압축력을 받는 Double Angle부재의 극한강도해석

최성준,최성준,윤순종,윤종열,이원복 대한토목학회 1995 대한토목학회 학술발표회 논문집 Vol.1995 No.1

부정경쟁행위에 관한 몇 가지 쟁점

최성준 서울대학교 기술과법센터 2009 Law & technology Vol.5 No.1

부정경쟁방지 및 영업비밀보호에 관한 법률 제2조 제1호는 부정경쟁행위를 한정적으로 열거하고 있다. 그 중 가목의 상품주체 혼동행위와 관련하여서는, ①‘간단하고 흔히 있는 표장’을 사용하는 것이 가목에 해당하기 위한 요건, ② 오픈마켓에서 판매자가 부정경쟁행위를 한 경우 오픈마켓 운영자의 책임을 어떤 요건하에 어느 범위까지 인정할 것인지, ③ 상품의 용기나 포장이‘타인의 상품임을 표시한 표지’에 해당하기 위한 요건 및 상품의 형태나 모양도 이에 해당할 수 있는지 여부 등을 살펴보았다. 다음으로, 나목의 영업주체 혼동행위와 관련하여서는, ① 병행수입업자의 광고, 선전 행위가 나목에 해당하는지 여부, ② 인터넷 포털을 대상으로 한 대체광고 등 서비스가 부정경쟁행위에 해당하는지 여부 등을 살펴보았다. 그리고 다목의 저명상표 희석화 행위와 관련하여서는 다목의 해석상 문제점과 메타태그에 타인의 저명상표를 사용하는 행위나 팝업 광고가 다목에 해당하는지 여부를 살펴보았다. 그 밖에 2004. 7. 21.부터 시행된 도메인이름의 사이버스쿼팅을 규제하는 아목 및 상품의 형태의 보호에 관한 자목에 대하여도 그 해석상의 문제점 및 구체적인 사례를 살펴보았다. Article 2, Paragraph 1 of the Unfair Competition Prevention and Trade Secret Protection Actspecifically lists proscribed unfair competition activities. In connection with the act of creatingconfusion with respect to the manufacturer of goods provided in subparagraph (a), this paperexamines (i) when the use of a “simple and ordinary mark”may fall under subparagraph (a), (ii)when and to what extent the operator of an open market should be held responsible for unfaircompetition activities committed by sellers through such open market and (iii) when the containeror package of goods may be considered as “a mark indicating the goods of another”and whetherthe form or shape of goods may also constitute such a mark. Then, in connection with the act ofcreating confusion with respect to the operator of a business provided in subparagraph (b), thispaper reviews (i) whether the advertising and promotional activities of parallel importers may fallunder subparagraph (b) and (ii) whether supplementary advertising activities on internet portalsmay fall under unfair competition activity. In connection with the act of diluting the value of well-known marks provided in subparagraph (c), whether the act of using a well-known trademark ofanother in a metatag or engaging in pop-up advertising may fall under subparagraph (c), as well asother issues relating to the interpretation of subparagraph (c), are examined. Finally, this paper alsoexamines some interpretative issues and precedents with respect to subparagraph (h), whichregulates domain name cybersquatting with effect from July 21, 2004, and subparagraph (i), whichprotects the form of goods.

말기심부전 환자의 부전심장에서 B형 및 C형 간염바이러스 감염양상

최성준,김효수,오병희 대한순환기학회 2001 Korean Circulation Journal Vol.31 No.1

엄지 내·외전을 구현한 전자의수 제작

최성준,이지은,강흠석,박혜선,김국원 순천향대학교 부설 산업기술연구소 2020 순천향 산업기술연구소논문집 Vol.26 No.2

The human hand has the most delicate and complex structure in the body, making it difficult to study the prosthetic hand. As a result, many disabled people are having difficulty purchasing assistive devices, making them very less accessible. In this paper, the internal and external functions of the thumb are added to enhance the accuracy of the gripping motion. A two degree of freedom joint was added to the thumb movement so that the abduction-adduction angle could be adjusted according to the user's intention. Therefore, it is possible to implement various movements, thereby improving the utility of the electronic prosthesis. In addition, by using a 3D printer, the cost burden is reduced and design changes are easy to compensate for the shortcomings of the existing electronic prosthesis.

뮤지컬과 관련된 저작권법상 쟁점 : 서울고등법원 2007. 5. 22 선고 2006나47785 판결, 서울중앙지방법원 2007. 3. 12.자 2007카합375 결정

崔成俊 서울대학교 기술과법센터 2007 Law & technology Vol.3 No.3

한국 성인 급성 골수성 백혈병에서의 염색체 분석

최성준,이규형,서을주,배창황,김정균,조세행,김태원,장대영,이제환 大韓血液學會 1998 大韓血液學會誌 Vol.33 No.2

가교자료생성 임상시험 한국인만을 대상으로 한 추가 3상 임상시험이 필요한가?

최성준 대한임상약리학회 2009 Translational and Clinical Pharmacology Vol.17 No.2

The registration of new drug is more difficult every year because health authority requests more data on efficacy and safety, especially in long-term clinical trials. In Korea, health authority usually requests bridging data in Korean subjects in order to evaluate the possibility of extrapolation of foreign data to Korean population. But multinational developmental clinical trials from phase 1 to 3 in Korea are ongoing increasingly and it is the time to evaluate the clinical data in the viewpoint of global drug development. Sometimes phase 3 trial for Koreans only may be the waste of resources and the barrier to delay the access for Korean patients even though the drug is available in other countries some years earlier. In scientific point of view, other methods such as Pharmacokinetics / Pharmacodynamics simulation and modeling may be the one of the options to evaluate the ethnic sensitivity. In this article, I explain the issues in the generation of brdiging data using additional Koreans only phase 3 trial and the possible alternative for the future. The registration of new drug is more difficult every year because health authority requests more data on efficacy and safety, especially in long-term clinical trials. In Korea, health authority usually requests bridging data in Korean subjects in order to evaluate the possibility of extrapolation of foreign data to Korean population. But multinational developmental clinical trials from phase 1 to 3 in Korea are ongoing increasingly and it is the time to evaluate the clinical data in the viewpoint of global drug development. Sometimes phase 3 trial for Koreans only may be the waste of resources and the barrier to delay the access for Korean patients even though the drug is available in other countries some years earlier. In scientific point of view, other methods such as Pharmacokinetics / Pharmacodynamics simulation and modeling may be the one of the options to evaluate the ethnic sensitivity. In this article, I explain the issues in the generation of brdiging data using additional Koreans only phase 3 trial and the possible alternative for the future.

Association Between Short-Term PASI90 Achievement and Drug Survival of Biologics in Patients with Psoriasis

최성준,오소희,윤현선 대한피부과학회 2022 Annals of Dermatology Vol.34 No.3

Background: With accumulating evidence that achieving a 90% improvement in the Pso- riasis Area and Severity Index score (PASI90) has better correlation with improved health- related quality of life as compared to PASI75 achievement, there has been demand for estab- lishing new treatment goals for psoriasis. Objective: We investigated whether the short-term PASI90 achievement would predict lon- ger drug survival as compared to PASI75 achievement. Methods: This single-center retrospective cohort study reviewed 180 treatment series in 128 patients with plaque psoriasis, who were treated with tumor necrosis factor-alpha inhibitors (n=12), ustekinumab (n=88), secukinumab (n=23), guselkumab (n=45), and ixekizumab (n=12). The first effectiveness assessment, usually performed within 12 to 20 weeks, was considered a short-term treatment response to biologics. Results: After adjustment for covariates, time-dependent Cox proportional hazards re- gression analysis showed that moderate responders (short-term achievement of ≥PASI75 but <PASI90) were more likely to discontinue therapy than the excellent responders (short-term achievement of PASI90; adjusted hazard ratio, 3.159; 95% confidence interval, 1.180~8.457; =0.0220). Conclusion: The short-term PASI90 achievement is a better predictor of longer drug sur- vival as compared to PASI75 achievement.

지방자치공청회지상중계 ( 3 ) 전남지역공청회

최성준,한완석,양남조,김중채,이광자,이정구,권진욱,박형구,황하택,서수정 대한지방행정공제회 1986 地方行政 Vol.35 No.395

N/A

노인 소화기 환자에서 경구용 항생제의 사용

최성준,이동호 대한노인병학회 2012 Annals of geriatric medicine and research Vol.16 No.3

Oral antibiotics are usually prescribed for geriatric patients for the treatment of infectious diarrhea and management of hepatic encephalopathy. But oral antibiotics have systemic adverse events, so many doctors face the issue of choosing the right antibiotics. Rifaximin, an intestinal topical antibiotic that exhibits a wide antimicrobial activity against both aerobic and anaerobic bacteria, has various indications, such as acute bacterial diarrhea caused by Gram positive and negative bacteria, traveler’s diarrhea, small intestine bacterial overgrowth, prevention of infection after gastrointestinal surgery, and the management of hepatic encephalopathy with hyperammoniemia. But there are few clinical trial data on the geriatric population. Hence we reviewed the clinical study data that included geriatric patients in their clinical trials. Based on our literature searches, only one clinical trial on acute bacterial diarrhea was performed only for geriatric patients. Other clinical trials for various indications usually recruited elderly patients, but the number of elderly patients was limited. However, generally speaking, rifaximin showed good efficacy and safety profile in acute bacterial diarrhea caused by Gram positive and negative bacteria, traveler’s diarrhea, small intestine bacterial overgrowth, prevention of infection after gastrointestinal surgery, and the management of hepatic encephalopathy with hyperammoniemia; and there were no differences in efficacy and safety, compared to the nongeriatric population. We concluded that rifaximin is a good therapeutic option for various gastrointestinal indications, and shows good efficacy and an excellent safety profile, compared to other oral agents. For more evidence on the geriatric population, we propose clinical trials on elderly patients for each indication. 리팍시민은 그람양성균 및 그람음성균에 의한 급성 장염,장내 세균상의 이상으로 인한 설사(여름철 설사, 여행자 설사,소장결장염), 위장관 수술 전, 후 감염의 예방, 고암모니아혈증 치료의 보조 요법에 폭넓게 사용되어 왔으나, 임상 시험의 근거는 노인 환자에게 그리 많지 않았으며 노인 환자를대상으로 한 연구는 급성 세균성 설사를 대상으로 한 하나의연구에 불과하였다. 그러나 다양한 적응증에 대한 많은 임상시험에서는 대부분 노인 환자가 소수이지만 포함되어 있었고,리팍시민의 특성으로 살펴보면 체내 흡수가 거의 되지 않는장점으로 적응증 및 그 외의 소화기 질환에서 확실한 유효성을보이면서도 위약과 유사한 안전성 프로필을 보여주고 있다. 이런 점이 노인 환자에서 리팍시민을 안전하게 사용할 수있다는 간접적인 증거를 제시하고 있다고 할 수 있겠다. 이논문의 제한점은 고연령군의 환자에서 약제의 안전성 및 유효성에 대한 언급을 하기 위해서는 연령별 대조군 연구 및 메타분석의 통계적 분석이 필요하나, 노인 환자에 대한 자료가많지 않고, 또한 원 자료에 대한 접근이 가능하지 않아서시행되지 못한 점이다. 향후 이 점은 보완의 가능성을 염두에두고 있다. 또한 확증적인 추가적인 근거의 확보를 위하여특히 우리나라에 많은 과민성 장 증후군, 간성 뇌증 환자중 노인 환자에 대한 임상 시험이 더 시행된다면 그 근거의신뢰가 더 높아질 것이며, 이로 인하여 리팍시민과 같은 경구용 항생제의 적절한 사용례가 증가할 것으로 사료된다.