간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

발전기 고정자 권선용 마이카/에폭시 수지의 표면 및 구조분석

이상교,심재선,정의남,송우창,박하용,심상흥,임윤희,박종국,심낙순 三陟大學校 1998 論文集 Vol.31 No.1

The purpose of this study is to determine the ageing mechanism of Mica/Epoxy composite material for large generator stator windings in order to estimate remaining life of generator. X-ray analysis is performed to investigate the position and structure of mica crystal in insulation materials. The phase change of aged and sound specimen under each atmosphere isn't observed. Surface analysis of insulation materials by optical microscope also show that the sound and aged specimen, sliding phenomenon by shear and thermal stress is observed both interface between mica and epoxy.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

텅스텐-Amine 錯物의 合成과 赤外線分光學的 및 熱分析的 調査

李善行 慶北大學校 師範大學 1975 敎育硏究誌 Vol.17 No.-

New tungsten complexes of WCl_4A_2 and WCl_4(NHPh_2)_3 have been prepared without reducing agents in acetone solution. The compositions of the tungsten-amine complexes were estimated from the elemental analysis for tungsten, chlorine, and nitrogen and by the infrared spec-trophotometry and thermal analysis. (A=Aniline, NHPh_2=diphenylamine)

二中心 H¨uckel M.O.法에 의한 알코올類의 電子密度와 結合 Energy에 대한 硏究

李武相,李善行 慶北大學校 師範大學 1977 敎育硏究誌 Vol.19 No.-

The electron densities and bond energies for alcohol derivatives are calculated by Two-Center Hu¨ckel M.O. method. Inductive effect for the long-chain alkyl or alkoxy substituents of alcohol does not occur. The branched amine-substituted alcohols have less inductive effect than the unbranched one. The more bulky the alkyl group of alcohols is, the less the C-H and C-C bond energies have. It is also concluded that the N-H bond of amine-substituted alcohols has a strong reactivity because of its weak bond force, and the O-H bond energies of alkoxy substituents are constant owing to the high electron affinity of their own oxygen atom. Almost no relationship occur between the S_N 2 reactivity of alkyl group and the electron densities of the α-carbon atom of alcohols or the bond energies of the O-H bond because the alcohol derivatives have steric effect.

함평만 갯벌 조간대의 식생분포 및 현존량

이승호,이점숙,김종욱,김하송,임병선 木浦大學校 沿岸環境硏究所 1998 沿岸環境硏究 Vol.15 No.1

함평만 조간대 염생식물조사를 위하여 염생식물군락이 형성된 6개지역을 선정하여 식생분포 및 현존량을 조사하였다. 우점군락은 퉁퉁마디군락(Salicoenia herbacea community), 칠면초군락(Suaeda japonic community), 나문재군락(Suaeda asparagoides community), 좀보리사초군락(Carex pumilalini community), 가는갯능쟁이군락(Atriplex gmelini community), 갯개미취군락(Aster tripolium community), 갯잔디군락(Zoysia sinica community), 해홍나물군락(Suaeda maritima community), 갯질경군락(Limonium tetragonun community), 갈대군락(Phragmites communis community), 실망초군락(Erigeron bonariensis community)으로 구분되었다. 염생식물 군락의 생산량은 1,680∼2,170 g.d.w./㎡으로 갈대군락이 가장 높았고, 갯잔디 군락이 310∼500 g.d.w./㎡으로 가장 낮았다. The coastal vegetation was classified by the Braun-Blanquet's method and the biomass was investigated at the wetland of Hampyung-Man. The vegetation of the study area was classified with 11 coastal communities as follows: Salicornia herbacea community, Suaeda japonica community, Suaeda asparagoides community, Carex pumilalini community, Atriplex gmelini community, Aster tripolium community, Zoysia sinica community, Suaeda maritima community, Limonium tetragonun community, Phragmites communis community, Erigeron bonariensis community, Biomass was highest in Phragmites communis community (1,680∼2,170 g.d.w./㎡) and lowest in Zoysia sinica community (310∼500 g.d.w./㎡).

생쥐 중이와 상기도 점막의 섬모세포운동

정하원,오승하,유원석,이강수,모지훈,전상준,김인상,김종선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

등줄쥐(Apodemus Agrarius)의 Superoxide Dismutase 다형현상과 유전적 다양성에 관한 연구

이하규,이영선 가톨릭대학교 자연과학연구소 1995 자연과학논문집 Vol.16 No.-

본 실험은 등줄쥐에서 채취한 간조직의 Superoxide dismutase의 다형현상과 유전적 다양성을 알아보기 위해 starch gel을 이용하여 전기영동하였다. 그 결과, SOD-A와 SOD-B의 표현형이 단일 band로 monomorphic하게 관찰되었으며, 각 유전자 빈도는 SOD-A가 1.0000, SOD-B가 1.0000로 등줄쥐의 다형현상이 나타나지 않았다. In order to investigate polymorphism and genetic variation of superoxide dismutase in the liver of Apodemus agrarius, electrophoresis was employed using starch gel. As the result, SOD-A and SOD-B were monomorphic ; each band of SOD-A and SOD-B was mono band. Allele frequencies of superoxide dismutase were calculated as SOD-A=1.0000 and SOD-B=1.0000. Therefore, this experiment suggest that there be no polymorphism in Apodemus agrarius.

氣體一液體 크로마토그래피에 의한 C_1-C_5 탄화수소류의 同時分析과 그 適用

李善行,李華心,徐幀起 경북대학교 과학교육연구소 1989 科學敎育硏究誌 Vol.13 No.-

The 18 components of C_1-C_5 hydrocarbons were well separated on a single, packed column operated around 40℃ within 20 min. The chromatographic column is 25% sebaconitrile/chromosorb P-AW(10m x 0.3㎝, 60-80 mesh). The optimum flow rate was determined by making a simple Van Deemter plot of the number of theoretical plates VS. Iinear gas velocity. The most efficient flow-rate of N_2 carrier gas was at 35㎖/min, and the mumber of theoretical plates was 5,000-10,000. The linearity of calibration curves were checked ranging ppm to % concentration of CH_4 and C_3 H_8. Peak area was used for quantitating the C_1 hydrocarbon through C_5 hydrocarbons, and relative standard deviations of 10 measures were less than 2.1%.