http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
12. MODY1 유전자 HNF-4α는 인슐린 분비에 관여하는 선택된 유전자를 조절한다.
윤건호 CMPMedica Korea 2005 Diabetes Research Digest Vol.2 No.2
본 연구진은 Kir6.2 유전자가 HNF-4α의 전사적 표적이 됨을 보여주었다. 본 연구결과는, 베타세포내에서 ATP-의존성 칼륨통로에 의존하는 인슐린분비 경로의 조절에 있어 HNF-4α가 필요하다는 유전자적 증거를 제공하고 있다.
10. 청년기 제2형 당뇨병 : 인슐린 저항성, 베타세포 부전 혹은 두가지 모두의 장애인가? insulin resistance, beta-cell failure, or both?
윤건호 CMPMedica Korea 2005 Diabetes Research Digest Vol.2 No.2
젊은 당뇨병 환자에서 인슐린 감수성과 베타세포 기능이 모두 장애를 보이기는 하지만, 비만한 대조군에 비하여, 인슐린 감수성보다 베타 세포 가능장애가 더 크게 나타났다. 베타세포 기능장애와 당화혈색소간의 음의 상관관계는 혈당 조절에 미치는 베타세포 기능장애의 영향을 반영하고 있거나 베타세포 기능에 대한 포도당 독성 현상의 결과로 볼 수 있다. 앞으로 젊은 제2형 당뇨병 환자에 대한 연구는 베타세포 부전의 자연 경과를 조사하고 이를 늦추거나 예방하기 위한 방법에 그 목표를 두어야 한다.
低溫法時의 몇가지 生理的變化에 關한 實驗的 硏究 : 第二編 ; 肝機能에 미치는 影響 Ⅱ. Effects on Liver Fuction
尹健鎬 慶北大學校 醫科大學 1967 慶北醫大誌 Vol.8 No.1
Liver function studies were carried out in 20 hypothermic dogs. Measurements were performed following 2 hours' maintenance of body temperacure at 20℃. The results were compared with those of precooling conditions. 1. While cooling and rewarming, no signficant changes were seen in plasma total protein, albumin, globulin and A/G ratio. 2. Though S-GOT and S-GPT activities remained on the same level with controls, the alkaline phosphatase activity increased following the 2 hours of 20℃, and did not return to the precooling level even when rewarmed. 3. No significant changes were seen in total bilirubin, thymol turbidity test and cephalin cholesterol flocculation test during hypothermia. 4. When the bodies were cooled, BSP dye showed a remarkable retention: in 5 cases, 51.9% retained 45 minutes following the injection, which is roughly 15.7 times the normothermic value of 3.3%. 5. Galactose tolerance test was done in each five dogs of normothermic and hypothermic dogs. The galactose retention rates in the blood of the cooled animals at 20℃ were 58.4% and 21.5% after 20 and 40 minutes respectively, while in the control, they were 22.1% and 11.9%. This active retention ratio indicated that synthesis of galactose to glycogen in the hypothermic liver tended to be retarded.
윤건호 한국보육학회 2003 한국보육학회지 Vol.3 No.2
The purpose of this study was to examine whether the policy of child care was operated satisfactorily in child care facilities. for attaining the purpose, six research questions were posed covering the satisfaction level at job relation scope. In order to see the level of job satisfaction, questionnaire survey was conducted over six job areas(companions, working condition, pay, job self, administrative system, relationship with principal) of early childhood education teachers. To address the research questions, the theoretical background was built, by which this study was unfolded. the instrument used in this study to see if the policy of early childhood education was operated satisfactorily in kindergarten. was questionnaire covering teacher satisfaction. the questionnaire consisted of 17 items covering 6 areas of teacher job relation. the areas of teacher job relation were categorized into 6 areas, in consideration of various things including earlier studies or current studies, and 17 items that had validity, reliability and internal congruence above a certain standard were selected from among 32 items. The objects in this survey were 215 selected teachers who were serving in early childhood education at Seoul and Kyunggi province. In Seoul, the questionnaire survey was conducted by professor and supporters, and in another regions, that was made by supporters. the collected data were analyzed with SPSS/PC program, ANOVA and posttests were carried out. the brief findings of the study on the satisfaction level at the job relation scope of early childhood education teachers were as below: The satisfaction level(3.42) of the early childhood education teachers investigated at the overall areas of the job relation scope was a little dissatisfied. Every group"s satisfaction level ranged from 2.83 to 4.29. The area they expressed most satisfied was companion area(4.77), which was satisfied. the administrative system appeared to be very dissatisfied(1.45). this level was the least satisfied. the satisfaction level of working condition was 2.89 and the satisfaction level of pay was 2.98. the satisfaction level of job self was 4.45.
11. SREBP-1c를 과발현하는 베타세포의 지질독성 모델에서 포도당-자극에 의한 인슐린 분비장애에 미치는 UCP-2 상향조절과 중성지방축적의 역할
윤건호 CMPMedica Korea 2004 Diabetes Research Digest Vol.1 No.3
이러한 결론은 UCP-2의 하향조절과 AMPK의 활성화가 베타세포를 지질독성으로부터 완화시키기 위한 목표가 될 수 있음을 시사한다.
15. 고농도 포도당에 노출된 췌장 소도 베타세포에서 산화 스트레스
윤건호 CMPMedica Korea 2004 Diabetes Research Digest Vol.1 No.4
췌장 소도 베타세포가 장기간 고농도 포도당에 노출되었을 때 PDX-1 및 RIPE-3b1 activator와 같은 인슐린 gene transcription factor 등이 감소 하여 비가억적으로 인슐린 분비능이 떨어지는 것을 포도당 독성(glucosetoxicity)이라고 하나, 포도당 독성의 정확한 기전은 밝혀져 있지 않다. 고농도 포도당에 노출되었을 때 세포내 free radical을 증가하고, 이러한 free radical이 췌장 소도 기능을 저하시킨다고 하며, 최근 췌장 소도 베타세포에서 항산화 제제가 포도당 독성을 부분적으로 방지한다는 보고도 있다. 한편, 여러 자극으로부터 췌장 소도를 보호하는 것으로 superoxide dismutase, catalase 및 glutathione peroxidase (GPx) 등의 항산화 효소, Heat Shock protein 70 (hso 70) 그리고 Heme Oxygenase-1 (HO-1) 등이 있다. 췌장 소도는 다른 조직에 비해 낮은 항산화 효소를 가지고 있으며, 이러한 효소를 췌장 소도에 과발현시켜 포도당 독성에 의한 산화 스트레스(oxidative stress)를 방지할 수 있다는 연구도 있다.