Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

고정희 시의 카니발적 상상력과 다성적 발화의 양식

김승희 ( Seung Hee Kim ) 국제비교한국학회 2011 비교한국학 Comparative Korean Studies Vol.19 No.3

The aim of this paper is to define the poet Goh Jung Hee`s Yeoseonghaebang chulsapyo (Memorial Concerning women`s liberation, 1990) as a text in polyphonic discourse manifesting a carnivalesque imagination, analyzing the carnivalesque, creative elements. In her Yeoseonghaebang Chulsapyo, Goh Jung Hee dreams of a space for women alone, a Utopia free of gender discrimination, and this text displays a carnivalesque quality through polyphony, eversion of existing ideologies, relative merriment, etc. According to Mikhail Bakhtin, the world of carnival is a world ruled by freedom and equality, a space overturning the hierachy of dichotomous oppositions such as male / female, sacred / secular, authority / people, reason / madness, noble / base, etc that postmodernism has brought to light, where everything is equal and pleasant, and absolute things become relative. So far as space, time, textual style, rhetorical form are concerned, Yeoseonghaebang Chulsapyo thus conceived strongly reveals carnivalesque aspects. In the first place, the poet summons four women who radically challenged the sexual repression the women of the middle Joseon Era must have experienced - Hwang Jini, Yi Ok-bong, Shin Saimdang, Heo Nanseolheon, into the space of the 1980s, when people`s liberation and feminism emerged as the spirit of the times, and develops a portrayal of a dreamed-off women`s liberation. In Part One, Hwang Jini and Yi Ok-Bong exchange correspondance; in Part Two, we find Shin Saimdang writing letters to Heo Nanseolheon, and Nanseolheon writing letters to the daughters of modern Korea. In a space where the boundaries between this world and that grow hazy, those between life and death are blurred, each individual woman deconstructs her symbolic value or her private myth using the terms of modern feminism while criticizing patriarchy. Romantic facts are reinterpreted, and their identities, venerated in Confucian society, are downgraded to mean quite the opposite. Second, time`s carnivalesque qualities emerge. The feudal period and the modern age are mixed, the age of Confucianism and the age of feminism are mixed. At the same time, there is a blending of discourses, of heterogeneous contexts, so that a carnivalesque mixture results. For example, the mythical symbol of good mother, chaste wife, Shin Saimdang belittles the patriarchal system as a culture of proxenetism. A carnivalesque blend of discourses arises, mocking other discourses, a cheerful relativity subverts absolute values by satire and humor. Third, the style`s variety and hybridity manifest a carnivalesque character. Yeoseonghaebang Chulsapyo, which includes elements of epistolary style, sijo, other classical forms, parody, shamanistic ceremony, protest demonstration, being both a work of vulgarization and a popular spectacle, is less a unified lyrical poem than a hybrid text combining multiple voices. The work`s carnivalesque polyphony or dialogic qualities are produced by collisions and blendings of differing speaking voices, their contexts and codes, and this paper attempts to analyze those aspects. Within the carnivalesque space and time of the first two parts of Yeoseonghaebang Chulsapyo, the four women employ heroic tones to criticize the Confucian society, the patriarchy and the oppression of women in the Joseon era, using the terms of modern feminism, and go on to urge modern women to ensure that their dream of women`s liberation becomes a reality. At the end of Part 2, the person leading the way declaring the war for women`s liberation is Heo Nanseolheon, who lived the most tragic life of them all and suffered most under the patriarchal system. In Parts 3 and 4, the female poetic voice, receiving the spirit of women`s liberation from Heo Nanseolheon and advancing toward reality, attempts to analyze realistically all that prevents the liberation of women today. Part 4 is a memorializing poem, a poem with a purpose, and mostly declaims loudly all that has to be done to liberate women, so that in parts 3 and 4 the carnivalesque elements of polyphony and dialogue are weaker, while the poetic narrator`s voice grows stronger in conviction in a solitary monologue. It may be wondered if the way the carnivalesque space produced by the Joseon-era women of parts 1 and 2 is abolished might not be the result of a realization by the solitary poetic voice advancing bearing the Memorial that here and now, in real space, the realization of women`s liberation is a difficult project. This work by Goh Jung Hee, expressing the dream of women`s liberation in a carnivalesque polyphony, should be seen as one of the outstanding feminist texts of Korea.

斗山그룹의 企業文化

Seung Hee Koh(高承禧) 한국경영사학회 2002 經營史學 Vol.28 No.-

This paper has the purpose that is to detect the basic corporate culture of Dosanism. It is derived from the establishing spirit of the founder, Seung-Jik Park of Doosan Group, and the innovative entrepreneurship of his son, Doo-Byung Park. Doosan Group was founded by Seung-Jik Park in 1896, and has been brought up one of top business conglomerates and oldest outstanding enterprises in Korea. The founder’s establishing creeds is composed of the peace and amity among the people, responsibility, honesty, diligence and economy. And the managerial thoughts of 2nd founder, Doo-Byung Park, is as follows: (1) respect for the human value, (2) reliability, (3) diligence and economy, (4) craftmanship, (5) social responsibility, (6) rationalism and (7) patriotic spirit, etc. Doosan-spirit or Doosan-manship as common values of Doosan Group is involved in their philosophies. So, the basic corporate culture of Doosanism is based on their entrepreneurships and management thoughts. However, 3 top executives, Yong-Gon Park, Yong-Oh Park and Yong-Sung Park under the tricar business system of the group have created and developed the new management ideologies for new vision of 21st century. It is as follows: (1) customers, (2) quality, (3) innovation and (4) human resources. The new future-oriented corporate culture of Doosanism is derived from this creeds and based on the excellence-driven growth as new start vision. These new cultural values of Doosanism is composed of (1) the Harmonization of human-oriented management, (2) the customer-oriented commensalism, (3) the principles of ethical management, (4) the challenging doctrine of pioneer spirit and can-doism, (5) the result-principles of excellence-driven growth for long-term vision, (6) the management principles that corporations must contribute to the well being of the nation and society as patriotism. Therefore, we can find that the basic culture of Doosanism is deeply rooted in striving for excellence-driven growth and development through challenge and exploration of potential by business creeds of the group.

`예륜(藝倫)`의 역사적 추이와 제도적 임계

이승희 ( Lee Seung Hee ) 민족문학사학회 2017 민족문학사연구 Vol.63 No.-

이 연구는 자율심의기구로 발족된 `예륜`이 국가권력과 문화주체의 역학관계의 변화에 따라 동태적으로 구성되어간 과정을 따라가면서, 그 제도적 임계를 통해 검열체제의 변동 징후를 살피고자 하였다. `예륜`의 창립은 `자율심의`를 통해 국가권력의 사회통제력으로부터 자율성의 영역을 확보하기 위한 문화세력의 기대와 그 궤를 같이 하지만, 사실 그 막후에는 `예총`을 내세워 그러한 기대를 제도화하도록 종용한 공보부가 있었다. 초기 3년여 동안 조직적 불비와 미숙함, 역능의 한계로 자율심의기구의 민낯을 드러냈지만, 이내 공보당국은 삼선개헌정국을 경과하면서 `예륜`의 사용법을 달리하기 시작했다. 대중문화의 비중이 점차로 증대되고 있는 와중에, 박정희체제를 위협하는 대내외 정세가 검열제도의 신속한 정비를 요구하고 있었기 때문이다. `예륜`의 조직개편과 권역확대는 바로 그러한 필요에 의해 취해진 것이었고, 이는 미디어의 대중적 파급력 여하를 관건으로 놓은 박정희정부의 문화통제에 대한 경제성 원리가 작용한 결과였다. 박정희의 종신집권을 위한 문화통제의 효율성 제고, 이것이 바로 `예륜`이 수행해야 할 몫이었다. 검열강화에 따른 피검열자에 대한 압력지수는 계속해서 높아져갔다. 이런 역사적 추이는 분명 `예륜`이 국가에 의해 장악되어간 과정이라 할 만한데, 역설적인 것은 국가권력의 강박적 검열이 강화될수록 여 기에 비/ 반동일화하는 새로운 피검열자가 구성되고 있었다는 점이다. 그 징후의 확실한 증거는 `예륜` 초창기부터 충실한 심의대상이었고 그저 고요하기만 했던 연극분야에서 심의 결과를 납득하지 못한 피검열자들의 반응이 공개되기 시작했다는 사실일 것이다. 이런 점에서 `예륜`의 10년은 뜻하지 않게 그러나 필연적으로 검열전선이 가시화되는 과정이기도 했다. 이를 정부가 감지했던 것일까. 비단 그렇지 않았을지라도, `예륜`은 거기서 끝나야 했다. 긴급조치 9호가 발동된 `비상시`의 검열권은 국가만이 가지고 있어야 하는 것이기 때문이다. 이렇게 보면 검열전선을 가시화한 것은 다름 아닌 박정희정부였던 셈이다. This study investigated the changes in the censorship system through the institutional criticality of the `Ye-ryun`, which was established as an self-censorship organization, following the process of dynamically changing according to the changes in the dynamics of state power and culture subject. The founding of `Ye-ryun` is coextensive with the expectation of the cultural power to secure the autonomy area to the social control power of the state power through `self-censorship`, but in fact, there was a Public Affairs Department at behind the scene, who operated `Ye-chong` to institutionalize such expectations. In the first three years, this self-censorship organization were exposed to organizational defects, inexperience, and limitations of their capabilities. However, the public authorities began to change the usage of `Ye-ryun` soon thereafter passing 1969. This period was noisy to the constitutional amendment issue for election for the third term. As the proportion of popular culture is gradually increasing, the internal and external situation that threatens the Park Chung Hee system demanded the quick maintenance of the censorship system. The organizational reorganization and enlargement of `Ye-ryun` were taken by such necessity, and this was the result of the economic principle of the cultural control of the Park government, which was the key to the media`s power to spread. It was the duty of `Ye-ryun` to enhance the efficiency of cultural control for to get tenurial seizure of power of Park Chung Hee. The pressure index on the censorship-object has continued to increase. This historical trend is obviously a process that has been dominated by the state, and the paradox is that as the obsessive censorship of the state power is strengthened, there has been constructed a new censorship-object who has non/anti-identification to censorship standard. The definitive proof of the indications was that in the field of the drama it had been a faithful censorship-object since the beginning of `Ye-ryun` and that was just calming, that the reactions of censorship-objects who did not understand the censorship results began to be revealed. In this sense, the decade of `Ye-ryun` was an unintended but inevitable process of visualizing the censorship front. Did the government detect this? Even if it was not so, the `Ye-ryun` had to end there. This is because only the state should have the right of censorship on emergency when the ninth Emergency Measure was triggered. In this way, it was nothing but the Park Chung Hee government that visualized the censorship front.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

냉기치료후 슬관절강내의 온도변화

백승석,최기섭,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

己亥通信使에 대한 各藩의 御馳走役

한승희(Han, Seung?Hee) 한일관계사학회 2006 한일관계사연구 Vol.25 No.-

만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

Ribosomal DNA의 ITS영역 염기서열 분석에 의한 기주특이적 독소 생성 Alternaria spp.의 계통분류학적 유연관계

高昇柱,洪承範,姜熙玩,劉勝憲,柳震彰 충남대학교 생물공학연구소 1998 생물공학연구지 Vol.6 No.-

기주특이적 독소 생성 Alternaria spp.와 비병원성 A. alternata의 계통분류학적 유연관계를 규명하기 위하여 기주특이적 독소 생성 Alternaria 6균, 비병원성인 A. alternata 그리고 비교균으로서 소형포자를 형성하는 A. brassicicola, 대형포자를 형성하는 A. solani의 ribosmal DNA의 5.8S를 포함한 ITS영역의 염기 서열을 분석하였던 바 다음과 같은 결과를 얻었다. 1. Alternaria spp.의 rDNA ITS영역의 염기서열 크기는 548∼562bp였으며 5.8S rDNA에서는 비교종간에 서로 일치하였고 ITS I에서는 종간 뚜렷한 차이를 보였다. 2. 기주특이적 독소 생성 Alternaria spp.의 rDNA의 ITS영역의 염기서열은 비병원성인 A. alternata의 염기서열과는 서로 일치하였으나 A. brassicicola와는 3%, A. solani와는 7%의 염기서열 차를 보였다. 3. 기주특이적 독소 생성 Alternaria spp.는 비병원성 A. alternata와 진화적으로 매우 가까운 유연관계를 나타내었다. The regions of internal transcribed spacer(ITS) including 5.8S ribosomal DNA(rDXA) from six host-specific toxin(HST) producing Alternaria spp. nonpathogenic A. alternata. A. solani and A. brassicicola were sequenced to assess their relationship in taxonomy. There was no difference in the sequences of ITS including 5.8S rDNA among the HST-producing Alternaria spp. and nonpathogenic A. alternata. However, the sequences of HST-producing Alternaria spp. were different from those of A. solani and A. brassicicola by about 7% and 3%, respectively. These results suggest that HST-producing Alternaria spp. are evolutionarily very close to non pathogenic A. alternata although they have host-specific pathogenecity.

심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.