고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

고령자 급성 췌장염의 임상적 고찰

이진헌,강진경,박인서,송건훈,정재복,백용한,송시영,서정훈 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3

Background/Aims: Inflammatory diseasas of the pancreas are not uncommon. The advanced age is one of the significant factors in assessing the severity of acute pancreatitis. It has been shown that the biliary tract disease is a more frequent cause of acute pancreatitis in the elderly than in the young. With the increased life span, the elderly are comprising a large proportion of the population. As a result, physicians are more often being faced with acute pancreatitis in the elderly. The purpose af this study was to evaluate clinical features of acute panereatitis in the elderly. Methods: A total of 188 patients with acute pancreatitis were reviewed. We investigated the differences of clinical characteristics between the elderly patients aged over 60 and the young patients aged under 60. Results: The sex distribution showed male preponderance in the young patients (M:F=2.4:1), but was nearly equal in the elderly patients (M:F=1.1:1). The most common cause of acute pancreatitis in the elderly was biliary tract disease (52.5%), while alcohol abuse was the most common cause in the young patients (38.8%), Local complications of acute pancreatitis, such as psuedocyst, necrosis, abscesses were not differently shown between the elderly (16.9%) and the young (20.2%) patients. Systemic complications including acute puhnonary failure occurred more frequently in the elderly patients than the young patients. The mortality rate of the elderly patients (5.1%) was not significantly different from that of the young patients (3.1%). Conclusions: To detect correctable underlying bihary tract diseases the elderly patients with acute pancreatitis should be completely investigated using endoscopic retrograde cholangiopancreatography (ERCP). In addition, the patient should be closely monitored for the development of the systemic complications during the disease process.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

스포츠생리학 : Creatine 투여가 쇼트트랙 스피드 스케이팅 선수의 운동 수행력과 혈중 피로 요인에 미치는 영향

백일영(Paik11-Young),우진희(WooJin-Hee),채지훈(ChaefJi-Hoon) 한국체육학회 2000 한국체육학회지 Vol.39 No.2

본 연구의 목적은 주니어 국가대표급 쇼트트랙 스피드 스케이팅 선수 5명을 대상으로 Creatine(Cr)을 구강 투여하여, 투여된 Cr이 최대 운동 부하 수행력에 미치는 영향과 혈중 젖산, 무기인산, 암모니아, pH등과 같은 생리학적 피로 요소의 변화를 고찰하여, Cr 투여가 운동수행에 미치는 영향뿐만 아니라, 피로 요소들의 변화에 미치는 영향을 연구하는데 있으며, 특히, 중추신경계의 피로물질로 알려진 serotonin(5-HT)의 변화를 고찰함으로써 Cr의 피로 유발 지연 효과를 규명하는데 그 목적이 있다. 운동 부하 테스트는 정규 국제규격인 쇼트트랙 전용 경기장에서 Cr을 투여하기 전 500m와 3,000m를 충분한 휴식을 두고 자신의 최대역량으로 주파하게 하는 형태를 취하였으며, Cr의 투여는 하루에 20g씩 5일간 투여하였고,6일째 되는 날 같은 조건으로 재측정 하였다. 운동 수행력의 변화는 각각의 실험 조건에서 Cr을 투여한 실험 조건과 투여하지 않은 실험 조건을 비교해서 유의한 향상이 나타나지 않았으나(p>.05), 쇼트트랙 경기의 특성을 고려할 때, Cr의 투여로 순위를 결정지을 수 있는 기록이 단축 되는 것으로 나타났다. 혈중 젖산의 변화는 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 더 낮은 혈중 젖산 농도를 보였으며, 통계적으로도 유의한 차이가 나타났다(p<.05). 혈중 암모니아와 무기인산의 변화 역시, 혈중 젖산 농도 변화와 마찬가지로 운동시 모든 경우에 증가하는 현상을 보였으며, 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 낮은 혈중 젖산 농도를 보였고 통계적으로 유의한 차이가 나타났다(p<.05). 혈중 pH의 변화는 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 높은 혈중 pH를 보였으나, 통계적으로 유의한 차이가 나타나지 않았다(p>.05). 혈중 5-HT의 농도 변화는 두 그룹 모두에서 Cr을 투여한 실험 조건에서 더 높은 5-HT의 농도를 보였고, 통계적으로도 유의한 차이가 나타났다(p<.05). 전체적으로 운동이 반복되면서 5-HT의 농도는 일정한 형태로 증가하다가 회복시에 감소하는 양상을 보였지만, 피로유발 요인이라고 단정하기엔 무리가 있다고 본다. 따라서, 쇼트트랙과 같은 단시간의 고강도 운동 형태의 경기 종목 선수에게 있어서, Cr의 효율적인 공급은 운동 수행시 에너지 보충제로서의 역할을 충분히 수행할 수 있는 잠재적 역량을 가지고 있을 뿐만 아니라, 피로 유발 물질의 감소와 그로 인한 운동 수행력의 향상에 많은 도움을 줄 수 있을 것으로 본다. 또한, 대사적 생성기전과 피로인식 기전의 개념으로 5-HT에 대한 연구가 추가적으로 수행되어, 피로유발 요인으로서 5-HT에 대한 과학적인 증거의 제시가 이루어져야 할 것으로 본다. The purpose of this study was to examine the effect of oral creatine supplementation on exercise performance, and to follow the changes of blood fatigue elements, such as lactate, ammonia, inorganic phosphate, pH & 5-HT. All of the tests were performed on a international standard arena ice rink. The subject of present study was divided into two groups; 500m skaters(500-AT), and 3,000m skaters (3,000-AT). Each skaters participated in their own skating distances(500 and 3,000m). After the preliminary test, all subjects were given a 5-day supplementation of Creatine monohydrate at a rate of 20g·d^-1.When the study was performed, we could not find a significant difference in developing a record by Cr supplementation(p>.05). However, as the rank of skating is determined by hundreds of second, we could find a result, which can change the rank of the skating competition by the Cr supplementation. There were significant differences in mean blood lactate between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p< .05). Also, there were big significant differences in mean blood inorganic phosphate and ammonia concentrations between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p < .05). The mean blood pH in Cr supplementation experimental condition was higher than Cr non-supplementation experimental condition, but we could not find a significant differences in mean blood pH between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p >.05).Blood 5-HT concentrations in Cr supplementation experimental condition was higher than non supplementation experimental condition, and there were significant differences between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups.(p<.05). However, it was difficult to explain that 5-HT occurs fatigue unless the physiological mechanism of 5-HT was provided.Therefore, this study concluded that Cr supplementation had a ergogenic effect on energy metabolism. Especially, in a high intensive exercise as short-track skating, Cr supplementation will help for fatigue elements reduction and exercise performance improvement. Also, we believe the additional research of 5-HT must be accomplished so that we can provide the scientific evidence of fatigue, which was cause by 5-HT.

Recognition of Pet Heart Failure Using Dual-stream Convolutional Neural Network

lae-Hyun Paik十,Jun-Young Oh+, Euijong Lee, and Ji-Hoon Jeong 충북대학교 컴퓨터 정보통신 연구소 2022 컴퓨터정보통신연구 Vol.30 No.2

본문 참고

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

칼슘수용액으로 처리한 상아질과 합착용 글래스아이오노머의 전단결합강도에 관한 연구

백영걸,이성복,박남수 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The objective of this paper was to evaluate the shear bond strength of luting glass ionomer cement with differ calcium based solution treatment on dentin surface. 120 extracted human teeth were classified into 12 group on presence of smear layer on dentin surface and type of treatment solution. Smear layer remove on dentin surfas was done using 6% citric acid for 60 seconds. Five different dentin surface treatment solutions(calcium acetaa calcium carbonate, calcium chloride, calcium hydroxide, and calcium phosphate) were evaluated in this study! After surface modification, metal ring(inner diameter: 3mm, depth:1mm) was placed to expose the same dentin surface area and inner space was filled with luting glass ionomer cement according to the recommended procedure for standard clinical procedure. The shear bond strength of glass ionomer cement was determined after 24 hours. SEM was used for the evaluation of the surface morphologic changes and EDAX analysis was done. for determination of the change of the calcium contents of treated dentin. Following conclusions can be drawn: 1. In the group of the dentin surface with smear layer, the calcium carbonate solution was the most effective for the increase of the calcium content and the shear bond strength of glass ionomer cement to dentin surfaces. 2. In the group of the calcium carbonate treated dentin with smear layer, the shear bond strength was increased two compared to the control group and cohesive failure mode was observed. 3. The shear bond strength of cement was increased significantly by the removal of smear layer using 6% citric acid. However, additional calcium solution treatments were not effective for further bond strength increase 4. The shear bond strength of cement was significantly improved by both of the removal of smear layer and the calcium solution treatment, and the former was more effective for bond strength improvement 5. The smear layer removed/calcium solution treated groups showed dentinal tubule obstruction and crystiattachment in SEM evaluation. However, the shear bond strengths of these groups were not increased compared to the smear layer removed/no dentin treatment group.

음극 아크 이온플레이팅법에 의한 박막상의 Microdroplets에 관한 연구

백영남,정창준 慶熙大學校 材料科學技術硏究所 1998 材料科學技術硏究論集 Vol.11 No.-

To measure the mechanical properties of titanium nitride films, on the silicon wafers, TiN films were coated by cathode arc ion plating(CAIP) method. The silicon wafers were selected for the calculation of the growing structure, microdroplets and roughnesses of titanium nitride films. The experimental variables were the substrate bias voltages, arc currents, distances between the target and substrate, and jig rpm. The morphologies of TiN films that surveyed by SEM. The creation of the microdroplet reduced with respect to the increase of the bias voltages, jig rpm and distances between the target and substrate, but the microdroplets were multiplied when the arc currents increased. The surface roughness of TiN films were under the influence of the droplets, and improved with increasing the bias voltages and distance between the target and substate, but the roughness became rough as the arc currents were increased.

Al 3원계 합금의 기계적 합금화에 따른 미세조직 변화에 관한 연구

백영남 慶熙大學校 材料科學技術硏究所 1993 材料科學技術硏究論集 Vol.6 No.-

The morphological phenomena on mechanically alloyed Al-8T₁-1B aircraft materials were studied. The optimum conditions of mechanical alloying were 300 rpm of the attritor rotation speed, under process control agent 3 weight of steric acid. Full alloyed structures were found after 15 hours rotating and homogeneous structures were detected after 20 hours rotating. Full alloyed powders under heat treatment for 1 hour were more homogeneous than non heat treatment. Al-ternary alloys by mechanical alloying had more exellent dispersion strenthening properties than any other alloy method.

포천천(포천군)의 관속식물상

백원기,정영재 대진대학교 2000 大眞論叢 Vol.8 No.-

This study was to establish the floristic composition in Pocheon stream(a total of 8 sites) of Pocheon-gun. Vascular plants were composed of 53 families, 129 genera, 150 species, 20 varieties, and 3 formae, totaling 173 taxa(inc1uded 21taxa of aquatic plants), Persicaria lapathifolia and Humulus japonica were the predominant species. A new forma-species, Quamoclit angulata for. alba (Convolvulaceae), is described from karae-ri, Pocheon-gun, Kyongkido, Korea. A naturalized plants were 25 species, correspond to 11.5% of totaling 218 species appeared in South Korea. The Life-form were Geophyte(6.9%), Magaphanerophytes(7.5%), Nanophanerophytes(5.8%), Microphanerophytes (4.1%), Chamaephytes (5.2%), Hemicryptophytes(l4.5%), Hydatophytes (12.1%). Therophytes (43.9%) respectively. Also the original aquatic plants were Sium suave, Potamogeton oxyphyllus, Najas minor, Lemna paucicostata and Spirodela polyrhiza.