정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조선대학교 의과대학 의학과 학사편입제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

공업화부재의 생산/운반/양중관리를 위한 정보가시화 시스템 개발에 관한 연구

임형철,송영석,김창덕,송성진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Recently, The construction field in the urban area is short of working space and securing processing place because it is surrounded by adjacent buildings and nearby roads and have difficulties in rising labor costs. The insufficient space causes problems of interference and conflicts in transporting materials and working at the site. Therefore, Construction Manager find many alternative method and select industrialized method. The objective of this paper is to develop and give a method of information visualization system for manufacturing, delivering and lifting these materials in construction project stakeholders, using tools visualizing informations. The tools supports to stakeholders so many informations in material manufacturing, delivering, lifting in construction site. That is, order information, manufacture information in factory, sending information, carrying information, unloading and lifting in Site, and so on. Case studies are performed to evaluate the feasibility and applicability of the proposed method.

위암의 진행에 따른 Fas관련 아포프토시스 유도의 상관성

임성철,황철기,오서진 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : The purpose of this study is to determine whether human gastric adenocarcinomas express Fas-L, sFas-L or Fas , whether serum sFas-L leyel is changed in gastric cancer patients after gastrectomy, whether Fas-L expression is associated with increased apoptotic induction, especially, tumor-infiltrating Iymphocytes(TIL) and whether apoptotic induction is associated with the tumor stage and histologic type. Materials and Methods : The author analysed 38 cases of early gastric carcinoma(EGC) and 61 cases of advanced gastric carcinoma (AGC) which received gastric resection from 1997 to 1998. Of them, the number of diffuse type is 38 cases and the number of intestinal type is 61 cases. The author used immunohistochemical staining for Fas, Fas L and CD45, TACS^TM in situ apoptosis detection kit, and sFas ligand ELISA kit. Results : Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40cases (40/61; 66%) of AGC group. The extent of Fas-L expression was variable, with both Fas-L was localized to neoplastic cells in 23 cases (23/38; 61%) of EGC group and 40 cases(40/61; 66%) of group. The extent of Fas-L expression was variable, with both FasL-positive and negative neoplastic region cccuring within. TIL were detected by co-expression of CD4S and TACS on serial histologic sections. TIL adjacent to Fas-L erxressing tumor regions were decreased in number and TIL adjacent to FasL-negative tumor regions were increased in number; apoptotic induction of TIL showed the opposite pattern (p<05). Fas expression was found essentially homogeneously throughout the tumor mass independent of tumor stage. Fas expression showed 39 cases (39/61; 64%) of intestinal type and 26 cases (26/38; 68%) of diffuse type. Labeling indces for tumoral apoptosis in EGC and AGC were 6.72% and 7.13%, respectively and this difference was statistically insignificant. Co-expression of Fas-L and Fas, which occurred over large areas of the tumors, did not result in an enhanced rate of tumor cell apoptosis. The mean serum sFas-L level was significantly higher in patients before treatment compared with controls, whereas in post-gastrectomy patients, it was significantly lower, In addition, tumor stage and other prognostic factors were not associated with Fas and Fas-L expression, serum sFas-L level, number of TIL and apoptotic induction. Conclusion: 'The author demonstrates a statistically significant reduction of TIL concomitant with significantly increased TIL apoptosis adjacent to FasL-expressing regions of gastric adenocarcinomas. Also an elevated level of ·serum sFas-L in the gastric adenocarcinoma group was noted. These findings suggest Fas-mediated apoptotic depletion of TIL in response to Fas-L expression by stomach cancers, and provide the evidence to support the Fas counter-attack as a mechanism of immune escape in gastric cancer. And These findings indicate that the serum sFas-L level is a useful indicator in evaluating postoperative follow-up. In addition, gastric carcinoma cells of the intestinal and diffuse type did not differ in their expression of the Fas-apoptotic system.

기관내삽관에 의한 후두손상

임상철,이준규,이동훈,윤태미 全南大醫大 2004 전남의대학술지 Vol.40 No.1

신경베체트병에 의한 신경인성방광 : 증례보고

이길용,임건한,소영석,노준,김철성,장대수 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

The co-existence of mouth and genital ulceration with iritis was first defined as a syndrome by Behcet. It is now known to be a chronic and relapsing systemic disease, which involves many other systems. Neurogenic bladder dysfunction due to Behcet's disease, however, is extremely rare, and only a limited number of cases have been reported in the international literature. Voiding disfunction in Behcet's disease can be due to neurological or direct bladder involvement and can be related to bladder and sphmctehc components in both phases of micturition. We report on a 35-year old patient with a neuropathic bladder secondary to Behcet's disease.

회전축계의 진동제어용 ER 유체 댐퍼의 설계 및 반능동 비례제어

임승철,채정재,박상민 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper is concerned with the design and application of an Electro-Rheological(ER) fluid damper to suppress vibration of rotor systems. The example system at hand is flexible with a slender shaft and a thin disk, being su pported by two ball bearings. In addition, to investigate the system performances also in the high speed range, the driving torque is made to transmit through a speed increasing gear train. Along with the experiments, to predict and compare the ER damper effect, the rotor system is simulated as to its free and forced vibration characteristics. Such simulations are done by means of a finite element analysis code, which includes the mathematical model of the designed ER damper.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

하지 절단자 보행의 운동역학적 분석

임규찬,박윤서,배성제,정철수,신인식,김복영 師範大學 體育硏究所 1994 서울大學校 體育硏究所論集 Vol.15 No.2

This study was conducted to investigate the biomechanical characteristics of the gait pattern in an amputee for the purpose of improving the proper gait posture and designing the prosthetic. The subjects were six males amputees and one normal person. The ground reaction force was measured using AMTI force platform. The conclusions were as follows; 1. In case of amputee group, the ground reaction force was revealed in specific figure according to position in which they used the prosthetic, whereas in case of normal person the ground reaction force was revealed in the figure of two humps in regard of vertical axis. 2. In case of amputee group, the ground reaction force in time between fight foot contact and left foot contact was deviated from a figure of rectangle, whereas in case of normal person the ground reaction force was revealed in the figure of rectangle. 3. In case of amputee group, the ground reaction force referred to both feet angle point of view was revealed in irregular figure, whereas in case of normal person the ground reaction force was revealed about 47。