정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

대구시 간선가로망 구축에 의한 입체 교차로의 효율성에 관한 연구

임채문,공창환,정우영 大邱大學校 科學技術硏究所 1994 科學技術硏究 Vol.1 No.-

It is necessary to establish a link organization to device the transportion planning relieving traffic congestion. Therefore, this study has established a principal link centering around Taegu city, and reviewed the efficienay of the grade intersations and the 3-Dimensional intersations. The results of this study are as fallow; This study has established each circulation lane by Grid partition and Daiiy Traffic Volume (the 1st circulation lane; 000m, the 2nd circulation lane; 800m, the 3rd circulation lane; 1000m) The delay model of a length is t₂= exp(3.0091 +0.001242x)k (R²=0.78). The conversion of traffic volume into turning point the grade and 3-Dimensional intersection at single intersection is different by the distance between intersections. The decrease of total link delay is minute by one or two 3-Dimension on a intersection, and the 3-Dimension on the 2nd and and circulation lane is more effective than the 1st circulation lane. In the case of multi-intersections, passing time on the 3-Dimension passing throuth the urban center and the bypassing road has a little difference. For that reason, the bypassing route must be considerd instead of the 3-Dimension passing throuth the unban center. So an examination and re-settlement of the future pricipal link is necessary to organze the principal link on Taegu city using other factor.

好氣性 固定床 生物膜 反應槽의 메디아로 폐칫솔의 利用可能性 檢討에 관한 基礎硏究 : 처리효율을 중심으로

임채영,김정권,성낙창,신남철,김형석,전기일 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study was conducted to evaluate the possibility to apply the waste toothbrush to aerobic fixed biofilm reactor for media. The media used for this research was waste toothbrush (WTB) and Pall-Ring. The feed used for this research was synthetic wastewater which was made at the laboratory. The COD, NH₄^(+)- N and PO₄^(-3)-P removal efficiency variations with the organic loading rate was examined at this research. The conclusions drawn from these experiments are listed below : 1. When the influent COD concentration was respectively 300mg/ℓ, 600mg/ℓ, the COD removal efficiency was decreased with the increase of the organic loading rate and the COD removal efficiency for Pall-Ring was higher than the COD removal efficiency was 0.4~1.9%. 2. When the influent NH₄^(+)-N concentration was respectively 13mg/ℓ (COD 300mg/ℓ), 25mg/ℓ (COD 600mg/ℓ ), the NH₄^(+)-N removal efficiency for Pall-Ring was slightly higher than the NH₄^(+)-N removal efficiency for Wastetooth brush. The difference of NH₄^(+)-N removal efficiency was about 0.5~1.5%. 3. When the influent PO₄^(-3)-P concentration was respectively 7mg/ℓ (COD 300mg/ℓ), 14mg/ℓ (COD 600mg/ℓ ), the PO₄^(-3)-P removal efficiency for Pall-Ring was higher than the PO₄^(-3)-P removal efficiency for Wastetooth brush. The difference of PO₄^(-3)-P removal efficiency was about 1.1~2%. 4. COD, NH₄^(+)-N and PO₄^(-3)-P removal efficiencies show very small difference between Pall-Ring and Wastetooth brush as media. So it was showed that wastetooth brush can be used as media very successfully.

자연과 수업시 교사가 아동에게 제공하고 있는 뇌친화적 요소에 관한 연구

임채성,김병철,류양순,이영아 부산교육대학교 과학교육연구소 1999 科學敎育硏究 Vol.24 No.-

Educational practices should be based on the sound information about the structure and function of human brain. Recently, with the result of advancement in technology, inner workings of our brain were sufficiently accumulated to actually apply to the educational practices. The eight brain-compatible elements suggested by Kovalik & Olsen(1994) were based on these knowledge about brain. This study was undertaken with the purpose of providing insights into science teaching-learning based on the brain-compatible elements derived from several brain-based learning principles. To accomplish this purpose, we explored how the elements were provided to children by teachers in science instruction. The results as follows. The levels of appreciation of the elements by teachers were high. Especially, the appreciation element of cooperation in science teaching was relatively higher than those of others. Furthermore, they had attitudes to have children relate the science subject to their real lives. For one particular element, that is, enriched environment, it was found to be relatively less appreciated, probably because of the lack of resources such as books, videos, CD, pictures, regularly scheduled guest speakers, and the others to support science contents. These findings provide a basis for understanding the roles of the brain-compatible elements in learning science. The results also highlight the need for teachers to aware of and implement the elements to create environments which encourage the maximization of the brain potentials of children when teach science subjects.

傳門大學 海洋土木科 敎育課情 開發硏究

林秉龍,鄭營采,申文燮,李東周,張仁奎,金榮燮 군산대학교 1982 群山水産專門大學 硏究報告 Vol.16 No.1

To carry out the study on the curriculum development for the ocean civil department in junior college, we collected and analyzed data which are on the curriculum development or improvement of the inside and outside of the country. We also gathered the opinion through the inquiring paper investigation and the consultation to the industrial organization, concerned school and authorities during 6 months from May, 1981. In addition, we analyzed and compared the present curriculum of special civil and ocean civil department in junior college. On the basis of above methods, a result we made a model curriculum shown in Table 10. Under current trend and circumstances of the industrial society, the best way for the curriculum development is to make like the course curriculum. But, it is is difficult to make the course curriculums of the ocean cavil department at present. Because the ocean civil is a branch of general civil engineering, furthermore the oceanic industry of our country is not developed well. So, dividing the major subjects in four fields for operating the model curriculum flexibly with the characteristics of the community and college, we developed the suitable curriculum in junior college course, such as general basic field, special basic field related to the ocean, special basic field related to the general civil and application field. We also tried to entensify the subjects of general basic field, special basic field related to the ocean, and to simplify the number of subjects in the model curriculum. Of course we can't say this model curriculum is perfect. But we believe firmly that the results of this paper will be a help to another curriculum development or improvement study for the ocean civil department in junior college.

평면선형의 편구배에 대한 안전성 검토 : 고속의 도시부 가로를 중심으로

임채문,박준,홍익상,박영환 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.6 No.1

This study investigates fitness of horizontal alinement design elements that has been used in Korea. Those elements are analyzed in consideration of road environment, drivers' characteristics, and traffic condition. In addition, reformed superelevation formula is produced to be fit to the conditions in Korea by considering horizontal alinement design elements on the base of 'AASHTO'. The results are summarized as follow 1. According to drivers' cognition analyzed by Factor analysis, drivers regard that road safety and horizontal alinement elements are the most important facts. 2. Superelevation value which is produced from radius of road curve in research area is shorter than standard superelevation value. Therefore, we should revise and supplement the standard superelevation in aspect of drivers' safety. 3. Superelevation value analyzed by 85 percentile running speed shows higher value than critical superelevation value used in Korea. So, we should upgrade the critical superelevation value.

신호주기에 따른 차량군 분석을 통한 속도 Model 구축

임채문,이영우,공창환,박영환 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.6 No.1

The purpose of this thesis is to develop a simulation model to estimate travel speed applicable to urban street transportation planning for interrupted traffic flow, influenced by signalized intersection. This simulation model is expected to be a better and more than previous studies. The results are summarized as follow ; 1. As a result of analyzing the travel speed to the ratio of vehicle stops, the high correlation between travel speed and the ratio of vehicle stops is obtained and is more likely to have a nonlinear shape than a linear shape. 2. The algebraic equation is the most appropriate equation among the linear algebraic and exponential equations which use the ratio of vehicle stops as a variable. 3. This study suggests that the maximum travel speed is 44.73km/h when the ratio of vehicle stops is 0.01 when speed is perceived to be high, if there are no standing vehicles on the road, there is a perfect offset. There fore. there is a little traffic volume considering the maximum travel speed to be appropriate, the minimum travel speed is 16.45km/h when the ratio of vehicle stops is 1. 4. Considering many variales such as the condition of city roads and the condition of traffic signals, this study suggests the equations.

여행속도에 따른 Q-V관계식 산정에 관한 연구

임채문,정우영,공창환,홍익상 대구대학교 과학기술연구소 1995 科學技術硏究 Vol.2 No.1

The purpose of this study is to estimate a suitable traveling speed model based on using the traffic data collected by test-vehicle traveling method and the data on road geometric and operating characteristics. The conclusions of this study are as follows. In travel speed model(Q-V), regression model (V=9.635+0.0169L - 0.00045Q - 2.1926N, R²=0.76) the important independent variables are speed is closely related with distance, traffic volume and the number of traffic lane, form the result of speed-flow regression analysis, link travel speeds are influenced by link distance, traffic volume, and the number of lanes. As expectedly by the most significant factor influencing link travel speeds. The changing of traveling speed according to section distance is appeared large. According to the result of analysis of travel speed and traffic density model(Q-K), as according the that density increases the travel speed is decreases, on the other hand travel speed increases, the density decreases. The speed equation (u=68.72e^(-k/22.6)) is derived by form the Q-K relationships founded form the study, traffic volume increases as traffic speed increase up to the critical traffic density. If traffic volume decreases when traffic density is abduce the critical traffic density. Using Q-V equation estimated by regression analysis and Q-K equation estimated by density, Traffic value test was accomplished by computer program(TRANPLAN). There were difference between too test, however, the deviation was small. On case of using program, the application extent we considered, is between 25Km/h - 60Km/h. Traffic volumes obtained from TRANPLAN are governably 10% larger than traffic volume estimated form Q-K model. However the difference of the critical traffic density bow Q-K model and TRANPLAN, are relatively small. It is desirable to reduce traffic volume by 0.7∼9% over all, speed range when TRAPLAN is applied in Q-K relationship.

자연 동굴 토양 방선균의 속 다양성 분포

임채영,권오성,김판경,박동진,이동희,김창진 한국산업미생물학회 1996 한국미생물·생명공학회지 Vol.24 No.5

국내에 소재 하는 자연 동굴 중 충청북도의 고수굴, 천둥굴, 노동굴, 강원도의 고씨굴, 경상북도의 성류굴, 제주도의 협재굴, 쌍용굴, 만장굴 등 8개 동굴의 내부에 존재하는 토양 방선균 분포를 조사하였다. 그 결과 전체적인 속 수준의 분포로서는 Streptomyces가 52.5%, Micromonospora가 16.3%, Nocardioform 22.8% 정도 분포하고 있었으며 Kineosporia, Actinomadura, Nocardiopsis, Streptosporangium의 순서로 방선균이 0.3~1.4% 정도 분포하고 있었다. 지금까지 보고된 일반적인 방선균 분포와 비교해 볼 때 특히 Streptomyces의 분포 비율이 낮고 상대적으로 Micromonospora, Nocardioform이 많이 분포하고 있었다. 한편 노동굴 지역을 대상으로 동굴 내부와 외부로 나누어 방선균 분포를 비교해 보았다. 그 결과 동굴의 내부에는 Streptomyces가 52.0%, Micromonospora가 16.8%, Nocardia가 32.0% 정도 분포하였고 외부에서는 Streptomyces가 75.8%, Micromonospora가 10.7%, Nocardia가 7.1% 정도 분포하였다. 따라서 동일 지역 내에서도 동굴의 내부와 외부에 따라서 큰 차이를 나타내고 있었다. 그리고 분리된 방선균 중에서 Streptomyces속 균주의 형태적인 특징을 조사한 결과, 기균사의 색에 있어서는 회색 계열 45.7%, 적색 계열 7.8%, 황색 계열 2.3%, 녹색 계열 13.2%, 백색 계열 27.1%, 불량 3.9%의 분포를 나타내었다. 일반적으로 Streptomyces속 방선균에서 잘 분리되는 회색과 적색 계열의 분리 비율은 크게 낮아 졌으나 희소한 녹색과 백색 계열은 분리 비율이 크게 증가하였다. 그리고 성류굴에서는 황색, 녹색, 백색, 계열등 다양한 계열의 Streptomyces속 방선균이 많이 분리되었다. 포자 연쇄의 형태에 있어서는 retinaculiaperti 형태가 35.7%, spirales 형태가 12.4%, rectiflexibiles 형태가 51.9%로 나타났다. Total 276 soil actinomycete strains were isolated from 46 soil samples collected at domestic natural caves; the Kosu, Chundong, and Nodong caves at Chungbook province, the Kossi cave at Kangwon province, the Sungruye cave at Kyungbook province, the Hyupjae, Ssangyoug, and Manjang caves at Cheju province. All of these isolates were identified to the genus level based n morphological and physiological characteristics. As the result, 52.5% of those isolates were Streptomyces, 16.3% were Micromonospora, 22.8% were Nocardioform group, 1.1% were Actinomadura, 0.3% were Nocardiopsis, 0.3% were Streptosporangium, 0.3% were Nocardioides, 1.4% were Kineosporia, 4.7% wee the others. Streptomycete strains were the most abundant, but were relatively less comparing to general distribution pattern. Nocardioform and Micromonospora strains were quite abundant, and other rare actinomycete groups were somewhat abundant comparing to general distribution pattern previously reported. Especially Nocardioform strains were highly abundant at almost of the natural caves.

실시간 GPS 차량의 주행자료를 이용한 링크통행시간 산정에 관한 연구

임채문,이영우,박영환 대구대학교 산업기술연구소 2003 産業技術硏究 Vol.14 No.3

Users of traffic information are demanding a wide range of real-time traffic information. However, the limitation in collecting real-time traffic information makes it difficult to analyze or provide the real-time traffic information. To improve the methods of collecting real-time traffic data, this research examines the possibility of collecting real-time traffic data using GPS. Real-time collection of traffic data is key to the production and provision of real-time traffic information. This research conducted real-time data collection using GPS-based RTK assessment to proceed with the study on link travel times. This research result showed that the patterns of going through traffic were divided up to 2 in the link travel times. The first pattern is the delay on the red ball at the downstream node before passing the link and the other is passing at the green ball without having to be held up by the red ball. Therefore, it will be more accurate to divide up the link travel time into the one involving delay and the other without delay, rather than using the average link travel time in terms of assessing the traffic situation.