정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

보호관찰 대상자를 위한 부모교육의 활성화 방안

정일환,최경희 효성여자대학교 법정연구소 1997 법정연구 Vol.3 No.-

Recently the number of juvenile crimes is continuously increasing and the nature of the crimes is also becoming more and more untolerably atrocious. Confronting severe violences in and out of the school, government is pouring a great of energies and resources in nation-wide scale on securing various strategies for preventing, guiding, and protecting youngsters from committing those unrestrictedly violent crimes. One of the protective and educative tactics is that of parents education. There have been a number of researches on the professional crime preventing officiers'. However, there are rare studies concerning unofficial helpers, including parents, relatives, and friends. Especially there is almost none in research on parents, with whom youngsters must have an intimate relationship. Thus, in this study, the researcher tried to investigate theoretical bases and practical problems of the present parents education for the probationary juvenile offenders. the result is as following. First, it needs to be emphasized that a great care must be put on the juvenile offenders and there must be intimate cooperative system among related agencies for helping them. Second, there must be some developing and effective implementation of professional programs for parents education. Third, the family counseling centers inside local probation facilities must be under systematic operation, recruiting professional counselors. Fourth, there must be much more closer cooperation between crime preventing officiers and parents of the probationary. Finally it is very urgent that there should be a sufficient amount of budget for caring and parents education of juvenile offenders of juvenile offenders of juvenile offenders under probation.

한국민족주의 연구 : 전개 과정,성격 및 과제를 중심으로

鄭京煥 동의대학교 인문과학연구소 1997 인간과 문화 연구 Vol.2 No.-

자동차용 브레이크 마찰재에서의 환원분철의 마찰특성에 관한 연구

정진오,이경환,김옥삼,김봉수 순천대학교 2000 순천대학교 자연과학논문집 Vol.19 No.1

In most automotive brakes, the friction material is used to convert the kinetic energy into heat. The friction material is a complex composite consisting of a resin, reinforcing fibers, lubricants and filler materials. In an attempt to enhance the friction performance of the friction material, a trial was done to examine the substitution of filler material by the reduction iron powder. In this study, two types of reduction powder M1 and M3 was prepared by the reduction process developed by Hanta M&B Inc. M1 and M3 which has reduction ratio of 1.5 and 92% respectively was used in place of BaSO_4, which was conventionally used as a filler material. The amount of M1 and M3 was varied as 10, 20, 30%, while the other component remains the same except the replaced BaSO_4. For those specimens with different amount of reduction iron powder, friction performance tests such as friction coefficient, rotor compatibility were conducted by using brake dynamometer. The bonding strength and hardness tend to decrease with use of M1 and M3, but specific weight decreased with increase of M1 and M3. The friction coefficient increased with use of M1 up to 10%, but decreased for use of M1 more than 20%. However the use of M3 resulted in a decrease of friction coefficient all the way. The surface roughness decreased with the use of M1 and M3, except for a case of excessive use of M1 of 30%. The rotor surface roughness did not show any correspondence with hardness of friction material in this study.

치아 마모 환자에서 수직고경 증가를 동반하여 단일구조 지르코니아 보철물로 완전구강회복을 시행한 증례

오경철,정문규,김지환,심준성 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

과도한 치아 마모는 교합면에 손상을 야기하고, 치수 병변, 교합 부조화, 기능장애, 심미적 문제 등을 야기할 수 있다. 과도한 치아 마모를 갖고 있는 환자들을 치료하고자 할 때 수직교합고경(vertical dimension of occlusion, VDO)의 상실 여부와 수복을 위한 악간 공간의 적절성 여부에 기반하여 분류를 할 필요가 있다. 본 증례의 환자는 다수 치아들의 마모를 지닌 50세의 남성으로, 과도한 치아 마모가 있지만 수직교합고경의 상실은 없으며 수복을 위한 악간 공간이 부족하였다. 이러한 경우 수직교합고경을 증가시켜 치료를 진행하는 것을 고려할 수 있다. 수직교합고경의 증가를 필요한 범위 내에서 최소로 줄이고, 증가된 수직교합고경 상에서 안정화 기간을 거친 뒤 안정된 교합 접촉을 제공할 수 있다면, 수직고경 증가를 동반한 치료법은 안정성을 가질 수 있다. 본 남성 환자를 치료하기 위해 수직고경의 증가를 동반하여 전치부와 구치부에서 단일 구조 지르코니아를 이용한 고정성 보철물로 수복을 하였다. 일련의 치료과정을 통하여 기능적인 면과 심미적인 면에서 만족스러운 결과를 얻었기에 보고하는 바이다. Excessive occlusal wear results in unacceptable damage to the occluding surfaces, and can cause pulpal injury, occlusal disharmony, impaired function, and aesthetic deformity. Patients with severely worn dentition need to be classified as several categories relative to the vertical dimension of occlusion (VDO) and the interocclusal distance for the prosthetic space. When treating patients classified as those who have excessive wear without loss of occlusal vertical dimension but with limited space, we could consider treating them at an increased vertical dimension of occlusion. Treatments at an increased vertical dimension of occlusion may provide stability, given that the amount of its increase was minimal, and a perfected occlusion was achieved after enough stabilization period. A 50-year-old male visited the department of Prosthodontics in Yonsei University Dental Hospital with the chief complaint of worn teeth on lower anterior area. Reconstruction at an increased vertical dimension of occlusion was planned. After the compatibility of the new vertical dimension of occlusion had been confirmed under interim fixed restorations, definitive fixed restorations composed of full-contour monolithic zirconia prostheses were placed. This case presents that a satisfactory clinical result was achieved by restoring the worn dentition at an increased vertical dimension of occlusion with an improvement in esthetics and function.

解放直後 尤史金奎植의 政治活動에 관한 硏究 : 南朝鮮過渡立法議院을 中心으로

정경환 부산정치학회 1994 부산정치학회보 Vol.1994 No.4

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

혈액정상치에 대한 고찰

정경환,차덕원,박재윤 順天鄕大學校 1977 의대논문집 Vol.2 No.-

We have determined the mormal ranges using the probability graph method to the laboratory data. From within ranges there were found that hematolgical normal values and ranges calculated from it were applied to the determination of those, except red blood cells

백범김구의 주체적 통일국가론

정경환 동의대학교 2004 인간과 문화 연구 Vol.- No.9

경쟁력있는 지역인재 육성방안 : 학교교육과 사회교육을 중심으로

鄭日煥,楊慶守 대구효성가톨릭대학교 1996 연구논문집 Vol.52 No.1

The purpose of the article is to suggest some policy directions and tasks of fostering competitive manpower for the local development. In order to accomplish this objective, current status and problems of local manpower policies were investigated in terms of educational programs and administrative systems including career education. The society is coping with glabalization and localization at the same time, therefore it is important to establish a variety of system meeting local needs for economic development. In general, industrial and economic development may be effective through manpower supply on time and on place. Competitive manpower, which contributes to local economic development and finally to enhance the quality of life of local residents, can be fostered and supplied by formal schooling with rational local educational administration system and its efficient implementation. This article suggested following policy tasks and alternatives for fostering competitive manpower. First, it should be established sound educational values of parents to their children and rational employment system by industrial employers according to employee's ability and credentials. Second, local educational planning should be based on not a demand-oriented but a supply-oriented. Third, it is necessary to renovate the contents and methods of school education in order to foster creative manpower. Fourth, each local college and university should emphasize and develop its own program considering personnel and material conditions. Fifth, teachers who are working at primary and secondary school should be able and with pride of their teaching to deliver educating high quality of education. Sixth, activation of life-long education and efficient industrial manpower system are needed. Seventh, it is necessary to establish rational local educational governance system to support excellent educational programs. Finally, in order to implement above-mentioned policy tasks efficiently, investment to local education should be increased.