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        도남용 中央醫學社 1988 中央醫學 Vol.53 No.10

        The author has recently experienced a case of two salivary stones in the submandibular gland on the right side. A 35 year old man visited the department of Otolaryngology Chosun University, on 4 August 1988 with complaints of walnut sized,"tender swelling on the right submandibular region and mastication difficulty. These symptoms have been graudally developed and aggrevated for past 2 years. Physical examination was not revealed fistula or inflammation on the posterior portion of the right side mouth floor. Plain A-P and right lateral mandibular X-ray views and sialography revealed a large, oval shaped radio-opaque density on the right submandibular region. Through an external approach under the general anesthesia, extirpation of the gland with stone removal was done. The removed two stones were contact with each other. Two stones were 1.5 x 1.5 x 1 cm. and 1 x 1 x 1 cm. in each size, 4.0 gm in weight, grayish-white in color, and the chemical composition of the stones were principally calcium phosphate. The extirpated gland was 3 x 2 x 2 cm in size and revealed chronic sialoadenitis on biopsy.

      • KCI등재

        후두에 발생한 평활근육종 1예

        도남용,임태승,이준한 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.12

        Leiomyosarcoma is a malignant tumor that originates in the smoth muscle tisues and represents 5- 10% of al soft-tissue Leiomyosarcomas of the larynx are extremely rare. Recently, we experienced a case of leiomyosarcoma of the larynx in a 82-year-old man who was considered initially to have as a benign tumor. Therefore we report a case of leiomyosarcoma of the larynx with a review of literature.

      • KCI등재

        비두부형 모균증의 임상적 고찰

        도남용,이준한,동근우 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.10

        Background and Objectives:Rhinocerebral mucormycosis is recognized as a potentially aggressive and commonly fatal fungal infection. The classic presentation involves nasal mucosa and the invasion of the paranasal sinuses and orbit. Treatment includes aggressive debridement, systemic antifungal therapy, and control of underlying comorbid factors. This study aimed to investigate the clinical feature of rhinocerebral mucormycosis and to determine relationships among the underlying disease, extent of mucormycosis, initial time of surgical intervention and prognosis. Subjects and Method:Five cases of mucormycosis were retrospectively reviewed. Prognosis was analyzed according to predisposing factors including the underlying disease, extent of disease and intial time of surgical intervention. Resuits:A 5-year overall survival rate of the patients with mucormycosis was 60%. There was significant survival gain in the group for which the underlying disease was well controlled and extent of disease was limited, No significant difference in survival was observed according to duration between symptom onset and surgical intervention. Conclusion:Survival is usually determined at the very early period of treatment. The most important prognostic factor is optimal control of the underlying disease and extent of disease.

      • KCI등재

        선양낭성암종에서 발생한 역분화 암종 1예

        도남용,임태승,박성용 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.6

        Adenoid cystic carcinoma of the salivary gland is an indolent tumor with an unfavorable long-term prognosis. Dediferentiation ly, the low-grade adenoid cystic carcinoma merge gradually into an extensive dediferentiated component composed of solid sheets and cords of anaplastic tumor cels with focal gland formation. We experienced dediferentiation in adenoid cystic carcinoma of the submandibular gland and report it with a review of the literature and immunohistochemical workup to elucidate the likely mechanism of dediferentiation.

      • 후두 및 하인두암에서 표피성장인자 수용체(EGFR)의 발현에 관한 연구

        도남용,노용훈,임태승,박영균,나한조,최봉남,전호종 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2

        The prognostic significance of the squamous cell carcinomas of the larynx and the hypopharynx have been evaluated to identify those features associated with aggressive biologic behavior according to the immunologic and histologic characteristics. For determining prognostic indicators, the authors performed immunohistochemical staining of epidermal growth factor receptor(EGFR) in 32 cases of squamous cell carcinomas of the larynx and the hypopharynx. The results were obtained as follows '. 1) The positive rate of EGFR expression was 96.6% and rate of EGFR overexpression was 50%. 2) There was no significant statistical correlation between EGFR expression and clinicopahtological parameters such as primary sites of tumor, primary tumor stage, nodal stage, distant metastasis, clinical staging and histopathological grade.

      • KCI등재

        후두 편평세포병변에서 CD44v3의 발현 의의

        도남용,조성일,이준한,임태승,최성준,임성철 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.3

        Background and Objectives:It is known that a part of laryngeal premalignant lesions progresses to an invasive carcinoma. Despite many previous reports, conventional histology is not sufficient to predict such tumor progression. Herein, the authors investigated the role of CD44v3 as a biomarker in predicting the progression of laryngeal premalignant lesion to an inavasive cancer. Subjects and Method:Paraffin-embedded tissue specimens from 40 patients were diagnosed accordingly as laryngeal invasive squamous cell carcinoma (n=10), Carcinoma in situ (n=10), dysplasia (n=10), and hyperkeratosis (n=10) between 1993 and 2002. They were immunohistochemically stained for CD44v3 protein. Results:In invasive squamous cell carcinoma, the expression of CD44v3 was diffused and gave a strong positive stain, and in carcinoma in situ, it was diffused and gave 3+-2+ stain. However, in dysplasia and hyperkeratosis, the proportion of CD44v3 expression was decreased by 2+-1+, and 1+ -0, respectively. Conclusion:These results suggest that the expression of CD44v3 in laryngeal premalignant and malignant lesions can be associated with tumorigenesis and invasion. Those strong positive expressions of CD44v3 may represent more aggressive pathology of the larynx. (Korean J Otolaryngol 2005;48:357-61)

      • KCI등재

        비강 및 부비동 종양에서 Cyclooxygenase-2 및 Matrix Metalloproteinases의 발현

        도남용,박성용,임태승,김종희,최성준,김성렬,임성철 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.4

        Background and Objectives:The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis by mediating the degradation of extracellular matrix components. Cyclooxygenase-2 (COX-2) plays an important role in promotion of carcinogenesis, tumor invasiveness and angiogenesis. Recently, some investigators have reported that may play a significant role in the invasive phenotype of malignant tumors. In the present study, the authors investigated the corelation between expressions of COX-2 and MMPs. Materials and Method:Imunohistochemical staining of MMP-2, -3 and -9, and COX-2 were performed on parafin-embedded tissue sections of 51 nasal cavity and paranasal sinuses tumors (27 inverted papillomas, 5 inverted papillomas with malignant transformation, and 19 squamous cell carcinomas). Co-expresion of these MMPs and COX-2 was visualized with confocal laser scanning microscope. Results:MMP-2, -3 and -9 were found were detected with significance. Conclusion:These results suggest a potentially important role for COX-2 in the regulation of MMPs, malignant transformation, and progresion of squamous cell carcinoma, and it points out the potential use of COX-2 in-hibitors, in the prevention and treatment of squamous cell carcinoma of nasal cavity and paranasal sinuses.

      • KCI등재

        제 4새성 낭종 1예

        도남용,박성용,최종선,박준희 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.3

        The fourth branchial pouch sinus is a developmental anomaly which most freqently manifests itself by recurrent episodes of neck abscess or acute suppurative thyroiditis. The most common developmental anomalies of the branchial apparatus are second cleft remnant, which constitute almost 95% of all anomalies. The remaining 5% are comprised almost exclusively of first and third arch remnants. So the fourth arch remnants are exceedingly rare. A high index of suspicion, combined with barium swallow pharyngogram and computed tomography scan can aid in diagnosis. Complete excision of the entire epithelial tract combined with ipsilateral thyroid lobectomy remains the mainstay of treatment. Authors experienced a case of lateral neck mass which was pathologically presumed to be the fourth branchial pouch sinus. We report this case with the related literature. (Korean J Otolaryngol 2003;46:246-9)

      • KCI등재
      • KCI등재

        상악동에 발생한 염증성 근섬유아세포성 종양 1예

        도남용,이준한,김성렬 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.3

        Inflamatory myofibroblastic tumor (inflammatory pseudotumor) is a term used to describe the space occupying the neoplastic the maxillary inflamatory myofibroblastic tumor is unknown. The diagnosis must be based on histological evidence to exclude other disease. We report a case of a 72-year-old patient with maxillary and nasal cavity inflamatory myofibroblastic tumor that simu-lated an invasive neoplasm in its clinical presentation, Radiologic findings showed near total coagulation necrosis histopatholo-gically.

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