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흉통(胸痛)의 정신분석적(精神分析的) 고찰(考察) -두사람의 증례(症例)를 중심으로-
이무석,Lee, Moo-Suk 한국정신신체의학회 1995 정신신체의학 Vol.3 No.1
This study presents the cases of two patients suffering from chest pain as the chief complaint and refers to related literatures to reveal the psychoanalytic meaning of chest pain. In the first case, the patient who was balked of the desire to be loved complained of her pain in the chest She had been bereaved of her husband and felt deserted by someone on whom she depended, and these experiences caused the chest pain. The drive related to this chest pain in a dependent and aggressive one. The second case, the chest pain of a 28-year-old unmarried woman, resulted from Oedipal conflict Her Oedipal conflict did not resolve successfully for the exessive sexual stimulation in her childhood such as her experiences of witnessing the primal scenes sleeping with her parents in the same room, even under a same blanket In addition, there were some other traumas which prevented her from that conflict: Her father bathed her until her puberty: She saw her father's back view as he urinated in a jerry: She heard her parents' frequent quarrels. This patient felt guilty about desire of Oedipal incest, and chest pain seemed to occur as a kind of self-inflicted punishment.
이무석,오태환 한국섬유공학회 1996 한국섬유공학회지 Vol.33 No.8
In melt spinning process of polypropylene hollow fiber, the effects of spinning conditions such as flow rate, die temperature, take-up speed on the diameter and hollowness of spun fibers were studied. For the spinneret of melt spinning, segmented arc type was used and the effect of air flow rate which dragged in hollow part of fibers was considered by taking account of extrudate swell from this type of spinneret. Experimental results show that when the flow rate, die temperature and take-up speed increase, the hollowness of spun fibers decreases. The development of hollow fiber characteristic along the spinline was investigated by the simulation of fiber forming process in which boundary conditions were determined experimentally. In this simulation hollowness of fiber along the spinline decreased and this trends were verified by experiment. In the simulation of spinning of hollow fibers, the freezing point distance is shorter than that of solid fibers and stress at freezing point is larger than that of solid fibers under the same spinning conditions.
백서 뇌내 Opiate 수용체의 일주기 변동에 대한 연구
이무석,김기원,조규박,Lee, Moo-Suck,Kim, Ki-Won,Cho, Kyu-Park 대한약리학회 1984 대한약리학잡지 Vol.20 No.2
실험적으로 명암주기 또는 암주기에 적응시킨 백서의 간뇌 homogenate에서 opiate receptor의 일중변동 유무를 검토하고, circadian rhythm에 영향을 미치는 것으로 알려진 수종 중추작용약물의 영향을 보고 저 7 group에서 4시간 간격으로 1일 6회 maximum $^3H-morphine$ binding을 측정하여 다음과 같은 성적을 얻었다. 1) L : D, 12 : 12에 적응시킨 대조군에서 maximum $^3H-morphine$ binding은 22시에 최고에 달하는 매우 유의한 일중변동을 보였고, 24시간 평균 $^3H-morphine$ binding치는 $0.45{\pm}0.03\;pmole/mg Protein이었다. 2) 지속적인 암적응을 시킨 D : D, 12 :12군에서 $^3H-morphine$ binding의 일중변동은 14시에 최하, 그리고 2시에 최고의 binding치를 보이는 만상성의 일주변동은 보였으며 대조군의 곡선과는 그 shape, Phase, 진폭, 최고 또는 최하 binding시기 및 24시간평균 opiate수용체의 수에 현저한 차이가 있었다. 3) 지속적인 암적응, reserpine, pargyline, imipramine, amphetamine 또는 chlorpromazine 처리는 opiate receptor의 일중변동을 변화시켰다. 4) 그러나 전 실험군에서 Kd치는 변동되지 않았다. 이상 실험성적으로 백서뇌내 opiate수용체의 일중변동은 수용체의 질적변동이 아닌 수적인변동에 의하고, 지속적인 암적응이나 circadian rhythm을 변동시키는 중추성 약물들이 opiate receptor의 일중변동을 변화시킬 수 있으며, 또한 동통을 포함하여 제종 진통제의 효과가 일중변동을 일으키는 것은 opiate receptor의 일중변동과 일정한 관계가 있을 것으로 추측하였다. To investigate diurnal variations of opiate receptor binding and its modification by experimental condition or treatment of various centrally-acting drugs, the amount of maximum $^3H-morphine$ binding in rat midbrain homogenates was measured at 4 hour intervals for 24 hours. Animals were conditioned under the controlled L : D, 12 : 12 cycle or D: D, 12 : 12 cycle, for 3 weeks and treated with 0.5 ml of physiological saline or drugs for 2 weeks. A highly significant diurnal rhythm with peak at 22 hour of early dark phase with an amplitude$(0.68{\pm}0.06\;pmole/mg\;protein)$ of +51.1% and nadir $(0.33{\pm}0.03\;mole/mg\;prtein)$ at 18 hour of late light phase with an amplitude of -26.6% was found in control group. 24 tour mean of $^3H-morphine$ binding was $0.45{\pm}0.03\;pmole/mg$ protein respectively. Constant dark adaptation or treatment of reserpine, pargyline, imipramine, amphetamine and chlorpromazine modified the diurnal rhythm in the time of peak and nadir binding shape, phase, amplitude of the diurnal curve and 24 hour mean of $^3H-morphine$ binding. However, Kd values were not changed in all experimental groups : Statistical analysis at times of least and great binding indicates that the differences in $^3H-morphine$ binding were due to changes not in the affinity, but in the number of binding sites. The results are interpreted with regard to the diurnal rhythm of opiate receptor finding. The modes of action of psychoactive drugs are closely related to postulated changes of receptor sensitivity in neuropharmacological aspects.