정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경도관 동맥색전술을 이용한 비정상 자궁출혈의 치료

양승부,최교창,이상진,정영진,임한혁,한효상,황인철,조환성 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Objective : Our purpose of this study is to evaluate the effectiveness of the transcatheter arterial embolization for the management of abnormal uterine bleeding. Materials and Methods : 14 patients with massive or recurrent uterine bleeding underwent percutaneous transcatheter arterial embolization between February 2003 and September 2004. We reviewed 14 cases of uterine artery or internal iliac artery embolization using gelfoam or PVA particles. Results : Good management of uterine bleeding was achieved in 13 of 14(93%) cases. The cause of abnormal uterine bleeding was myoma(5 case), post D & E bleeding(3), acquired vascular malformation(3), pseudoaneurysm(1), adenomyosis(1), and endometrial hyperplasia(1). Conclusion : Transcatheter artery embolization is an effective and life-saving procedure in massive or recurrent uterine bleeding. Early diagnosis and prompt transcatheter arterial embolization is a useful mangement of uterine bleeding.

지리산 계류수의 천연수질에 관한 연구

양운진,김승현 경남대학교 환경문제연구소 2001 환경연구 Vol.24 No.-

Stream water quality is important because stream eventually flows into a river and lake and is relatively less contaminated by human activities than the corresponding receiving water bodies. Despite such importance, stream water quality has received less attention. This study was initiated to provide background information of water quality for Baekmudong and Jungsanri streams which leads to Jinyang lake. For this purpose, samples were collected from six different locations at four times. The samples were analyzed 10 Parameters of the drinking water standard, heavy metals (Zn, Pb, Fe, Cu, Ni, Cr) and NOM. This study found that the investigated stream consisted of intermediate runoff rather than surface runoff. It was supported by low saturation ratio of DO(70%) and high pH value. The DO saturation ratio showed high correlation with conductivity. Concentrations of sulfate and nitrate ions in the stream were lower than those in other streams, but chloride ion concentration was higher than that in other streams.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

축산분뇨중의 암모니아성 질소 제거

진양오,최성우,김성우,김익성,신남철,박승조 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

The purpose of thus study were to investigate the proper conditions of struvite formation in synthetic wastewater and then to apply these conditions to effluent of anaerobic digester of livestock wastewater The conditions of struvite formation had been studied by many researchers. But a little conditions were different among them. Especially, according to suspended solid variation in livestock wastewater was investigated by few researchers. In experiment of synthetic wastewater, the proper conditions of struvite formation were pH 105, l50rpm of mixing rate, 10 minutes of reaction time, and 20 minutes of precipitation time. At same time, the ammonia nitrogen removal rates were about 99.7%, 95.5%, and 96% of synthetic wastewater, raw wastewater, and effluent of anaerobic digester of livestock wastewater at molar ratio of 2(Mg):l(N)2(P) respectively. The larger factor of NH₄/SS constant was, the more effective the removal rate of ammonium nitrogen, SS was, but the less effective COD_(cr), and TOC was. By using XRD analysis, the most certain compound in precipitate of synthetic wastewater was struvite.

高等學生의 衣服에 대한 態度와 欲求 및 家庭의 價値指向性과의 관계 硏究 : 原州市 男·女 高等學生을 中心으로

梁承珍 한국의류학회 1986 한국의류학회지 Vol.10 No.1

The purposes of this study were: 1) to investigate four aspects of high school students' clothing attitudes as compared with their needs and family value orientations. 2) to ascertain whether differences existed between boys and girls on four aspects of clothing attitudes. Needs were measured through The Need Diagnosis Scale (Jaung-Ku Whang: 1965). Family value orientations were measured through The Home Environment Inventory(Won-Sik Jung: 1970). Four aspects of clothing attitudes were assessed by means of Lee; Kahng; Lee; Yang's questionnaires. The questionnaires were administered to a sample of 576 senior high school students(285 boys and 291 girls) in Won-Ju. The data was analyzed by correlations, multiple regression, t-test. The results were as follows: 1) Need for exhibition was positively related to clothing exhibition and fashion interest for both boys and girls, and clothing conformity for boys only. Need for exhibition was negatively related to clothing modesty for boys only. Need for affiliation was positively related to clothing exhibition for both boys and girls, fashion for girls only, and clothing conformity for boys only. 2) Social climber family value orientation was positively related to clothing conformity and clothing modesty for boys only. Materialistic family value orientation was positively related to clothing exhibition. Traditional family value orientation was positively related to clothing modesty for both boys and girls, and negatively related to clothing exhibition. 3) Girls scored significantly higher than boys on attitudes toward fashion and clothing modesty, whereas boys scored significantly higher than girls on attitudes toward clothing conformity.

자궁선근증의 방사선학적 진단 : 경질초음파의 유용성과 유용한 소견 Usefulness of Transvaginal Sonogram and Useful findings

양승부,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Object : To evaluate the usefulness of transvaginal sonogram for radiologic diagnosis of adenomysis uteri and useful trasvaginal sonogram findings. Materials and Methods : Thirty five patients who were performed both ulㅅrasonography and hysterectomy proved as adenomyosis were analysed by sonographic finding of myometrial echo texture and also included 4 cases of combined myoma. Results : Four pattern of myometrial echo texture were analyzed. The most common type is ill defined heterogenous echo(19 case) but sensitivity is low(69%). And then ill defined heterogenous echo with multiple small cystic echoes(3 case), multiple alterating striation echo pattern(11 case), and single cystic echo(2 case) were followed. Ill defined heterogenous echo with multiple small cysts and multiple alterating striation echo pattern were most reliable findings(100% of sensitivity). Conclusion : Most reliable myometrial echo texture of adenomyosis are ill defined heterogenous echo with combined multiple small cyst or multiple alterating striation echo pattern. Multiple alteraing striation echo is the suggested charateristic finding of adenomyosis.

Photolithography 공정을 이용한 resonator 제작에 관한 연구

梁辰承,朴亨俊 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - A series of stress-free silicon nitride resonator for nano-electromechanical system device and wireless telecommunication applications are microfabricated. The fundamental resonance frequency of doubly clamped beam can be calculated from the mechanical properties and the geometry of the resonator. Fundamental frequencies of the resonator made in this study are ranged 1.0 to 420㎒

한강변 응급센터에 내원한 익수환자에 대한 임상적 고찰

양진홍,박규남,최승필,김영민,김세경 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: There are approximately 2,400 drowning deaths reported every year in Korea, but there are few good reports about submerged patients visiting the emergency room, so this study was designed to investigate the clinical characteristics and outcomes of submerged patients treated at an emergency medical center near the Han river. Methods: A retrospective review of 123 cases of submerged patients admitted to our emergency medical center over a 5 year period from 1996 to 2000 was conducted. Results: Among the 123 submerged patients, there were 66 males and 57 females, and their mean age was 33.18. The common cause of submersions was a suicide attempt, followed by lack of attention, unknown etiology, and water sports such as swimming. Most of the patients were transported to ER by 119 ambulance. In-hospital CPR was performed on 27(22%) cases. At initial ECG rhythm of these cases, asystole was noted if 25 patients; VF and pulseless electrical activity, respectively, were noted in two others. Prehospital CPR had been performed on all in-hospital CPR cases except 2. Prolonged ROSC after succesful CPR was noted in 13 cases, The mean duration of CPR was 26 minutes. Five patients survived after CPR. Their neurologic outcomes were assessed on CPC(cerebral performance category). Three patients were categorized in CPC1, the other two patients were categorized in CPC3 and CPC4. Conclusion: Submerged patient's visits to emergency medical center near the Han river were most frequent in summer for suicide purposes. Drowned patients were more hypothermic than other cardiac arrest cases, and resulted in better outcome even with prolonged arrest time, if they were given appropriate prehospital CPR and aggreissive in-hospital resuscitation.

의복 디자인 감각 선호와 라이프 스타일의 관련성에 관한 고찰

양승진 淸州大學校 1992 淸藝論叢 Vol.6 No.-

This paper has discussed and summarized the relationship between the image preferences of clothesdesings and the styles of life on the basis of previous studies. The studies done in Korea regarding to the relationship between the image of clothes-designs(or the image of clothes-brand) and the styles of life were as followings ; 1)The revolutionary and fashion pursuing group, actively idea leading type, preferred progressive, modernized, and manish design-feelings. 2)The status symbols recognizing group, brand concious and formal value seeking type, preferred the elegant design-feelings. 3)The improvement pursuing group in practical life, economical and practical type, preferred the casual, manly design-feelings. 4)The group inclined to feminity preferred the womanly elegance, charming images, and full dresses. 5)The group inclined to masculinity preferred the casual, sporty design-feelings. 6)The conservative group preferred the formal design-feelings.