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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
A Novel Homozygous LIPA Mutation in a Korean Child with Lysosomal Acid Lipase Deficiency
Kim, Kwang Yeon,Kim, Ju Whi,Lee, Kyung Jae,Park, Eunhyang,Kang, Gyeong Hoon,Choi, Young Hun,Kim, Woo Sun,Ko, Jung Min,Moon, Jin Soo,Ko, Jae Sung The Korean Society of Pediatric Gastroenterology 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.4
Patients with lysosomal acid lipase (LAL) deficiency and glycogen storage disease (GSD) demonstrated hepatomegaly and dyslipidemia. In our case, a 6-year-old boy presented with hepatosplenomegaly. At 3 years of age, GSD had been diagnosed by liver biopsy at another hospital. He showed elevated serum liver enzymes and dyslipidemia. Liver biopsy revealed diffuse microvesicular fatty changes in hepatocytes, septal fibrosis and foamy macrophages. Ultrastructural examination demonstrated numerous lysosomes that contained lipid material and intracytoplasmic cholesterol clefts. A dried blood spot test revealed markedly decreased activity of LAL. LIPA gene sequencing identified the presence of a novel homozygous mutation (p.Thr177Ile). The patient's elevated liver enzymes and dyslipidemia improved with enzyme replacement therapy. This is the first report of a Korean child with LAL deficiency, and our findings suggest that this condition should be considered in the differential diagnosis of children with hepatosplenomegaly and dyslipidemia.
조정희,강신복,김혜수,김영림,오미현,강인호,박성수,심영훈,지선경,함일권,하광원,김영중,박만기 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
후박』창출 및 백출은 건위제로서 널리 사용되는생약이고,대한악전 7개정에서 모두 기원식물과 이화학적인 실험항목이 겔정됨으로서 윤통생딱의 품질확보가요청되고 있다. 이에 본 연구에서는각각 생약의 국내유통품 30여종, 일본약국방품, 중국유통품을 확보하여 꽉인, 함량 및 순도시험을 실시하여 이들 생약을 규격화하고자 하였다. 후박의 함량시험결과 magnelol의 경우 대부분 약전기준인 0-8% 미만이었으며,조선후박인 machilus thunbergii가 아직도 유통됨으로써 약효와 품질에 문제점을 가지고 있었다. 백출의 확인 및 순도시험에서 국내유통품 30종 묘두 적합하였고, 창출의 확인 및 순도시험을 실시한 결과 국내 창출유통품 32종중 11종롸 일본약전품 2종만 창출로 판명되었다. 후박을 함유하는 엑스레제의 경우 처방에 따라 magnolol은 2.t~23.3%, honokiol은 2.6~26-8%코 나타났으턱, 백출함유제제에서는 atractylenolide 111는 46.S~76.3%, atractylon은 12.2~17.2%를 창출함유제제에서는 atractylen III만이 5.7~20.1%를 나타내었다. 춘박, 창출 및 백출의 운통품에 대해서 중금속과 잔류농약둥의 유해물질을 분석한 결고 일부에 잔류농약이 검출되었지만 현 기준께는 적합하였다. 대부분의 생약이 거의 수입되어 국내 유통되므로안전성 및 품질관리 차원에서 꾸준한 연구검토가 이루어져야될 것으로 사료된다. This study was carried out for the standardization and quality control of Magnoliae Cortex, Atractylodes Rhizoma and Atractylodes Rhizoma White. The contents of magnolol in Magnoliae Cortex are not more than 0.,8% criterion established in KP. Machilus thunbergci is still circulated as Magnoliae Cortex instead of Magnolia species. So there has been some problems in efficiency and quality control. The contents of atractylenolide ]f were 0.04―0.45% for Atractylodes Rhizoma White and they were all suitable for identification and purity test. In the case of Atractylodes Rhizoma, only 11 samples were suitable for identification and purity test in 32 species circulated in Korea. This method was used in determination of each component in crude drug preparations containing Magnoliae Cortex, Atractylodes Rhizoma and Atractylodes Rhizoma White. The availability of magnolol in the decoction process was 2.1―23.3%, that of honokiol was 2.6―26.8%. The availability of atractylenolide If in the decoction process was 46.5―76.3% for Atractylodes Rhizoma White and 5.7―20.0% for Atractylodes Rhizoma, that of atractylon was 12.217.2% for Atractylodes Rhizoma White. We also analysed pesticide residue and heavy metal for the circulated crude drug and found that all of them were safe.
배성훈(Seoung Hun Bae),임정선(Jung Sun Lim),신광민(Kwang Min Shin),윤진선(Jin Seon Yoon),강상규(Sang Kyu Kang),이솔희(Sol Hee Lee),김민관(Min Kwan Kim),이정우(Jung Woo Lee),김준현(Jun Hyun Kim),신민수(Min Soo Shin),한창희(Chang Hee H 한국산업경영시스템학회 2015 한국산업경영시스템학회지 Vol.38 No.1
It is difficult to make an accurate estimate of the economic value and effects on societal economy of Nano-technologies. This research measures an economic value of Nano-technologies quantitatively and analyzes its influences on societal economy. This paper chooses some major industries as analysis targets and adapts the DEFRA comparative methodology model which has been developed in the UK and recommended by OECD. For this reason, some industries which are in range of economic value assessment were investigated and related data were collected. Also, the economic value and societal influences of Nano-technologies were calculated, through the procedure of the model. In addition, this study conducts a questionnaire to experts for the validity of measurement results and procedures. This paper suggests a guideline for economic value and effects on societal economy of Nano-technologies assessments through quantitative Defra comparative methodologies.
체외수정 - 배아이식 시술후 발생한 양측 난관임신 1 예
김희철,김희철(Hee Chul Kim),최범채(Bum Chae Choi),이재훈(Jae Hoon Lee),양광문(Kwang Moon Yang),홍수정(Soo Jung Hong),김혜선(Hye Sun Kim),김석훈(Seog Hun Kim),김창헌(Chang Heon Kim),강인수(Inn Soo Kang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.4
Over the last 20 years, the frequency of multiple pregnancy has increased mainly because of the introduction of exogenous pituitary gonadotropins in the treatment of infertility. Since the advent of assisted reproductive technology, the concern about ectopic implantation of embryos has increased dramatically and it continues to be a major complication of in vitro fertilization and embryo transfer (IVF-ET). Bilateral tubal pregnancy is the least common type of ectopic implantation of two embryos. Of all extrauterine pregnancies, 1:725∼1:1580 are bilateral1,2. Simultaneous tubal pregnancies have been reported in natural cycles, recently, after ovulation induction, in-vitro fertilization2,3. The high incidence of ectopic pregnancy associated with IVF-ET continues to be a problem and frequencies of between 2.4 and 12.4% have been only a few reports of simultaneous bilateral tubal pregnancies following IVF-ET4. This paper describes a case of a simultaneous bilateral tubal pregnancy after IVF-ET in a 33 year old patient. The diagnosis was confirmed by diagnostic laparoscopy performed 25 days after embryo transfer(sixth week of gestation), which revealed bilateral tubal pregnancy. Bilateral salpingectomy was performed. With a review of the literature on this topic, diagnostic aspects and treatment options are discussed.
강창구(Chang Gu Kang),정석(Seok Jung),배유영(Yu Yung Bae),박애별(Ae Byule Park),김경수(Kyung Soo Kim),선진규(Jin Gyu Sun),기광수(Kwang Soo Kee),임헌정(Hun Jung Im) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.5
Ovarian granulosa cell tumor is a uncommon low-grade feminizing malignancy. Its natural history shows slow growth without pain. It often reveals to be very large sized mass when diagnosed, and is confined to the involved ovary in many cases. Complete surgical removal is primary treatment and recurrences thereafter are relatively common. Postoperative adjuvant therapy including reoperation, chemotherapy, radiation therapy or a combination therapy has been used with various degrees of success. We experienced a case of huge ovarian granulosa cell tumor occupying whole abdominal cavity by rapid growth, which is presented with a brief review of corresponding literatures.