지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Sulforaphane protects against acetaminophen-induced hepatotoxicity

Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Kim, Kyoung-Shim,Oh, Won-Keun,Lee, Chul-Ho Elsevier 2015 Food and chemical toxicology Vol.80 No.-

<P><B>Abstract</B></P> <P>Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity <I>in vitro</I> and <I>in vivo</I>. Pretreatment of primary hepatocyte with SFN induced nuclear factor E2-factor related factor (Nrf2) target gene expression, especially HO-1 mRNA and protein expression, and suppressed APAP-induced glutathione (GSH) depletion and lipid peroxidation, which eventually leads to hepatocyte cell death. A comparable effect was observed in mice treated with APAP. Mice were treated with 300 mg/kg APAP 30 min after SFN (5 mg/kg) administration and were then sacrificed after 6 h. APAP alone caused severe liver injuries as characterized by increased plasma AST and ALT levels, GSH depletion, apoptosis, and 4-hydroxynonenal (4-HNE) formations. This APAP-induced liver damage was significantly attenuated by pretreatment with SFN. Furthermore, while hepatic reactive oxygen species (ROS) levels were increased by APAP exposure, pretreatment with SFN completely blocked ROS formation. These results suggest that SFN plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. SFN has preventive action in oxidative stress-mediated liver injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SFN pretreatment increases the cell viability against APAP-induced toxicity. </LI> <LI> SFN pretreatment protects depletion of cellular GSH after APAP treatment. </LI> <LI> SFN pretreatment enhances Nrf2 target gene expression, especially HO-1 after APAP treatment. </LI> <LI> SFN has protective effect against APAP overdose-induced liver injury <I>in vivo</I> model as well. </LI> </UL> </P>

영화 대 영화' 형(型) 방송 프로그램에 대한 미디어 서사교육적 연구 : KBS의 「배칠수의 종횡무진」 분석을 중심으로

김근호 한국문학교육학회 2005 문학교육학 Vol.16 No.-

This paper aims to explore theories of media narrative education and suggest the method of educational activity centered on productive narrative culture. Nowadays media education is very important in Korean education, so the study of it is fiercely processed. But the educational content is insufficient. To work out this problem, I give attention to a narrative activity through movie, and investigate the mechanism of it. Nowadays we have the three major Korean broadcasting station. They are KBS, MBC, and SBS. All of them have the program of introducing movies on weekend. Especially, they have the `Movie vs Movie'. `Movie vs Movie' is very interesting to television audience. This corner has the same narrative format. It has four principles as follows. First, a rivalry game format. Second, a interpretative discourse centered on intertextuality. Third, a simultaneity of telling and showing in narrative. Last, a combination of narrative and criticism. These narrative systems are due to new media technology. So Korean education should have the content of media narrative activity. I think it has three levels and methods. First, the investigation of story between two movies. Second, the comparison of structural peculiarities between two narrative texts. Last, the storytelling based on the combination of interpretation and criticism about two movies. This educational activity integrates critical and creative media literacy, and activates productive narrative culture.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

급성 심근 경색증과 혈장 Paraoxonase activity와의 관계

김건영,윤상준,박근호,조영신,장성종,장경식,홍순표 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

연구배경: 혈장 파라옥소나제의 감소는 HDL-cholesterol의 항 산화작용의 중요한 요소로 알려져 있어 이의 감소는 항산화작용의 저하로 인해 동맥경화의 진행을 촉진시킬 수 있어 허혈성심장병의 주요 위험인자로 추정하고 있다. 본 연구에서는 급성 심근 경색증 환자를 대상으로 혈장 파라옥소나제의 활성도를 측정하여 정상군과 비교하여 혈장 파라옥소나제 활성도의 감소가 급성 심근 경색증의 위험인자인지 알아보고자 하였다. 대상 및 방법: 급성 심근 경색증으로 입원한 39 명의 환자(남자 : 여자 = 19 : 20, 평균나이: 61±4.3세)와 정상 대조군 36명(남자 : 여자 = 17 : 19, 평균나이: 55±10세)을 대상으로 정맥혈을 채혈 후 파라옥소나제 활성도와 LDL-cholesterol, total cholesterol, HDL-cholesterol를 측정하였다. 두 군간의 비교는 Student T-test를 이용하였다. 결과: 건강 대조군과 급성 심근 경색 환자군 간에 측정치를 비교해본 결과 혈장 콜레스테롤 수치는 182.10± 12mg/dl, 194.87± 40mg/dl이고 HDL 콜레스테롤은 54±5.4mg/dl, 37.52± 13mg/dl 였다. LDL 콜레스테롤은 94.45±13mg/d1, 122±34mg/d1로 급성 심근 경색증 환자의 경우 통계학적으로 의미있는 차이를 보였다. (P<0.05). 그러나 혈장 파라옥소나제 활성도는 건강 대조군 112.35±15U/ml, 급성심근 경색증 환자군 96.10±43.50U/ml로 급성 심근 경색증 환자군이 건강 대조군에 비해 낮은 수치를 보이는 경향이 있었으나 통계학적으로 유의한 차이(P=0.071)는 보이지 않았다(Table 2참조). Background : Human plasma paraoxonase is a HDL-associated ester hydrolase that catalyzes the hydrolysis of organophosphates, aromatic carboxylic acid esters and carbamates. HDL has been implicated in the prevention of LDL lipid peroxidation. Low paraoxonase activity in the Plasma may have responsibility to the development of coronary artery disease partially because oxidized LDL has intimate relationship with atherosclerosis. We studied plasma paraoxonase activities in the plasma of acute myocardial infarction patients in order to evaluate the relationship between these enzyme activities and the acute myocardial infarction. Materials and Methods : plasma samples were obtained from 39 individuals with acute myocardial infarction(M: 19 cases, F: 20cases, mean age: 61(4.3 years) and 36 individuals of healthy control(M: 17 cases, F: 19cases, mean age: 55(10 years). We determined paraoxonase activities, total cholesterol, LDL-cholesterol &DL-cholesterol levels in the plasma samples. Paraoxonase activities were measured spectrophoto metrically in 0.1M Tris-HCl buffer (pH=7.4) at 25℃ with paraoxon as substrate(5.5mM) at 405 nm. We used student T-test to compare the results of both groups. Results : Comparison of the results between myocardial infarction patients and normal control groups revealed that plasma total cholesterol, HDL-cholesterol and LDL-cholesterol levels showed statistically significant differences between groups but plasma paraoxonase activity does not. Conclusion : Our study showed that there was no significant difference of plasma paraoxonase activity between acute myocardial infarction and normal population. So low plasma paraoxonase activity may not be a risk factor of acute myocardial infarction. but further prospective large scale study will be needed to conclude.

21세기의 정보통신 콘텐츠와 문화

김호근 국제기독교언어문화연구원 1998 기독교언어문화논집 Vol.2 No.-

Ho Keun Kim, 1998. 21 ST Century Information Communication Contents and Culture. Collected papers on Christian Language Culture. We are living in the information society. Nowadays one of our urgent demands is how we can communicate abundant information farther and faster. The way of success for everybody is to understand the advancements in science and technology and apply them for practical use. The 21st Century will demand an information society in which the product. treatment and distribution of information becomes the nucleus of economic activity. We must recognize that high-speed information communication is more important than value added material or energy. But to make practical use of such information. we need multimedia devices that can handle a variety of information and make it convenient to use. The development of digital technology and various media fields are now unifying and creating new industries leading to this multimedia revolution. As these global networks develop, our domain of thinking and living is not only becoming globalized, but also our daily lives are moving toward cyber space. Such changing patterns are predicting great changes in our lives. This is why Korea is not only exporting goods but also software. In this way, Korea is exporting its culture to a global and cyber world. This globally emerging 'Super Culture' which is superior to the existing one, is a kind of 'Cyber Super culture' that is rapidly creating a language of its own and values based on ultramodern science and a technologically driven flow of information.

벼 大單位 增産團地栽培에 關한 經營實態調査 : 慶南地方의 5個 團地를 中心으로

金厚根,金正敎,尹泰圭,河湖成,張權烈 慶尙大學校 1975 論文集 Vol.14 No.-

Recently large scale cooperative rice production system has been promoted. This cooperative rice production system is intended to promote introducing a set of new technology which may not be suitable for individual small scale farms to adopt. And this system is believed to be one of important public programs to achieve productivity growth policy goal in Korea. Nevertheless, there seem to exist several problems for this public program to widely introduce to over-all nation. This is one of main objectives that this study intends to investigate. In order to study comparative characteristics of the large scale rice cooperative farm in terms of resource base and organization 99 farms which are member farms and 100 farms which are non-member individual farms have been selected and interviewed from five large scale cooperative farm areas in Gyeong-Nam Province in 1974. The important findings can be summarized as follows: 1) Most of operators af both classes belong to age cohert 40∼50, but the average educational level for member farm operators is higher than that for non-member. 2) The average scale Of rice paddy for member farms, 13.1 tanbO, is larger than that for non-member, 10.6, and the same thing is true for average size of rice paddy plots which is, respectively, 805 pyeong and 690. 3) Completely irrigated paddy for member farms is 99 percent of total paddy owned whereas that for non-member is 81, and consolidated paddy for member farms is 67 percent while that for non-member is 26.4. On the other hand, technically improved paddy other than indicated above for member farms is 32 percent, but that for non-member is only 8.3. 4) Number of rice varieties adopted is 9 for both classes. The most popular variety for member farm is Akibare(36%) whereas that for non-member is Sadominori(29.3%) and Akibare (28.4%). 5) Labor used is 13.5 man per tanbo for member farms and 12.4 for non-member. More labor is used for improving soil quality and protection for member farms whereas less labor is used for preparatory works such as seed bed, sterilization, and water management in the case of the member farm. 6) In the case of member farms, the type of work which is achieved cooperatively by more than 70 percent is purchasing or exchaging seeds, sterilization, and plant protection. Despite seed bad, water management, transplanting and the like being more or less suitable for cooperative work, the proportion of those works done cooperatively is relatively small as compared to what we expected. 7) According to farmers interviewed, variety selection, plant protection, seed bed, transplanting fertilization, water management, and harvesting works are more easier for cooperation, in order importance. 8) Cooperative farmers were cultivating a leading variety, Tongil, which showed higher yields than ordinary varieties and had a desire to be released a new high yielding variety which has a characteristics of highly resistance to dsease and insect. 9) Cooperative farmers were forced to begin the nusery bed earlier than the individual farmers and to emphasize on the disease and insect control with more frequencies. 10) Cooperative farmers had benefits in the seedling transplanting earlier and higher planting density than individual farmers. 11) Cooperative farmers had an intention to apply a deep fertilization method arid to dress heavier nitrogen with a reasonable ratio of the basal fertilization to the top dressing. 12) Cooperative farmers had a convenient irrigation system and were available to adopt a summer drainage method. 13) Cooperative farmers controlled the weed with agricultural chemicals arid recognized the control effect of weedcides. 14) In general, it was recognized that there happened somewhat benefit result in disease control in the cooperative farm while a reasonable control effect was not found in heavy prevailing case. The dominant diseases found in the cooperative farm were sheath bright, strip disease and they were to he prevented with a strong efforts. 15) Rice stem borer and grass leaf roller were effelctivey controlled in the cooperative farm, however, plant hoppers was not completely controlled by the usual method because of its unexpected prevalence. 16) The most difficult thing to cooperate they indicate is to supply an adequate amount of labor at appropriate time in tire labor peak season. In this sense, it seems necessary to introduce field machinary in order to achieve the objective of large scale cooperative rice production. 17) Farmers interviewed believe that technology concerning yield increase is most important. in this respect, it is important to develop such new technology, to diseminate its results and to train good quality extension workers. 18) 42 percent of member farm operators indicate that the cooperative system was successful and 25 percent indicate failed. 29 percent of non-member farmers think that the cooperative farm system was successful and 7 percent of them think failed. Thus 55 percent of non-member farmers indicate they are willing to join to the system in the next year, 7 percent of them are not and others have not decided yet. 19) 60 percent of member farmers think that the scale and number of members of the system were too much large to successfully cooperate and 67 percent of them believe that cooperation among members were not very developed, and 42 percent of members suppose what the leader of individual active farms were not very well functioning. 20) Number of member farmers who believe that the yield level in this year is increased as compared that before joining to the system is 3,4 percent, and no one indicated that the yield level is decreased. On the other hand, 22 percent of them believe that by participating to the system the same quality of paddy could produce more rice. 21) About 93 percent of member farmers believe that the system may not lie survived without support of government and i priority must be given to yield technology. 22) About 80 percent of member operators indicate that they would partioipate to the program in the next production year and 23 percent of them indicate that they would participate with the same amount of paddy land as this year. 23) The rice yield level for member and non-member farms is, respectively, 406kg and 346 per tanbo, and the former is 17.3 percent higher than the latter. 24) The cash expenses per tanbo for member and non-member farms is, respectively, 12,311 won and 10,398. 25) The gross revenud per tanbo for both classes is, respectively, 60,024 won, and 51,303 when evaluated by the official price level, and the net income is, respectively, 47,713 won and 40,905. As seen above, the fact that the rice yield level of member farmers, hence, the income level turns out to be higher seems to stem from two basic factors; that is, on the average, the member farmers are operating farm with an improved resource base and they seem to use more the so called conventional inputs with a better yield technology and management. Thus we may conclude that it is important to invest to improve resource quality, to innovate new yield technology and diseminate this innovation. At the same time, in order to more promote the cooperative system, it seems desirable to solve the following problem areas: 1) Number of member farms and paddy area covered by one cooperaitve unit seems better not to he very large. This seems so because there is on much scale economies owing to the nature of technology available to adopt, whereas a large member unit may restrict opportunity of individual members to deeply involve in the process of decision making. Thus we recommend to continue to study finding an optimum size of the unit. 2) As implied already, quality as well as quantity of extension workers and other local officers who lead this program area crucial factor to expand number of unit of the system and hence to achieve the objective of the program. 3) In order to get rid of labor deficit, especially in the labor peak season farm mechanization seems necessary. For this matter, it is worthwhile to promote, first of all, to invent suitable field machinery, secondly, land consolidation and other land improvement projects, and thirdly to innovate a new technology system suitable to mechanized farming. At any rate, it is also necessary for the government to supply an adequate amount of credit and other administrative support.

Dimethylphthalate 와 1,4-butanediol간의 에스테르 교환반응에 관한 연구

김난화,박근호 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

Transesterification reaction between dimethylphthalate and 1,4-butandiol was kinetically investigated in the presense of various metal acetate catalysts at 140-180℃. The reaction rates measured by the amount of distilled methanol from the reaction vessel. The transesterification reaction was carried out under the first order conditions respect to the concentration of reactants, respectively. The overall reaction order was 2nd. The linear relationship was shown between apparent rate constant and reciprocal absolute temperature. By the Arrhenius plot the activation energy have been calculated as 6.29 kcal/mole under lead acetate catalyst and also apparent rate constant, k' was found to obey first kinetics with respect to the concentration of catalyst. The maximum reaction rate was appeared at the range of 1.4 to 1.6 of electronegativity of metal ions.

날씨 마케팅 적용을 위한 기후 데이터의 군집 분석

김원태,이양구,류근호 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.2

최근 환경오염으로 인한 날씨의 변화, 자원 고갈에 따른 국제 유가의 상승 등 날씨 및 에너지 문제가 기업이나 국가 심지어 개인의 일상생활, 경제활동에 크나큰 영향을 미치고 있다. 이와 같은 이유로 대체에니지 중 태양 에너지 개발에 필요한 일사량 관리와 기후 데이터의 변화 특성 등을 근거로 지역성 규명에 관한 연구가 많이 이루어지고 있다. 그리나, 아직까지는 데이터 마이닝을 통한 지역적 특성에 따른 군집 및 체계적인 분석 데이터 검색 서비스가 효과적으로 제공되지 않고 있다. 이 논문에서는 국내에서 측정된 기후데이터를 저장 및 관리하기 위한 데이터를 모델링하고, κ-means 기법을 이용하여 국내 기후 데이터를 지역적 특성에 따라 군집함으로써 체계적인 데이터 정보를 제공한다. 그리고 이 정보를 날씨 마케팅에 적용될 수 있는 방법을 제시한다. 제안 시스템은 기업의 날씨 마케팅 연구 및 이에 영항을 미치는 요소와 분석 정보를 제공할 수 있는 기본 데이터베이스 구축에 유용하게 활용될 것이다. Recently, the weather is influenced by the environmental pollution and the oil price is rising because of the lack of resources. So, the weather and energy are influencing not only enterprise or nation, but also individual daily life and economic activity very much. Because of these reasons, there are so many researches about management of solar radiation needed to develope solar energy as alternative energy. And many researchers are also interested in identifying the area according to changing characteristics of climate data. However, so far, the researches have not been developed how to apply the cluster analysis, retrieval and analytical results according to the characteristics of the area through data mining. In this paper, we modeled the data for storing and managing the climate data tested in twenty cities in the domestic area. And we provided the information according to the characteristics of the area after clustering the domestic climate data, using κ-means clustering algorithm. And we suggest the way how to apply to the department store and amusement park as an applied weather marketing. The proposed system is useful for constructing the database about the weather marketing and for providing the elements and analysis information, influencing to the weather change.