위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

거동 가능한 정읍지역 노인층에서 영양 지표의 정상분포

이은주,심선진,김정호,이무송,이영수 대한노인병학회 2002 대한노인병학회지 Vol.6 No.1

절수에 의한 Mongolian Gerbil 장기중량변화에 관한 분석연구

김무강,이기훈,이강이,송치원,이경열,권효정,박미선,정승혁,이행연,김명철 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study, authors measured the each organ weight of the long term water deprived Mongolian gerbil, after then we calculated the mean, standard deviation, variance coefficient of the real measured organ weight and induced the organ weight change quantity, rate of quantity, deviation between measured and theological organ weight, deviation rate, sum of deviation rate, organ weight change rate, rate of organ weight by the mathematical formula. The results obtained as follow 1. The weight of the brains, lung, and testis were abruptly decreased after water deprived until the 5th day, after then slowly decreased until the 20th day. 2. The weight of the heart was decreased gradually from the first day until the 20th day. 3. The weight of the liver was abruptly decreased until the 10th day, after then the more slowly decreased until the 20th day. 4. The weight of the thymus, spleen, kidney, and pancreas were abruptly decreased until the 15th day, after then increased slowly until 20th day but the weight of the kidney was abruptly increased from the 10th day. 5. The organ weight change rate and the rate of the each day organ weight were very diversified.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

흉통과 생활변화, 대처행동양식 및 사회적 지지의 관계 : 관상동맥조영술을 받은 환자들을 중심으로 Focused on Patients Undergone Coronary Arteriography

정진대,국승희,이무석 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.3

본 연구는 흉통을 주소로 관상동맥조영술을 시행받은 환자 중 조영술상 양성군과 음성군, 대조군의 일반 인구학적 특성, 관상동맥질환의 관련요인, 흉통의 양상, 년간 생활변화량, 대처행동양식, 사회적 지지에 대한 지각의 차이, 기능장애정도 등을 비교하고자 하였다. 처음으로 관상동맥조영술을 시행하는 40명의 환자를 대상으로 의무기록지 검토, 반구조화된 면접, 사회재적응 평가척도, 대인관계지지 평가지, 대처행동 평가지, 기능장애 척도 등을 실시한 후 조영술 결과에 따라 양성군과 음성군으로 분류하였으며 이들과 흉통의 과거력이 없었던 정상대조군을 비교하여 살펴보았다. 요약하면 1) 음성군이 양성군에 비해 유의하게 여성이 더 많았고(p<0.05), 비전형적인 흉통을 호소하는 환자가 유의하게 많았다(p<0.01). 2) 년간생활변화량에서는 음성군, 양성군이 정상대조군에 비해 통계적으로 유의하지는 않지만 생활변화가 많았음을 알 수 있었고, 특히 건강과 관련한 생활변화량에서는 유의하게 높은 점수를 보였다(p<0.05). 3) 대처양식에 있어서는 음성군, 양성군이 소극적인 대처양식(정서완화적 대처)을 유의하게 많이 사용하였다(p<0.01). 4) 사회적 지지도는 음성군이 가장 부정적으로 지각하는 경향이었으나 유의한 차이는 없었다. 5) 기능장애에 있어서는 음성군과 양성군이 현저한 기능장애를 보였으나 두 군간에 유의한 차이는 없었다. 본 연구에서는 흉통환자에서 심리, 사회적인 면이 관여하는 것으로 나타났다. 그러나 다른 많은 연구결과에서 지적하듯 흉통을 호소하는 환자의 많은 수에서 이러한 심리적인 어려움이 있음에도 불구하고 지금까지 정신과적 진단과 치료가 제한되어 있었다. 본 연구는 흉통을 가진 환자들 특히, 관상동맥에 유의한 협착이 없으면서도 지속적인 흉통과 기능장애를 갖는 환자들에게 잘못된 대처양식의 수정과 같은 행동치료, 부정적 지각과 같은 왜곡된 인지에 대한 치료와 같은 정신과적 치료적 중재를 통해 증상의 재발방지와 재활에 도움을 줄 수 있을 것으로 기대된다. 향후 좀더 구체적인 심리적 프로그램에 대한 연구가 계속되어야 할 것으로 생각된다. The purpose of this study was to compare the life change unit, coping behaviors, percived social support, functional disability in patients who had a negative coronary arteriogram and those who had arteriographic evidence of coronary artery stenosis with the matched controls. Patients admitted for coronary arteriography to the cardiovascular department of the Chonnam University Hospital were assessed, on the day before coronary arteriography, on the psychological characteristics using self-rating scales such as Social Readjustment Rating Scale, Interpersonal Support Evaluation List, The Ways of Coping Checklist, and Functional Disability Scale. The results of comparing the psychological characteristics of groups with and without significant coronary artery stenosis and normal controls are as follows : In life change unit, patients with chest pain had significantly elevated health-related life events but no statistically significant differences in total life change. In coping behaviros, patients with chest pain were showed to have more passive coping(especially, tension-reduction coping) than normal controls. In social support, patients with chest pain and negative coronary arteriogram were the most negative cognition but there no statistically significant differences. In functional disability, patients with chest pain showed much higher functional disability score than normal controls. We recognized the relationship of psychological factors to the chest pain patients, psychological terapeutic intervention may provide prevention of symptom relapse and rehabilitation for the negative coronary arteriogram patients with persistent chest pain, and functional disability.

各種 植物生長調節物質의 生檢法에 關한 硏究 : Ⅱ. 綠豆發根에 미치는 環境條件, 摘葉 및 核酸複合調味料 아이미의 效果 Ⅱ. Effects of Environmental Conditions, Leaf. Removal, and Aimi on the Rooting of Mungbean Cuttings

李政明,沈相七,金武成 경희대학교 부설 식량자원개발연구소 1981 硏究論文集 Vol.2 No.-

Experiments were conducted to find out the effects of environmental conditions and some other factors influencing the rooting and growth of mungbean cuttings in 1980 and 1981. More roots were formed in the cuttings grown under high light intensity. However, the effect of auxin(indole butyric acid) was more apparent under led light intensity condition. Removal of the growing point significantly increased the root number, but the removal of 1/2∼1 leaf did not influence the root number. The food seasoning material, Aimi(99.5% sodium-L-glutamate and 0.5% sodium-5'-ribonucleotide), showed auxin-like activities.

한국인 심부전증 환자 심근에서의 인형 거대 세포 바이러스 감염

이명용,이무용,김영권,한성식,최성준,김효수,이영우,서정돈 단국대학교 1998 論文集 Vol.33 No.-

Objectives: In order to evaluated the prevalence and the site of infection of cytomegalovirus in terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. Methods: DNA extractions were performed from explanted failing hearts(N=22) and normal hearts(N=5) and polymerase cain reactions(PCRs) were done for detection of late gene sequence coding pp150 glycoprotein. The products were confirmed by electrophoresis on the 1% agarose gel. n order to improve the detectability of cytomegaloviral genome, nested PCRs were executed with the primers designed for the original 607 bp products. In situ PCRs also were done with the samples which were confirmed as positive for CMV viral genome by nested PCRs. Results: All patients had IgG anti-cytomegalovirus antibody and did not have IgM anti-cytomegalovirus antibody. Cytomegaloviral genomes in myocardium were detected by polymerase chain reaction. The 607bp products by PCRs were found in both explanted failing heart(3 cases/22. 13.5%) and normal hearts( 1 case/5, 20.0%). In nested PCRs, 186bp products were found in both failing hearts(LV 4/22, LA 3/2, RV 4/22, RA 0/17) and normal hearts(LV 2/5, LA 1/4, RV 2/5, RA 2/5). These was no significant change in positivity of cytomegaloviral DNA genome between failing and normal hearts. Total positivity of cytomegaloviral genome in explanted hearts was 44.4% according to the nested PCR results. The positivity of cytomegaloviral DNA by n situ PCR was 33.3%(4/12), and the site of positive reaction was the nuclei of the myocardial cells. Conclusion: Cytomegalovirus was rarely observed in explanted hearts of terminal heart failure and nested PCR could enhance the sensitivity of cytomegaloviral genome detection. The result of the in situ PCR showed the site of the cytomegaloviral infection was nuclei of the myocardial cells. Cytomegalovirus, however, might have no direct causal relationship in the development of terminal heart failure.

신체화장애 환자의 스트레스 대처방식 및 심리적 특성

이주연,이무석,윤진상,양종철,문지웅,정해원,은성종 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study was to investigate the stress coping strategies and psychological charactehstics, such as combined psychopathology and tendency of symptom interpretation, in patients with somatization disorder. Methods : Thirty patients meeting the criteria of DSM-IV somatization disorder were compared with thirty controls. We evaluated the subjects using Symptom Checklist-90-Revised (SCL-90-R), Somato-Sensory Amplification Scale (SSAS), Symptom Interpretation Questionnaire (SIQ), and The Ways of Stress Coping Questionnaire (SCQ). Independent t-test and Pearson correlation analysis were used. Results : From the results of SCL-90-R subscales, the scores of somatization, obsession-compulsion, depression, anxiety, and psychoticism were significantly higher in patients with somatization disorder than nonnal controls. Somatization disorder patients had greater amplification of physical sensation in SSAS and significantly higher score in physical interpretation of SIQ compared with psychological or environmental interpretation, In the SCQ of somatization disorder patients, we observed generallylower levels of total coping scores than the control group and significant positive correlation between passive coping style of SCQ and psychological interpretation of SIQ. Conclusion : These results show that patients with somatization disorder have various psychopathology, greater amplification of physical sensation, physical interpretation tendency of symptoms, and insufficient copying strategy.

'선도 추격'에서 '동반 추격'으로의 전환을 위한 서비스 산업의 역할과 전략 : 한일 생산성 비교의 시사

이근,정무섭,김윤지 韓國東北亞經濟學會 2008 동북아경제연구 Vol.20 No.2

The Korean economy has grown very fast over the last decades, but it was an uneven catch-up led by a big business and manufacturing. Now it is time for co-catchup led by both manufacturing and services. This paper analyzes the weight and productivity of the service sector in Korea and suggests for policies for its improvement in productivity. The service sector in Korea is featured by low and declining productivity (both TFP and labor productivity), and a big trade deficits, which is in contrast to the trade surplus in manufacturing. This performance is worse, compared with the situation in Japan. For example, the ratio of labor productivity in service to that in manufacturing is only 14%, compared to 46% in Japan. Causes for the low performance in service include too much regulation and lack of competition due to the closed market. Thus, measures to boost up productivity in service include deregulation and market opening, which would open up the opportunity for learning from foreign companies. Industrial policy should also change from input-oriented one to network-oriented one emphasizing the unity of commodities and services.

이면(지구)도로특성을 고려한 과속방지턱에 관한 기초연구

이호무,금기정,최정한 명지대학교 공학기술연구소 1994 공학기술연구소 논문집 Vol.9 No.-

This paper describes the hump. It is a kind of traffic safety construction which is estabished in the community road. Its function is that reduce the running speed of vehicles. In the community road, we need a ensured safety of pedestrian ane exept of many kind of danger. And also it is very effective connect with improvement of residence enviroment or side of local traffic. By the way the problem in our case is the contents which provided present Road Traffic Law is took from standard of TRRL(Transport and Road Research Laboratory) in British without verification. So there are many kind of this construction removed primar function, reduce of running speed. The basic objective of this study is about to hump which has been used this traffic construction. (1) Standard of fundation, design criteria and all kind of condition. (2) After assessment including maintenance problem. 3) The study of driver's thought, considered driver's opinion. (4) Analogy of problem according to the actual conditions etc. We endeavored to find a guide of construct method, suit our actual circumstances on this study.