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김찬형 대한방사선방어학회 2022 대한방사선방어학회 학술발표회 논문요약집 Vol.2022 No.04

강박장애

김찬형 약업신문사 1998 의약정보 Vol.1998 No.5

조기 및 후기 발병 강박장애 환자의 임상양상 및 경과

김찬형,천근아,구민성,남윤영,홍창형,이홍식 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.2

Objectives: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder with a bimodal pattern in age onset and treatment outcomes. This study attempted to ascertain the importance of the age factor for a better phenotypic precision. Therefore, the authors compared adult OCD patients with an early symptom onset to adult OCD patients with a later symptom onset. Methods: One hundred sixty five patients with OCD were evaluated with semistructured interviews; 79 with symptom onset before the age of 17 (early onset group) and 86 with symptom onset after the age of 18 (late onset group). The two groups were analyzed in terms of Y-BOCS (Yale-Brown Obsessive Compulsive Scale) scores and demographic data including clinical variables. Results: Early onset group has more comorbidity of tic disorder and lesser of depression and anxiety disorder than late onset group. Early onset group showed more family history of tic disorder than late onset group. The treatment response to SSRI is relatively declined after 18 months of initiation in early onset group. Conclusion: The results indicate that age at onset may be an important factor in subtyping OCD. Early onset group may have more biological and familial tendency that might be differentiate the two groups.

동방을 지배하라!

김찬형 한국철도학회 2016 철도저널 Vol.19 No.6

지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

신전에 의한 Glycogen synthase kinase-3β의 억제 및 허혈 내성 획득

김찬형,가호 충북대학교 의과대학 충북대학교 의학연구소 2005 忠北醫大學術誌 Vol.15 No.1

Purpose: It has been previously shown that inhibition of glycogen synthase kinase-β (GSK-3β) is protective and may play an important role in ischemic preconditioning. Therefore, we determined whether phosphorylation of GSK-3β through PI3K is also involved in stretch-induced cardioprotection (SIC). Furthermore, we determined if GSK inhibitors, lithium emulate SIC. Materials and Methods: The perfused hearts in langendorff mode were subjected to 30 min of global no-flow ischemia followed by 60 min of reperfusion. In the control group, end-diastolic pressure (LVEDP) was set at 3 mmHg. In the stretch group, LVEDP was increased to 40 mmHg for 5 min before 30 min of ischemia. Myocardial lactate contents were measured at the baseline and at the end of stretch. Results: Stretch preconditioning reduced infarct size compared with control (15.9 + 2.2 versus 39.1+3.0%, respectively: P<0.001). GSK-3β phosphorylation and PI3K-dependent protein kinase B (PKB) phosphorylation increased by mechanical stretch and completely blocked by wortmannin (a PI3K inhibitor). Hearts treated with lithium before ischemia, mimicked the protective effects of SIC. Furthermore, SIC was abrogated by wortmannin. Conclusion: These findings indicate that inhibition of GSK-3β plays an important role in SIC, and that this is regulated by the PI3K/PKB pathway. 연구목적: 최근 glycogen synthase kinase 3β (GSK-3β) 억제가 허혈 전처치의 또 다른 기전으로 보고 되었으며 또한, 심근에 신전을 미리 가하면 차후의 허혈애 대한 내성이 획득될수 있음이 알려져 있다. 이에 본 연구에서는 신전에 의한 허혈내성 획득에도 GSK-3β가 관여하는지 확인하고자 하였다. 대상 및 방법: 흰쥐 적출심장에 좌심실 이완기 압력을 40 mmHg로 높여 5분간 신전자극을 준 후 30분 허혈, 60 분 재관류를 실시하였다. 결과: 신전 전처치에 의해 protein kinase β (PKβ or Akt) 와 GSK-3β의 인산화가 증가 되었으며, 심근괴사가 현저히 억제되었다. 이 같은 신전 전처치의 효과는 Phosphatidylinositol 3-kinase (PI3K) 억제제인 wortmannin 처치에 의해 완전히 소실되었다. 또한 신전자극 대신 lithium을 전처리하여 GSK-3β의 활성을 직접 억제한 경우에도 심근 괴사가 감소되었다. 결론: 신전자극은 PI3K/PKβ 경로를 통하여 GSK-3β를 억제하여 심근의 허혈내성을 유도한다고 생각된다.

The Biological Treatment of Obsessive Compulsive Disorder

김찬형,구민성,Eun-Joo Kim 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.2

Obsessive-compulsive disorder (OCD) is a mental disorder characterized by obsession, in which intrusive thoughts or images that cause anxiety and stress are repeated, and by compulsion, in which behaviors aimed at reducing such anxiety are repeated. In this paper, drug treatment for OCD is described based on randomized controlled trials (RCTs) and open-label trials listed in PubMed (www.pubmed.gov; US National Library of Medicine, National Institutes of Health). In addition, we will summarize recent challenges in the treatment of obsessive-compulsive disorder.

대한신경정신의학회 연구학회의 발전방향

김찬형,전양환,김재진,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Recently, the Korean Neuropsychiatric Association (KCNP) has been expanded greatly in the number of members as well as the qualities in the area of practice and research. There are also 23 affiliated academic societies : Korean Academy of Psychotherapists, Korean Society for Analytical Psychology, the Korean Psychoanalytic Society, the Korean Association for Clinical Art, Korean Academy of Child & Adolescent Psychiatry, the Korean Association of Social Psychiatry, The Korean Society of Biological Therapies in Psychiatry, Korean College of Neuropsychopharmacology, the Korean Society of Biological Psychiatry, Society of Korean Women Psychiatrists, the Korean Society of Clinical Hypnosis, the Society for Human Sexuality, Korean Society of Sleep Research, the Korean Society for Psychopathology and Psychiatric Classification, Korean Academy of Psychiatry and the Law, Korean Psychosomatic Society, Korean Academy of Sleep Medicine, Korean Association for Geriatic Psychiatry, Korean Academy of Psychiatrists in Alcoholism & Addiction, Korean Academy of Adolescent Psychiatry, Korean Academy Schizophrenia, Korean Society for Depressive and Bipolar Disorders, and Korean Academy of Anxiety Disorders. To further encourage the progress of the KCNP affiliated academic societies, the KCNP planning committee has developed the proposed criteria for assessing the societies.

원자력 산업용 컴프턴 카메라 개념 설계

김찬형,서희,박진형,Andriy Ushakov,이주한,이춘식,이재성,최영완 대한방사선방어학회 2010 대한방사선방어학회 학술발표회 논문요약집 Vol.2010 No.11

상법상 실제운송인의 손해배상책임에 관한 비판적 고찰과 입법론

김찬형,KIM, Chan-Young 한국무역상무학회 2016 貿易商務硏究 Vol.69 No.-

Under the Korean legal system, as an actual carrier is not the contractual party to the contract for carriage of goods by sea, it has been tortiously liable for the damage to, or loss of cargo, should there be the negligence by its part. However, the Rotterdam Rules introduces a revolutionary liability regime for the actual carrier. According to the Rotterdam Rules, the liability of the actual carrier is same with that of a contractual carrier with the result that a shipper is entitled to bring the direct action to the actual carrier, as well as the contractual carrier on the same basis. Nevertheless, it is expected to take long time for the new approach in respect of actual carrier's liability to be confirmed by many countries, and furthermore most of shipping countries including Korea still adopt the Hague-Vis by Rules where the shipper is not allowed to bring the direct action to the actual carrier. This study reviews on whether or not the alteration of actual carrier's liability based on Rotterdam Rules would be reasonable, considering the current Korean legal system. Furthermore, this study, whilst recognizing that the overall introduction of the new liability regime is somewhat premature, suggests the imposition of contractual liability to the actual carrier from a long-term perspective. Having in mind that the article 809 of the Korean Commercial Act allows the shipper to bring the direct action to the shipowner only in the case that a time charterer is the contractual carrier, this study explores a method to apply the contractual liability to the actual carrier in the case that a slot charterer or freight forwarder is the contractual carrier, in order to establish the uniform liability system.