. Background: It is very important to endow patient with satisactory quality of life (QOL). However, little is known about QOL after hematopoietic stem cell transplantation (HSCT) in Korea. In this study we tried to measure QOL in the patients treated with HSCT and compare QOL scores with those of patients treated with usual chemotherapy and normal populations. Methods: The QOL evaluation was performed with EORTC QLQ-C30 questionnaires interpreted to Korean language. The study populations were consisted with 53 patients treated with HSCT (Group 1), 55 patients treated with usual chemotherapy (Group 2), and 55 normal populations (Group 3). The QLQ-30 scores of each group were evaluated and compaired with x² test. Results: Global quality of in group 1, 3 (score: 73.5, 79.3, respectively) were higher than that (score: 51.7) of group 2. Role and social function were lower in group 1, 2 (score: 64.3/68.9, 57.6/70.3, respectively) than those (score: 85.2/85.5) of group 3. The degree of nausea and vomiting was more severe in group 1 (score: 8.7) than those of group 2, 3 (score: 4.5, 3.2 respectively). Pain scores of group 1, 2 (score: 17.0, 19.2, respectively) were more higher than that of group 3 (score: 9.6) In other parameters of QLQ-C30, there was no significant difference between each groups. Conclusion: Our perliminary result may suggest that HSCT is not necessarily associated with deterioration of QOL. This underlines the necessity of undertaking perospective studies using reliable and well-validate methods for measuring QOL

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Highly Tunable Self-Assembled Nanostructures from a Poly(2-vinylpyridine-<i>b</i>-dimethylsiloxane) Block Copolymer

Jeong, Jae Won,Park, Woon Ik,Kim, Mi-Jeong,Ross, C. A.,Jung, Yeon Sik American Chemical Society 2011 NANO LETTERS Vol.11 No.10

<P>An extraordinarily large degree of tunability in geometry and dimension is demonstrated in films of a self-assembled block copolymer. A poly(2-vinylpyridine-<I>b</I>-dimethylsiloxane) block copolymer with highly incompatible blocks was spun-cast on patterned substrates and treated with various solvent vapors. The degree of selective swelling in the poly(2-vinylpyridine) matrix block could be controlled over an extensive range, leading to the formation of various microdomain morphologies such as spheres, cylinders, hexagonally perforated lamellae, and lamellae from the same block copolymer. The systematic control of swelling ratio and the choice of solvent vapors offer the unusual ability to control the width of very well-ordered linear features within a range between 6 and 31 nm. This methodology is particularly useful for nanolithography based on directed self-assembly in that a single block copolymer film can form microdomains with a broad range of geometries and sizes without the need to change molecular weight or volume fraction.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-10/nl2016224/production/images/medium/nl-2011-016224_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2016224'>ACS Electronic Supporting Info</A></P>

Proximity Injection of Plasticizing Molecules to Self-Assembling Polymers for Large-Area, Ultrafast Nanopatterning in the Sub-10-nm Regime

Jeong, Jae Won,Hur, Yoon Hyung,Kim, Hyeong-jun,Kim, Jong Min,Park, Woon Ik,Kim, Mi Jeong,Kim, Bumjoon J.,Jung, Yeon Sik American Chemical Society 2013 ACS NANO Vol.7 No.8

<P>While the uses of block copolymers (BCPs) with a high Flory–Huggins interaction parameter (χ) are advantageous for the improvement of resolution and line edge fluctuations of self-assembled nanoscale patterns, their slow chain diffusion results in a prolonged assembly time. Although solvent vapor annealing has shown great effectiveness in promoting the self-assembly of such BCPs, a practical methodology to achieve a uniform swelling level in wafer-scale BCP thin films has not been reported. Here, we show that a solvent-swollen polymer gel pad can be used as a highly controllable vapor source for the rapid, large-area (>200 mm in diameter) formation of sub-10-nm patterns from a high-χ BCP. The proximal injection of solvent vapors to BCP films and the systematic control of the swelling levels and temperatures can significantly boost the self-assembly kinetics, realizing the formation of well-aligned sub-10-nm half-pitch patterns within 1 min of self-assembly. Moreover, we show that the gel pad can be used for the shear-induced alignment of BCP microdomains in an extremely short time of ∼5 s as well as for the generation of three-dimensional crossed-wire nanostructures with controlled alignment angles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-8/nn401611z/production/images/medium/nn-2013-01611z_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn401611z'>ACS Electronic Supporting Info</A></P>

인터넷을 활용한 영어작문 능력향상에 관한 연구 : MOO를 중심으로

원정원(Jeong Won Won),김익환(Ik Hwan Kim) 현대문법학회 2001 현대문법연구 Vol.23 No.-

The Multi-User Dimensions Object-Oriented(MOO) is a synchronous interacting program unlike other asynchronous programs such as e-mail, mailing lists, or Usenet. This study is an attempt to suggest ways of improving students’ writing ability by exploring the Schmooze University, one of MOO sites for ESL or EFL English learners. Schmooze University offers language learners opportunities to communicate with native speakers and other English learners from all over the world. Through this system they are able to exchange on online their ideas about each other’s culture, customs, and about learning a language. This authentic, task-based learning environment creates a more attention-attracting and interesting learning situation for those learners of the English language.

Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-관B.

Hwang, Jeong Won,Oh, Jung Han,Yoo, Hwa-Seung,Lee, Yeon-Weol,Cho, Chong-Kwan,Kwon, Ki-Rok,Yoon, Jung-Ho,Park, Junsoo,Her, Song,Lee, Zee-Won,Jang, Ik-Soon,Choi, Jong-Soon Institute for Advanced Research in Asian Science a 2012 The American journal of Chinese medicine Vol.40 No.1

<P>Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-관B. In addition, BX-MG activated p53 and p21, resulting in the attenuated proliferation of A549 cells. Reduced activity of the NF-관B promoter and increased activity of the p53 promoter indicate that BX-MG regulates apoptosis at the level of transcription in lung cancer cells. Furthermore, BX-MG blocked the nuclear translocation of RelA and the associated reduction in surviving. These results suggest that BX-MG inhibits lung cancer cell growth by activating tumor suppressors and inhibiting nuclear translocation of NF-관B.</P>

Distribution and Characterizations of Salmonella enterica Subspecies enterica Serotype Bareilly Isolated from Environmental Samples of Laying Poultry Farms and Ratail/Wholesale Eggs in Korea

So Jeong Jeong,Min Chan Im,Se ji Cho,Ji A Jung,Sang Ik Oh,Ara Cho,Ha Young Kim,Jae Won Byun,Jong Wan Kim,Myoung Heon Lee,Young Ju Lee 대한수의학회 2014 대한수의학회 학술대회발표집 Vol.2014 No.-