정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Genetic Characterization of Haemagglutinin 1 Domain of Influenza B Viruses Isolated in Korea during $1988{\sim}1999$

Shin, Gu-Choul,Na, Byoung-Kuk,Lee, Joo-Yeon,Ahn, Jung-Bae,Park, Jong-Won,Lee, Jin-Soo,Kim, Jee-Hee,Kim, Woo-Joo,Kang, Chun The Korean Society for Microbiology 2003 Journal of Bacteriology and Virology Vol.33 No.4

Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have 'analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been co circulated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.

발바닥에 발생한 혈관내 유두상 내피 증식증 1예

이선영,김영조,정병수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

우울증 환자 치료에 있어서 Tianeptine과 Sertraline의 효과와 안전성 비교

이민수,강성민,기백석,연병길,오병훈,이철,채정민,백인호 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 주요 우울증의 치료에 있어서 티아넵틴과 써트랄린의 임상적 효과와 안정성을 비교하기 위하여 연구를 시행하였다. 방법: DSM-IV 진단 기준에 의거하여 주요 우울증의 진단기준에 부합되고 17항목 해밀턴 우울척도 점수가 14점 이상인 환자를 대상으로 하였다. 총 40명의 환자를 무작위적 방식에 따라 티아넵틴 치료군과 써트랄린 치료군으로 분류하였다. 선탠된 환자에서 다른 항우울제를 복용하고 있는 경우 7일 이상의 약물 배설기간을 가진 후 티아넵틴과 써트랄린을 각각 6주간 투여하였으며, 기준점, 1주후, 2주 후, 4주 후, 6주 후에 HAM-D, MADRS, 그리고 CGI, COVI 등을 사용하여 평가하였다. 본 연구기간 중 발생된 모든 부작용은 부작용의 발생 및 소실 시기, 심한 정도, 발생 빈도, 관련 조치 및 결과에 대하여 증례기록서에 기록하도록 하였다. 결과: 30명(티아넵틴군 15명 ; 써트랄린군 15명)이 6주간의 연구를 완결하였고 티아넵틴 치료군에서는 1일 37.5mg을 투여하였으며 써트랄린군에서는 1일 평균 64.0±22.5mg을 투여하였다. 본 연구 결과 HAM-D, MADRS, CGI 상에서 두 군 모두에서 치료 1주 후부터 유의한 감소를 나타내었으며 이는 2주 후, 4주 후, 6주 후에도 지속적인 감소를 보였고 두 군간에 항우울 효과의 차이는 없었다. 활력징후, 일반 혈액학, 생화학, 심전도 검사 등에서는 두 군 모두 유의한 변화는 없었다. 티아넵틴과 관련된 부작용으로 흔히 보고한 증상은 오심(33.3%), 복부 불쾌감(26.7%), 구강 건조(20.0%), 두통(13.3%)등 이었고 써트랄린 치료군에서는 구강 건조(53.3%), 두통(46.7%), 오심(33.3%), 그리고 식욕 부진(33.3%)등으로 티아넵틴군에서 보다 적은 발현빈도를 보였다. 결론: 티아넵틴은 우울증의 치료에 있어서 효과적이고, 내약성이 우수한, 안전한 항우울제이다. Objective: This study was designed to evaluate the efficacy and safety of tianeptine and sertraline in the treatment of patients with depression. Method: The study was done on the patients with major depression diagnosed by DSM-IV, who had aHamilton Rating Scale for Depression(HAM-D) score ≥ 14 on the first 17 items of the HAM-D. A total of 40 patients were randomly assigned to tianeptine group and sertraline group. Tianeptine and sertraline were prescribed to each group. 6 weeks of each medication was carried out after 7 days of drug excretion period. Evaluation using 17 item HAM-D, Montgomery and Åsberg Depression Rating Scale(MADRS), Clinical Global Impression Scale (CGI), and Covi Scale was done on the baseline and after 1 week, 2 weeks, 4 weeks, and 6 weeks. Regrding all side effects that had occurred during the period of our study such as their developed/disappeaed time, severitien, incidences, managements and results have been recorded. Results: A total of 30 patients(tianeptine group 15 ; sertraline froup 15) finished the 6 weeks of research. 37.5mg of the daily dose was regularly prescribed to the tianeptine group, the average amount of 64.0±22.5mg of the final daily dose was prescribed to the sertraline group. Total 17 item HAM-D scores, total points of MADRS and CGI showed significant decrease after 1 week in each treatment froup and continous decrease after 2, 4 and 6 weeks ; and no difference was found between tianeptine group and sertaline group in the antidepressant efficacy. Also there were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The common reported side effects of tianeptine were nausea(33.3%), epigastic distress(26.7%), dry mouth(20.0%), headache(13.3%) and those of sertraline were dry mouth (53.3%), headache(46.7%), nausea(33.3%), anorexia(33.3%). Conclusion: According to the results, tianeptine was effective in improvement of depressive symptoms and was well tolerated and safe in patients with depression.

복부비만의 지표로서 부위별 허리둘레 측정값의 신뢰도

이영미,박혜순,천병철,김현수 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 비만 자체보다 복부비만이 심혈관질환과의 관련성이 높아 복부비만에 대한 평가는 점점 그 중요성이 강조되고 있다. 허리둘레는 측정이 간편하여 복부비만의 평가에 가장 적절한 지표로 알려져 있다. 그러나 기관에 다라 권고하는 측정부위가 다르고, 우리 나라에서는 아직 허리둘레 측정위치에 대하여 표준화되어 있지 않다. 이에 허리둘레 측정부위 중 신뢰도가 가장 높은 방법을 찾고자 연구를 시행하였다. 방법 : 본 연구에 자발적 참여를 원하는 자원자 111명 (남자 53명, 여자 58명) 을 대상으로 하였다. 허리 둘레는 (1) 늑골 하단부와 장골능 상부의 중간 부위 (WHO 권고 방법 ) (2) 배꼽 부위 (3) 장골능 상부 (NIH 권고 방법) 세 곳의 해부학적 위치에서 측정하였다. 공복 상태에서 훈련된 2명의 검사자에 의해 측정부위별로 각각 2회씩 허리둘레를 측정하였다. 측정자내 및 측정자간 변이의 비교는 일반선형모델 (general linear model)을 이용하였다. 결과 1) 대상자의 평균연령은 38.4세였으며 체질량지수 25 kg/㎡를 기준으로 정상 체중군은 66.1%, 비만군은 33.9%였다. 2) 세 가지 측정법의 비교 결과, WHO 방법과 배꼽 부위가 NIH 방법보다 측정자내, 측정자간 및 총 변이가 유의하게 적었다. WHO 방법과 배꼽 부위에서의 측정값은 WHO 방법이 변이가 더 적었으나 통계적으로 유의하지는 않았다. 3) 여자, 40세 이상 및 체질량지수가 25 kg/㎡ 이상인 군에서는 변이에 유의한 차이가 없었다. 결론 : 늑골 하단부와 장골능 상부의 중간 부위에서 허리둘레를 측정하는 WHO 방법과 배꼽부위에서 측정하는 방법이 장골능 상부에서 측정하는 NIH 방법보다 측정자내, 측정자간 및 총 변이가 더 적었다. 허리둘레의 측정은 복부비만을 평가함에 있어 중요한 도구이므로 이러한 자료를 바탕으로 허리둘레 측정부위를 표준화하는 것이 필요하다. Background : Assessment of waist circumference is being emphasized for the evaluation of fat distribution. However, the sites for measurement of waist circumference differ depending on the associations or the investigators. the standardization of waist circumference has not yet established in Korea. The purpose of this study was to find the site for reliable measurement of waist circumference in the subjects with various range of age, and BMI. Method : The participants were recruited 111 persons (53 males and 58 females) participated in this study voluntarily. All anthropometric values of study subjects were measured in fasting state with swimming suit. Waist circumference was measured by two trained personnel at 3 different sites; (1) WHO recommended site : midpoint between the lower border of the rib cage and the iliac crest; (2) umbilical level; (3) NIH suggested site: top of the iliac crest. Intra-observer, inter-observer, and total variations were analyzed. Results : Intra-observer, inter-observer, and total variations of waist circumference measured at which WHO recommended, and umbilical level were lower than that of waist circumference measured at which NIH suggested. However, the difference of variations between the values of WHO method and that measured at umbilical level was not significant. The difference of variations was more prominent in female, subjects aged over 40 years, and subjects with BMI <25 kg/㎡. Conclusion : The variations of waist circumference measured at which midpoint between the lower border of the rib cage and the iliac crest, or umbilical level were lower that measured at which top of the iliac crest. It is needed to standard the site for measurement of waist circumference to assess abdominal obesity precisely in practice.

자일리톨, 후노란, 제2인산칼슘 및 카제인포스포펩타이드배합껌이 법랑질의 광질재침착에 미치는 영향에 관한 실용실험연구

이병진,배광학,박우철,양준영,황수정,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

The object of this study was to investigate caries preventive effect of chewing gum containing xylitol, funoran, calcium hydrogen phosphate and casein phosphopeptide by examining Vickers' hardness and surface roughness with confocal laser microscope. Early caries-like lesions were created using 0.1 M lactic acid-sodium hydroxide buffer(pH 4.0). 8 pieces of 3am diameter bovine enamel specimen with early caries-like lesions were mounted into the recesses of lingual surface of the acrylic mandibular removable appliance. 13 subjects were the appliance for daytime and chewed control and experimental gums 7 times in a day, for 3 days. In order to evaluate the remineralization effect of chewing gum on specimens, we measured vickers' hardness number after chewing gum, 1 day, 2 days, 3 days after and calculated surface roughness immediately after chewing gum. Vickers' hardness number of experimental chewing gum was significantly higher than control in 2 and 3 days after. Surface roughness of experimental chewing gum was significantly lower than control immediately after chewing gum. These results showed that experimental gum has more effective in remineralization of bovine tooth enamel, and it is more effective at immediately after chewing.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

수소엔진의 특성에 관한 연구

이병수 한밭대학교 산업과학기술연구소 1994 논문집 Vol.2 No.-

The characteristics of the hydrogen fuel are the substitution of petroleum as well as the purification of the exhaust gas in the view of the environmental consideration. The various problems like the incomplete combustion of the hydrogen fuel that is easily combustible could not be broke out in spite of the serious problems like the back firing and knocking. The storage and transport capabilities of the hydrogen fuels are the key points of the practical usage of the hydrogen engine. For solving the problems mentioned above, it is strongly recommended that the systematic programs should be set up and the developments of the synthetic programs in the long term be immediately driven.

한국 어린이와 성인의 표준잇솔규격개발에 관한 연구

이원재,이병진,배광학,김영수,노정,문혁수,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

Purpose of this study was to obtain basic anatomical data for developing optimal toothbrush which is appropriate for Koreans Dental study models were examined by measuring the length from labial midline of deciduous canine to distal surface of deciduous second molar, from labial midline of permanent canine to distal surface of second premolar, from mesial surface permanent first molar to distal surface of permanent second molar, cervico-incisal length of deciduous central incisor, cervico-incisal length of permanent central incisor, from mesiobuccal cusp of deciduous maxillary second molar to mesiolingual cusp of deciduous maxillary second molar, from mesiobuccal cusp of permanent maxillary first molar to mesiolingual cusp of permanent maxillary first molar, from distolinual cusp of deciduous mandibular second molar to mesiolingual cusp of deciduous mandibular second molar, from mesiobuccal cusp of permanent mandibular first molar to mesiolingual cusp of permanent mandiblar second molar in 241 subjects. And the width of right hand was examined on each subjects by measuring the length of landmarks which were selected in handwrist X-ray film. Commercial toothbrushes sold in Korea were collected and the head length, head width, bristle length and handle length of toothbrushes were measured. The obtained results were as follows; 1. The head length of toothbrush which were appropriate for Koreans aged 6 to 8 was less than 21.8 mm. The head width length of toothbrush which were appropriate for Koreans aged 6 to 8 was less than 8.4 mm. The bristle length of toothbrush which were appropriate for Koreans aged 6 to 8 was more than 5.7 mm. The handle length of toothbrush which were appropriate for Koreans aged 6 to 8 was more than 84.3 mm. 2. The head length of toothbrush which were appropriate for Koreans aged 9 to 11 was less than 20.4 mm. The head width length of toothbrush which were appropriate for Koreans aged 9 to 11 was less than 8.4 mm. The bristle length of toothbrush which were appropriate for Koreans aged 9 to 11 was more than 9.3 mm. The handle length of toothbrush which were appropriate for Koreans aged 9 to 11 was more than 95.2 mm. 3. The head length of toothbrush which were appropriate for Koreans aged over 12 was less than 25.5 mm. The head width length of toothbrush which were appropriate for Koreans aged over 12 was less than 8.6 mm. The bristle length of toothbrush which wee appropriate for Koreans aged over 12 was more than 9.6 mm. The handle length of toothbrush which were appropriate for Koreans aged over 12 was more than 101.1 mm. 4. Some toothbrush for children was not appropriate because of its big size, and toothbrush sells in Korea must be diversified for appropriate selection.

창면불쾌글레어 평가를 위한 인공창 실험의 타당성 검토 연구

이진숙,김병수,김선화 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

The purpose of this study is to find the base experimental data by testing the recovery time of human eye with administrating experimental conditions, source luminance, background illuminance and the position of subjects, by examining the appropriateness of evaluating discomfort glare caused by actual window and by simulated window. The process of this study is as follows: 1) In terms of the previous experiment, the large of Mock-up, evaluation values and subjective positions were administrated. 2) The experiment on the recovery time of human eye is conducted by source luminance, background illuminance and the subjective position. 3) At the same Mock-up condition, the experiments for evaluating discomfort glare caused by actual window and by simulated window were conducted and contrasted. Rationally tested recovery time of human eye is 120 seconds with source luminance, background illuminance and the subjective position. And the difference on the boundary of evaluating values caused by actual window and by simulated window ranges from 13% to 5%. On the basis of the result, the validity of discomfort glare evaluation caused by simulated window is presented.