인천지역 TDI 노출 작업자에서 직업성천식 유병율

김형렬,김철우,홍윤철,전형준,김치년,김현수,이지나,신주연,고동희,노재훈 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : TDI는 직업성천식을 일으키는 대표적인 물질로 알려져 있다. 과거 TDI에 노출된 작업자들의 천식 발생률을 5~6%가량 보고하였고, 국내에서도 2-20%에 이르는 유병율을 보고한바 있다. 작업환경이 많이 개선되고, 노출량이 감소된 최근에도 TDI에 의한 직업성천식에 대한 보고가 많이 이루어지고 있어, 이에 대한 적극적인 조사와 진단과정을 통해 유병율을 구하고 질병발생의 변화양상을 파악해 보고자 하였다. 방법 : 인천지역에서 특수건강진단을 수행하는 2개 기관의 TDI 노출 근로자 400여명 중, 사업장의 규모가 50인 이상이며 사업주가 연구진행을 허락한 사업장에서 근무하는 근로자 중 직접적으로 TDI에 노출되는 작업에 종사하는 근로자 170명을 연구대상으로 하였다. 이들에 대해 설문지와 산업의학의사의 면담을 통한 작업관련성 평가를 근거로 정밀대상자를 선정하고 이들에 대해 메타콜린 유발시험, TDI 유발시험 등을 수행하여 직업성천식을 확인하였다. 결과 : 설문조사 결과 11명이 직업과 관련하여 천식증상을 보이는 것으로 나타났고(6.9%), 이중 7명에서 메타콜린 유발검사 양성소견을 보였다. TDI에 의한 특이유발시험 결과 1명에서 양성반응이 나타나, 이 집단에서 TDI에 의한 직업성천식의 유병율은 0.58%였다. 결론 : 과거 국내연구에서 TDI에 의한 직업성천식의 유병율이 2~20%에 이르렀던 데 비해, 본 연구에서는 0.58%로 나타났다. 이는 국외 논문에서도 나타나는 경향으로 작업장 노출량 감소로 점차 발생률이 감소하는 양상을 보이고 있다. 그러나 이미 증상이 나타난 근로자들이 부서를 옮기거나, 직장을 그만둠으로 인해 그 유병율이 과소평가되었을 가능성도 있다고 판단된다. Objecdives: This study was carried out to estimate the prevalence of isocyanate-induced occupational asthma in toluene diisocyanate (TDI) exposed workers. Methods: We examined 170 workers who had been directly exposed to TDI through a medical questionnaire, physical examination, and pulmonary function test. Based on screening examination, workers with suspected occupational asthma were selected for further evaluation such as methacholine and TDI challenge tests. Results: Eleven (6.9%) among 170 workers complained of symptoms of occupational asthma. and 7 among these 11 symptomatic workers showed positive responses to the methacholine challenge test (4.1 %). One spray painter was confirmed as having the TDI induced occupational asthma following a positive response to TDI challenge test. Conclusions: The prevalence of TDI-induced asthma was at 0.58% was lower than that for former studies (2-20%). Improved workplace environment, lower level of TDI exposure compared to the past, and the healthy workers effect may have contributed to this low rate of asthma prevalence in workers with TDI exposure.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

만성 B형 간염환자에서 인터페론 치료 후 간 조직검사 소견의 변화와 Tumor Necrosis Factor의 임상적 의의

김홍수,윤동진,김은주,정일권,박상흠,이문호,김선주 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background: Interferon has been widely used in the treatment of chronic hepatitis B, but its effectiveness is debatable. The clinical indices as the loss of HBeAg, HBV DNA, and improvement of liver function are applicated to identify the effectiveness of interferon therapy, but the mechanism of hepatohistological change is not well known. We investigated the changes of histologic finding and plasma tumor necrosis factor(TNF) in the patients with chronic hepatitis B after treatment with interferon-alpha. Methods: 11 patients with chronic hepatitis B who had treated by interferon-alpha were enrolled for this study. Liver biopsy was done before and after treatment of interferon and plasma TNF was evaluated at the same time. A semiquantitative study using a histologic scoring system was applied on pre and post liver biopsy specimens and the changes of HBeAg and HBV DNA were also evaluated. Results: Among subjects, the response group, recurrence group, and non-response group based on serologic response with clearance of HbeAg were6, 3, and 2 patients, respectively. The changes of serum ALT level and HBV DNA titer on pre and post therapy decreased significantly in the response group. The change of mean plasma TNF level in the response group decreased insignificantly to 19.4 from 19.9. The histological improvements of grading and staging were shown 4 patients in the response group. Conclusions: Serologic response with clearance of HBeAg was associated with histolofical improvement. The loss of HBsAg in the serum was significant indicator of reduction in the amount of HBV core antigen and HBV surface antigen in the hepatocytes. Plasma TNF level was not associated with response of interferon-alpha therapy and histologic activity.

결장 직장암 환자에서 근치적 절제술 후 혈청 CEA치의 변화에 대한 임상적 의의

김영훈,배병노,김기환,한세환,김홍주,김영덕,김홍용 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.6

연령증가에 따른 혈압요소들의 좌심실비대 및 관동맥질환과의 관련성

박재석,박창규,박미영,박재형,김용현,나진오,신성희,서순용,홍순준,박성미,임홍의,김응주,서홍석,오동주,노영무 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

충주ㆍ중원지역 관광공예품 개발에 관한 연구

김홍대,주예경,곽태영,강재진 한국공예학회 1999 조형디자인연구 Vol.2 No.1

The objective of this project is to develop excellent tourist craftworks that can effectively represent characteristics of the local culture of Joongwon province. For the production of tourist souveniors with useful function, various shapes and popularity, four coworkers have designed and produced craftworks after researching individually in the area's tourist circumstances. Since long before Joongwon province has been a famous tourist place with its surrounding mountains, the Choongju Lake and the tourist industry of the area. To draw more tourists to this province, and to activate the local tourist industry, the development of excellent tourist crafts that can be gaining general currency is a very important job. Thus this study aims at recognizing the problems of tourist souveniors with low quality now having an extensive currency in general tourist area, and also at developing superior tourist craftworks with characteristics of tourism and the local culture. On the basis of motifs that have been various tastes and prices by adopting an effective method of production and material selection.

척추 수술시 자가혈액 수혈기를 이용한 자가수혈의 효과

김명호,유문집,유석주,박진영,정홍근,박희곤,문기혁 단국대학교 2000 論文集 Vol.35 No.-

Study Design : Spine fusion with fixation procedure is associated with substantial operative blood loss, which frequently necessitates transfusion. The authors evaluated the safety and efficacy of intraoperative autotransfusion using Cell Saver during spinal surgery. Summary of Literature Review : It has been reported that the contraindications to the use of intraoperative autologous transfusion are malignancy, infection, and gross wound contamination. Objectives : The purpose of this study was to evaluate the safety and efficacy of intraoperative autotransfusion using Cell Saver during spine surgery. Material and Methods : We retrospectively reviewed 62 patients who had operation for lumbosacral spinal stenosis and hypotensive anesthesia. Among them, Group Ⅰwhich received autotrans fusion using Cell Savers included 26 patients with fusion of 2 segments, and Group Ⅱ as control group included 13 patients. Group Ⅲ which received autotransfusion using Cell Savers included 17 patients with function of 3 segments, and Group Ⅳ as control group included 6 patients. We analyzed the amount of intraoperative blood salvage using a Cell Saver, the amount of total homologous transfusion amount, intraoperative blood loss, the amount of postoperative drainage amount and perioperative changes of hemoglobin, hematocrit and platelet count. Results : There was no statistical significance between Cell-Saver group and control group in amount of total homologous transfusion and intraoperative(except in 2 segment of fusion using cell saver: 86.5% increased) & postoperative blood loss(p>0.05). The circulatory balance(amount of intraoperative blood salvage using a Cell Saver plus amount of total homologous transfusion minus amount of total blood loss) was statistical significance between Cell-Saver group and Control group. The Cell-Saver group had positive balance and Control group had negative balance. There were no statistical differance in the evolusion of hemoglobin, hematoocrit and platelet count between Cell-Saver group and Control group(p>0.05). There was no transfusion reaction and thromboembolic disease in all group. Conclusion : In retrospective study, Cell Savers was safe and immediate availability in orthopedic surgery such as spinal surgery. It was effective methods for storing a sufficient volume of blood for spine surgery without affecting the patient's postoperative hemodynamic ststes, too. It was possible to operation without intraoperative homologous blood transfusion in 2 or 3 segment fusion. We may need further study.

잣나무림의 林冠構造 및 分光特性에 關한 硏究

朱榮特,金英彩,金洪律 경희대학교 부설 식량자원개발연구소 1996 硏究論文集 Vol.17 No.-

잣나무 인공림의 林冠構造의 분석과 분광특성, 엽록소 함량을 비교 조사하기 위하여 Standard Cosine Receptor(LI-COR-1800-11)와 Portable Spectroradiometer(LI-COR-1800-22), 比色計(UV-spectrophotometer)를 이용, 경기도 광주군 퇴촌면 소재 경희대학교 연습림에 시험조사구를 설치 측정 조사한 결과를 요약하면 다음 과 같다 1. 조사대상지의 林冠構造는 평균수고 11.03±0.10(m)에 대하여 平均 樹冠長은 6.69±0.67(m)로서 약 63.4%의 수관심도를 갖는 우수한 林冠溝造를 나타내었다. 2. 樹冠構造에 따른 光合成 效率을 알아보기 위한 分光特性에서 잣나무 잎의 연령별 光反射 係敎는 당년생 잎이 가장 높은 값(0.063~0.49)를 보였으며 대체로 엽령이 높아질수록 광반사계수는 낮아졌다. 3. 또한 엽령별로 측정된 光透過率에 있어서 透過係數는 당년생 잎이 가장 높은 값(0.003~0.139)을 보였으며, 1년생, 2년생, 3년생의 葉齡別 順으로 점차 잎의 노령화에 따른 감소경향을 보이고 있었다. 4. 이상의 光透過率과 反射率에 있어서 斜面 位置別로 채취한 잎에서 나타난 결과는 항상 태양광선을 많이 받는 임목의 상부에서 가장 높은 反射率(0.06~0.47)을 보였으며, 光透過率은 斜面 中部의 잎에서 그 값이 가장 높게(0.002~0.130) 나타났다. 5. 각 조사 대상목의 잎에 대한 전체적인 葉綠素의 含量은 1년생 잎에서 Chlorophyll a : 1.59㎎/g, Chlorophyll b : 0.54㎎/g 로 제일 높게 나타났으나, 葉綠素 構成比에 있어서는 Chlorophyll a/b : 3.51 로 당면생 잎이 가장 높은 측정치 를 보였는데, 연령이 낮을수록 이들 값은 감소하는 경향을 보였다. This study was carried out to examine the variation of chlorophyll contents and spectral properties in the needle of Pinus koraiensis. The sample needles were collected from Kyung Hee Univ. experimental forest located on kyunggi province by slope gradients with lower, middle and upper levels. Clorophyll contents and spectrum analysis was conducted on current year, 1 year old, 2 years old and 3 years old needles. The best condition of forest canopy structure of investigation area was approximately 63.4% of crown depth. This study also shows the following results on the photosynthesis effiency of crown structure : (1) The higest values of reflection coefficient was 0.063∼0.490 obtained from the needle of current year. (2) The highest tansmittance coefficient was 0.003∼0.139 from the needle of current year. (3) Reflexibillity at upper position of trees and the transmittance at the middle slope had the highest values(0.06-0.47 and 0.002∼0.130, respectively). (4) The chlorophyll content of the 1 year old needle had the highest values(chlorophyll a : 1.59㎎/g), but a rate of chlorophyll content of current year showed highest values(chlorophyll a/b : 3.51).

Monasucs anka의 적색조 생산 특성

김희구,박근태,손홍주 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.6

Monascus anka KFCC 4478의 적색소 생산력을 증가시키기 위하여 배지조성 및 배양조건에 대하여 검토하였다. 공시균주의 색소 생성력은 탄소원으로 glucose 4.0%, 유기질소원으로 peptone 3.0%, 무기질소원으로 NaNO_3 0.15%, 비타민 성분으로 thiamine-HCI 및 nicotinic acid 각 10㎍/l였으며, 배양온도 30℃, 초기 pH 7.0이었다. 특히 유기질소원과 무기질소원을 복합 처리함으로서 색소 생성력이 향상되었다. 결정된 색소생성 최적조건하에서 본 공시균주는 배양 5일만에 최대 균체 증식과 색소 생성력을 나타내었다. Optimal media and cultural conditions for the production of red pigment were established using Monascus anka KFCC 4478. The optimal temperature and initial pH for the production of red pigment were 30℃ and 7.0, respectively. Glucose turned out to be most suitable carbon source for red pigment production. Optimal glucose concentration was 3.0%. Addition combined of nitrogen sources of peptone and NaNO_3 induced good red pigment production. Thiamine-HCL and nicotinic acid were increased the production of red pigment. Under optimal conditions, maximum red pigment production and cell growth were observed after 5 days of incubation.