정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

부인두강 종물로 발현된 갑상선 유두상암종

우정수,김용환,정관윤,최건,최종욱 한국의학사 1996 診斷과治療 Vol.16 No.3

임대아파트 장기수선 대체안 검토를 위한 CAFM 시스템 개발

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

In the case of rental apartment. the special Quality continuously preservation administration business consist and saves up Long-term Maintenance expense voluntarily. Because business surrounding that this can control preservation administration business whole is possible. administration of repair work is easy. Do system development that introduce technique for long-term strategy establishment in CAFM by purpose. Estimation of system to develop is as following: Can reduce time that take in LCC calculation because approach automatically to information of necessary facility in LCC calculation and know repair time as is easy. It is possible that execute selection of item that is examined in long-term maintenance plan as efficient and correct. Priority injection of budget by facility deteriorated degree is consisted preferentially using FCI.

老人의 園藝活動參與에 따른 餘暇 및 生活滿足度의 關係

정재은,이광우,심우경 한국식물인간환경학회 2001 인간식물환경학회지 Vol.4 No.1

This study was designed to probe the relation between participation in horticultural for all activities and leisure and life satisfaction of the older adults. A total of 388 older adults over the age of 60 were included as subjects of the study, The subjects of this study were divided by two groups: 250 participants in horticultural activities and 138 non-participants. The data collected from the questionnaires designed for this study were consisted of responses to items constructed to represent each variable. For data analysis, t-test, anova, frequency and answer tree were used. The major findings resulted from this study were as following; First, it found that participants in horticultural activities of the older adults showed greater leisure satisfaction than non-participants. Second, the longer than 20 years in participating horticultural activities and attending the least 30 minutes horticultural activities a day, the higher leisure satisfaction. Third, participants in horticultural activities of the older adults showed greater life satisfaction than non-participants. Fourth, the attending time of horticultural activities a day and duration of participation in horticultural activities do not effect the life satisfaction. Fifth, there existed significant relation among daily participation in horticultural activities of the older adults, leisure satisfaction and life satisfaction. It was also found that participation in horticultural activities of the older adults facilitated the leisure satisfaction, it finally leaded to the life satisfaction.

韓國에서 中國學의 現況과 그 方向

鄭雨光 中國語文硏究會 2001 中國語文論叢 Vol.21 No.-

自韓中理交以來.在輪國撚越了一"中國熱." 各大學紛紛設立中國學系.原有的中文系部新設立的中國學系需要重新親定巳們的範疇. 本論文所提及的中文系和中國學系之間存在不少酪適.我們可以參考美國的中丈系部中國學系之間的互撚及其硏究, 範圍和成果.桑新考庶韓國領撚.參照美國的繼驗.根據韓國約國情.本論文從出一奈適合於韓國的烈湖學和舊漑脚脚的具體方向.

《漢園集》에 나타난 李廣田의 詩

鄭雨光 中國語文硏究會 1999 中國語文論叢 Vol.16 No.-

공공대응성과 주민참여에 관한 연구

정우열,이광수 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

The purpose of this study is to public responsiveness and citizens. The major meaning of this paper are sa follow: First, this study indicates that conception, general relation of public responsiveness and citizens partication. Second, research that interrelation of public responsiveness as typologic of citizations participation, study of mutual appropriateness relation by both groups. Finally, importance of this paper will contribute to the theory framework for emprical research.

임대아파트 유지관리를 위한 성장형 데이터베이스 모델에 관한 연구

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In making social sympathy about the drafting of a mid-long term of maintenance plan and the development of building maintenance database for technique support, the target of this study is rental apartments admitting a variety of objects to data model in maintenance. For the development of database in maintenance, it shows that the database model is possible for the references of AS-IS modeling and function model and continuous work analysis by function and process analysis. Also, the structure of model at this study will be applied in maintenance as well as construction needed the development of database. To get continuous growth in maintenance information, it has been necessary to take a standard of information in plan, design, construction, and management. After this, it would be required to develop the South Korea-type FMS(Facilities Management Classes) based on IFC(Industry Foundation Classes)

자치경찰제 모형개발을 위한 시도

정우열,이광수 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

Recognizing that the korean governments very important the necessary of autonomy police systems, this paper attempt to design the appropriate model development of autonomy police systems. First, it explores logical criteria which are applicable to the redistribution of authority to police. Second, it analyzed how the efforts to autonomy police systems have been exerted in 1990s and why these efforts have not achieved results. Based upon the analysis, this paper attempts to mutual cooperation and interactions between the central and local police, the enlargement of the citizen participations, the setting of the local police council, the coordination of the local tax and a raise of tax local shared tax.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5