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이대성,이정현,박재선,김미향 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3
Aplastic anemia following acute hepatitis with or without acute hepatic failure is an uncommon and known to have a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 13 year-old boy. He had been admitted because of jaundice and lethargy for 2 weeks and clinical findings of acute fulminant hepatitis. Serum studies for antibodies and antigens related to hepatitis A, B, C viruses and cytomegalovirus, Ebstein-Barr virus, and, parvovirus B19 were negative. He had been recovered and discharged. He was readmitted because of lethargy and stuporous mentality 5 months later. Laboratory finding showed pancytopenia in peripheral blood smear and hypocellularity of all hematopoietic elements in bone marrow biopsy. Patient had been treated by s teroid and oxymetholone for a month before he died of sepsis
비글개에서 l-muscone의 급성독성 및 아급성독성시험 연구
유아선,권오경,성하정,곽형일,방명주,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of l-muscone, a major active ingredient of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dosage of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of l-muscone, 0.2㎎/㎏/day(low dosage group), 2 ㎎/㎏/day(middle dosage group), or 20 ㎎/㎏day(high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korean Food and Drug Administration(1996.4.16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ on oral route for both male and females. In animals administered with l-muscone, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, eye examination, hematology, serum chemistry, organ weight and other findings. No histolopathological lesions were observed in both control and treatment groups. Above data strongly suggest that l-muscone in beagle dogs is considered to be safe.
추간공 경유 경막외 차단술 환자의 합병증에 대한 조사 연구
최선주,배성열,서성화,김상대,김세훈,박정율 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
Objective: To study on the incidence of complications from C-arm guided lumbar transforarninal epidural injections in patients with radiculopathy caused by either lumbar spinal stenosis or herniated intervertebral disc. Materials & Methods: A total of 1200 patients with back/leg pain for more 3 months and received therapeutic injections in recent 1-year period was evaluated. All procedures were performed by one neurosurgeon with careful monitoring by nursing staffs during and after the procedures. Two party observers reviewed medical charts including immediate postprocedure complications using standardized questionnaire. Results: Average 1.9 injections per patient were done. Complications per injection seen included 12 transient headaches (0.9%), 5 increased back pain(0.4%), 4 increased leg pain(0.3%), 4 facial flushing(0.3%), 2 increased blood sugar in an insulin-dependent diabetic(0.2%), I vasovagal reaction(0.08%), and I hypertension(0.08%). All of these complications resolved within several hours to 2 weeks and there were no need for further specific management. There were no major or permanent complications. The incidence of minor complications was 2.3% per injection. All reactions resolved without morbidity. Conclusion: Although effectiveness varies with different pathologies, the C-arm guided lumbar transforaminal epidural injection seems to be a safe and effective procedure for these patients when carefully performed and closely observed with appropriate nursing care.
Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.
김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.