정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

갑상설관 낭종에서 발생한 유두상 선암 1례

윤종근,노환중,왕수건 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.2

大邱 都心部再開發事業의 改善方案에 關한 硏究

尹炳九,金正煥 啓明大學校 産業技術硏究所 1988 産業技術硏究所 論文報告集 Vol.10 No.-

The future will confront us with other tasks, probably even lager assignments for urban planning. There will have to be a gradual intergration of "urban renewal planning" into the scope of encompassing urban planning measures. Urban renewal planning is a task for many branches of science. This study attempted to pressent the concepts and objectives of urban renewal planning for CBD Daegu and describe the legal foundations, Preparatory work. excution and financing.

일부 지하철 근로자와 소방공무원의 직무 스트레스 요인 비교

윤석환,최숙정,신동훈,정인성,하정숙 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3

무균성 수막염 환자에서 분리한 enterovirus의 혈청형 및 계통발생학적 분석

이정희,안병윤,반성환,김상현,김의종 대한임상미샐물학회 2000 Annals of clinical microbiology Vol.3 No.2

울릉군 도동항 해변광장 조성 기본계획

황정환,윤국진 경주대학교 건설환경연구소 2005 建設環境論叢 Vol.- No.7

The seaside plaza at the Dodong-port of Ulleung-gun is cognized having characters of space. these characters are a gateway connecting to land, the image of Ulleung's symbol, cleanness as a whole and The scenery is beautiful beyond expression. But the seaside plaza be jammed up and be disordered with visitors, natives and mobiles, and then they didn't make the best use of the expressionist nature and landscape on the images of Ulleung of cleanness and pleasant. Therefore this study was to plan on the seaside plaza at the Dodong-port toward the heightening of Ulleung's symbol, identity, individuality through the presentation of images on cleanness and pleasant, and the expropriation of variety activities on the visitors and natives. The seaside plaza was designed with seven schemes those can be summarized as follows. The first was the adaptation of an existing variety outer functions and activities, the second was the efficient distribution of hard-pavements and green-fields, the third was the treatment of existing slopes and terraces, the fourth was the adaptation of the existing understructures and facilities, the fifth was the creation of nightscape for a night use, the sixth was for harmony of forms and functions like a meet, chat, rest, stroll and assembly, the last was the preparation for erecting a symbolic structure in the future.

세포브러쉬와 면봉도말법에 의한 부인과 세포학적 검사의 효율비교

김정란,김성숙,배한익,김용탁,심재철,임문환,윤혜원,이상식 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

A study was undertaken to evaluate the efficiency of the sytobrush compared with the cotton swab for obtaining cells from the uterine cervix. In 300 patients, the cytobrush technique was employed and in control 300 patients was smeared by the cotton swab. In 12 out of 300 patients(4%) endocervical cells were found on the cotton swab technique. A total of 252 out of 300 cytobrush sampler specimen(84%) contained endocervical cells. With the X²method for statistical comparison, the difference in endocervical cell yield between the cotton swab and the cytobrush sampler was significantly different(p<0.01). This was particularly true in older patients. We conclude from study that the cytobrush sampler is of value for obtaining as adequate cervical cytologic specimen.

멀티미디어 데이타 처리를 위한 함수형 데이타베이스 언어 ADL의 설계

엄윤섭,진정환 慶星大學校 1999 論文集 Vol.20 No.2

As the computing technologies treating multimedia data have been developed rapidly, there are a lot of efforts in research and development for the construction of multimedia database systems. In this paper, we design an object-oriented database language called Algebraic Database Language(ADL). ADL is a database language for Algebraic Data Model which is a formal defined object-oriented data model based on an algebra. ADL uses algebraic expressions as the language constructs, and tries to express temporal and spatial information naturally for displaying multimedia data via output devices.

홉스의 정치적 의무의 정당화

채정민,서윤환 효성여자대학교 법정연구소 1997 법정연구 Vol.4 No.-

This article is to analyse the ground of political obligation in Thomas Hobbes. Political obligation is concerned with the relationship between people and the political community of itsmembers. The problem of the political obligation appeared in the era which was religiouscoflict and civil war in the 17th century In this circumstnace of the modem society, theimportant problem was in reconciling the needs of individuals with those of the political community. Political obligation concerns the moral bonds between individuals and politisal community.The justification of political obligation accounts of the morality of freedom and authority. So,political obligation is said to be defined by the moral obligation to obey the law. Hobbes divided the concept into the natural obligation and prudential one. But the conceptisn't incosistent in his thought. By analyzing its moral justification it can be evident. He asserted the natural 1aw and the Prudencial Principle based on the selfish psychology asthe ground of political obligation. The subjects is obliged to the soverign by the renounce ofthe natural right. According to Hobbes, the state of nature is that of the disorder and fear.They want to establish the common power in order to resolve the self. Such an authorization is based on the consent of the original contractor. The political obligation theoryof Hobbes by the arguments of the social contract was based on the consent logic. However, it is natural to say the moral obligation to obey the authority to secure the justice and well-being. So, I think he empathized on the utility of self-preservation.

설근부종양 절제시 측인두 접근법의 의의

노환중,윤종근,왕수건,전경명 釜算慶南耳鼻咽喉科學會 1996 임상이비인후과 Vol.7 No.2