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서재홍,임성철,기근홍 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2
In gastric carcinomas including 20 cases of intestinal type and 20 cases of diffuse type, in adenoma (10 cases), and in metaplastic gastritis(10 cases), the presence of lactoferrin was investigated by immunohistochemistry. An evident reactivity for lactoferhn was encountered in intestinal type carcinomas, adenomas, and incomplete intestinal metaplasia. The problems in identifyng the steps in the pathogenesis of gastric cancer and in the calssification of its preneoplastic lesions led to a throughout analysis of the morphologic features of metaplastic gastritis, adenoma and adenocarcinoma of the gastric mucosa. Recently, several morphologic features with possible diagnostic significance have been identified among these parameters, several cytologic features seem to be of major importance for the quantitative analysis of the stepwise develop merit of malignancy. We have chosen to study nuclear and cytoplasm measurements as seen in gastric biopsied specimens. The results obtained were as follow: 1) Incomplete intestinal metaplasia, adenoma and intestinal type adenocarcinoma were stained with lactoferrin 2) Nuclear and cytoplasmic areas of incomplete metaplasia (50±14㎛_(2), 147±38㎛_(2)), Adenoma (56±16㎛_(2), 149±44㎛_(2)), Well differentiated adenocarcinoma(57±16㎛_(2), 152±48㎛_(2)), Moderate differentiated adenocarcinoma (44±14㎛_(2), 118±33㎛_(2)), Poor differentiated adenocarcinoma (54±16㎛_(2), 97±30㎛_(2)) and diffuse type adenocarcinoma (33±10㎛_(2) 434±124㎛_(2)) were noted. 3) Nuclear and cytoplasmic ratio of incomplete metaplasia(0.34±0.02), adenoma (0.38±0.02), well differentiated adenocarcinoma( 0.38±0.02), moderately differentiated adenocardnoma (0.37±0.02), Poor differentiated adenocarcinoma(0.56±0.01), and diffuse type adenocarcmoma (0.08±0.02) were noted.
LSTM-VAE를 활용한 기계시설물 장치의 이상 탐지 시스템
서재홍,박준성,유준우,박희준 한국품질경영학회 2021 품질경영학회지 Vol.49 No.4
Purpose: The purpose of this study is to compare machine learning models for anomaly detection of mechanical facility equipment and suggest an anomaly detection system for mechanical facility equipment in subway stations. It helps to predict failures and plan the maintenance of facility. Ultimately it aims to improve the quality of facility equipment. Methods: The data collected from Daejeon Metropolitan Rapid Transit Corporation was used in this experiment. The experiment was performed using Python, Scikit-learn, tensorflow 2.0 for preprocessing and machine learning. Also it was conducted in two failure states of the equipment. We compared and analyzed five unsupervised machine learning models focused on model Long Short-Term Memory Variational Autoencoder(LSTM-VAE). Results: In both experiments, change in vibration and current data was observed when there is a defect. When the rotating body failure was happened, the magnitude of vibration has increased but current has decreased. In situation of axis alignment failure, both of vibration and current have increased. In addition, model LSTM-VAE showed superior accuracy than the other four base-line models. Conclusion: According to the results, model LSTM-VAE showed outstanding performance with more than 97% of accuracy in the experiments. Thus, the quality of mechanical facility equipment will be improved if the proposed anomaly detection system is established with this model used.
Analysis of privacy-preserving element reduction of a multiset
서재홍,HyoJin Yoon,Seongan Lim,천정희,홍도원 대한수학회 2009 대한수학회지 Vol.46 No.1
The element reduction of a multiset S is to reduce the number of repetitions of an element in S by a predetermined number. Privacy-preserving element reduction of a multiset is an important tool in private computation over multisets. It can be used by itself or by combination with other private set operations. Recently, an efficient privacy-preserving element reduction method was proposed by Kissner and Song [7]. In this paper, we point out a mathematical flaw in their polynomial representation that is used for the element reduction protocol and provide its correction. Also we modify their over-threshold set-operation protocol, using an element reduction with the corrected representation, which is used to output the elements that appear over the predetermined threshold number of times in the multiset resulting from other privacy-preserving set operations.
자궁경부의 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53 및 E-cadherin 발현양상
서재홍,양정원,성정희,오수섭,이미자 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2
Background and Objectives: Correlation of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression was analyzed in cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and microinvasive and invasive squamous cell carcinoma (SCC) according to human papilloma virus (HPV) inffection. Materials and Methods : (23 CIN 1, 28 CIN 2, 23 CIN 3), 18 CIS, and 24 SCC. Results: Expression of cyclin E was significantly higher in CIN 2, CIN 3, CIS and SCC than CIN 1 with or without HPV infection. Expression of bcl-2 was significantly higher in CIN 3 than SCC. There was no association between expression of p27 and VEGF and progression of CIN 1 to SCC. Expression of p53 was significantly high in CIN 3, CIS and SCC with or without HPV infection. Expression of the E-cadherin was significantly high in CIN 2, CIN 3, CIS and SCC with or without HPV infection. Conclusion: There was correlation between expression of cyclin E, b치-2, ㅔ53, E-cadherin and progression of CIN to SCC. It is suggested that cyclin E may play an important role in the neoplastic transformation of cervical squamous cell.
A SLIP-based Robot Leg for Decoupled Spring-like Behavior: Design and Evaluation
서재홍,김정영,박상신,조정산 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.9
We present a spring loaded inverted pendulum (SLIP) based robot leg to enable decoupled swing motion and spring-like behavior. The two SLIP principles (decoupled swing motion and spring-like behavior) allow an improved understanding of robot locomotion and its control. Proposed leg mechanism include one degree of freedom (DOF) straight-line generating mechanism to perform ideal spring-like behavior and the pantograph to amplify that. The spring-like behavior can be implemented using mechanical constraints with Chebyshev linkage and the virtual spring method. For applying the virtual spring method to the radial motion controlled by one actuator, the relationship between the actuator force and radial force acting on the foot end was determined by using a kinematic interpretation. A 1-DOF test bed including the suggested leg was built and tested to verify the decoupled motions. The spring-like leg behavior was demonstrated during the free fall experiment and the experiment in which external force was applied.