http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
비인강암에서 Glutathione S-Transferase-pi와 Multidrug Resistance-Associated Protein 발현의 예후인자적 의의
임상철,조재식,김승현,김판수,김창국,윤제환 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.8
Background and Objectives:For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. ment modality with chemotherapy is applied, although resistance to chemotherapy makes chemotherapy les effective. The Cisplatin-based chemotherapy has been widely used in the field of nasopharyngeal cancer. The Cisplatin resistance is known to be caused by the multidrug resistance-asociated protein (MRP), which is one of the drug-export pumps and the glutathione S-transferase (GST)-pi which catalyzes the conjugation of the GSH (glutathione) and the cisplatin. The aim of this study is Subjects and Method:We analyzed tumor tissues from 49 cases of parafin block specimens which were diagnosed with NPC and treated at Chonnam National University Hospital. The imunohistochemical study for the GST-pi and the MRP was perfor-med with parafin block specimens of nasopharyngeal cancers. Results:In the GST-pi, the relationship betwen the early stage (64.3%) and the advanced stage (91.4%) was statistically significant (p=0.020). The expresion of the GST-pi and the MRP had no relationship with the clinical factor, the response to chemotherpy and the survival rate. Conclusion:Because the expresion of the GST-pi and the MRP in the nasopharyngeal carcinoma could not predict the response to chemotherapy. So the efforts to find the predictive value of the chemotherapy are needed. (Korean J Otolaryngol 2002;45:791-5)
비인강암에서 방사선치료와 항암화학요법의 병행요법의 예후인자로서의 의의 및 치료성적
임상철,조재식,조연,김판수,이준규,서덕중 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.9
Background and Objectives:The diagnosis of a nasopharyngeal carcinoma is frequently made at an advanced stage. The anatomic complexicity of the nasopharynx makes a surgical approach difficult, so the radiation therapy is traditionally used as a primary option. Because of the high incidence of a locoregional failure folowing the radiotherapy and the distant metastasis, the combined treatment modality with the chemotherapy has been applied. The author attempted to investigate the clinical characteristics and the treatment outcomes of nasopharyngeal cancer patients treated with the combination of the radiotherapy and the chemotherapy. Subjects and Method:We retrospectively analyzed 82 patients who were diagnosed with the naso-pharyngeal carcinoma in Chonnam National University Hospital. Results:The cumulative survival rates for a 5-year period were 42%. The pathologic type, the clinical stage, the cranial nerve invasion, and the response to the radiotherapy were related to the survival rate of the Kaplan-Meier test (p<0.05). In the Cox proportional hazard model, only the response to radiotherapy was related to the survival rate (p=0.05), as the clinical stage wasnt (p=0.06). In the multivariate analysis betwen the responses to radiation and the clinical factor, the histological type (p=0.018) and the response to the chemotherapy (p=0.021) was statisticaly significant. Conclusion:The response to radiation is the most important in the patients survival. The cli-nical stage is a probable prognostic factor. Factors affecting the response to radiation are the histological type and the response to chemotherapy. (Korean J Otolaryngol 2002;45:897-901))
Laryngopharyngoscope를 이용한 후두개곡낭종의 치료
임상철,조재식 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.2
Cystic lesion which is located in vallecular area is sometimes symptomatic and need surgey. But surgical route to this area is divided external approach into internal one. Internal approach via transoral route with suspension laryngoscope can avoid disadvantages of external approach but conventional laryngoscope is not suitable for this type of procedure. We used Steiner laryngopha-ryngoscope in surgery for vallecular cyst and we could excise cyst easily. Of 20 cases, complete excision was tried in 18 cases and marsupialization in 2 cases. Recurrence was 1 case. We suggest that surgery using laryngopharyngoscope is effective in treating cyst which is located in vallecular area.
임상철,박호영,최정섭 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.2
Cystic lesions of the neck are frequently encountered on clinical basis. The usual differential diagnosis includes branchial cleft, cystic hygroma, dermoid cyst, tuberculous lymphadenitis, benign detached goiterous thyroid cyst, and Cavitation epidermoid carcinoma. Most of cysts are benign and malignant cysts are rare. The most common form of cystic malignancy in the lateral neck is cystic degeneration of epidermoid carcinoma metastatic to cervical lymph nodes. Cystic neoplasia may result from malingnant changes occurring within the wall of a previously benign cyst Complete head and neck examination on the primary focus is important Especially, when palpation of thyroid is negative, thyroid carcinoma is easily overlooked. Recently, we experienced papillary carcinoma of the thyroid seen as lateral neck cyst. So we report this case with review of literatures.
술전색전술과 경상악법을 이용한 비인강 혈관섬유종의 치료
임상철 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.1
Nasopharyngeal angiofibroma is rare highly vascular tumor and occurs almost exclusively in adolescent boy. This tumor is histologically benign but clinically malignant because of massive bleeding, destruction of surrounding tissue, difficulty in surgical access and recurrence. Preoperative embolization is required to decrease bleeding during operation Surgical method varies according to staging of angiofibroma. Recently, we had experienced a case of angiofibroma that was resected by transmaxillary approach after preoperative embolization.
임상철,조재식 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.2
Most of bronchial foreign bodies can be removed by ventilation bronchoscopy through transoral route but sometimes, ventilation bronchoscopy through tracheostomy is helpful procedure. Recently, we have experienced a case of bronchial foreign body which could be easily removed by nasal endoscopy and Blakesley forcep instead of bronchoscopy. So we report this case with a review of literatures.
임상철,장일권,임성철,박경옥 대한기관식도과학회 1998 大韓氣管食道科學會誌 Vol.4 No.1
Relapsing polychondritis is a rare disesase involving any cartilaginous structure of entire body and is characterized by recurrent episode of inflammation and degeneration of cartilage and most commonly involve ear, nose, larynx, trachea, ribs, Eustachian tube, etc. Its signs and symptoms are recurrent swelling of auricle, saddle nose deformity, polyarthralgia, hoarseness and dyspnea, audiovestibular disturbance and cardiovascular abnormality, etc. Characteristic histologic findings are loss of normal basophilic staining of cartilage, perichondrial inflammatory infiltration with plamsa cells, lymphocytes and neutrophils, and finality, destruction of cartilage and replacement with scar tissue. Our case had saddle nose deformity, arthralgia, tracheal collapse, hearig loss and positive histologic finding but no auricular perichnodritis. Her major problem was airway. obstruction due to tracheal collapse. This case was diagnosed with relapsing polychondritis according to the Damiani's criteria. This case indicates that any patients complaining of airway obstruction have to be examined systemically.