위의 장형화생과 동반된 비정형 병소의 H-ras, erb B2, p53 단백의 발현 양상

배한익,김동훈,김정란 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.9

주산기 심근병증 1 부검례

배한익,박동일,김정란 東國大學校 1993 東國論叢 Vol.32 No.-

Peripartum cardiomyopathy (PPCM) is a rare form of dilated cardiomyopathy. Onset is from the last trimester of pregnancy to 5 months postpartum. Diagnosis is made by excluding other causes of acute heart failure, such as infections or toxins, and by determining that the patient does not have an underlying cardiac problem that has been unmasked by pregnancy. Its clinical and hemodynamic findings are similar to idiopathic dilated cadiomyopathy : however, peripartum cardiomyopathy shows a high incidience of myocarditis. In addition to congestive heart failure, the occurrence of complications such as sepsis, hepatorenal failure, and arrhythmia were the major causes of death. We experienced an autopsy case of peripartum cardiomyopathy, which is the first in Korea, recently at Pohang hospital of Dongguk University. And we report a pathologic findings of that case with brief review of literatures. The major cause of death in this case is carbon monoxide intoxication with an accelerating association of peripartum cardiomyopathy.

Gastric Mixed Adenoneuroendocrine Carcinoma with Squamous Differentiation: A Case Report

배한익,이채윤,조영민,권오경,유완식,김미선,서안나 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.4

위암에서 Epstein-Barr Virus 연관성의 예측 인자

배한익,김영수,남상철,한만훈,정지윤,박선균,서인수 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.4

Background : It is important to detect Epstein-Barr virus (EBV) in the setting of gastric cancer so that early viral targeted therapy and prevention can be undertaken. The aim of this study was to investigate the predictive clinicopathologic factors for EBV-related gastric cancer. Methods : The archival tumor tissues from 335 patients with gastric cancer were examined using tissue microarray. The detection of EBV was performed using EBV mRNA in situ hybridization (EBV-ISH), and the results were compared against clinicopathologic factors. Results : EBV-related gastric cancers were identified in 21 of 335 investigated cases (6.27%). The anatomical predisposition of EBV-related cancers to manifest in the upper stomach was statistically significant (p<0.001). EBV-related cancers were almost always (20/21) accompanied by lymphoid stroma. No differences in age, sex, histologic differentiation, or T or N stage were noted between EBV-positive and EBV-negative gastric carcinomas. Conclusions : The association of EBV with gastric adenocarcinomas could be predicted when tumors with lymphoid stroma occurred in the upper stomach.

c-kit, PDGFRA의 면역조직화학적 발현 양상과 변이 분석을 통한 위장관기질종양 진단의 접근

배한익,김정식,김재훈,오현진,서인수,김종광,강병욱,유완식,정호영 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.2

Background : Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors in the gastrointestinal tract. Recently, many methods for the diagnosis of GIST have been developed including molecular diagnosis. Methods : We selected 90 cases of GIST that had presented at Kyungpook National University Hospital between 1998 and 2007. Tissue microarrays were made using core areas of tumor tissues. Immunohistochemical staining for c-kit, protein kinase C-theta, and platelet-derived growth factor receptor alpha (PDGFRA) was done. Direct sequencing of hot spot exonal areas for c-kit and PDGFRA were done using extracted DNAs of all 90 paraffin block tissues. Results : Among the 90 cases, 83.3% (75/90) were c-kit positive, 16.6% (15/90) were c-kit negative, 93.3% (84/90) were PDGFRA positive, and 6.6% (6/90) cases were PDGFRA negative. Fifteen cases of c-kit negative GIST included 1 case of PDGFRA negative and 5 cases of PDGFRA negative GIST were ckit positive. The one case in which both c-kit and PDGFRA were negative, showed a c-kit mutation in exon 11. Conclusions : Combined immunohistochemical staining of c-kit, discovered on GIST 1 (DOG1) and PDGFRA is helpful for the diagnosis of GIST. When all staining tests are negative for immunoreactivity, c-kit mutation analysis for exon 11, 9 should be done. Genotyping of kit and PDGFRA do not need to be examined initially, if it is only for the diagnosis of GIST.

1998년도 대구지역 법의 부검 통계

배한익,김은석,채종민,조현정,곽정식 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

This is a report revealing statical cause of death brought to the department of forensic medicine, Kyungpook National University School of Medicine based on the result of autopsy. The summary of result is as follows. 1. The number of autopsy made during 1998 were 356, of these 225 cases(63.2%) were male, and 131(36.8%) were female. 2. 30's, 40's, 20's and 50's was the order according to the number of violent death, and in case of natural death, 30's, 50's, 40's was the oder. 3. August is the period during which autopsies are made most, with December placing second, and the other months are similar. 4. In distributing deaths by cases, violent deaths were 241 cases(67.7%), natural deaths were 105(29.5%) and unknown cases were 10(2.8%). 5. For the violent deaths, deaths due to injury were 128 cases(5301%), asphyxia were 63(26.1%), intoxications were 30(12.4%) and abnormal temperature were 19(7.9%). According to relationship with deaths, homicide is outstanding with 101 cases(41.9%), while suicide and accidental death was the same with 62 cases(25.7%). 6. for death due to injury, death due to blunt injury were 48 cases, sharp force injury which was used most in case of homicide were 43. 7. For the asphyxia, drowning is the most 20 cases, 13 cases of which is accidental death. 8. The deaths of intoxication is the largest part of suicide, and most of intoxication were involved in agrochemical. 9. Of 105 cases of natural death, deaths due to the disease of cardiovascular system were 51 cases(48.6%), of which deaths due to myocardial infraction were 35 cases. 10. Of all autopsy, alcohol intake were checked out in 90 cases and 21 cases of medical controversy took places. 11. Of all violent deaths, the cases involved in the discord between man and woman occupied percentage of 9.6. Of these, homicides were 18 cases, with all sacrificed being females, and of 16 cases of suicide, 13 cases were female.

Genome Analysis Using Array-base Comparative Genomic Hybridization(CGH)

Bae, Han Ik 가톨릭 의과학연구원 2002 가톨릭 의과학연구원 국제학술대회 Vol.6 No.-

Array-based CGH is similar to preexisting chromosomal CGH but uses cytogenetically defined landmarks on the draft sequence of the human genome instead of normal metaphase chromosomes. The landmarks are large-insert clones mapped to chraomsome bands by fluorescence in situ hybridization(FISH). Each clone contains a sequence tag that is positioned on the genomic sequence.

후종격 응모막암종 -1 례 보고-

김수성,배한익 대한흉부심장혈관외과학회 1997 Journal of Chest Surgery (J Chest Surg) Vol.30 No.4

원발성으로 종격동에서 발생한 융모막암종은 드문 질환으로 젊은 남자에서 주로 발견되었으며, 기침, 흉통, 여성형 유방 등의 증상을 보이는 것으로 알려졌다. 33세 여자로 약 3개월 전부터 가벼운 기침으로 시작하였으나 심한 호흡곤란과흉통증 등 증상이 급격히 악화되어 내원하였다. 방사선학적 검사상 후종격에서 직경 13cm크기의 종양이 발견되었고, 혈중 $\beta$-HCG가 20만 mIU 이상 증가하였으며, 적출된 종양은 $\beta$-HCG에 대한 면역조직화학적 검사상 양성반응을 보였다. 융모막암종 절제술을 받고 EMA-CO투여 받은후 약 7개월만에 뇌에 전이된 종양 때문에 뇌출혈을 일으켜 다시 뇌종양 적출술을 받았다. 환자는 그 후 약 7개월동안 두통외의 증상은 없었고 흉부단순촬영상 종격종양의 재발소견도 없었다. Primary mediastinal choriocarcinoma is characteristically seen in young males presenting with the symptomes of cough, chest pale, and gynccomastia. A 33-year-old woman was admitted to the hospital because of severe dyspnea and chest pain which was aggravated rapidly 2 or 3 days ago. Posterior mcdiastinal mass measuring about 1 cm in diameter was seen in Chest P-A, left lateral view of chest, and chest CT. Serum $\beta$-HCG level was markedly elevated up to 200, 000 mIxt. Whole body CT and other studies could not find any lesion on ovary and uterus. But, a single nodule nEeasuring about 1 cm in diameter was identified in the brain CT. The tumor cells (syncytiotrophoblastic cells) from resected mass revealed positivity on i histochemical staining for $\beta$-HCG. She was treated with EMA-CO after resection of tumor, But, 7 months later, she was readmitted and showed cerebral hemorrhage due to metastatic choriocarcinoma. She was operated again for the brain tumor, and was doing well for further 7 months.

內膜1號丸 子宮內膜症 白鼠의 治療效果에 對한 硏究

권은정,배한익,이태균 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Endometriosis is characterized by ectopic growth of tissue resembling endometriosis in various extrauterine locations. So we surgically implanted endometrial tissue to serosal wall of small intestine in rats. After that we administrated Naemak-1-ho-hwan for 10, 20, 40, 60, 80, 100 days. The results were as follows: 1. After 4weeks we could observe tissue resembling endometrium in serosal wall of small intestine. Endometrial tissue which was located serosal wall of intestine had the function of growing, secreting and bleeding. 2. The size of the endometrial tissue in the Naemak-1-ho-hwan administrated group was significantly reduced when we compared with water administrated group (control group) . Further more, as the time goes on, the effect of Naemak-1-ho-hwan much better. 3. In case of infected group, we could find abscess and fibriotic change, also like that case Naemak-1-ho-hwan was not effect. 4. There was no difference between Naemak-1-ho-hwan administrated group and control group in the shape of primordial follicle, primary follicle, maturing primary follicle and ovary size. So these results suggest that Naemak-1-ho-hwan will be effect for the patient who suffer from slight endometriosis.

단순 한선 극세포종 3예

신동주,배한익,전재복,이석종,장재원 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12

Hidroacanthoma simplex (HS) is a rare benign intraepidermal tumor thought to originate from the intraepidermal eccrine duct. Many authors regard it as an intraepidermal form of eccrine poroma but there is still a discussion as to the histogenesis of HS. Clinically, it is more common in older adults and affects both sexes equally. It is found more often on the lower extremities and trunk. The clinical appearance is not characteristic, but the lesions are usually flat or slightly elevated verrucous brown plaques. Histopathologically, the tumor shows characteristic intraepidermal nests and is one of a number of cutaneous lesions showing Borst-Jadasshon phenomenon, that is, tendency to form nests within the epidermis. The tumor cells composing nests show a uniform cuboidal appearance and a round, deeply basophilic nucleus typically. The cytoplasm of tumor cell gives a positive PAS reaction that is diastase-labile. We report herein three cases of HS with the results of immunohistochemical studies.