한국 지형에서의 지표-대기 상호 작용 연구 : 3. 환경 변화에 따른 벼의 기공과 광합성 반응

권효정,채남이,김준,김정우 한국기상학회 1997 한국기상학회 학술대회 논문집 Vol.1997 No.-

Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

권효정,홍성국,남기환,최인표,김대용,김형진,원영석 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.3

Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout (KO) mice exhibited accelerated liver regeneration because such animals could effectively control the expression of cell cycle regulators that drive the G1-to-S phase progression. In the present study, we further investigated the role played by VDUP1 in initial priming of liver regeneration. To accomplish this, VDUP1 KO and wild-type (WT) mice were subjected to 70% partial hepatectomy (PH) and sacrificed at different times after surgery. The hepatic levels of TNF-α and IL-6 increased after PH, but there were no significant differences between VDUP1 KO and WT mice. Nuclear factor-κB (NF-κB), c-Jun-N-terminal kinase (JNK),and signal transducer and activator of transcription 3 (STAT-3)were activated much earlier and to a greater extent in VDUP1KO mice after PH. A single injection of TNF-α or IL-6 caused rapid activation of JNK and STAT-3 expression in both mice,but the responses were stronger and more sustained in VDUP1KO mice. In conclusion, our findings provide evidence that VDUP1 plays a role in initiation of liver regeneration.

Umbilical trocar port site keloid management using a transposition flap after laparoscopic surgery

권효정,김정휴,Chae Rim Lee,최장연,문석호,전영준,오득영 대한미용성형외과학회 2021 Archives of Aesthetic Plastic Surgery Vol.27 No.4

Background Keloids can occur anywhere in the human body. They are difficult to remove and can cause distress in patients. Although many options are available to treat keloids, no single method is considered the optimal treatment of choice. The authors encountered cases where an umbilical keloid developed at the trocar site after laparoscopic surgery and managed the keloid using a transposition flap. Methods A total of 10 umbilical keloid patients treated from 2013 to 2020 were included in this study. All patients developed a keloid due to the placement of a laparoscopic trocar incision port, and their major complaints varied from an asymptomatic nodule to pruritus or pain. All excisions were performed under local anesthesia, and transposition flaps were planned afterward. The surrounding tissue was rearranged so that the shape of the umbilicus was deformed to the minimum extent possible. The keloid scars were examined both preoperatively and 6 months postoperatively using the Patient and Observer Scar Assessment Scale (POSAS). Results All surgical wounds healed well without complications. The average time interval from laparoscopic surgery to keloid scar revision was 4.3 years. The mean postoperative follow-up period was 10.9 months, and no patient underwent reoperation. Four patients were treated with triamcinolone after surgery due to mild hypertrophy or pruritus. The POSAS observer scale showed significantly decreasing scores over time in all patients (P=0.002). Conclusions Cosmetically unfavorable keloids that form in the umbilicus following laparoscopic surgery can be improved with a simple procedure using excision and transposition flaps.

A Review on the Clinical Use of the Eight Extra Meridians

권효정,박동석,남상수,김용석 대한침구의학회 2009 대한침구의학회지 Vol.26 No.3

목적 : 기경팔맥의 임상활용을 위하여 기경팔맥의 개요와 기경팔맥을 이용한 침 치료법의 장점과 기존의 침 치료와의 차이점을 알아보고자 하였다. 방법 : 기경팔맥의 기원과 학문적 이론의 체계를 알아보기 위하여 한국학술정보(주)를 통해 검색한 국내 논문 9편을 참고하고, 기경팔맥을 이용한 치료법에 관한 국내외 서적 2편을 수집하였다. 또한 MedLine에서 기경팔맥을 이용한 치험례와 임상연구에 대해 영어로 작성된 논문 2편을 소개하였다. 결론 : 기경팔맥을 이용하면 정경 치료와 달리, 통증 등의 실체가 있는 질환에 대해 즉각적인 효과를 보이는 치료를 소수의 혈자리 자침으로써 간편하게 행할 수 있다. 또한 병증과 경락 유주 사이의 공간적 불일치가 있거나, 복잡한 정황으로 인해 四診을 통한 변증이 어려운 경우에 팔맥교회혈 또는 영구팔법 등의 기경팔맥을 이용한 치료를 사용할 수 있다.

Effect of Sim-eui Point on Allergic Rhinitis, Rhinosinusitis, and Other Causes of Nasal Obstruction

권효정,김재규,이상훈,김창환,김용석 대한침구의학회 2010 대한침구의학회지 Vol.27 No.3

목적: 이 연구는 알레르기 비염 또는 비부비동염으로 인한 비폐색증에 대한 침치료의 효과를 입증하고, 신혈인 심의혈의 임상적 효과를 알아보고자 시도하였다. 방법: 2009년 9월 22일부터 11월 3일 까지 2회 이상 경희의료원 동서 비염 클리닉 내원하여 침 치료를 받은 비염환자를 대상으로, 무작위배정방법에 따라 실험군 또는 대조군으로 배정하였다. 실험군은 routine 혈위인 신회, 상성, 신정, 양두유, 양찬죽, 양지창에 심의혈을 추가하였고, 대조군은 routine 혈위에 양영향을 추가하였다. 유침 시간은 각 군에서 15분 간으로 하였다. 유효성 평가 도구로는 SNOT-20를 사용하여 비염 전반적 증상의 점수 변화를 측정하였고, VAS를 사용하여 비폐색 완화 효과의 정도를 측정하였다. 평가 시기는 치료 전후로 하였고, 통계분석은 치료 전후 SNOT-20 차이의 경우 Wilcoxon Signed Ranks Test로, VAS 비교는 Mann-Whitney Test를 이용하여 검정하였다. 결과: 침 치료 전과 후의 SNOT-20의 변화는 실험군과 대조군 모두에서 유의한 결과를 나타내었으나 실험군과 대조군 사이의 유의한 차이는 나타나지 않았다. SNOT-20 항목 중 ‘수면 중 깸’, ‘숙면 어려움’ 등 2개 항목을 제외한 모든 항목에서 침 치료 전과 후의 유의한 차이가 나타났다. VAS는 실험군에서 대조군에 비하여 유의한 증상 호전을 나타내었다. 결론: 심의혈 자침이 비폐색의 즉각적인 완화와 부비동염으로 인한 삶의 질을 개선시키는데 유용할 것으로 사려된다.

Reply to Comment by Kang and Kim on “Estimation of Net Radiation in Three Different Plant Functional Types in Korea”

권효정 한국농림기상학회 2009 한국농림기상학회지 Vol.11 No.3

I thank Kang and Kim (this issue) for their interests and constructive comments on Kwon (2009) in which the objectives were to find the site-specific relationship between net radiation (RN) and solar radiation (RS) in major plant functional types in Korea and to examine its applicability for estimating RN. The authors addressed six major points requesting clarification and suggesting improvement. Below, my replies are provided. I thank Kang and Kim (this issue) for their interests and constructive comments on Kwon (2009) in which the objectives were to find the site-specific relationship between net radiation (RN) and solar radiation (RS) in major plant functional types in Korea and to examine its applicability for estimating RN. The authors addressed six major points requesting clarification and suggesting improvement. Below, my replies are provided.

심방세동 환자의 연령별 와파린 초기용량 적정성 평가 및 새로운 용량조절 기준설정

권효정,정지은,민경아,이영미,손기호 한국병원약사회 2008 병원약사회지 Vol.25 No.2

There are limited data on the initial dose of warfarin therapy in outpatients. The Anti-coagulation Service(ACS) of the Samsung Medical Center(SMC) confirmed that patient age is the most important determinant of warfarin requirement in Korean, and has set up age-related warfarin initial dosage guideline: warfarin 3.5 mg/day for under 50-year-old, 3 mg/day for age between 51~60, 2.5 mg/day for age between 61~70, 2 mg/day for over 71-year-old patients, followed by checking INR weekly. In the context, the purpose of this study is to analyze the appropriateness of age-related warfarin initial dosage guideline and propose a new dosage protocol. Study was processed as follows. First, targeted patients who initiated warfarin therapy with age-related warfarin initial dosage guideline(target INR 2.0-3.0) in ACS of our out-patient medical center and had indication of atrial fibrillation were investigated. For the study, 81 patients' records were analysed retrospectively. Before age-related warfarin initial dosage guideline was applied, the average period of achieving therapeutic levels was 32.42 days, on the other hands, 18.07 days for age-related warfarin initial dosage guideline. No patient suffered any thrombotic or hemorrhagic complications during taking age-related warfarin initial dose. The age-related initial warfarin dosage guideline has proposed safe and effective in out-patient warfarinization. But the group of age between 61~70, it took 5 days longer than other group, and needs increase in initial warfarin dose. The INR checked within 1 week and the ratio of the warfarin dose of maintaining therapeutic level to initial dose was analysed. The less INR checked within 1 week, need the more warfarin dose to maintain therapeutic level(p<0.0001). All things considered, this study allowed new protocol for warfarin dose regulation like followings; 100% increase of initial warfarin dose for checked INR under 1.2, 50% increase for INR 1.2~1.4, 30% increase for INR 1.4~1.6, 10~20% increase for INR 1.6~1.8, 10% increase for INR 1.8~1.9, maintain initial dose for INR 1.9~2.0, decrease 10% for INR over 2.0. The study was designed to the appropriateness of age-related warfarin initial dosage guideline. The guideline was shortened required period of achieving therapeutic levels. And based on the results, this study proposed a new dosage protocol.

욕창예방활동

권효정,김기남,문경희,박정순,신지철,오정숙,이혜경,홍도선 한국의료QA학회 2009 가을학술대회 Vol.2009 No.2

飮食物쓰레기의 效率的 管理를 위한 物理的 特性 및 處理

권효정,정영헌,김임경,심언봉,오광중 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

This study was conducted to manage food wastes in Korea efficiently. We carried out an experiments on food wastes generated from Yeonjae gu, Pusan as a representative boundary according to the measurement of apparent density, generation quantity, physical characteristics, proximate analysis, and elemental analysis as well as drying and carbonizing, and also tested the hazardous materials in fertilizer and compost from public and private recycling center in operation. The purposes of this study are to investigate current status of food wastes recycling methods and facilities, to examine the fuelization of food wastes, and to suggest the cost effective food wastes treatment plans. Based on the results of the analysis of apparent density and water content in food wastes, it was revealed that the apparent density of food wastes was in inverse proportion to the water content. The water content of food wastes was highly influenced by the fruit and vegetables such as watermelons. These results indicate that the food wastes with about 75 ~80wt% initial moisture content should be reduced under 70wt% moisture content by drying process pier to throwing away. Comparing the heating values of the food wastes which were calculated by Dulong's equation and Steuer's equation it was revealed that Steuer's equation(HHV 5,186 kcal/kg, LHV 880 kcal/kg) was more compatible than Dulong's equation(HHV 4,676 kcal/kg, LHV 330 kcal/kg) because the results of proximate analysis for the food wastes were very similar to those of sewage sludges. Additionally, to reduce water contents of food wastes under 60wt% as acceptable water contents for fuelization, it was also found that blending with 25wt% chars made from food wastes was more efficient than the drying of food wastes itself at 105°C, 45minutes in view of completion time. Furthermore, these chars generated from food wastes (about LHV 6,608 kcal/kg) comparable to commercial charcoal(LHV 7,134 kcal/kg) generated from oak trees and lower ash contents(under 15wt% of chars) than those.

모래상자놀이가 이혼가정 아동의 자아존중감에 미치는 효과

권효정,김현주 한국아동심리재활학회 2016 놀이치료연구 Vol.20 No.2

The purpose of this study was to examine the impact of sandtray play on the self-esteem of children from divorced family. The subjects in this study were three selected children who attended a welfare center in an urban community. They were raised in divorced single parent families, and they were selected from among six children of whom the social worker was asked to take care because of poor expressions of intentions. They got a score of 90 or less on a self-esteem scale. A sandtray play program was provided in 10 sessions, once a week, 60 minutes each. The findings of the study were as follows: first, sandtray play contributed to raising the self-esteem scores of the children from divorced family. second, there were increase in their verbal expressions related to high self-esteem. third, there were increase in their nonverbal expressions related to self-esteem. The findings of the study might not be generalizable because of the small size of the subject group, but the findings of the study suggest that sandtray play had an effect on the improvement of the self-esteem of the children from divorced family. 본 연구는 모래상자놀이가 이혼가정 아동의 자아존중감에 미치는 영향을 알아보는데 목적을 두고 실시하였다. 연구대상은 D시에 있는 사회복지관 방과후 공부방에 다니며, 자신의 의사를 제대로 표현하지 못하여 사회복지사에게 의뢰된 아동 6명 중 자아존중감 검사를 실시하여, 90점 이하인 아동 3명을 선정하여 실험집단에 배정하였다. 모래상자 놀이 프로그램은 주 1회, 총 10회기, 회기당 60분 진행하였다. 본 연구의 결과는 다음과 같다. 첫째, 모래상자놀이는 이혼가정 아동의 자아존중감을 향상시켰다. 둘째, 모래상자놀이는 이혼가정 아동의 자아존중감이 낮은 언어표현을 감소시키고 자아존중감이 높은 언어표현을 증가시켰다. 셋째, 모래상자놀이는 이혼가정 아동의 부정적 비언어표현을 감소시키고 긍정적인 비언어표현을 증가시켰다. 본 연구는 소수사례 연구로서 일반화하는데 제한점은 있으나, 모래상자놀이가 이혼가정 아동의 자아존중감을 향상시키는데 효과가 있음을 알 수 있다.