Monocrotaline투여 백서 폐동맥고혈압에서 폐혈관내피세포와 폐신경내분비세포의 변화에 대한 형태학적 연구

양우익,조상호,최인준,이유복 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.6

조혈림프조직의 종양성 질환 - 새로운 세계보건기구 분류법 -

양우익 대한병리학회 2002 Journal of Pathology and Translational Medicine Vol.36 No.3

Encouraged by the success of the Revised European American Classification of Lymphoid Neoplasms (REAL) which was published in 1994 by the International Lymphoma Study Group (ILSG), the European Association of Pathologists and the Society for Hematopathology have started a collaborative classification project in 1995 under the auspices of World Health Organization (WHO). The two collaborators employed the same consensus building process used by ILSG for the REAL to the classification of myeloid, histiocytic/dendritic, and mast cell neoplasms and listed real biologic entities defined by morphologic, immunophenotypic, cytogenetic, and clinical findings. In contrast to the REAL, Clinical Advisory Committee composed of expert hematologists and oncologists evaluated the clinical relevance of the classification scheme proposed by the pathologists before the publication of new WHO classification of hematologic malignancies. While the classification of lymphoid neoplasms contained minor changes compared with the REAL, there were major changes in the classification system of myeloid neoplasms compared with the previously used French-American-British (FAB) classification. The new WHO classification of hematologic malignancies, published last year, is a product of the first true worldwide consensus among leading pathologists and clinicians alike, and it overcomes the drawbacks of old fashioned classification schemes; therefore, we can expect progress in the understanding and treatment of hematologic malignancies.

전종격동의 융모상피암 부검 1예

양우익,김한겸 中央醫學社 1987 中央醫學 Vol.52 No.10

A 21-year-old male, complaining of dyspnea, expired. An autopsy was performed to clarify, the cause of death. A huge tan tumor mass, measuring 13 x I1 x 7cm, was present at the anterior mediastinum in close anatomic relationship with the thymus. Large vessels around the heart were compressed by the tumor mass and hemopericardium by extensive hemorrhagic necrosis of the tumor was noted. The tumor was diagnosed as choriocarcinoma by histopathologic and immunoperoxidase method using HCG. The cause of death was right heart failure due to compression of large vessels and hemopericardium.

폐동맥종양색전증에 의한 돌연사 부검 1예

양우익,이기범 中央醫學社 1987 中央醫學 Vol.52 No.9

This study is intended to recognize mental and physical health status of Nursing Junior Collegians. The sample data for the study have been collected applying C.M.I. from 462 collegians selected randomly at 4 nursing junior colleges in Taegu city and Kyungbuk province over a period of three months from September to November 1986. The data was treated by a computer (SPSS) using Mean, Standard Deviation, F Ratio, Chi-square test and Pearson's Correlation. The summary of the results in the study are as follows: 1) The relationship between general mental-physical health of Nursing students and places which they have grown up, showed to be not significant. 2) The relationship between mental(p < 0.01), physical (p < 0.05), general mental- physical health (p < 0.01) and living expense satisfaction showed to be significant. 3) In the relations to pride as a nurse, musculoskeletal system (p < 0.01), Fatigability(p < 0.05) Miscellaneous disease (p < 0.01), Inadequacy (p < 0.05), Depression (p < 0.001), Sensitivity(p < 0.01), Anger (p < 0.01), and Tension (p < 0.05) showed to be significant. 4) In the relation to anxiety on registered Nurses Examinication, The frequency of Respiratory (p < 0.05), Cardiovascular (p < 0.001), Digestive (p < 0.05), Musculoskeletal (p < 0.05), Nervous system(p < 0.05) and frequency illness (p < 0.05), Inadequacy (p < 0.05), Depression (p < 0.01), Anxiety (p < 0.05), Sensitivity (p < 0.05), Anger (p < 0.05) and Tension (p < 0.001) showed to be significant.

간외담도에서 발생한 악성혼합종양 1예

양우익,문상훈,최인준 대한병리학회 1984 Journal of Pathology and Translational Medicine Vol.18 No.4

국균증의 임상적 고찰

고윤웅,한지숙,오제덕,이선주,이광재,양우익 대한감염학회 1991 감염 Vol.23 No.2

The Aspergilli are among the most common and ubiquitous saprophytic fungi in the environment. Aspergillosis is divided into several cartegories, among which the invasive aspergillsois (IA) causes significant morbidity and mortality in immunocompromized host especially from pulmonary infection. The clinical aspect off 40 cases of aspergillsois were studied. who were admitted Severance Hospital between January, 1985 and June, 1990. The following results were observed. 1) Among these 40 cases, 1 was diagnosed as allergic aspergillsois, 25 as aspergilloma (pulmonary 22, paranasal sinus 3), 11 as IA (pulmonary 5, brain 3, sinus with contiguous invasion 3) and 3 as pleural aspergillsois. 2) Among 22 cases of pulmonary aspergilloma, the most frequently associated underlying diseases were pulmonary tuberculosis in 17 and others were COPD in 3, bronchiectasis in 2 and bronchial asthma in 1. Among 5 cases of invasive pulmonary aspergillsois (IPA), acute lymphocytic leukemia was the underlying disease in 3, acute myelogenous leukemia in 1 and myelodysplastic syndrome in 1. 3) The specific diagnosis of aspergilloma was made by surgical biopsy in 15, transbronchial lung biopsy in 4 and compatible finding of chest X-ray with positive antibody against Aspergillus antigen in 6. Among 3 cases of pleural aspergillsois, 2 were diagnosed by pleural biopsy and 1 by culture of pleural fluid. 4) In cases of IA, the specific diagnosis was made by histopathologic findings in 9. Among 5 cases of IPA, 2 were diagnosed by needle aspiration biopsy, 2 by clinical diagnostic criteria and 1 by open lung biopsy. 5) The severe granulocytopenia (<500/㎣) before pulmonary infiltrates was noted in all cases of IPA. 6) All the 22 cases of pulmonary aspergilloma were improved with surgical resection in 13 and 9 with conservative treatment. In contrast, 3 of 5 IPA were dead inspite of amphotericin B treatment and 2 were recovered with improvement of underlying disease or granulocytopenia. Six cases of invasive sinus or brain aspergillosis were improved with surgical removal and amphotericin B treatment, and 2 pleural aspergillosis with surgical drainage. With the above results, several types of aspergillosis were confirmed and the prognosis seemed to depend on underlying disease. Because of high fatality of IPA, it is more stressed that the pro-phylactic measures, efforts of discernible diagnostic approaches and as early empirical antifungal treatment as possible might give rise to not only the therapeutic success of IPA but also the improvement in prognosis of underlying diseases.

악성 림프종의 진단

楊宇翼 대한의학협회 1995 대한의학협회지 Vol.38 No.11

전종격동의 융모상피암 부검 1예

김한겸,양우익 大韓法醫學會 1987 대한법의학회지 Vol.11 No.2

A 21-year-old male, complaining of dyspnea, expired. An autopsy was performed to clarify the cause of death. A huge tan tumor mass, measuring 13×11×7cm, was present at the anterior mediastinum in close anatomic relationship with the thymus. Large vessels around the heart were compressed by the tumor mass and hemopericardium by extensive hemorrhagic necrosis of the tumor was noted. The tumor was diagnosed as choriocarcinoma by histopathologic and immunoperoxidase method using HCG. The cause of death was right heart failure due to compression of large vessels and hemopericardium.

증례 : 혈액종양 ; AML1-ETO 양성인 양표현형 급성 백혈병의 1예

서주희 ( Ju Hee Seo ),이혜원 ( Hye Won Lee ),임주은 ( Ju Eun Lim ),정주원 ( Joo Won Chung ),최종락 ( Jong Rak Choi ),양우익 ( Woo Ick Yang ),민유홍 ( Yoo Hong Min ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5

BAL은 일반적으로 기타 급성 백혈병보다 예후가 나쁘다고 알려져 있으나, 그 치료방침이 아직 확립되어 있지 않다. AML1-ETO 유전자 재배열은 BAL에서도 좋은 예후인자 중 하나로 제시된 적이 있으며 본 증례에서도 1차례의 관해 유도요법 후 완전관해를 보였고, t(8:21) 즉, AML1-ETO 정량검사상 전사 정도가 현저히 감소함을 경험하였다. 특히, AML에 준한 치료만으로 성공적 관해가 유도되었으며, 이는 BAL에 있어서도 AML1-ETO 종양단백이 병태생리에 주 역할을 할 것임을 짐작할 수 있다. AML에서와 마찬가지로 AML1-ETO 유전자 재배열은 향후 BAL 환자의 치료 효과와 예후를 알 수 있는 지표로 사용될 수 있을 것이다. Biphenotypic acute leukemia (BAL) is a subtype of acute leukemia that expresses two different immunophenotypic lineages, most commonly myeloid and either B- or T-lymphoid lineages. This entity has been defined by a scoring system proposed by the European Group for the Immunological Characterization of Leukemias (EGIL). The prognosis of BAL is regarded as being worse than either acute lymphoid or myeloid leukemia that does not show lineage ambiguity. However, a treatment strategy for BAL has not yet been established. We experienced a case of BAL with the t(8;21) translocation, a favorable cytogenetic rearrangement in acute myeloid leukemia (AML). The patient was successfully treated with cytarabine and anthracycline for induction and consolidation. The quantitative value of the AML1-ETO gene decreased after achieving complete hematologic remission. Thus, the AML1-ETO gene rearrangement in BAL may be associated with an acceptable response to the treatment strategy for AML. (Korean J Med 76:617-621, 2009)

폐동맥종양색전증에 의한 돌연사 부검 1예

이기범,양우익 大韓法醫學會 1987 대한법의학회지 Vol.11 No.2

A 23-year old male patient expired suddenly. He was managed at the hospital under the impression of lumbar intervertebral disc herniation. An autopsy was performed and the cause of death was pulmonary tumor embolism, which occluded the main pulmonary artery completely. The primary tumor was located at the left psoas muscle and it was alveolar rhabdomyosarcoma. The primary tumor infiltrated to the iliac vein and sciatic nerve and patient's symptom was due to nerve compression by the tumor.