철도교통안전진단제도 발전방향 제시

정연욱(Yeun Wook Jung),이주영(Ju Young Lee),김영선(Young Sun Kim),노남진(Nam Jin Noh),이승열(Seung Yeoul Lee),송병호(Byung Ho Song) 한국철도학회 2015 한국철도학회 학술발표대회논문집 Vol.2015 No.10

철도실시설계단계에서 이용자 중심의 안전성을 강화하고자 교통안전법 및 교통안전진단 지침이 개정됨으로써 14 년 10 월 13 일 철도교통안전진단제도가 시행되었다. 이후 중앙선, 하남선 등 15 개 철도건설사업 실시설계에 대하여 철도교통안전진단이 시행되었고, 그 결과 이용자 및 열차운행측면에서의 안전위험요인이 도출 및 개선되었다. 본 연구에서는 철도교통안전진단제도가 보다 더 실효성 있게 시행될 수 있도록 진단대상 · 진단시기 등을 명확화 하였고, 진단항목 고도화를 위하여 기존 진단항목 보완 및 신규진단항목을 개발하였다. 이와 함께, 철도교통안전진단에 대한 평가제도 도입의 필요성 및 시행방안을 제시하였다. To enforce safety of passenger at enforcement design stage of rail, Railroad Traffic Safety Diagnosis is introduced at Oct 13, 2014 by revising Traffic Safety Act and Traffic Safety Diagnosis. Railroad Traffic Safety Diagnosis is implemented about enforcement design which is for 15 railroad construction like Jung-Ang Line and Ha-Nam Line, therefore, danger factors about safety are deducted and improved in respect of passenger and train operation. In this study, diagnosis object, diagnosis time and other article are clarified for effectiveness of the Safety Diagnosis and diagnosis articles are supplemented and developed for enhancement. In addition, necessity and execution plan of evaluation system are proposed.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

신장기증자들의 심리적 특성

정승아,김재환,강종명,이장한,김경욱 漢陽大學校 精神健康硏究 1998 精神健康硏究 Vol.17 No.-

DNA Microarray를 이용한 인유두종 바이러스(Human Papilloma Virus:HPV)의 진단

정운원,이승관,이창규,조경진,김성욱 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.1

Human papillomavirus(HPV) has been known as one of the important pathogenic agent in uterine cervical carcinoma. The molecular works such as PCR enable the detection of large number of HPV genotypes obtained from viginal swab. Many of the PCR-based methods for HPV detection involve an amplification step followed by any of a number of methods for distinguishing different HPV types. In this study, we adopted the DNA chip technology enabling a HPV type-specific differentiation both low-risk group(type-6, 11, 34, 40, 42, 43, and 44) and high-risk group(type-16, 18, 31, 33, 35, 39, 45, 51,52,54, 56, and 58). MY09/MY11 and GP5+/GP6+primers covered LI region are used in nested PCR to improve PCR amplification. HPV type-specific probes for DNA chip were modified with NH2-C6, followed by spotting on silylated slides, washing slides and hybridization with each PCR products. Of 163 DNA samples chosen randomly, 42 samples were negative, 8 ones for low-risk group of HPV and 96 ones for high-risk group of HPV. Especially, co-infections with various HPVs were shown in 17 samples. A recent study found that multiple HPV is a factor in persistent HPV infection, resulting in the development of cervical dysplasia. This result emphasized the necessity to detect multiple HPV infection. The application of DNA-chip to determinate specific HPV typing will be a stronger candidate than any other PCR-based methods. Furthermore, the sequencing data of the positive PCR products were shown no discrepancy with DNA chip results. This means that DNA chip is very useful tool for both HPV detection and typing.

부정교합이 성인 여자대학생의 자존감에 미치는 영향

정민호,허욱,백승학 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

Objective: The purpose of this study was to evaluate the effects of malocclusion on the self-esteem of female university students. Methods: The subjects were composed of 67 female university students who showed Class I molar relation, no missing or supernumerary teeth and has had no orthodontic treatment experience. Each subject was evaluated with Rosenberg's Self-esteem Scale to measure the level of self-esteem and also evaluated the degree of anterior crowding and lip protrusion through model analysis and cephalometric soft tissue profile analysis. Results: The results showed that a protrusive profile and crowding of upper anterior teeth had significant reducing effects on the level of self-esteem. The protrusion and crowding groups showed no significant differences in self-esteem between groups. Conclusions: Malocclusion had significant negative effects on the self-esteem of female university students. Further research to investigate the negative psychological influence of malocclusion and the education of lay people about this influence is necessary. 본 연구의 목적은 성장이 끝난 성인 여대생들에 있어 가장 흔한 부정교합의 하나인 전치부의 crowding과 입술주위 돌출감이 자존감(self-esteem)에 미치는 영향을 알아보는 것이다. 연구를 위하여 대학에 재학중인 여자대학생 67명을 대상으로 구강검진과 두부계측방사선 사진촬영, 모형계측을 실시하여 상악전치부의 치아배열과 입술의 돌출도를 평가하였다. 또한 Rosenberg의 자존감 평가 설문조사문항을 이용하여 이들의 자존감을 평가한 후 전치부의 치아배열, 입술주위 돌출도와 자존감 간에 어떠한 관계가 있는지 통계처리 하였다. 실험결과, 입술의 돌출을 가졌거나 전치부의 치아배열이 고르지 못한 학생들은 치아배열이 고르고 돌출되지 않은 안모를 가진 학생들에 비하여 유의하게 낮은 자존감을 보여주었다. 부정교합이 심리적으로 미치는 부정적 영향력에 관하여 더욱 체계적인 연구와 교육, 홍보가 필요하다고 생각한다.

정상과 만성염증성 활막배양세포에서 Corticotropin releasing hormone(CRH)이 cyclooxygenaase-1(COX-1)과 cyclooxygenase-2(COX-2) mRNA발현에 미치는 영향

정운원,이승관,이창규,조경진,김성욱,하주희,서장훈 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1

Corticotropin-releasing hormone(CRH) is a major regulator of the hypothalamic-pituitaryadrenal axis(HPA). In inflammatory stress, the cytokines TNF-, IL-6 stimulate the production of CRH, a 41 amino acids neuropeptide, in the hypothalamus. The release of CRH leads to pituitary production of adrenocorticotropic hormone, followed by glucocorticoid secretion by the adrenal cortex. Glucocorticoids suppress namy components of the inflammatory process. Recently, CRH and CRH receptor were reported to be located in the periphery such as Immune system and chronic inflammatory sites as rheumatoid arthritis (RA). Cyclooxygenase consisted of two isoforms, COX-1 and COX-2, converts arachdonate to prostaglandins(PGs) which are important mediators of inflammation. insymoviocyte in RA, it was described that COX-2 mRNA was markedly increased by inflammatory agents, PMA or IL-1 and COX-1 transcripts were not modulated. We examined the modulation of COX by immune CRH in cultured normal and rheumatoid synoviocytes. Our results were shown that COX-1 mRNA expression decreased with the each stimulation of PMA and IL-1 in normal synoviocyte. In RA synoviocyte, PMA and IL-1 were increased mRNA expression of COX-1. In simultaneous treatment with CRH, PMA group was decreased, but IL-1 group was increased mRNA expression of COX-1. COX-2 mRNA expression was slightly increased by the treatment with PMA and highly increased by IL-1. After CRH treatment, PMA and IL-1 addictively increased COX-2 mRNA expression. We think that these results are contributed to the influence of increased cANP by CRH on the promoter of COX-2 in normal and synoviocytes. Because many cytokines, neuropeptides, and signal transduction pathways are involved in chronic inflammation, the exact role of CRH on inflammation is not fully elucidated. To achieve this goal, further experiments are needed.

결핵균 동정을 위한 microplate colorimetric assay의 개발

정진욱,황승용 한양대학교 이학기술연구소 2003 이학기술연구지 Vol.6 No.-

Polystyrene(PS) microplate는 DNA hybridization 방법을 이용하여 미생물의여러 특정 염기서열들을 동시에 간단하게 검색할 수 ㅣㅇㅆ기 때문에 임상에서 많이 사용되고 있다. 본 연구에서는 결핵균 유전자에 같은 염기서열로 반복되는 direct repeat(DR) sequence region 사이에 위치한 서로 다른 염기서열들을 PS plate microplate를 사용하여 손쉽게 검색할 수 있는 방법을 개발하였다. 이들 DR sequence 사이의 유전자들은 서로 다른 염기배열로 이루어져 있으며 배열이 안정하기 때문에 이것을 이용한 결핵균의 동정이 가능하다. DR regiion을 통한 결핵균 동정을 위하여 DR region 사이에 존재하는 43종류의 염기서열들을 phosphorylated oligonucleotide로 제작하여 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide)와 1-methylimidazole을 매개체로 microplate와 공유결합시켰다. 결핵균의DR region을 이용하여 이들 사이의 유전자들을 PCR로 증폭한 수, 이 증폭산물들과 microplate에 결합되어 있는 oligonucleotide probe들과 hybridizaton하였다. PCR primer에는 biotin이 붙어있기 때문에 alkaline phosphatase가 붙어있는 streptavidin 을 발색반응 매개체로 사용하였다. 마지막으로alkaline phosphatase와 substrate의 발색반응을 이용하여 M.tuberculosis H37Rv 와 M. bovis BCG를 동정할 수 있다는 것을 확인하였다. Developing a fast method for detecting mutations is very important in diagnosis. Some mutations cause genetic disorders and often cause drug resistance in mycobacterium. Many different detection methods have been used to find mutations such as RFLP, sequencing and oligonucleotide dot blotting. However, most of them are not easy to detect many different mutaions simultaneously and are not easy to use. In order to overcome these problems, we have developed a simple micro well hybridization method for detecting mutations. This method has three main steps including oligonucleotide coating on to microwells as probes, PCR amplification of target DNA and colorimetirc detection after hybridization. In order to test this assay system, we have amplified direct sequence (DR) region of bacterium bovis BCG strain using biotinylated primer. Modified oligonucleotides which are complement to DR region were covalently immobilized onto microwells by 1-ethyl-3-(3-dimethylaminoprophyl) -carbodiimide and 1-methyl-imidazeole. Each set of oligonucleotides contains a normal oligonucleotide as a control and also has mutated oligonucleotides which have substitution, deletion and insertion. We have found that this microwell detection system is very reliable and fast method to detect multiple mutations. All of the mutated oligonucleotides did not hybridize to target DNA. As a matter of fact, this method can be made as a cheap and fast detection kit for multiple mutations .

베체트병에서 만성 기침으로 발현한 폐동맥류 1예

정승현,송주경,정성수,강성욱 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

저자들은 만성 기침이 있었으나 정확한 원인을 찾지 못한 채 보존적 치료만 받던 베체트병이 있는 37세 여자환자를 경험하였고 흉부 방사선사진과 흉부 전산화 단층 촬영으로 폐동맥류로 진단하고 고용량의 스테로이드로 치료하였고 이 과정에서 대량 객혈이 있었으나 보존적 치료로 호전된 베체트병 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pulmonary Artery Aneurysm Manifesting as Chronic cough in Behcet's disease Behcet's disease is a relapsing chronic inflammation disorder of unknown etiology. Although Behcet's disease has originally been described as a triad of recurrent oral aphthous ulceration, genital ulceration and uveitis, it is now recognized as a multisystem disease with vasculitis as the main pathological finding. Clinical manifestations additional to this triad include involvement of the skin, joints, large vessels, lung, gastrointestinal and genitourinary tracts, brain. We report a case of pulmonary artery aneurysm manifesting as chronic cough in Behcet's disease. She was a 47 year-old woman with Bechet's disease treated with prednisolone and colchicine. She had suffered from chronic cough for several years, but been treated only with antitussive agents. Chest CT revealed multifocal patchy consolidation in lung parenchym and aneurysmal dialatation of pulmonary artery. We diagnosed pulmonary aneurysm with CT finding as the cause of chronic cough.

미용사의 요통 경험에 영향을 미치는 요인

백승룡,남철현,배성욱,김성우,권현숙,이정옥,전연숙 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

The purpose of this study is to analyze and grasp the actual lumbaginous condition and relevant factors of 1,182 beauty artists of beauty shops in 5 metropolitan cities, small-to-medium cities, and fishing or agrarian villages for 3 months from June 20 to September 25, 2000 through questionnaires. 1) They showed 61.0 percents in her twenties, 66.4 percents of unmarried women from all the female objects, 70 percents in high school graduates as educational background, 52.4 percents in metropolitan city as service place, 25.4 percents in smoking rate, 71.6 percents in drinking rate, 48.1 percents in general bed as condition of bedroom, 17.9 percents in exercising rate, 53.6 percents in 'little eating', 39.6 percents in two or three centimeters of heel, and 89.5 percents in hair as beauty-related professional field. 2) The rate of lumgaginous experience of beauty artists was 83.5 percents. They showed higher rate of 91 percents in the thirties and forties, 92 percents of the married, 93.9 percents in junior college graduates, 97.2 percents in higher economic classes, 88.7 percents in smokers, 85 percents in general bed, 89.3 percents in sleeping on one's face, 85 percents in swimming, 92 percents in stretch, 86.7 percents in 56 to 60 kilograms of weight, 89.7 percents in group O blood, 90.5 percents in experienced women of abortion, 97 percents in heel over 8 centimeters, 58.3 percents in 'feel much fatigue', 93.6 percents in inconvenient chair of beauty shop, and 89.4 percents in a lack of recess than other group. 3) The more women who have been experienced in lumbago, the higher their social treatment(p<0.01), income(p<0.001), working time(p<0.05), job potentiality(p<0.05), inner affinity(p<0.05), and job satisfaction of environment(p<0.001) were. Women who suffered much stress related to job environment(p<0.001), client(p<0.01), and their duty(p<0.01) showed high rate of lumbaginous experience. 4) In degree of lumbago by characteristic, there was the significant difference in age over 50-years-old, unmarried women, college graduates, service of small-medium cities, higher economic classes, smokers or drinkers, hot-floored room, sleeping with ransack, stretch or swimming, group A blood, fat body, experience of abortion, 6 to 7 centimeters of heel, convenient chair of beauty shop, insufficient recess, lumbago continued for one to the three months in comparison of other group. 5) There were variables of posture such as to place materials under one foot(p<0.001), to lay arm on armrest and desk(p<0.001), to pull materials near body while lifting them (p<0.05), to sometimes use anodyne(p<0.01), not to lift also light materials(p<0.001), to be inconvenient in sleeping(p<0.001), to be absent at job for two or three days(p<0.01). The degree of depression(p<0.001), had the significant effect on the degree of lumbago(32.7%). The results are as follows : Beauty artists have faced upon dangerous job environment to cause lumbago. The more the industrial society will be developed, the more their burden of service will be increased. In addition, the occupational stress and posture of beauty artists who showed high job satisfaction and high economical level became major factors which have had an effect on their lumbago. In conclusion, it is desirable for beauty-related organizations and professionals to positively develop program of health education with much concern as well as to lessen stress of beauty artists through education of job posture and rightful life in order to prevent lumbago of those beaut.

환율결정이론에 대한 실증분석

홍승기,김정욱 동국대학교 경제경영연구원 무역연구부 1999 國際貿易硏究 Vol.23 No.2