現下 韓國에 있어서 中小企業金融의 重要性과 그 方向 : 현하 한국에 있어서 중소기업금융의 중요성과 그 방향

김석현 釜山大學校 商科大學 1961 釜山商大學報 : 부산대 Vol.7 No.1

체외수정시술시 배아의 보조부화술을 이용한 임신율 향상에 관한 연구

김석현,김광례,채희동,이재훈,김희선,류범용,오선경,서창석,최영민,김정구,문신용,이진용,Kim, Seok-Hyun,Kim, Kwang-Rye,Chae, Hee-Dong,Lee, Jae-Hoon,Kim, Hee-Sun,Ryu, Buom-Yong,Oh, Sun-Kyung,Suh, Chang-Suk,Choi, Young-Min,Kim, Jung-Gu,Moon, S 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1

In spite of much progress in vitro fertilization and embryo transfer (IVF-ET) program, the pregnancy rate remains at 20-30%, and the endometrial implantation rate per embryo transferred at 10-15%. As a result, about 90% of embryos may fail to implant to the endometrium, and many attempts such as optimization of follicular development, improvement of in vitro culture system including coculture, and micromanipulation of zona pellucida have been made to improve embryonic implantation after IVF-ET. Recently, several procedures of assisted hatching (AH) using micromanipulation have been introduced, and pregnancies and births have been obtained after AH. To develop and establish AH as an effective procedure to improve embryonic implantation, AH with partial zona dissection (PZD) was performed in 116 cycles of 89 infertile couples who had previous repeated failures of standard IVF-ET more than two times (Group I: 71 cycles in 54 patients), or who had implantation failure of embryos with good quality (Group II: 15 cycles in 13), or who had undergone AH without specific indication (Group III: 30 cycles in 22) from January, 1995 to Februry, 1996, and the outcomes of AH were analyzed according to pregnancy rate. The number of oocytes retrieved after controlled ovarian hyperstimulation (COH) was $9.9{\pm}7.1$ in Group I, $11.5{\pm}4.5$ in Group II, and $7.9{\pm}6.4$ in Group III. The number of embryos transferred after AH was $4.7{\pm}1.8$ in Group I, $5.3{\pm}1.3$ in Group II, and $3.5{\pm}2.4$ in Group III. The mean cumulative embryo score (CES) was $56.8{\pm}30.0$ in Group I, $76.1{\pm}35.9$ in Group II, and $38.5{\pm}29.9$ in Group III. The overall clinical pregnancy rate per cycle and per patient was 12.7% (9/71) and 16.7% (9/54) in Group I, 33.3% (5/15) and 38.5% (5/13) in Group II, and 6.7% (2/30) and 9.1% (2/22) in Group III, respectively. There were significant differences in the numbers of oocytes retrieved and embryos transferred, CES, and the clinical pregnancy rate per cycle among three groups. There was a significant inverse correlation between basal serum FSH level and CES, and no pregnancy occurred in patients with CES less than 20. In conclusion, AH of human embryos with PZD prior to ET has improved the implantation and pregnancy rates in IVF-ET patients with the past history of repeated failures, especially in spite of transfer of embryos with good quality, and AH will provide a range of novel techniques which may contribute much to effective management of infertile couples.

Polydithiocarbamate 수지의 제조와 특성연구

金石鉉 울산과학대학 1985 연구논문집 Vol.10 No.2

교체형 수지의 제조와 흡착특성에 관해서 검토하였다. 수지는 경금속 존재하에서 Hg^(2+), Pb^(2+)와 같은 중금속 선택성이 크며 pH 4∼8에서 금속과 안정하게 배위한다. 또한 우라늄의 흡착능도 크게 나타났다. 수지의 흡착엔탈피는 8∼27KJ mole^(-1) 정도이며 금속흡착은 단순한 물리적 흡착이나 이온교환반응이 아닐것으로 추정된다. Preparation and adsorption properties of solid form resin was investigated. The resin has appreciable selectivity for the heavy metal ions such as Hg^(2+), Pb^(2+) in the presence of light metal ions and showed to coordinate metal with high stability at pH 4∼8 range. It was observed that uranyl ion also has great adsorptivity. Enthalphy change of metal adsorption showed the order of 8∼27KJ·mole^(-1), which eliminate the possibility of physical adsorption or ion exchange reaction.

바이오칩의 국내 특허동향

김석현 한국바이오벤처협회 2003 Bio news Vol.1 No.-

2001년도 식품관련 특허출원동향

김석현 한국바이오벤처협회 2003 Bio news Vol.3 No.-

直接 接觸方式 熱 및 物質交換 裝置의 傳達現象(I)

金錫賢 大韓機械學會 1984 大韓機械學會誌 Vol.24 No.5

체외수정시술 후 임신된 환자에서 혈중 ${\beta}-hCG$ 측정에 의한 임신 결과 예측에 관한 연구

김석현,서창석,최두석,최영민,신창재,김정구,문신용,이진용,장윤석,Kim, Seok-Hyun,Suh, Chang-Suk,Choi, Doo-Seok,Choi, Young-Min,Shin, Chang-Jae,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1

Serum level of ${\beta}$ subunit of human chorionic gonadotropin (${\beta}-hCG$) was studied to evaluate its predictability of pregnancy outcome in 98 in vitro fertilization and embryo transfer(IVF-ET) patients using gonadotropin-releasing hormone(GnRH) agonist. Serial serum ${\beta}-hCG$ levels were established for 42 singleton pregnancies, 20 normal multiple pregnancies, 18 preclinical abortions, 14 clinical abortions and 4 ectopic pregnancies. In comparison to normal singleton pregnancies, multiple pregnancies showed significantly higher ${\beta}-hCG$ levels on the post-ET day 10 to 13 and day 24 to 25. Clinical abortions did not show significantly lower ${\beta}-hCG$ levels in early pregnancy except the post-ET day 16-17, but showed significantly lower ${\beta}-hCG$ levels from the post-ET day 22, compared with singleton pregnancies. Preclinical abortions showed significantly lower ${\beta}-hCG$ levels than those of singleton pregnancies. Ectopic pregnancies showed lower ${\beta}-hCG$ levels than those of singleton pregnancies without statistical significance. In conclusion, determination of serum ${\beta}-hCG$ level in early pregnancy is a useful tool for the prediction of preclinical abortions and multiple pregnancies and serial measurement of serum ${\beta}-hCG$ levels will be helpful in predicting clinical abortion.

생식세포 난관내이식시 잉여난자의 체외수정 결과에 따른 임신 예측도

김석현,전종관,신창재,김정구,문신용,이진용,장윤석,Kim, Seok-Hyun,Jun, Jong-Kwan,Shin, Chang-Jae,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1

By means of the results of In vitro fertilization(IVF) of supernumerary oocytes, the possibility of predicting a pregnancy outcome following gamete intrafallopian transfer(GIFT) and the prognostic implications for future pregnancy were evaluated in 46 GIFT cycles excluding simultaneous program of GIFT and IVF from February, 1989 to July, 1991. IVF of supernumerary oocytes were identified in 21 cycles, but not in remaining 25 cycles. There was no significant difference in age, duration and etiologic factors of infertility, and serum levels of FSH, LH and $E_2$ on MCD #3 and $E_2$ on the day of hCG injection between fertilized(N=21) and unfertilized group(N=25). The number of oocytes retrieved was similar in both groups. The number of supernumerary oocytes available for IVF after transfer was $5.43{pm}2.95$ ranging from 2 to 12. The prenancy rate in fertilized group, 33.3%(7/21), was higher without statistical significance, compared with 8.0%(2/25) in unfertilized group. Using IVF of supernumerary oocytes as a test of pregnancy following GIFT, sensitivity was 77.8 %; specificity, 61.2%; positive predictive value(PPV), 33.3%; negative predictive value(NPV), 92%. The fertilization rate of supernumerary oocytes in pregnant group, $86.4{\pm}22.8%$ was significantly higher compared with $56.1{\pm}20.2%$ in nonpregnant group. In cases with fertilization rate ${\geq}80%$, pregnancy was expected with PPV of 85.7%. In conclusion, IVF of supernumerary oocytes in GIFT program can be a profitable method as a prognostic indicator of pregnancy following GIFT. More aggressive diagnostic and therapeutic measures should be performed in cases with failure in IVF of supernumerary oocytes.

2006년 하천정책 추진방향

김석현,Kim, Seok-Hyeon 한국하천협회 2006 하천과 문화 Vol.2 No.2

등가 종 모델을 이용한 맥놀이 주기 조절법

김석현,이중혁,Kim, Seock-Hyun,Lee, Joong-Hyeok 한국음향학회 2012 한국음향학회지 Vol.31 No.8

This study proposes a method of an equivalent bell model in order to tune the beat period of a Korean bell. In a Korean bell having a slight asymmetry, each circumferential mode splits into a mode pair which has a slight difference in frequency, and the interaction of the mode pair makes a beat in vibration and sound. An equivalent bell model which consists of an axi-symmetric bell and an equivalent point mass, has the same mode property as in a real bell. The equivalent bell model is constructed by the finite element analysis based upon the theory of a revolutionary shell. Using the equivalent bell model, the beat period is predicted when the bell thickness is locally decreased to improve the beat property. The predicted result is verified by experiment on a test bell. The proposed method is useful to save the time required for tuning the beat period of a large bell.