40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

폐결핵의 조기진단에 있어서 이중중합효소연쇄반응법의 유용성

조성란,최영진,김용훈,이철세,김영창,김휘준 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Background: Pulmonary tuberculosis is a great public health problem in Korea. Early detection of Mycobacterium tuberculosis (M. tuberculosis) in clinical samples becomes more and more important in the control of tuberculosis. Recently, molecular methods have been applied to early detection of M. tuberculosis. Methods: To elucidate the effectiveness of nested polymerase chain reaction (PCR) in early diagnosis of pulmonary tuberculosis, we peformed Acid-fast bacilli (AFB) stain, AFB culture, and nested PCR on 84 sputa. Results: 8 (9.5%) specimens were positive by AFB stain, 17 (20.2%) by AFB culture, and 15 (17.9%) by nested PCR. Using AFB culture as standard method, the sensitivity of AFB stain and nested PCR was 47.1% and 82.4%, respectively. The specificity of AFB stain and nested PCR was 100% and 98.5%, respectively. Conclusions: Nested PCR was more sensitive than AFB stain and had shorter processing time(24-48hrs) than AFB culture. So it may be effective to use nested PCR in order to detect M. tuberculosis when AFB smear Is negative.

뇌졸중 환자의 경상운동이 상지기능에 미치는 영향

조영남,김홍근,권혁철 대구대학교 특수교육재활과학연구소 2008 再活科學硏究 Vol.26 No.2

경상운동은 다른 쪽의 신체에서 일어나는 의도된 움직임의 경상 반전으로 발생하는 한 쪽 신체의 무의식적인 운동이다. 본 연구는 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동이 상지기능에 미치는 영향에 대해 알아보고자 하였다. 65명의 뇌졸중 환자를 대상으로 연구한 결과, 경상운동이 나타나지 않은 환자군의 상지기능은 경상운동이 나타난 환자군의 상지기능과 통계학적으로 유의한 차이를 보였으며, 경상운동이 나타난 환자군에 비해 상지기능이 좋은 것으로 나타났다. 또한, 경상운동이 나타나지 않은 환자군과 경상운동이 경한 환자군, 경상운동이 중한 환자군의 상지기능을 비교한 결과 경사운동이 적게 나타날수록 상지기능이 좋은 것으로 나타났다. 연구의 결과를 종합하여 볼 때, 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동은 상지기능을 감소시키는 요인 될 수 있는 것으로 나타났다. The purpose of this study was to compare upper extremity's motor function according to the mirror movements in hemiparetic patients with stroke. Mirror movements are involuntary movements in one side of the body that occur as mirror reversals of the intended movement on the other side of the body. The subjects of the study were 65 stroke patients who were admitted from May, 2004 to April, 2005 in the Y University medical center. This study used the Manual Function Test(MFT) and the Purdue pegboard test to evaluate upper extremity‘s motor function. The severity of mirror movements were assessed according to the criteria of Woods and Teuber. The results of the study was as follow; First, The upper extremity‘s motor function in hemiparetic patients without mirror movements was significantly different in hemiparetic patients with mirror movements(p< .05). Second, The upper extremity's motor function in hemiparetic patients with mild mirror movements was significantly different in hemiparetic patients with severe mirror movements(p< .05). The result showed that the mirror movements in hemiparetic stroke patients are correlated with upper extremity's motor function and the severity of mirror movements affected upper extremity's motor function. 경상운동은 다른 쪽의 신체에서 일어나는 의도된 움직임의 경상 반전으로 발생하는 한 쪽 신체의 무의식적인 운동이다. 본 연구는 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동이 상지기능에 미치는 영향에 대해 알아보고자 하였다. 65명의 뇌졸중 환자를 대상으로 연구한 결과, 경상운동이 나타나지 않은 환자군의 상지기능은 경상운동이 나타난 환자군의 상지기능과 통계학적으로 유의한 차이를 보였으며, 경상운동이 나타난 환자군에 비해 상지기능이 좋은 것으로 나타났다. 또한, 경상운동이 나타나지 않은 환자군과 경상운동이 경한 환자군, 경상운동이 중한 환자군의 상지기능을 비교한 결과 경사운동이 적게 나타날수록 상지기능이 좋은 것으로 나타났다. 연구의 결과를 종합하여 볼 때, 뇌졸중으로 인한 편마비 환자에게서 나타나는 경상운동은 상지기능을 감소시키는 요인 될 수 있는 것으로 나타났다. The purpose of this study was to compare upper extremity's motor function according to the mirror movements in hemiparetic patients with stroke. Mirror movements are involuntary movements in one side of the body that occur as mirror reversals of the intended movement on the other side of the body. The subjects of the study were 65 stroke patients who were admitted from May, 2004 to April, 2005 in the Y University medical center. This study used the Manual Function Test(MFT) and the Purdue pegboard test to evaluate upper extremity‘s motor function. The severity of mirror movements were assessed according to the criteria of Woods and Teuber. The results of the study was as follow; First, The upper extremity‘s motor function in hemiparetic patients without mirror movements was significantly different in hemiparetic patients with mirror movements(p< .05). Second, The upper extremity's motor function in hemiparetic patients with mild mirror movements was significantly different in hemiparetic patients with severe mirror movements(p< .05). The result showed that the mirror movements in hemiparetic stroke patients are correlated with upper extremity's motor function and the severity of mirror movements affected upper extremity's motor function.

상아질의 깊이에 따른 단일 단계 접착제의 결합강도 비교

조영곤,진철희,민정범 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.4

본 연구는 단일 단계 접착제의 표충과 심층 상아질에 대한 미세인장 결합강도의 차이를 평가하기 위해서 시행되었다. 발거된 상·하악 대구치의 교합떤측에 있는 표층 상아질과 심층 상아질을 각각 15개씩 노출시킨 후, 사용된 접착제에따라 AQ 군, L-Pop 군, Xeno 군으로 분류하여 복합레진을 축조하였다. 각 시편은 상아질과 복합레진 계면의 단면적이 1.0 ㎣이 되도록 절단하였고, 각 군 당 20개의 시편을 사용하였다. 각 군의 미세인장 결합강도의 측정하여 다음과 같은 결과를 얻었다. 표층과 심층 상아질 모두에서 Xeno Ⅲ는 다른 접착제보다 가장 높은 결합강도를 나타내었다 (p<0.05). 또한 모든 접착제는 심층 상아질에서 보다 표층 상아질에서 더높은 결합강도를 나타내었으나 이들 간에 통계학적인 유의성은 접착제의 종류에 따라 다르게 나타났다. This study compared the microtensile bond strength (μTBS) of single step adhesives to different dentin depths. Superficial or deep dentin was exposed in 30 molar teeth by sectioning immediately under the DEJ or 1.5 mm area from central pit, respectively. After polishing with 600-grit SiC paper, the dentin surfaces were assigned to three groups: AQ group-AQ Bond, L-Pop group-Adper Prompt L-Pop, Xeno group-Xeno Ⅲ. The bonded specimens were sectioned into sticks and subjected to μTBS testing with a crosshead speed of 1 mm/minute. The results of this study were as follows; The μTBS to superficial dentin was higher than that to deep dentin in all group. The μTBS of Xeno group was significantly higher than that of L-Pop group and AQ group in both superficial and deep dentin (p<0.05).[J Kor Acad Cons Dent 30(4):319-326,2005]

활성슬러지에서 생분해성 플라스틱의 일종인 polyhydroxyalkanoate의 분해

조영철 경희대학교 2004 環境硏究 論文集 Vol.13 No.-

Polyhydroxyalkanoate (PHA) is an intracellular storage material produced by various bacteria. Because the physical characteristics are similar to those of synthetic plastics, PHA can be used at an alternative of synthetic plastics, which are potential environmental pollutants. On this study, the degradability of PHA was evaluated through the estimation of the weight lost of PHA films in, activated sludge. Approximately 9A% of PHA was degraded for 40-days of incubation. The pattern of degradation showed sigmoid' consisting with lag, exponential, and stationary phases. Sated on the weight loss in exponential phase, the degradation, rate was 3.36%/day indicating that PHA film with 0.1 mm of thickness can be degraded in 30 days in activated sludge.

Ti-Ni 형상기억합금의 변형특성에 미치는 pre-strain의 효과

조용배,오세욱,김득진,박영철 東亞大學校 海洋資源硏究所 1994 硏究論文集 Vol.7 No.1

In SMA(Shape Memory Alloy), the degradation by fatigue is one of the most important problems to be overcome, when SMA is used for robot-actuator materials. The acuator is operated repetitively for long time and its repeating operation develops the fatigue degradation of SMA. The fatigue degradation changes the transformation temperature and deformation behavior and results in inaccurate operation control of robot. Accordingly, the changing behavior of transformation temperature and deformation which results from repeating operation is to be investigated in advance and the scheme to resolve those problems have to be made for the design of actuator. In this paper, for the improvement of the fatigue degradation by repetive movement and better control of the correct movement by the stability of martensite transformation in the developement of Robots actuator, Pre-strain(0, 1.5, 5, 8%)were loaded in the specimens and fatigue testing were carried out by the method of heating and cooling in direct condition. From the results of these experiments, the effects on pre-strain which affect the transformation characteristic and fatigue degradation phenomena were correctly investigated